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PubMed1977

[Studies on the effects of intravenous administration of glucose, fructose, invertose and sorbitol on various blood constituents of blood plasma (monosaccharides, insulin, lactate, pyruvate and free fatty acids as well as glutamate-oxaloacetate transaminase) in the horse].

Horses were examined for the behaviour of various blood constituents prior to and following infusions of solutions of glucose, fructose, invertose, and sorbitol. Infusion of 0.5 g/kg live weight glucose to six horses was followed by half-life variation between eleven and 23 minutes. Subsequent infusion of invertose to the same animals usually caused prolongation of glucose half-life. Half-life values were between 17 and 33 minutes for fructose and between 21 and 80 minutes for glucose. Infusion of 0.5 g/kg live weight fructose to two horses was followed by half-life values between 17 and 18 minutes, while the half-life values of sugar alcohol were 16, 16, 27, and 29 minutes in four horses who had received sorbitol. Sugar or sorbitol infusion was not followed by substantive change of lactate and pyruvate concentrations in the blood or free fatty acids in the blood plasma or GOT activity. The rise of insulin in the blood plasma was differentiated. Invertose and sorbitol solutions, consequently, can be recommended for application to horses.

Animals↗
PubMed1981

[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy patients, patients with liver diseases and diabetic patients. I. Physiopathologic aspects in the parenteral administration of monosaccharides].

The biochemical basis of the metabolism of glucose and non-glucose-carbohydrates (fructose, sorbitol, xylitol) is presented. The potential draw backs of the parenteral application of large doses of these carbohydrates in internally ill patients, based on the results of experiments with isolated perfused livers or animals and case reports, are reviewed. These considerations form the basis for investigations in internally ill patients (liver cirrhosis, diabetes mellitus) and healthy controls in order to find out if low dose, long term, parenteral infusion of glucose or mixtures of glucose with non-glucose-carbohydrates are applicable to these patients without major side effects. The results of these investigations will be published in following papers.

Blood Glucose↗
PubMed1982

Protein glycosylation in Trypanosoma cruzi. I. Characterization of dolichol-bound monosaccharides and oligosaccharides synthesized "in vivo".

Trypanosoma cruzi cells, the causative agent of Chagas disease, incubated with [U-14C]glucose in the presence of 5 mM sodium pyruvate or 5.5 mM glucose, were found to synthesize Man9GlcNAc2-P-P-dolichol as the main and largest dolichol disphosphate derivative. No traces of glucosylated derivatives or of dolichol-bound oligosaccharides with a size larger than that of a Man9GlcNAc2 standard could be detected in any case. The synthesis of mannose-P-dolichol but not that of glucose-P-dolichol was found to occur in vivo in these cells. The inability to synthesize glucose-P-dolichol may explain the absence of glucosylated dolichol diphosphate derivatives. The lipid moiety of the dolichol derivatives appeared to have about 13 isoprene residues, the first of which was saturated.

Animals↗
PubMed1981

[Interest of the determination of reference values for the monosaccharide composition of the human erythrocyte membrane (author's transl)].

The carbohydrate composition of the human erythrocyte membrane was just established ten years ago. Carbohydrates have crucial functions in the membrane structures and the determination of this composition may have an important semeiological signification. In this way, reference values are necessary. The existence of possible variations of the composition with two physiological parameters: the groups in the ABO system and the age of erythrocytes have been investigated and are reported. Their repercussion on the determination of reference values is discussed.

Blood Group Antigens↗