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At least 847 records · Page 47Linked to original sources
PubMed1983

Penile plethysmography useful in diagnosis of vasculogenic impotence.

Pulse-volume recordings were obtained in 40 normal subjects and 62 patients with history of impotence. In office practice, this study proved to be valuable for estimating penile perfusion. Penile plethysmography is a unique and adaptable screening method for penile blood flow. It measures the contributions of all vessels at the root of the penis. Pulse-volume recordings also were found to correlate with the severity of pelvic angiographic patterns of occlusive disease. Further investigation is necessary to determine the precision with which the method can detect penile blood flow in patients with early vascular compromise.

Blood Volume↗
PubMed1977

Reversal of uraemic impotence by zinc.

In eight impotent haemodialysed men with low plasma-zinc levels sexual function, including potency, frequency of intercourse, libido, and plasma testosterone, follicle-stimulating hormone, and luteinising hormone levels, was determined before and after therapy with zinc (four patients) or placebo (four patients). Dialytic administration of zinc strikingly improved potency in all patients and raised the plasma-testosterone to normal in the two with low pretreatment plasma-testosterone levels. Placebo did not improve sexual function in any patient. Zinc deficiency is a reversible cause of gonadal dysfunction in uraemia.

Adult↗
PubMed1999

Male impotence.

Erectile dysfunction can be devastating for men and for their partners. A good sexual history and focused physical examination can provide clues as to whether the underlying cause is psychogenic or organic. Diagnostic investigation should be tailored to the clinical picture. Oral medications now represent first-line therapy. Penile injection therapy and vacuum constrictive devices are reasonable choices for men in whom oral therapy falls or is contraindicated. The penile prosthesis provides a reliable long-term solution with high satisfaction rates. Psychotherapy may be indicated. Physicians can have a positive impact on the quality of life of patients by providing a non-judgmental and supportive environment for discussion and management of impotence.

Diagnosis, Differential↗
PubMed2001

Impotence-free hormonal treatment of prostate cancer.

Since the protein-specific antigen (PSA) test is systematically used in some countries for cancer detection, many asymptomatic and latent cancer patients are uselessly victims of anxiety, hormonotherapy, and impotence, when they are not demolished by surgery and/or radiotherapy's local and/or regional complications. We propose to conduct a study of dexamethasone as treatment of such latent, small and even wrongly diagnosed cases. Certainly it exerts at small doses a discrete hormonal effect. But it has an anti-growth factor effect, which may explain its often beneficial action on prostate cancer with resistance to androgen inhibitors.

Aged↗
PubMed1998

Comparison between plasma concentrations of testosterone, nitric oxide and endothelin 1-2 in penile and brachial venous blood: preliminary results in men with psychogenic impotence.

In the present study venous plasma concentrations of testosterone (T), nitric oxide (NO) and endothelin 1-2 (ET1-2) in the flaccid penis and brachial blood were measured in men with psychogenic impotence. T and NO were significantly lower in the penile venous blood, while ET1-2 showed no statistical difference. These data support the hypothesis of testosterone dependence of penile nitric oxide synthesis (NOS).

Adult↗
PubMed2002

[Sexual fantasies and impotence. Apropos of 2 cases].

Sexual fantasies, drawn of the erotic memory that constitutes himself the long of the sexual history of each, are indispensable, for the good sexual working. Some authors tend to consider the imagination like a "veritable intra psychic erogenous zone". However, people who, for a reason or an another, persisted to avoid all sexual activity before the marriage and to separate all erotic velleity, don't they risk to have an erotic imaginary atrophied, who could sound negatively once on their sexual behaviour, after the marriage, when all is suddenly authorized for them? Through two clinical observations of secondary sexual impotence, we are going to try to show the ominous consequences of such a relentlessness (imposed by the education, the social morals or the religion), against sexual stimulation, on the sexuality. These consequences are more easily observable in men, of the fact of their active role, in the sexual activity. Our purpose is to insist on the necessity to explore the sexual history owing all sexual dysfunction, and to place it in the biographic setting of the impatient; but also and especially to attract the attention on the importance of a precocious sex education, adapted to age, to the personal maturation and the cultural and educational context.

