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PubMedDate not supplied

[Hydrochloric acid, gastrin, parietal cell mass in active and quiescent phases of duodenal ulcers].

The A. studied the behaviour of gastric acid secretion, of gastrinemia and of the parietal cell mass in 14 patients with duodenal ulcer (in active state and then in quiescent state) and in 20 symptom free control subjects, in absence of circumscribed gastroduodenal lesions. The analysis of the results demonstrates the persistence in the quiescent state of the physiopathological behaviour found in the active duodenal ulcer.

Adult↗
PubMedDate not supplied

[Effect of thiamine deficiency in hydrochloric acid secretion in the stomach].

The effect of the thiamine deficiency on the H+ secretion in an isolated gastric mucosa and also on the functional properties of the mitochondria was investigated. The thiamine deficiency was called forth through introduction of oxythiamine or by exclusion of thiamine from the ration. It is shown that the thiamine deficiency in an isolated gastric mucosa of the frog produced inhibition of the H+ secretion and in the gastric mitochondria of rats--a higher activity of succinate-dehydrogenase and a diminution of the exogenous cytochrome oxidation rate.

Animals↗
PubMed1981

Inhibition of gastric hydrochloric acid secretions in the rat given Ostertagia ostertagi (a gastric parasite of cattle) extract.

The immersion of freshly collected Ostertagia ostertagi adults into saline solution (NaCl, 0.9%; pH 1.0) resulted in 100% mortality of worms within a 10-minute period. At pH 7.0, mortality was 58% after 270 minutes. At pH 2.2, which approximates the usual abomasal pH, 100% mortality resulted within 60 minutes. In the stomach of rats injected with an extract of O ostertagi (from the abomasum of cattle), there were decreased total secretion of hydrogen ions and volume of secretion (P less than 0.05) and increased mean pH of gastric secretion (P less than 0.05). These effects were similar to those found in stomach of rats treated with cimetidine. Results indicated that the pH of the abomasum was detrimental to parasitic survival and that hypochlorhydria found during ostertagiosis may be mediated partially by a chemical released from the parasite.

Animals↗