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PubMedDate not supplied

[Biophysical foundations of magnetoencephalograhy].

OBJECTIVE: It is sought to expose in a simple but rigorous way the physical, neurobiological and methodological foundations of the magnetoencephalography (MEG). DEVELOPMENT: We start from the basic properties of the classical electromagnetism, analyzing in detail the concepts of electric and magnetic fields, the Maxwell s equations and the multipolar development of potentials. All these tools are very important to know the peculiarities of the MEG studies. Later on, they are reviewed very briefly the different types of potentials generated by the neurons and their implication in the MEG. Lastly, some necessary technical characteristics will be commented for detection of the very weak neuromagnetic fields. It is shortly exposed the concept of tunnel effect, in one that detection systems used at the present time are based (SQUID). CONCLUSION: MEG is a very promising recent technique that is used in epilepsy studies, evoked potentials and other functional pathologies. Its utility in clinic continues being even controversial. However, it is fundamental to know the mechanisms that justify their use in order to know better their benefits and limitations.

Action Potentials↗
PubMedDate not supplied

A three-dimensional, anatomically detailed foot model: a foundation for a finite element simulation and means of quantifying foot-bone position.

We generated an anatomically detailed, three-dimensional (3-D) reconstruction of a human foot from 286 computerized topographic (CT) images. For each bone, 2-D cross-sectional data were obtained and aligned to form a stacked image model. We calculated the inertial matrix of each bone from the stacked image model and used it to determine the principal axes. Relative angles between the principal axes of the bones were employed to describe the shape of the foot, i.e., the relationships between the bones of the foot. A 3-D surface model was generated from the stacked image models and a detailed 3-D mesh for each bone was created. Additionally, the representative geometry of the plantar soft tissue was obtained from the CT scans, while the geometries of the cartilage between bones were obtained from the 3-D surface bone models. This model served dual purposes: it formed the anatomical foundation for a future finite element model of the human foot and we used it to objectively quantify foot shape using the relationships between the principal axes of the foot bones.

Aged↗
PubMedDate not supplied

[Foundations of the diagnosis of clinical syndromes].

AIMS: The aim of this paper is to offer a reflection on the principles used to define a syndromic entity and for the evaluation of its manifestations and the aetiopathogenesis. METHOD: First, the paper looks at several of the different definitions of syndrome available and examines which are the essential features for this term to be employed in a clinical entity. The topographical and semiological perspectives are then dealt with, so as to be able to sort clinical syndromes and charts are used to offer representative examples. The main deficiencies in the use of terms to describe syndromes and the possible causes of such situations are also investigated. Following that, the chief semiological aspects in the diagnosis of a syndrome are assessed. Emphasis is placed on the factors that influence the variability of clinical behaviour, on the factors that come to bear on the recognition of the manifestations using the research methods available to us, on the rule of iterative confirmation of the symptom and on the characterisation and coordination of the symptom with other related phenomena. Lastly, the aetiopathological foundations of clinical syndromes are evaluated. We highlight the importance of determining the underlying anatomofunctional disorder, the classical distinctions concerning this, and the relation between syndrome and disease. The diagnostic criteria from numerous neurological syndromes are used as examples. CONCLUSIONS: The concept of syndrome has been defined in an attempt to illustrate the presence of inappropriate, incorrect terms with adverse repercussions in the theoretical and practical areas. We also propose ways of resolving the faults found.

Diagnosis, Differential↗
PubMed2002

[Evaluation of the burdens of rheumatoid arthritis and osteoarthritis: a questionnaire survey in Japan Rheumatism Foundation registered rheumatologists].

OBJECTIVES: To evaluate the burdens of rheumatoid arthritis (RA) and osteoarthritis (OA), focusing on quality of life (QOL). METHODS: A questionnaire survey was conducted with 3407 qualified doctors of Japan Rheumatism Foundation (response rate 20%). Subjects were asked to assume three patient groups characterized by treatment status (outpatient, inpatient with inactive treatment and inpatient with active treatment) and to answer the questions about (1) percent distributions of the groups a decade ago and today and (2) QOL, including physical functions, daily living activities and social activities, of each group. RESULTS: More than 70% of patients with RA and OA were included in the outpatient group, who had problems in social activities rather than in physical functions and daily living activities. During the last decade, percentage of he outpatient group was increased, while those of the inpatient groups were decreased, and QOL of patients with RA and OA was improved. Compared with OA, RA showed lower percentages of the inpatient groups and greater losses in physical functions, daily living activities and social activities. Accordingly, the burden of RA was greater than that of OA. CONCLUSIONS: In order to improve QOL and reduce the burden of RA, not only development of effective treatment but also assistance to social activities of the patients is required.