Adult↗
PubMed1992

The role of intracavernosal vasoactive agents to overcome impotence due to spinal cord injury.

Twenty-two spinal cord injured men (mean age 35.2 years) referred because of impotence were treated with intracavernosal vasoactive agents. Papaverine 2-20 mg, papaverine 40 mg plus phentolamine 0.5 mg or prostaglandin E1 (1-20 micrograms) were used. Nineteen responded and were taught to self administer the medication with varying degrees of assistance from their partners. Fourteen men participated in a postal survey; 12 (86%) continued to use the drugs every 1 to 4 weeks and reported satisfaction with the method. Partner responses were positive in half of the group and when not so it influenced the patients to abandon or reduce the frequency of treatment. Counselling was essential to allay anxiety. Clinical management was not compromised and side effects were minimal. Overall we found this treatment effective, safe and worthwhile.

Adult↗
PubMed1999

Maximisation of the erectile response in the investigation of impotence.

UNLABELLED: The aim of this study was to assess whether redosing with a combination of intracavernosal (IC) vasoactive agents could produce a complete erectile response, thereby providing a reliable and reproducible method of dynamic investigation of erectile dysfunction. Forty-one impotent men were redosed with a combination intracavernosal agents until a constant penile rigidity was achieved. They were then shown audiovisual sexual stimulation (VES) by means of a videotape. The erectile responses were monitored continuously by RigiScan (Dacomed). RESULTS: Despite a constant rigidity with intracavernous injection (ICI), 16 men (39%) still had an improved response with VES that was clinically detectable. CONCLUSION: Dynamic investigation of erectile dysfunction with a combination and redosing of IC agents may still lead to an incomplete erectile response. This may potentially lead to patients being incorrectly labelled and confirms the limitations of follow-up studies using dynamic tests of erectile function.

Aged↗
PubMed2001

Rabbits as models for impotence research.

The anesthetized rabbit model is useful and has many advantages: ability to perform neurophysiological studies; more administration routes, including intracavernous injection; haemodynamic measurements in parallel to measurements of intracavernous pressure or penile volume; and direct measurement of intracavernosal pressure and blood flow. This model has been evaluated with many different types of drugs. The conscious rabbit model is a simple and valid model for the assessment of compounds with potential for treatment of ED. It offers several methodological advantages as a screening model for compounds with erection stimulating properties. It was clearly successful in demonstrating the efficacy and the mechanism of the new potent and selective PDE5 inhibitor vardenafil. The model was also effective in demonstrating erection-generating properties through other mechanisms, eg PDE3 inhibitors and alpha-receptor blockers. In conclusion, both anaesthetized rabbit model and the newly developed conscious-rabbit models are well-suited for studies in impotence research.

3',5'-Cyclic-GMP Phosphodiesterases↗
PubMed1993

[Retrograde venous occlusion--therapy of impotence of venous origin].

Retrograde occlusion of penile drainage veins can produce improvement in patients with impotence due to venous leaks. We performed 50 transfemoral and three transjugular procedures; 46 (86%) were technically successful. Clinical improvement was found in 24 out of the 46 procedures (52%). In 20 patients spontaneous intercourse became possible, in four this occurred after intracavernous injection of vaso-active substances. In eleven patients there was deterioration after one to twenty months; in seven this was treated by repeated venous occlusion. In 13 patients improvement has been maintained over a period of one to thirty months (average 10.5 months). There were no complications.

Angiography↗
PubMed1986

[DSA and conventional angiography compared in the angiographic diagnosis of impotence].

Twenty-three patients complaining of impotence were examined angiographically as part of their investigation. In all patients, DSA as well as conventional angiography was carried out. The purpose of this investigation was to compare the two methods with regard to their diagnostic value. By means of sequential analysis it was shown that, with an error level of 10%, DSA was superior to conventional angiography.

Adolescent↗
PubMed1984

[Arteriographic diagnosis of erectile impotence].

