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PubMed1953

Psittacosis among birds in South Australia. I. A survey of infection in some common species in 1951 and 1952.

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Animals↗

PubMed1956

Clinical variations in the diagnosis of psittacosis.

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Humans↗

PubMed1964

A VIROLOGIC STUDY OF CHRONIC BRONCHITIS.

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Adenoviridae Infections↗

PubMed1952

Factors related to the growth of psittacosis virus (strain 6BC). I. Pteroylglutamic acid, vitamin B12, and citrovorum factor.

The inhibitory action of sodium sulfadiazine on the growth of psittacosis virus (6BC) in embryonated eggs is readily reversed by citrovorum factor but not by small amounts of vitamin B(12). In embryonated eggs, the pteroylglutamic acid analogues, 9-methylpteroylglutamic acid and 4-aminopteroylaspartic acid, produced some suppression of the growth of psittacosis virus (6BC). 4-Aminopteroylglutamic add, 4-amino-N(10)-methylpteroylglutamic acid, and 4-aminopteroylaspartic acid inhibited the growth of this virus in tissue cultures at concentrations which were not toxic for the host tissue. The inhibitory action of 4-amino-N(10)-methylpteroylglutamic acid and 4-aminopteroylaspartic acid was readily overcome by addition of citrovorum factor. Growth of meningopneumonitis virus in embryonated eggs or tissue culture is suppressed by 4-aminopteroylaspartic acid. The advantages of the tissue culture technic for studies on the growth of viruses are discussed.

Chlamydophila psittaci↗

PubMed1952

Factors related to the growth of psittacosis virus (strain 6BC) II. Purines, pyrimidines, and other components related to nucleic acid.

In various amounts and mixtures, adenine, guanine, xanthine, hypoxanthine, thymine, thymidine, cytidylic acid, and an enzymatic digest of desoxyribonucleic acid all failed to influence the inhibition by sulfadiazine of the growth of psittacosis virus (6BC) in embryonated eggs. A number of purine analogues, including benzimidazole, 2,6-diaminopurine, and 8-azaguanine, inhibited the growth of psittacosis virus (6BC) in tissue cultures at concentrations which had no obvious toxic effects on the host tissues. The virus inhibitory action of 2,6-diaminopurine was reversed by addition of adenine and that of 8-azaguanine by guanine. The growth of psittacosis virus (6BC) was inhibited by the pteridine compounds 2-ammo-4-hydroxy-6-formylpteridine and xanthopterin, while other related substances had little or no inhibitory activity. Xanthine reversed the inhibitory effects of 2-amino-4-hydroxy-6-formylpteridine. There was no correlation between the inhibitory activity of the pteridines on xanthine oxidase and multiplication of the virus.

2-Aminopurine↗

PubMed1953

Psittacosis.

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Psittacosis↗

PubMed1964

PLAQUE ASSAY FOR PSITTACOSIS VIRUS IN MONOLAYERS OF CHICK EMBRYO FIBROBLASTS.

Piraino, F. (City of Milwaukee Health Department, Milwaukee, Wis.), and C. Abel. Plaque assay for psittacosis virus in monolayers of chick embryo fibroblasts. J. Bacteriol. 87:1503-1511. 1964.-A tissue culture system for the assay of 6BC psittacosis virus by plaque production on chick embryo fibroblast cells is described. Experiments are given which characterize the specificity of the reaction and identify factors found to cause variations in plaque counts. The statistical data obtained indicate this assay to be a precise and highly reliable procedure for the detection of 6BC virus and antibody.

Antibodies↗

PubMed1965

FLUORESCENT CELL-COUNTING NEUTRALIZATION TEST FOR PSITTACOSIS.

Hahon, Nicholas (Fort Detrick, Frederick, Md.), and Kenneth O. Cooke. Fluorescent cell-counting neutralization test for psittacosis. J. Bacteriol. 89:1465-1471. 1965.-A sensitive, precise, and specific serological procedure, the fluorescent cell-counting neutralization test, was developed to detect and to measure quantitatively psittacosis serum-neutralizing antibodies within 24 hr. The test is based on the reduction of fluorescent cells in McCoy cell monolayers resulting from the neutralization of infective agent particles by specific antiserum. Small but significant rises in neutralizing titers were measured in serum specimens from monkeys previously exposed to the psittacosis agent and from humans with diagnoses of subclinical or established psittacosis infections.

Animals↗

PubMed1952