Activities of Daily Living↗
PubMed2003

Mothers' scaffolding of children's problem solving: establishing a foundation of academic self-regulatory competence.

The study examined relations between dimensions of mothers' scaffolding and children's academic self-regulatory behaviors in school. Mothers and their preschool children (68 dyads) were visited in their homes the summer before the child entered kindergarten. Mothers' metacognitive content and manner of instruction, emotional support, and transfer of responsibility were coded as mothers provided assistance to their children during 4 problem-solving tasks. Children's self-regulatory behaviors were assessed the following school year. Metacognitive content and manner of instruction were predictors of child behaviors related to cognitive awareness and management: metacognitive talk, monitoring, and help seeking. Emotional support and transfer of responsibility were related to children's task persistence and behavior control in school. Mothers' scaffolding appears to lay the foundation for children's subsequent academic self-regulatory competence.

Child↗
PubMedDate not supplied

[About the 350th anniversary of the foundation of the chair of anatomy of the faculty of medicine at Strasbourg (1652-2002)].

Some historical and bibliographical elements are given at the occasion of the 350th anniversary of the foundation of the chair of anatomy at Strasbourg. Strasbourg played an important role in the dissemination of the anatomical knowledge in the end of the 15th and the first half of the 16th century. In 1517, the first official human dissection organized in Strasbourg was performed. In 1652, a specific chair of anatomy founded, and the first holder was J. A. Sebiz (1614-1685). In 1670, an anatomical lecture theatre was created. Strasbourg became a French town in 1681 with no modification of the university and of the chair of anatomy. In 1872, after the annexation of Alsace, a new German university was founded ; normal anatomy and pathology were separated and each chair attached to a particular institute. In 1919, when the Faculty of Medicine was reorganized after Alsace was restored to France, specific chairs and institutes were founded for histology and embryology. Among the famous morphologists and scientists who worked in Strasbourg were in anatomy : H. Brunschwig (?-1534), W. H. Ryff (c. 1505-1548), J. Winter von Andernach (1497-1574), T. Lauth (1758-1826), F. D. Reisseissen (1773-1828), J. F. Lobstein (1777-1835), E. A. Lauth (1803-1837), E. Koeberlé (1828-1915), E. Beaunis (1830-1921), H. D. Bouchard (1833-1899), J. G. Joessel (1838-1892), W. Waldeyer (1836-1921), G. Schwalbe (1844-1916), W. Pfitzner (1853-1903), F. Keibel (1861-1929), A. Forster (1878-1957), and P. Bellocq (1888-1962) ; in pathology : F. D. von Rechlinghausen (1833-1910), H. Chiari (1851-1916), J. G. Mönckeberg (1877-1925), P. Masson (1880-1959), and L. Géry (1883-1957) ; in histology : P. Bouin (1870-1962), M. Aron (1892-1974), R. Courrier (1895-1986), and M. Klein (1905-1975) ; in embryology : P. Ancel (1873-1961), P. Vintemberger (1891-1983), J. Benoit (1896-1982), E. Wolff (1904-1996), and J. Clavert (1912-1994).

Anatomy↗
PubMed2003

Strategies in treating newly diagnosed or untreated multiple myeloma patients. From the Multiple Myeloma Research Foundation.

Treatment regimens for multiple myeloma are evolving because of new advances in both pharmacotherapy and transplantation strategies. The Multiple Myeloma Research Foundation (MMRF) has gathered the top thought leaders in myeloma research to prepare an engaging, interactive series of case studies in multiple myeloma, which are available online at www.multiplemyeloma.org and will be published on a regular basis in ONCOLOGY.

Analgesics, Opioid↗
PubMedDate not supplied

Occupational health nursing in Canada: its social foundation and future.

