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[Sensitization to powdered latex gloves: prevalence in hospital employees].

INTRODUCTION: The prevalence of latex allergies in industrial countries has skyrocketed since the 1980s. Between 2.6 and 22% of hospital workers are diagnosed with latex allergy, which has been recognized as an occupational hazard in France since 1997. AIM: To assess the prevalence of latex allergy among Montpellier University Hospital Center staff. METHODS: From 1999 to 2002, we interviewed and conducted skin-prick tests on 537 hospital staff members from different departments and with different degrees of exposure to airborne latex allergens. RESULTS: Symptoms while using natural-rubber latex gloves (most often contact dermatitis) were reported by 88 (16.4%) staff members. Overall work-related allergic symptoms included rhinitis, reported by 65 (12.1%), contact urticaria by 28 (5.2%), and bronchial symptoms by 16 (1.1%). In all, sensitization to latex was identified in 7.1% of our staff, and this percentage was higher (11.3%) in units where latex gloves were used more often. Sensitization was associated with high latex exposure and atopy. CONCLUSION: This high rate of latex sensitization and the risk factors are similar to those already published. Based on this study, we have eliminated powdered latex gloves, as have many other hospitals.

Adult↗

Speciation of chromium in tanned leather gloves and relapse of chromium allergy from tanned leather samples.

There are concerns that wearing chromium tanned leather gloves can provoke a lapse of hand dermatitis in chromium sensitive patients. Various forms of chromium have different biological effects and the determination of total chromium (both soluble and insoluble), which often is used in clinical studies, may therefore not be an adequate measure of the adverse exposure. However, investigations, where dissolution of hexavalent chromium from leather gloves has been experimentally studied, could not been found in the literature. The aim of this pilot study was therefore to determine the total amount of chromium and the amount of sweat leachable chromium in different leather glove materials and also to apply samples of these materials in a patch test to chromium sensitive patients to see if they could provoke a reaction. The results showed tha chromium tanned leather contained about 3% (m/m) chromium. Chromium can also be found in dyed vegetable tanned leather, probably emanating from the leather dye. Small amounts (average 0.08% m/m) of leachable hexavalent chromium were found in both chromium and vegetable tanned leathers. Thus, the risk of relapse of chromium dermatitis cannot be disregarded and further studies on the causes of relapse of chromium dermatitis are necessary.

Chromium↗

Permeation of glove materials by physiologically harmful chemicals.

The breakthrough times and permeation rates of 1,4-dichloro-2-butene, benzene, carbon tetrachloride, and 2-chloro-1,3-butadiene for eleven commercially available gloves were determined. Four methods of determining the breakthough time and permeation rate were evaluated. A wide variation in the glove material thickness and protection time was found showing that the adequate protection time can only be determined by testing the proposed glove with the chemicals to be handled.

Acrylonitrile↗

Testing of gloves for permeability to UV-curable acrylate coatings.

The handling of UV-curable acrylate formulations used in the coating of optical fiber requires protective measures to prevent contact dermatitis and/or allergic dermatitis. To characterize the permeability of various glove materials to a UV-curable acrylate coating, a study was undertaken using a modification of a standard ASTM permeability test, which demonstrated that nitrile rubber gloves provided the best protection of those glove materials tested.

Acrylates↗

Evaluation of glove material resistance to ethylene glycol dimethyl ether permeation.

Some glycol ethers have been reported to cause adverse reproductive effects in exposed male and female workers, and skin absorption has been determined to be an important route of entry of this class of chemicals. Because ethylene glycol dimethyl ether (EGDME) is a possible component of lithium-based primary battery electrolyte systems, a study was undertaken to determine the resistance of various commercially available gloves to permeation of this liquid. The gloves were tested by the ASTM Method F-739-81, and butyl rubber was found to be the most effective barrier to permeation. Further studies determined that the butyl gloves could be reused if they were reconditioned overnight in a vacuum oven at 50 degrees C. When a mixture of ethylene glycol dimethyl ether (30% v/v) and propylene carbonate (70% v/v) was tested, the results indicated that the propylene carbonate retards the permeation of the glycol ether by a factor of 10. This is believed to be caused by the propylene carbonate coating the surface of the butyl membrane to reduce the sorption of EGDME.

Elastomers↗

Latex glove allergy among hospital employees: a study in the north-west of England.

The frequency of use and duration of wearing latex gloves among hospital employees has increased due to concerns about AIDS and hepatitis. In many countries there is increased consciousness about latex sensitization. In the UK, the Medical Device Agency has been monitoring latex allergy for a number of years but has not found any conclusive evidence of any significant problem. We report following a detailed questionnaire study in two hospitals in the north-west of England. A total of 1,827 members of staff were questioned about latex allergy at work. One hundred and twenty-four (7%) of these hospital employees had experienced symptoms strongly suggestive of latex allergy. Of this group, 56 had a-RAST test (IgE specific to latex), which was positive in seven (12.5%). There was a history of atopy in 31%, and a family history of atopy in 17% of the individuals. As a result of the study it was found that 17% (21 of the affected individuals) had already changed their working practice by using latex-free gloves. We were able to increase awareness of latex allergy within the hospitals. Both individuals and health care organizations need to be aware of the problem and hospital organizations should encourage staff to seek guidance to address the problem and, if necessary, to take appropriate measures to improve working practices. Practical guidelines are given with regard to identifying the problem and glove use for hospital staff.

