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At least 847 records · Page 47Linked to original sources
PubMedDate not supplied

[Anabolic effects of sodium selenite, vitamin E and retabolil in experimental hypotrophy induced by a pesticide].

Forty Chinchilla rabbits of both sexes were examined for changes in some parameters of protein, lipid and trace elements metabolism (total protein, protein fractions, urea, residual nitrogen in blood serum, lipids, total cholesterol, free cholesterol, diglycerides, phospholipids, triglycerides, free fatty acids and the trace elements selenium, iron, zinc and so forth in the liver) during the animals' poisoning with the defoliant magnesium chlorate. A study was made of the effect on these changes of the administration for 3 weeks of sodium selenite (15 micrograms/kg), vitamin E (25 mg/kg) and retabolil (2 mg/kg once a week). It has been established that the combined administration of these agents removes and prevents the changes in protein, lipid and trace elements (hypoproteinemia, dysproteinemia and impairment of the nitrous balance) and lipid metabolism because of the animals' poisoning with magnesium chlorate.

Anabolic Agents↗
PubMedDate not supplied

[The effect of protein enpit and retabolil on the physical development of young children, patients with prenatal hypotrophy and encephalopathies].

Combined treatment with protein enpit and retabolil was conducted in infants with prenatal hypotrophy and encephalopathy (42 infants). The combined treatment led to a rise in the mean daily increase in body mass, length. Positive dynamics of the physical development lasted during 3 months after the combined treatment was finished.

Body Weight↗
PubMed1988

[Effect of various biologically active substances and hormonal preparations on the pathogenetic mechanisms of manic-depressive psychoses].

Combined investigation in patients with maniac-depressive psychosis revealed the close relation of depression to the direction in which changes of central and peripheral links of bodily neurohumoral system occur. With even some of the homeostatic functions normalized as a result of an adaptogenic effect of hormonal and biologically active drugs (triiodothyronine, thyrotropin, insulin, Sodium succinate, pituitrin (vasopressin), somatotropin, retabolil), the depressive affect weakened or disappeared. Combined therapy of depression is recommended comprising antidepressants and some hormonal drugs promoting the adaptation processes of the body.

Action Potentials↗
PubMedDate not supplied

[Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats].

Impairments of protein metabolism, expressed as predominance of catabolism over anabolism and hypoproteinemia, were observed in one month old rats with experimental burns of the IIIA-IIIB degree, when 20-25% of a body surface was impaired. After administration of steroid drugs (retabolyl at a dose of 1 mg/100 g of body mass or oxymetacyl--4-methyl-5-oxyuracil---at a dose of 5 mg/100 g of body mass) content of protein and urea normalized in blood serum, activity of cathepsin D decreased in tissues, the rate of 35S-methionine incorporation into tissue proteins increased. The pyrimidine derivative oxymetacyl exhibited higher effect on protein metabolism in burns of preadolescent rats as compared with retabolyl.

Aging↗
PubMed1986

[Experimental substantiation of the treatment of patients with rheumatoid arthritis with prednisolone and its combination with retabolil (clinico-experimental study)].

Fifty RA patients receiving prednisolone and prednisolone combined with retabolil were examined. Prednisolone made a negative effect on central hemodynamics, the effect being less with the use of retabolil. A dystrophic action of prednisolone on the myocardium and the weakening of this effect in a combined use of prednisolone and retabolil were shown on a RA model in rabbits.

Adult↗
PubMed1987

[The effect of ratibol, retabolil and solasodin on the blood coagulation system].

It has been established that ratibol, retabolil and solasodin in doses 5 and 10 mg/kg proved to have a slight anticoagulative effect. The same effect has been observed during 20 days of oral retabolil and solasodin intake. Ratibol was characterized by a two-step action. All three steroids activated factors II, VII, XIII and diminished factor I concentration. These changes were accomplished with the fall of antithrombin activity and decrease in resistance to streptokinase. The fibrinolysis level has been raised under the effect of the steroids studied.

Androstenols↗
PubMed1987

[Hormonal homeostasis (somatotropin, thyrotropin, triiodothyronine and cortisol) and the histomorphologic indicators of the gastric mucosa during treatment with preparations enhancing protein synthesis (alvesin-new and retabolyl)].

The paper is devoted to a study of hormonal homeostasis and indices of histomorphological and endoscopic examination of the gastric mucosa in 96 patients with stomach ulcer with ulcerative defect of different site using the combination of an anabolic steroid nandrolene and alvezine-new. The incorporation of anabolic steroids and alvezine in multiple modality therapy was accompanied by a rise of epithelial mitotic activity, faster disappearance of inflammatory and dystrophic processes in the gastric mucosa and improved differentiation of cells of the main glands. A positive time course of histochemical indices was accompanied by favorable shifts in clinical signs of disease and hormonal homeostasis.

Adult↗
PubMedDate not supplied

[Effect of sodium selenite, vitamin E and retabolil alone and in combination on certain parameters of protein metabolism in experimentally hypotrophic rats of different ages].

Two types of hypotrophy (complete starvation and aurantin administration) were simulated in experimental rats. Significant changes were revealed in certain parameters of protein metabolism (decreased content of total protein, RNA and DNA in the blood, liver and skeletal muscles, dysproteinemia) leading to the drop in the mass of the body and internal organs of the test animals. The degree of these disorders expression was studied in relation to the hypotrophy genesis and the animals age. It was shown that the shift in the protein metabolism taking place in hypotrophy could be corrected with the use of sodium selenite, vitamin E, retabolil and their varying combinations.

Animals↗
PubMedDate not supplied

[Possibilities for pharmacological correction of regional osteoporosis in an unsupported extremity].

In 20- and 40-day rat studies the prophylactic effect of retabolil and calcitrin (calcitonin) against hypodynamics-induced osteoporosis was investigated. Hypodynamics was produced by surgical amputation of the lower third of the leg and hence by loss of the support function of the limb. Retabolil was injected intramuscularly at a dose of 0.2 ml once a day for 10 days and calcitrin was injected subcutaneously at a dose of 2 units MRC in 0.5 ml distilled water once a day. The results indicate that osteoporosis in the supportless bone of the experimental animals and that seen during space flight developed in a similar way. In the experiment retabolil and calcitrin inhibited the progressive development of osteoporosis but the strongest effect was obtained upon a combined application of the two drugs.

Amputation, Surgical↗
PubMed1986

[Course of Duchenne muscular dystrophy and its treatment].

The results of a 12 month follow-up of 3 groups of age-matched children (7 boys in each group) with an identically malignant course of Duchenne's myodystrophy determined by means of a genealogical analysis are presented. The fastest progression of the disease was observed in children receiving conventional treatment. Untreated children showed slower progression of the disease. In patients on allopurinol treatment the process was somewhat checked or there was some regression of symptomatology.

Allopurinol↗