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At least 847 records · Page 47Linked to original sources
PubMed2003

[Functional significance of "blind" outgrowths of the lymphatic capillary network].

The work was aimed at the study of the structural peculiarities of "blind" outgrowths of the lymphatic capillaries and to define their role in the pathogenesis of some diseases. In experiments performed in rabbits by studying the resorption of colloidal solutions, suspensions and hen's blood the subsidiary functional significance of the portion of "blind" outgrowths of the lymphatic capillary network of tendinous center of diaphragm was established. The clavate outgrowths with the narrow mouth may accumulate and store the exogenous material in their lumen. It is concluded that they may accumulate the microorganisms that provoke the relapses of diseases.

Animals↗
PubMed2005

The effectiveness of long-acting penicillin (penidur) in preventing recurrences of dermatolymphangioadenitis(DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema.

Dermatolymphangioadenitis (DLA) is a common and serious complication of so-called "filarial" and bacterial non-filarial lymphedema of the limb, affecting skin, lymphatics and lymph nodes. In our previous studies, we demonstrated that more than 60% of patients revealed presence of bacterial isolates in deep tissues, tissue fluid and lymph from the lymphedematous limbs. The question remained open whether elimination or suppression of bacteria dwelling in lymphedematous tissues by administration of low doses of penicillin for long time periods would prevent recurrence of DLA attacks. In this study, we retrospectively evaluated a self/community-selected group of patients with lymphedema of the lower limbs with respect to the efficacy of long-acting penicillin in preventing episodes of DLA. There were no microfilariae or anti-filarial antibodies detected in the investigated group. The questions we asked were: (a) how effective is the benzathine penicillin in preventing recurrences of DLA attacks and (b) how does its long-term administration influence the bacterial spectrum of leg skin, deep tissues, lymph and lymph nodes and sensitivity to antibiotics. Two randomly selected groups of patients, receiving and not receiving penicillin during the same period of time, were compared. Evidently lower recurrence rate of DLA was observed in the treated group (p < 0.002). There was increased prevalence of cocci and gram-positive bacilli with a concomitant decrease of gram-negative bacilli on the foot and calf skin surface. Simultaneously, decreased prevalence of gram-positive cocci and gram-negative bacilli isolates in limb deep tissues and lymph was seen. No resistance to penicillin and other tested antibiotics developed in isolates from the skin surface, deep tissues and lymph. We conclude that long-lasting penicillin is effective in preventing recurrent DLA attacks.

Adult↗
PubMed2006

[Clinical features and diagnosis of pulmonary lymphangitic carcinomatosis].

BACKGROUND & OBJECTIVE: Pulmonary lymphangitic carcinomatosis (PLC) is a special type of pulmonary metastasis of carcinoma. It is easy to be misdiagnosed as other pulmonary interstitial diseases. This study was to discuss the clinical features of PLC, and provide experience information for diagnosis, differentiated diagnosis, and evaluation of prognosis of PLC. METHODS: A retrospective comparison analysis was performed on 43 PLC patients with pathologic diagnosis and 46 patients with other pulmonary interstitial diseases with clear etiology in the first affiliated hospital of Sun Yat-sen University within the past decade. RESULTS: In PLC group, 20 patients were found with primary lung cancer; 23 patients were found with primary non-pulmonary carcinoma: 9 cases of breast cancer, 8 cases of large intestinal carcinoma, and 6 cases of gastric carcinoma. The changes of imaging included linear and radiating appearances from the hilum to the outer part even extending to the pleura with nodules, ground-glass opacity of the lung. Enlargement of lymph nodes in mediastinum was present in 51.2% (22/43) and that in pleural effusion was present in 53.5% (23/43) of patients. Extrapulmonary manifestations (metastasis) included 19 cases (44.2%) of lymph nodes to the supraclavicular region, axillary fossa, and post-peritoneal region, 15 cases (34.9%) to the pleura, 9 cases (20.9%) to the bones, 6 cases (14.0%) to the liver, 3 cases (7.0%) to the pericardium, and 3 cases (7.0%) to the brain. The elevated serum level of CEA was commonly observed (23/43, 53.5%). Respiratory manifestations of PLC, such as coughing, panting, dyspnea, and so on, could not be cured by anti-spasm treatment. The development of PLC was so progressive that 31 patients (72.1%) were followed for only 2-7 months before death. The changes of imaging in other pulmonary interstitial disease group included irregular linear or reticular appearances, enlargement of lymph nodes in the mediastinum and hilum, and extrapulmonary manifestations like pleural effusion were not observed. Respiratory manifestations, such as coughing, panting, dyspnea, and so on, could be cured by anti-spasm treatment. Moreover, the development of PLC was relatively slow. CONCLUSIONS: PLC often occurs in patients with primary carcinoma in lung, breast, large intestine, stomach, and so on. More attention should be paid to the diagnosis of PLC in patients who have pulmonary interstitial lesions as described above, and whose respiratory symptoms could not be relieved by anti-spasm treatment and developed progressively. The prognosis of PLC is poor.

Adult↗
PubMed1989

Pulmonary involvement in infectious mononucleosis: histopathologic features and detection of Epstein-Barr virus-related DNA sequences.

Symptomatic pulmonary parenchymal involvement is rare in infectious mononucleosis, and few pathologic descriptions of this lesion exist. We describe an unusual patient who presented with adenopathy and rapidly progressive interstitial lung disease. An open lung biopsy showed a predominantly interstitial infiltrate of mononuclear cells distributed along lymphatic routes. A patchy alveolar exudate was also seen. Biopsy of a paratracheal lymph node showed paracortical hyperplasia typical of infectious mononucleosis. The diagnosis was suspected only after thoracotomy and was established by appropriate serological studies for Epstein-Barr virus. Epstein-Barr virus genomic sequences were also detected within routinely processed lung and lymph node tissues using polymerase chain reaction technology. Infectious mononucleosis should be considered in the differential diagnosis of certain lymphoid lung lesions.

Antigens, Viral↗
PubMed1989

Changes in complement C3 levels following treatment of patients with Brugia malayi infection.

Serum IgG levels and complement C3 levels were assayed on Day 0, 1, 3-4, 7 and 56-70 post-treatment with diethylcarbamizine citrate (DEC) in a series to 26 patients with Brugia malayi infection and 6 volunteers without infection. On treatment, the microfilariae were cleared from the blood within 24 hours. The eosinophils decreased dramatically on Day 1 post-treatment but increased rapidly by Day 4 to 7 and then dropped to normal levels in 45 days. The serum IgG mean levels decreased briefly following treatment with DEC but then returned to original levels. However, the complement C3 levels gradually increased over the 2 months period of study reaching statistical significance levels (p less than 0.01) in patients with initial high blood microfilariae. The observation suggests that Brugia malayi infection probably induces a high rate of synthesis of complement C3 and this process continued in the post-treatment phase. Since, DEC treatment did not cause a decrease in complement C3 with the elimination of blood microfilariae, it would appear that the complement C3 is consumed following antibody attachment to the microfilariae as they enter the blood circulation.

Adult↗