Adult↗

Computer-drafted pressure support gloves.

Using computer-drafted pressure support gloves during a six-month period, we greatly increased our accuracy of fit. Only eight alterations were required out of 214 gloves manufactured, and none of the alterations was due to computer error. Our time to calculate and lay out patterns decreased by a 4:1 ratio, thus reducing a two-hour time period to one-half hour per glove. The cost of hardware and software was offset by reduced labor costs over a period of approximately eight months. Use of the computer was cost effective, produced error-free patterns, and allowed better control of pattern consistency.

Burns↗

An instrumented glove for grasp specification in virtual-reality-based point-and-direct telerobotics.

Hand posture and force, which define aspects of the way an object is grasped, are features of robotic manipulation. A means for specifying these grasping "flavors" has been developed that uses an instrumented glove equipped with joint and force sensors. The new grasp specification system will be used at the Pennsylvania State University (Penn State) in a Virtual Reality based Point-and-Direct (VR-PAD) robotics implementation. Here, an operator gives directives to a robot in the same natural way that human may direct another. Phrases such as "put that there" cause the robot to define a grasping strategy and motion strategy to complete the task on its own. In the VR-PAD concept, pointing is done using virtual tools such that an operator can appear to graphically grasp real items in live video. Rather than requiring full duplication of forces and kinesthetic movement throughout a task as is required in manual telemanipulation, hand posture and force are now specified only once. The grasp parameters then become object flavors. The robot maintains the specified force and hand posture flavors for an object throughout the task in handling the real workpiece or item of interest. In the Computer integrated Manufacturing (CIM) Laboratory at Penn State, hand posture and force data were collected for manipulating bricks and other items that require varying amounts of force at multiple pressure points. The feasibility of measuring desired grasp characteristics was demonstrated for a modified Cyberglove impregnated with Force-Sensitive Resistor (FSR) (pressure sensors in the fingertips. A joint/force model relating the parameters of finger articulation and pressure to various lifting tasks was validated for the instrumented "wired" glove. Operators using such a modified glove may ultimately be able to configure robot grasping tasks in environments involving hazardous waste remediation, flexible manufacturing, space operations and other flexible robotics applications. In each case, the VR-PAD approach will finesse the computational and delay problems of real-time multiple-degree-of-freedom force feedback telemanipulation.

Biomechanical Phenomena↗

A low-cost instrumented glove for monitoring forces during object manipulation.

A rehabilitation program toward restoring upper limb movements based on neuromuscular electrical stimulation (NMES) depends on closed-loop control performance, which has been limited by the development of sensors for practical daily use. This work proposes a system to obtain force feedback. The system is comprised of a Lycra commercial glove with force sensing resistors (FSR's) attached to the distal phalanxes of the thumb, index and long fingers. After amplification and filtering, the signal is digitized through an analog-to-digital (A/D) converter. The polynomial fitting coefficients for the characteristic curves, obtained during the sensor calibration process, were inserted in the software thus enabling the reading of forces exerted during object manipulation. The system was applied to 30 normal subjects in order to verify its feasibility and to acquire knowledge of the normal hand function. Different ways of grasping have been detected according to the Force versus Time curve pattern and to the fingers predominantly used in grasping. Results have also shown the influence of parameters such as gender, age, hand size, and object weight in the normal function. The system did show efficacy. It was able to determine grasp forces during object manipulation for up to 73% of the studied sample. This is significant since a single glove was used in a wide range of subjects. For best results in medical applications, the glove should be tailored to the particular characteristics of an individual user.

Adolescent↗

Early histopathologic changes in purple glove syndrome.

An 86-year-old African-American man presented with tonic-clonic seizures. Intravenous phenytoin was urgently administered into the dorsum of the right hand. The patient developed a raised purple area of discoloration around the intravenous insertion site within 2 h and edema and vesiculobullous lesions of the distal forearm, hands, and fingers within 8 h. Microscopic sections from a biopsy at 12 h revealed epidermal necrosis, superficial ulceration, and a mild superficial and deep perivascular lymphoid infiltrate, associated with numerous thrombi of small vessels throughout the dermis. The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome. Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands. It is comprised by pain, discoloration, and edema in the vicinity of intravenous infusion of phenytoin through dorsal veins of the hand. The histopathologic features of fully developed lesions have been reported; however, early-stage findings have not been previously described, and the histogenesis of this lesion is controversial. The presence of thrombi in this early-stage lesion suggests that thrombosis plays a role in the initial pathogenesis of this condition.

Aged↗

Anaphylaxis produced by rubber glove contact. Case reports and immunological identification of the antigens involved.

