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PubMed1995

Trypanosoma cruzi: both chemically induced and triatomine-derived metacyclic trypomastigotes cause the same immunological disturbances in the infected mammalian host.

Infection of BALB/c mice with chemically induced metacyclic forms of Trypanosoma cruzi clone Dm28c led to characteristic changes of experimental Chagas' disease, with protracted but marked parasitemia, intense splenomegaly, and splenic T cell hyporeactivity to TcR;CD3-dependent stimulation. Infection of BALB/c mice with either chemically induced or triatomine-derived Dm28c metacyclic forms led to comparable parasitemias, a synchronous increase in the number of splenic large lymphocytes, and a similar reduction in T cell responsivity to immobile anti-CD3 antibody. A marked and selective reduction in the level of CD8 expression per cell was also seen in mice infected with either form of metacyclic parasites. Large inflammatory mononuclear cell infiltrates were present in the hearts of mice infected with either chemically induced or insect vector-derived metacyclic forms, at both acute and chronic stage, with predominance of CD8 over CD4 T cells in the lesions, in both cases. These results indicate that infection with chemically induced metacyclic forms of T. cruzi can be a useful model of Chagas' disease, resembling infection caused by the insect vector.

Animals↗
PubMed1998

Ticks are not Insects: Consequences of Contrasting Vector Biology for Transmission Potential.

Quantitative analyses of vector-borne parasite systems are dominated by insect systems. In attempts to formulate general statements concerning vectors and their indirectly transmitted parasites, ticks are usually ignored or they are implicitly or explicitly assumed to obey the same rules as insects. Here, Sarah Randolph shows that contrasting biological attributes of these two different arthropod classes (ticks and insects) directly affect their performance as vectors. The equations for estimating their respective potential to transmit parasites differ in important respects, as does the relative impact of each factor on these estimates. These conclusions direct attention towards the empirical field data most appropriate for quantifying the spatially and temporally variable risk of infection from these contrasting vector-borne parasite systems.

Journal Article↗