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PubMed1995

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels.

NMDA receptors, ATP receptors, and nicotinic ACh receptors respond to agonist by undergoing conformational changes that open weakly selective cationic channels that are permeable to calcium. We determined the fraction of the current carried by calcium by simultaneously measuring membrane current using whole-cell patch-clamp techniques and intracellular Ca2+ using the fluorescent indicator Fura-2. The Fura-2 response to free Ca2+ was calibrated individually for each cell. Two different calibration methods are compared: one uses voltage-activated Ca2+ channels, and the other uses the same ligand-gated channels that are being tested but in a pure Ca2+ solution. The two methods give quantitatively different results. The method using pure Ca2+ currents through ligand-gated channels calibrates the Fura-2 signal through the same influx pathway that generates the test response, thus controlling for the distribution of channels and ensuring a similar interaction between the incoming Ca2+ and Fura-2. In a physiologic solution containing 2.5 mM Ca2+ at a holding potential of -50 mV, the percentage of inward current carried by Ca2+ through NMDA receptors in hippocampal neurons is 12.4%. By comparison, in sympathetic neurons the percentage of current carried by Ca2+ through neuronal nAChRs is 4.7%, and through ATP-activated purinergic receptors it is 6.5%. These percentages can be used to estimate the amount of Ca2+ entry through these receptors during synaptic activation, but care must be exercised in considering the many subtypes of each receptor.

Adrenal Medulla↗
PubMed2000

Socio-economic deprivation and stage of disease at presentation in women with breast cancer.

BACKGROUND: This study describes and compares the pathological prognostic factors and surgeon assessment of stage of breast cancer of women living in affluent and deprived areas to assess whether clinical stage at presentation may explain the known poorer survival outcomes for deprived women. PATIENTS AND METHODS: A population-based review of the case records of 417 women with breast cancer was carried out. RESULTS: No difference in pathological criteria was found between the 88% of women living in affluent and deprived areas for whom such data were available. Clinical assessment of the remaining 50 cases showed that women living in deprived areas were more likely to present with locally advanced or metastatic disease. CONCLUSION: The poorer survival of women from deprived areas with breast cancer may be explained by more deprived women presenting with advanced cancers.

Breast Neoplasms↗
PubMed2006

High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity.

Homologous recombination plays a key role in generating genetic diversity, while maintaining protein functionality. The mechanisms by which RecA enables a single-stranded segment of DNA to recognize a homologous tract within a whole genome are poorly understood. The scale by which homology recognition takes place is of a few tens of base pairs, after which the quest for homology is over. To study the mechanism of homology recognition, RecA-promoted homologous recombination between short DNA oligomers with different degrees of heterology was studied in vitro, using fluorescence resonant energy transfer. RecA can detect single mismatches at the initial stages of recombination, and the efficiency of recombination is strongly dependent on the location and distribution of mismatches. Mismatches near the 5' end of the incoming strand have a minute effect, whereas mismatches near the 3' end hinder strand exchange dramatically. There is a characteristic DNA length above which the sensitivity to heterology decreases sharply. Experiments with competitor sequences with varying degrees of homology yield information about the process of homology search and synapse lifetime. The exquisite sensitivity to mismatches and the directionality in the exchange process support a mechanism for homology recognition that can be modeled as a kinetic proofreading cascade.

Adenosine Triphosphate↗
PubMed2005

Wider income gaps, wider waistbands? An ecological study of obesity and income inequality.

OBJECTIVES: To see if obesity, deaths from diabetes, and daily calorie intake are associated with income inequality among developed countries. DESIGN: Ecological study of 21 developed countries.Countries: Countries were eligible for inclusion if they were among the top 50 countries with the highest gross national income per capita by purchasing power parity in 2002, had a population over 3 million, and had available data on income inequality and outcome measures. MAIN OUTCOME MEASURES: Percentage of obese (body mass index >30) adult men and women, diabetes mortality rates, and calorie consumption per capita per day. RESULTS: Adjusting for gross national per capita income, income inequality was positively correlated with the percentage of obese men (r = 0.48, p = 0.03), the percentage of obese women (r = 0.62, p = 0.003), diabetes mortality rates per 1 million people (r = 0.46, p = 0.04), and average calories per capita per day (r = 0.50, p = 0.02). Correlations were stronger if analyses were weighted for population size. The effect of income inequality on female obesity was independent of average calorie intake. CONCLUSIONS: Obesity, diabetes mortality, and calorie consumption were associated with income inequality in developed countries. Increased nutritional problems may be a consequence of the psychosocial impact of living in a more hierarchical society.

