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Plasma corticosterone in stressed magnesium-deficient weanling rats.

A study was undertaken to learn whether the young Mg-deficient mammal can respond to major stress with increased levels of plasma corticosterone. Plasma corticosterone was determined in 48 weanling rats with dietary Mg deficiency and in 48 Mg-sufficient controls fed a Mg-supplemented diet, studying 12 animals at a time on experimental day 14. Each animal was studied once, either in an unstressed state or after the stress of audiogenic or strychnine seizures. Plasma corticosterone was determined using a radioimmunoassay; Mg was analyzed by atomic absorption spectrophotometry. On experimental day 14, unstressed Mg-deficient rats were tremulous, hyperirritable and showed slightly increased plasma corticosterone levels that exceeded controls levels. After strychnine shock, the mean plasma corticosterone levels of Mg-sufficient and Mg-deficient rats were both significantly increased over resting levels, and were not statistically different. Moreover, the spontaneous mortality rate that occurred during the experimental period in all Mg-sufficient rats was 0 compared to 27% among all Mg-deficient animals (p less than 0.0001). It was concluded that young rats deficient in Mg for 2 weeks could respond to major stress with levels of plasma corticosterone that were not significantly different from values of equally stressed Mg-sufficient controls. The deficient animals suffered a higher mortality, providing support for the concept that Mg deficiency increases stress-induced mortality in animals.

Animals↗
PubMed1994

Magnesium deficiency in the eosinophilia-myalgia syndrome. Report of clinical and biochemical improvement with repletion.

We describe a patient with the eosinophilia-myalgia syndrome (EMS) with persistent myalgias, cramping, and weakness that were not responsive to treatment. Despite a normal serum magnesium level, a loading study was performed, and the results suggested low tissue levels of magnesium. He was given parenteral magnesium and had dramatic improvement in symptoms as well as in muscle intracellular levels of this cation. After cessation of magnesium therapy the symptoms recurred, and magnesium repletion again led to an improvement in symptoms and ATP levels. Low tissue levels of magnesium, even in the setting of normal serum levels, may lead to the neuromuscular symptoms in EMS and related disorders.

Adenosine Triphosphate↗
PubMed2004

Development of cellular magnesium nano-analysis in treatment of clinical magnesium deficiency.

A novel technique, using energy dispersive X-ray microanalysis (EXAtm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg2+ is found in the intravascular space, serum levels of Mg2+ give little information about a patient's overall Mg2+ status with respect to this essential mineral. Using the EXAtm analysis it has shown been determined that Mg2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg2+]i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg2+ deficiency. Examples of the application of EXAtm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA.

Animals↗