Our purpose in examining the social foundation of occupational health nursing is to better determine the future direction of the profession and its impact on a diverse workforce. Part of what makes up the profession of occupational health nursing is found in its definition: a process that is determined by the interaction between the occupational health nurse, worker, work and workplace; its goal is to assist the worker to achieve his or her optimal level of functioning, primarily through health education, health promotion, prevention of disease and injury and crisis intervention. Much of occupational health nursing is also based on its history and the traditions that have been established. A true understanding, then, of what occupational health nursing's future can be comes from a solid understanding of the history of the profession. As social trends in the past affected the profession, so will they in the future.

Canada↗
PubMed2003

From clinical records to regulatory reporting: formal terminologies as foundation.

Achieving goals of healthy people and populations is dependent on available and relevant data for health care decisions. New technologies enable reuse of data for decisions, however it is clear that uniform data standards and in particular standards around terminological data will be required to achieve reuse. Terminological data related to functioning and disability presents unique challenges because of the conceptual ambiguity within the field. The International Classification of Functioning, Disability, and Health (ICF) provides a clarifying conceptual foundation for functioning and disability data, but is not structured as a formal terminology. The need for a concerted and coordinated effort is emphasized.

Activities of Daily Living↗
PubMed2003

[Long-acting antipsychotics in the maintenance treatment of schizophrenia: Part I. Foundations of its development, benefits and acceptance level in different countries and cultures].

In this study, the foundations of long-acting antipsychotics development, the adherence to treatment, the factors that make difficult the following of the prescription and their consequences, the benefits and acceptance of long-acting antipsychotics are revised. Based on the data obtained from the first part of this study, the following issues must be highlighted: the non-adherence treatment level in schizophrenia is about 60%. Considering schizophrenia a chronic disease with high relapse risk, the maintenance treatment helps its control. The long-acting antipsychotics were developed exactly for the purpose of guaranteeing the administration of the medication and its regularity, which are essential requirements in preventing a relapse. In spite of the immensurable benefits of the long-acting antipsychotics, several factors have contributed to their usage below their potential.

Antipsychotic Agents↗
PubMed2003

High blood pressure: the foundation for epidemic cardiovascular disease in African populations.

High-blood pressure is a powerful independent risk factor for death from heart disease and stroke. It is also a common clinical condition affecting more than 600 million persons worldwide and seen in nearly all populations. Although reliable, large-scale, population-based data on high blood pressure in sub-Saharan Africa (SSA) are limited, recent studies provide important and worrisome findings in both epidemiology and clinical outcomes. Although overall hypertension prevalence is between 10%-15%, prevalence rates as high as 30%-32% have been reported in middle-income urban and some rural areas. Importantly, hypertension awareness, treatment, and control rates as low as 20%, 10%, and 1%, respectively have also been found. Stroke has been by far the most common clinical sequela. In most SSA settings, hypertension control assumes a relatively low priority and little experience exists in implementing sustainable and successful programs for drug treatment. Rapid urbanization and transition from agrarian life to the wage-earning economy of city life continue to fuel increases in average blood pressure levels and prevalence of hypertension. Although the true burden of high blood pressure in sub-Saharan Africa remains largely unmeasured, compelling preliminary evidence suggests that it is the foundation for epidemic cardiovascular disease in Africa and already contributes substantively to death and disability from stroke, heart failure, and kidney failure in this region. Success in limiting this epidemic in SSA will depend heavily on the implementation of sustainable and aggressive population-based programs for high blood pressure awareness, prevention, treatment, and control. It will be critical to obtain investments in improved surveillance and program-relevant research to provide the evidence base for policy development and effective hypertension prevention and control.

Africa South of the Sahara↗
PubMed2003

Four-square. Practice profitability stands on four foundations.

A medical practice's profitability stands on four legs: physician productivity, accounts receivable, overhead costs and ancillary revenue. The author describes where weakness can occur in each of these foundations and how to remedy such structural defects.

Accounts Payable and Receivable↗
PubMed2003

The AANA Foundation Closed Malpractice Claims Study on nerve injuries during anesthesia care.

