Puromycin analogs. Aminoacyl derivatives of 9-(3'-amino-3'-deoxy-beta-D-arabino-furanosyl)adenine.
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Methods↗
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The synthesis of certain 9-(3-acylamino-3-deoxy-beta-D-ribofuranosyl)-6-dimethylaminopurines, analogues of the antibiotic puromycin.
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Adenine↗
Branched-chain N-sugar nucleosides. 2. Nucleosides of 3-C-cyanomethyl-, carboxamidomethyl-, and N,N-dimethylcarboxamidomethyl-3-deoxyribofuranose. Synthesis of a homolog of the amino sugar nucleoside moiety of puromycin.
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Amino Sugars↗
High-yield immobilization of a puromycin analogue for the solid support synthesis of aminoacyl-tRNA fragments.
[reaction: see text] An efficient procedure for the immobilization of 3'-deoxy-3'-(O-methyltyrosyl)aminoadenosine was developed. A poly(ethylene glycol)-derived diacid linker/spacer was attached to aminomethyl polystyrene. Coupling of the 2'-hydroxy instead of the 2'-O-succinylated ribonucleoside resulted in high immobilization yields (over 80%) and allowed for the recovery of valuable unreacted material. This specific procedure should be applicable to other ribonucleosides containing a bulky modification at the 3'-position and can be used for the stepwise construction of 3'-aminoacyl- or 3'-peptidyl-RNA conjugates.
Adenosine↗
Effect of ECS and puromycin on memory in fish.
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Animals↗
Structural requirements for puromycin inhibition of protein synthesis.
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Anti-Bacterial Agents↗
Inhibition of the biological action of thyroid hormones by actinomycin D and puromycin.
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Anti-Bacterial Agents↗
Effect of puromycin on the replication of Western equine encephalitis and poliomyelitis viruses.
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Animals↗
Stimulation of Sendai virus multiplication by puromycin and actinomycin D.
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Antimetabolites↗
Induction of enzyme activity in pea tissues by animal hormones and by puromycin.
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Aspartic Acid↗
Release of peptide chains from rat liver polysomes by the N,N-dimethyl-p-methoxy-L-phenylalanyl analogue of puromycin.
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Animals↗
Effects of actinomycin D and puromycin on chromosomes of cultured human leukocytes.
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Cell Division↗
Inhibition by puromycin of incorporation of tritiated uridine into nucleolar and cytoplasmic ribonucleic acids.
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Cell Nucleolus↗
Effects of puromycin and actinomycin D on the increase of cystathionase and cysteine sulphinic acid decarboxylase activities in the liver of thyroidectomized rat.
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Animals↗
Effect of puromycin on insulin-stimulated amino-acid transport in muscle.
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Amino Acids↗
Differential effects of actinomycin D and puromycin on the release of interferon induced by double stranded RNA.
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Animals↗
Puromycin stimulation of rat liver ornithine decarboxylase activity.
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Animals↗