Adult↗
PubMedDate not supplied

A new scale for assessing perceptions of chance: a validation study.

BACKGROUND: Clinicians and researchers often wish to know how patients perceive the likelihoods of health risks. Little work has been done to develop and validate scales and formats to measure perceptions of event probabilities, particularly low probabilities (i.e., <1%). OBJECTIVE: To compare a new visual analog scale with three benchmarks in terms of validity and reliability. DESIGN: Survey with retest after approximately two weeks. Respondents estimated the probabilities of six events with the new scale, which featured a "magnifying glass" to represent probabilities between 0 and 1% on a logarithmic scale. Participants estimated the same probabilities on three benchmarks: two linear visual analog scales (one labeled with words, one with numbers) and a "1 in x" scale. SUBJECTS: 100 veterans and family members and 107 university faculty and students. MEASURES: For each scale, the authors assessed: 1) validity-the correlation between participants' direct rankings (i.e., numbering them from 1 to 6) and scale-derived rankings of the relative probabilities of six events; 2) test-retest reliability-the correlation of responses from test to retest two weeks later; 3) usability (missing/ incorrect responses, participant evaluation). RESULTS: Both the magnifier and the two linear scales outperformed the "1 in x" scale on all criteria. The magnifier scale performed about as well as the two linear visual analog scales for validity (correlation between direct and scale-derived rankings = 0.72), reliability (test-retest correlation = 0.55), and usability (2% missing or incorrect responses, 65% rated it easy to use). 62% felt the magnifier scale was a "very good or good" indicator of their feelings about chance. The magnifier scale facilitated expression of low-probability judgments. For example, the estimated chance of parenting sextuplets was orders of magnitude lower on the magnifier scale (median perceived chance 10(-5)) than on its linear counterpart (10(-2)). Participants' assessments of high-probability events (e.g., chance of catching a cold in the next year) were not affected by the presence of the magnifier. CONCLUSIONS: The "1 in x" scale performs poorly and is very difficult for people to use. The magnifier scale and the linear number scale are similar in validity, reliability, and usability. However, only the magnifier scale makes it possible to elicit perceptions in the low-probability range (<1%).

Adult↗
PubMedDate not supplied

Bayesian extensions of the Tobit model for analyzing measures of health status.

Self-reported health status is often measured using utility indices that provide a score intended to summarize an individual's health. Measurements of health status can be subject to a ceiling effect. Frequently, researchers want to examine relationships between determinants of health and measures of health status. In this article, Bayesian extensions of the classical Tobit model are used to study the relationship between health status and predictors of health. The author examined models where the conditional distribution of health status was either normal or lognormal, and allowed for both homoscedasticity and heteroscedasticity. Bayes factors were then used to compare the evidence for a given model against that for a competing model. The author found very strong evidence that the distribution of the Health Utilities Index, conditional on age, gender, income adequacy, and number of chronic conditions, was normal with nonuniform variance, compared to the competing models.

Bayes Theorem↗
PubMed1996

[Socioeconomic characteristics of patients with stroke].

We studied the socioeconomic status of 206 stroke patients seen at Escola Paulista de Medicina--São Paulo in the period of 1991-1992. We found that 25% of patients were less than 50 years old; men were married significantly more often than women; 82% of patients had less than 8 years of formal education and 60% of the families survived with US$ 98 to 198. The socioeconomic impact caused by a stroke is very important. Low education and poverty influence the treatment and prevention of the disease. The Social Assistance Service can detect and attempt to solve the social problems in order to obtain a better control of systemic diseases and risk factors for stroke, and to give orientation concerning the local resources.

Adolescent↗
PubMed1998

Youth suicide attempts: a social and demographic profile.