Anesthesia-associated nerve injury is a common cause of patient morbidity and litigation. To identify factors associated with perioperative nerve injuries and rationalize preventive strategies, 44 cases from the American Association of Nurse Anesthetists (AANA) Foundation Closed Malpractice Claims Database pertaining to nerve injuries in which nurse anesthetists provided care were analyzed. Emerging patterns and themes related to the development of injury were identified. The database is a collection of medical liability claims filed against CRNAs insured by the St Paul Fire and Marine Insurance Company; 44 claims of anesthesia-related nerve injury were analyzed. The most common injury was to the brachial plexus (15 [34%]), followed by ulnar nerve injury (7 [16%]), radial nerve injury (5 [11%]), peroneal nerve injury (4 [9%]), paraplegia (4 [9%]), lumbosacral injury (3[7%]), and a variety of "other" injuries (8[18%]). These numbers and percentages total more than 44 (100%) as some patients incurred multiple injuries. Documentation on the anesthesia record of the use of intraoperative protective padding and patient position was lacking or inadequate in a majority of the claims. Effective strategies for the prevention of nerve injury during anesthesia are reviewed. Abnormal body habitus, several disease states, anesthesia technique, improper positioning, lack of adequate padding, and tourniquet use have been implicated as risk factors.

Adolescent↗
PubMed2003

Quality of health care: informatics foundations.

OBJECTIVE: To discuss in what ways computer systems can contribute to the quality of healthcare and on which principles of informatics successful systems are based. METHODS: Part of the information was obtained via a literature search and part is based on the knowledge of the authors. RESULTS: The results of the literature search are reported. The answers to the questions whether decision support is useful and which factors determine its success, the foundations of computerized guidelines systems and applications of physician order entry and medical risk management are presented. CONCLUSIONS: Despite many publications concerning diagnostic support systems their use in clinical practice is limited. Reminder systems do appear to have an impact on health outcomes. Standards for guideline models are being developed for effective sharing of guidelines across systems. Electronic patient records and physician order entry systems are useful aids in medical risk management.

Decision Support Systems, Clinical↗
PubMed2003

Logic-based remodeling of the Digital Anatomist Foundational Model.

This paper describes a development cycle for the engineering of large knowledge bases: A graphical tool is used for editing and the content is transformed into a logic-based representation language. This representation is used to check the consistency of the knowledge base as well as to facilitate the reviewing process. Showing the usefulness of this approach, aspects of the Digital Anatomist Foundational Model will be transformed into a Description Logics representation. We introduce a special modeling technique to account for the representation of the complex part/whole relationships in the biomedical domain.

Anatomy↗
PubMed2003

A prototype natural language interface to a large complex knowledge base, the Foundational Model of Anatomy.

We describe a constrained natural language interface to a large knowledge base, the Foundational Model of Anatomy (FMA). The interface, called GAPP, handles simple or nested questions that can be parsed to the form, subject-relation-object, where subject or object is unknown. With the aid of domain-specific dictionaries the parsed sentence is converted to queries in the StruQL graph-searching query language, then sent to a server we developed, called OQAFMA, that queries the FMA and returns output as XML. Preliminary evaluation shows that GAPP has the potential to be used in the evaluation of the FMA by domain experts in anatomy.

Anatomy↗
PubMed2003

Representing complexity in part-whole relationships within the Foundational Model of Anatomy.

The Foundational Model of Anatomy (FMA) is a frame-based ontology that represents declarative knowledge about the structural organization of the human body. Part-whole relationships play a particularly important role in this representation. In order to assure that knowledge-based applications relying on the FMA as a resource can reason about anatomy, we have modified and enhanced currently available schemes of meronymic relationships. We have introduced and defined distinct partitions for decomposing anatomical structures and attributed the part relationships in order to eliminate ambiguity and enhance specificity in the richness of meronymic relationships within the FMA.

Anatomy↗
PubMed2003

An approach to the anatomical correlation of species through the Foundational Model of Anatomy.

The increasing need for extrapolating information from one species to another has been highlighted by contemporary research in bioinformatics, genomics, proteomics, and animal models of human disease, as well as other fields. We propose an approach to correlating the anatomy of Homo sapiens with selected species, using the Foundational Model of Anatomy (FMA) as a framework, and graph matching as a method, for determining similarities and differences in the nodes and relationships (edges) defined by the attributed graph of the FMA. We illustrate our approach by comparing anatomical structures of mouse and human that present prototypical mapping problems.

Anatomy↗