The complex interactions of psychological, neurological, hormonal and vascular aspects of erectile dysfunctions require a standardised multidisciplinary diagnostic evaluation. The recent establishment of new noninvasive and invasive investigative procedures has led to a fundamental change in the assessment of erectile dysfunctions. Selective angiography of the internal pudendal artery and its branches represents the crucial diagnostic step before treatment can start. Indication, technique and results of 26 bilaterally performed pudendal angiographies on impotent patients are described.

Adult↗
PubMed1983

[Angiographic diagnosis of vascular impotence].

Twelve patients (average age 40 +/- 15 years) with impotentia coeundi were angiographically examined under suspicion of a vasculogenic impotence. Overview angiographies of the pelvis and selective iliaca interna injections were performed. The normal anatomy of the pudendal artery and the penile branches is shown. Ten patients were suffering from a stenosis or total occlusion of the dorsal pudendal artery, the dorsal penile artery or the profound penile artery with or without filling of a peripheral segment. The role of arteriography in surgical treatment is discussed.

Adult↗
PubMed1986

[Diagnosis and therapy of organic impotence].

A stepwise diagnosis using objective and reproducible methods of examination makes it possible to distinguish between psychogenic and organic causes of impotence. Among 104 men who had organic disorders of erection half were due to local penile disease, the remainder to vascular disease (diabetic angiopathy, arteriosclerosis, abnormal venous drainage). Cavernosal through-flow measurements revealed differences among the various groups of disorders with regard to the flow rates required for achieving and maintaining an artificial erection and made it possible, in conjunction with other tests (Doppler perfusion measurements and papaverine response), to arrive at a precise diagnosis and plan for surgical intervention. Of 91 men who had been operated upon 79 had good results (87%). Largely noninvasive diagnostic measures thus achieved effective treatment and thus contributed to an improved feeling of self-esteem.

Erectile Dysfunction↗
PubMed2001

Sloughing of the scrotal skin and impotence subsequent to bilateral hypogastric artery embolization for endovascular aortoiliac aneurysm repair.

Sloughing of the scrotal skin is an extremely rare event due to pelvic ischemia. We report herein one case of scrotal skin sloughing and impotence after bilateral hypogastric artery embolization for endoluminal aortoiliac aneurysm repair. Postoperative penile plethysmography demonstrated a 75% reduction in the penile brachial index, suggesting that pelvic ischemia is the main culprit for this complication. The devastating morbidity in our patient underscores the importance of maintaining pelvic collateral circulation when planning for endovascular aortoiliac aneurysm repair.

Aged↗
PubMed1990

Hypnotic techniques for smoking control and psychogenic impotence.

In the past 35 years I have used a variety of hypnotic techniques to help patients stop smoking. The most successful method has been to see the patient for 3 consecutive days with a follow-up session about 3 weeks later. With this technique, about 81% of patients stopped smoking. Psychogenic impotence has many possible causes and must be approached with an understanding of the dynamics involved. However, hypnotic suggestions can be helpful in restoring erectile function. I have used the technique described here with almost 3000 patients with a success rate of 88%.

Erectile Dysfunction↗
PubMed1987

Treatment of impotence. 1. Nonsurgical methods.

Male sexual dysfunction is a problem that is quite prevalent in our society. Until recently, the only treatments for impotence were testosterone injection, sex therapy, and implantation of a penile prosthesis. These methods remain in use when appropriate. However, now that the pathophysiology of erection is better understood, the dopamine agonist, intracorporal injection, and the alpha 2-adrenergic receptor blocker have been added to the treatment list. Gadgets that artificially increase the blood supply to the penis are sometimes used. The withdrawal of drugs that affect sexual function may be sufficient.

Bromocriptine↗
PubMed1987

Treatment of impotence. 2. Surgical methods.

Most patients with an organic or physical cause of their impotence can be helped, because noninvasive diagnostic testing to identify the disorder and specialized surgical techniques to repair it are available. Occlusion or leakage of the blood supply to the penis is treated with graft bypass, endarterectomy, transluminal balloon angioplasty, or vein ligation. Patients with persistent Peyronie's disease may require plaque excision and graft placement, and sometimes, a penile prosthesis. Different types of penile prostheses have been used successfully.

Arterial Occlusive Diseases↗