OBJECTIVE: The social and demographic characteristics of a New Zealand sample of young people making medically serious suicide attempts were examined and compared with those of a control sample of similar age. METHOD: Using a case control design, 129 young people making serious suicide attempts were contrasted with 153 randomly selected community controls on a series of social and demographic characteristics including educational achievement, socioeconomic status, income, occupation, religious affiliation and ethnicity. The age and gender distribution of the sample, and the methods of suicide attempt, were examined. RESULTS: Almost equal numbers of young males (45.7%) and females (54.3%) made medically serious suicide attempts. The clear majority of serious suicide attempts were by overdose or poisoning (78.3%), with tricyclic antidepressants (38.6%) and paracetamol (37.6%) together accounting for three-quarters (76.2%) of all drug overdoses. Young people who were less well educated and who were from lower socioeconomic backgrounds had elevated risk of serious suicide attempts. CONCLUSIONS: Young people from socially disadvantaged backgrounds have elevated risk of serious suicide attempt.

Adolescent↗
PubMed1999

Women in general practice in New Zealand.

AIM: To investigate the role of women general practitioners (GPs) in New Zealand. METHOD: A five-page questionnaire was posted to 200 randomly selected women GPs from throughout New Zealand. One follow-up mailing was sent. RESULTS: A response rate of 79% was achieved. Twenty-four percent of women GPs work less than 5/10 but 46% earn less than $40000. Forty-eight percent of women GPs' partners also earn less than $40000. The most common reason for working part-time was parenting responsibilities. Eighty-seven percent are married or live with a partner, 77% have children, 48% have preschool-aged children. Only 15% have Membership of the RNZCGP and 57% are owner or partner in their practice. CONCLUSION: Women GPs suffer both professional and financial difficulties because of their dual motherhood/professional roles.

Age Distribution↗
PubMed2000

[Secular trends in postanal growth in the city of São Paulo, Brazil (1974-1996)].

OBJECTIVE: Data from three household surveys undertaken in the city of S. Paulo, Brazil, from mid-80s to mid-90s allow to characterize and analyse secular trends in infant and child linear growth. METHODS: In the three surveys, random population samples aged from zero to 59 months (1,008 children in the period of 1974-75; 1,016 in 1984-85 and 1,280 in 1995-96) were studied. Recumbent length was obtained from children up to 24 months of age and then stature was recorded. The international growth standard was used to evaluate the child's height according to age and sex. For the study of the social distribution of growth status, tertiles of the per capita family income was taken into account in each survey. For the study of the determinants of secular trends, hierarchical causal models, multivariate regression analyses and calculations analogous to the ones used to assess population attributable risks were applied. RESULTS/CONCLUSIONS: In the period of 22 years covered by the three surveys, the secular trend of child growth in S. Paulo City showed a positive, continuous and apparently uniform curve. It was equivalent to a total average gain of 0.650 z scores of the international growth reference, or near 2.3 cm at the age of 30 months. The higher gain was observed among the third poorest fraction of the population--3.3 cm--and the lower gain--1.7 cm--among the third richest. Positive changes in distal determinants (family income and maternal schooling) and intermediate determinants (housing, sanitation, access to health services and reproductive past history) of child growth explained substantially part of the improvements seen from the mid-80s to mid-90s.

Anthropometry↗
PubMed1988

Decree No. 2006 partially amending Decree No. 1906 of 30 December 1987, published in La Gaceta Oficial of the same date, 18 February 1988.

This Decree and Decree 1906, which it amends, mandate the formation of a Special Commission charged with reviewing all loan applications in Venezuela for the acquisition or construction of low-income housing filed in mortgage banks, financing institutions, or savings and loan institutions. Under the Decrees, builders of low-income housing complexes can receive up to 60% of the cost as a loan and buyers up to 75%. Loans will be granted to individual buyers only if they lack housing or their current housing does not meet minimum standards; they can make an initial payment of 15% of the selling price, and monthly payments on the loan do not exceed 30% of their salary. Loans are, in general, to be made at a 9% yearly interest rate. Repayment for loans made for the construction of rental units or the individual purchase of units is set at 20 years. Repayment for loans for the construction of units for sale is set between 18 and 36 months.