A study was carried out on six subjects suffering from anaphylactic reactions including asthma, rhinoconjunctivitis, contact urticaria and hypotension following contact with rubber gloves. All of them showed skin sensitivity and serum specific IgE to various preparations of natural latex, and not to other chemicals used in glove manufacturing. Immunoblotting techniques demonstrated that at least four soluble polypeptides from natural latex had the ability to bind specific human IgE. The results suggested that natural latex proteins present in rubber gloves can cause severe specific hypersensitivity reactions.

Adolescent↗

Exfoliated malignant cells in glove and instrument washings following head and neck surgery.

Loco-regional recurrence following resection of squamous cell carcinoma of the upper aero-digestive tract is a major problem. Cells exfoliated from malignant tumours have been considered capable of implanting and giving rise to local recurrence or metastatic deposits. A prospective study was performed examining washings from the gloves and instruments used in major head and neck operations to determine if exfoliated cells were indeed present. Following removal of the main tumour specimen all surgeons washed their hands in a solution containing a cell fixative and all instruments were soaked in the solution. Samples were then centrifuged and stained using a modified PAP technique. On occasions nuclear fragments consistent with squamous cell carcinoma were present in both glove and instrument washings. We recommend that all surgeons change gloves and instruments following removal of the main tumour specimen and prior to irrigation of the operative field with a tumoricidal agent.

Carcinoma, Squamous Cell↗

Penetration of protective gloves by epoxy resin.

A gas jointer developed dermatitis from epoxy resin of Bisphenol A type. This substance penetrates plastic and rubber gloves. The man was compelled to change his job. There is a need for new types of gloves which are impermeable. The wearing of the existing types of glove by those not sensitised may be worthwhile because it probably lessens the dose of allergen absorbed and hence lessens the incidence of sensitisation.

Adult↗

Contact dermatitis due to endotoxin in irradiated latex gloves.

This case report describes contact dermatitis of the dyshidrotic type of the hands of a worker subjected to minor trauma. The source of the irritation was linked to bacterial endotoxin in latex gloves. Irradiated sterilized gloves and software may contain significant endotoxin levels because the irradiation does not affect endotoxin itself. The irradiation of the bacteria actually increases endotoxin levels when the bacterial count is elevated. Sweating under these gloves may enhance entry into the skin with subsequent reaction as endotoxin is water soluble.

Adult↗

Flexible protective gloves: the emperor's new clothes?

The risk of developing skin cancer is estimated for interventional radiologists who do and do not wear thin, flexible protective leaded gloves. The use of these gloves is extremely expensive in terms of dollars per potential cancer prevented. Good radiographic practice without the use of flexible protective gloves provides adequate protection.

Cost-Benefit Analysis↗

Gloves and socks syndrome associated with parvovirus B19 infection.

The spectrum of disease caused by parvovirus B19 infection ranges from asymptomatic to a serious disease. Parvovirus B19 plays a role in the pathomechanism of gloves and socks syndrome, erythema infectiosum, acute polyarthralgia, aplastic crisis in persons with hemolytic anemia, and birth defects. Gloves and socks syndrome has an acute febrile course. Painful edema of hands and feet, and numerous small confluent petechiae in the same localization are the most characteristic signs. Blisters and erosions may occur in oral mucosa. General discomfort and arthralgia accompany skin lesions. The disease tends to be self-limiting. A typical case of gloves and socks syndrome in a 36-year-old woman is reported. Serological tests disclosed the parvovirus B19 infection, confirming the causal relationship between the syndrome and this infection.

Adult↗

Mesh-glove. 1. A method for whole-hand electrical stimulation in upper motor neuron dysfunction.

A newly devised method for electrical stimulation via a wired mesh-glove is described. The stimulation paradigm is novel in that a whole hand is the target of stimulation. Specific standardized stimulation modalities are reviewed. The protocol for mesh-glove stimulation for patients with and without volitional movements, but increased muscle tone is outlined. A sequenced program based on restoration of motor functions is described. The mesh-glove stimulation is well suited for home use. On the basis of our experience working with 40 patients after stroke, head and spinal cord injuries, we concluded that this procedure is beneficial and safe.

Adult↗

An experimental histopathologic study of surgical glove powders.

Tissue reactions to surgical glove powders, ie, talc (magnesium silicate) and Keoflo (low cross-linked cornstarch) were studied histologically from day 1 to 16 weeks. These materials were tested as a contaminant on the surface of surgical suture or in a pellet form implanted in abdominal muscle of rat. Use of Keoflo resulted in an intense acute inflammatory response, with a progressive decrease in the amount of starch with time after implant. By the fourth week, most of the starch had disappeared with minimal tissue damage and scar formation. Rats implanted with talc showed an initial mild to moderate acute inflammation followed by chronic inflammatory response and granuloma formation by the third day. From the fourth week on, granulomas showed talc crystals within the giant cells surrounded by histiocytes, lymphocytes, some collagen, and fibroblasts. This study indicates that talc molecules are not absorbed, whereas low cross-linked cornstarch is an absorbable substance; therefore the latter is a safe material for use as surgical glove powder.

Drug Implants↗