Americas↗
PubMed2002

[Failure to thrive among hospitalized 0-2 year-old children].

INTRODUCTION: Failure to thrive, defined as insufficient weight gain according to age, is a well-known condition among infants and toddlers. The aim of the study was to investigate the prevalence of diagnosed failure to thrive and possible comorbidity in hospitalised 0-2 year-old children in the County of Copenhagen. MATERIAL AND METHODS: It resulted from inquiries sent to all paediatric departments in Denmark that the most frequently used ICD-10 diagnoses for failure to thrive were R62.8, E64.9, and E34.3. Data concerning patients with these three diagnoses hospitalised in two paediatric departments in the County of Copenhagen during a two-year period were drawn from the Patient Registry System. The following parameters were registered: sex, age, diagnoses, hospitalizations, and address. RESULTS: Among referred children below the age of two years, 173 or 4% were diagnosed with failure to thrive. Girls were in excess, the ratio girls-boys being 107:66. More than half, 60% were below one year of age, 40% were below six months of age. We found equal distribution of index children from municipalities with low and high incomes. The diagnosis R62.8 was found in 170 patients, of whom 155 had the diagnosis as either main diagnosis or side diagnosis. Out of these 155 patients 46% had additional somatic diagnosis, whereas 5% had child psychiatric comorbidity. DISCUSSION: Failure to thrive was diagnosed in 4% of hospitalised children under two years of age. Nearly half of the children diagnosed with failure to thrive had a comorbid somatic diagnosis, whereas only a few was diagnosed with psychiatric or social disturbances.

Child↗
PubMed1994

Women in dermatology. Challenges and recommendations.

The total number of women physicians in the United States tripled between 1970 and 1990. Almost 50% of incoming residents in dermatology are women. This article discusses some of the changes, opportunities, and challenges within our profession wrought by these demographic changes. The incorporation of women into all aspects of our specialty is a subject that warrants review, consideration, and creative solutions.

Dermatology↗
PubMed2006

Socioeconomic status and childhood solid tumor and lymphoma incidence in Canada.

The authors examined the relation between neighborhood income, as a measure of socioeconomic status, and childhood cancer. Incident cases of childhood solid tumor and lymphoma in 1985-2001 were identified from provincial cancer registries in Canada. Residential postal codes at the time of diagnosis were used to assign cases to census neighborhoods. Person-years at risk were determined from quintiles of population by neighborhood income, sex, and 5-year age group, constructed using census population data. Poisson regression was used to calculate incidence rate ratios across neighborhood income quintiles. Compared with the incidence rate in the richest income quintile, moderately lower rate ratios of 0.73 (95% confidence interval: 0.63, 0.86) and 0.84 (95% confidence interval: 0.69, 1.04) were observed, respectively, for carcinomas and renal tumors in the poorest income quintile. No association was found for other types of cancer. Although a potential relation between socioeconomic status and childhood cancer cannot be excluded, the overall pattern seems compatible with random variation.

Adolescent↗
PubMed2000

EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts.

EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of incoming endocytic vesicles before fusion with early endosomes. Because of the presence of complex endosomal pathways in polarized and nonpolarized cells, we have examined the distribution of EEA1 in diverse cell types. Ultrastructural analysis demonstrates that EEA1 is present on a subdomain of the early sorting endosome but not on clathrin-coated vesicles, consistent with a role in providing directionality to early endosomal fusion. Furthermore, EEA1 is associated with filamentous material that extends from the cytoplasmic surface of the endosomal domain, which is also consistent with a tethering/docking role for EEA1. In polarized cells (Madin-Darby canine kidney cells and hippocampal neurons), EEA1 is present on a subset of "basolateral-type" endosomal compartments, suggesting that EEA1 regulates specific endocytic pathways. In both epithelial cells and fibroblastic cells, EEA1 and a transfected apical endosomal marker, endotubin, label distinct endosomal populations. Hence, there are at least two distinct sets of early endosomes in polarized and nonpolarized mammalian cells. EEA1 could provide specificity and directionality to fusion events occurring in a subset of these endosomes in polarized and nonpolarized cells.

Animals↗