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[Right cardiac echinococcosis with coronary compression. Description of a clinical case].

An outstanding case of cardiac echinococcosis is described. Clinical symptomatology was characterized by typical nitroglycerin-responsive crisis of angina pectoris associated to an electrocardiographic pattern of negative T wave on anterolateral and inferior leads. The diagnosis was suspected on the basis of thoracic computerized tomography and coronary arteriography. The anatomical localization was mainly pericardial but the right ventricle was involved too. Left anterior descending artery was dislocated and squeezed.

Adult↗

Echinococcosis multilocularis in Turkey.

We present 20 new cases of Echinococcosis multilocularis (EM) and have also reviewed all 137 previously reported cases from Turkey. The total number of cases is now 157 up until the end of 1983. Of 146 cases with information on their place of occurrence, 133 (91%) were from eastern and central parts of Turkey or the region of the Black Sea where the cold climate is predominant. This area should be considered as part of the geographic distribution of Echinococcus multilocularis which extends from the Caucasian Republics (Azerbaijan and Georgian S.S.R.) to Siberia in the Soviet Union. EM is more frequent among the people involved in raising livestock in the rural areas of Turkey. Most of the cases (76%) were between the ages of 30 and 50; 53% were males. One hundred and thirty nine cases (92%) were liver infections, and most of the cases (60%) were clinically diagnosed as liver tumour.

Adolescent↗

[Echinococcosis of the orbit].

A 5 year old girl with an echinococcuscyst in the right orbit is reported. The final diagnosis was made by removal of the cyst. A second cyst was found in the liver. The epidemiology, clinical and diagnostic problems of echinococcosis are reviewed. Radical surgery is still the only reliable treatment. For inoperable cases chemotherapy with Mebendazol seems promising. Many problems of chemotherapy remain to be solved and Mebendazol therapy is still in an experimental stage.

Child, Preschool↗

[Role of computed tomography in the diagnosis and surveillance of hepatic alveolar echinococcosis].

Based on findings in 28 cases of hepatic alveolar echinococcosis, the most frequently encountered signs constituting a true "scannographic profile" are described. These include global hypodensity with poor or absent intensification of image after iodized contrast, very high frequency of intralesional calcifications often combined with necrotic plaques, peripheral retraction. Employed after standard radiologic imaging and ultrasonography, the scanner should be used to provide positive confirmation of the diagnosis of the parasitosis, and as a reference element in evaluation of intra- and peri-hepatic extension, both during the moment of choice of initial therapy and during follow-up reviews.

Adult↗

[Hepatic echinococcosis. Surgical treatment].

After some general observations on liver echinococcosis (epidemiology, liver topographic anatomy, diagnostics), various surgical techniques proposed for the treatment of this disease are described. Case series observed from 1967 to 1978 and the technique of choice, cystotomy with partial cysto-resection, are presented. The favourable results obtained are underlined.

Adult↗

Evaluation of selected drugs for the treatment of canine echinococcosis.

Results are reported from 26 trials of various drugs for the treatment of canine echinococcosis. In all, 613 dogs were employed. Arecoline hydrobromide and Anthelin, in single trials of each, failed to remove even half the E. granulosus worms in 50% of the dogs treated with these compounds. A total of 24 trials were carried out with a series of 8 naphthalene derivatives and compounds of this series were effective in eliminating E. granulosus; at least one of them, bunamidine hydrochloride, seems to show sufficient promise as an improved method of treatment for field application and evaluation trials to be made.

Animals↗

[Liver echinococcosis].

On the basis of the experience with surgical treatment of 168 cases of hepatic echinococcosis in Algeria the author has concluded that such cases need an intense therapy both in pre- and postoperative period. To prevent from the recurrence of the disease it is sufficient to process the hydatid cyst fibrosal tunic with a tampon moistened with 5% formaline or 1% tripaflavine solution. The excision of the fibrosal tunic extended down to the cyst "bottom", followed by the suturing of the capsule stump to the liver wound margins, or primary suturing, before the drainage is started, in cases of a narrow wound cavity, result in 98.8% of recovery.

Adolescent↗

[The Auvergnan focus of alveolar echinococcosis. Research on the intermediate host, description of the lesions].

Echinococcus multilocularis larvae occurred in 23 (2.44%) of the 943 adult vole rats (Arvicola terrestris scherman Shaw, Mammal Microtidae) collected in the mountanous center of France (Massif Central, departments of Puy-de-Dôme and Cantal, province of Auvergne) and obtained from August 1981 to Aug. 1982 in seven different localities. According to this localities, the average percentage of parasitized voles changes from zero to 4.65%; according to the month of the year, these percentages change from 0.6 to 3.6 in the active sites while unusual peaks can be reached (17.5 in January in the Allanche focus with yearly prevalence of 3%). The favorable focuses remain active the whole year. The different aspects of the anatomo-pathological changes of the livers are described, particularly those due to young larvae. 14 (60%) of the 23 larvae are young, small and infertile hydatids. Only 2 (8.7%) of the 23 are fertile. One of these two larvae seems to degenerate and produces a few protoscolex alive; the other simulates a plurilocular larva of E. granulosus, restricted to a single lobe well delimited by the fibrous adventitia and produces the protoscolex in great number. These observations prove the good receptivity of the vole rat to the local strain of the parasite but seem to attest its relative inaptitude to bring the larva to maturity. The dispersion of the alveolar echinococcosis among the wild animals in Auvergne (8.5 of the foxes parasitized and 2.44% of the vole rats) realised a permanent threat of contamination as regard rural population or people on holiday during the summer. The risk seems to be weak (5 human cases of hepatic alveolar hydatid disease for ten years) but actual.

Animals↗

[Role of echography in the diagnosis and monitoring of hepatic alveolar echinococcosis].

By means of a review of a series of 30 cases of hepatic alveolar echinococcosis, the authors propose a classification of the various sonographic patterns; they point out the heterogeneous form which associate necrosis and calcification inside an hyperechoic mass and is the most frequent. The interest of ultrasonography for detection of lesions, its limits for diagnosis of extension, the contribution of percutaneous biopsy are discussed, as its place in the survey of the affection.

Adult↗

[Modern diagnosis of genito-pelvic echinococcosis in women].

From 1927 to 1983, out of 25,388 laparotomies, 10 cases (0.038%), and out of 1,463 vaginal hysterectomies, only one case (0.068%) of genito-pelvic echinococcosis were recorded. Ultrasound (exemplified by a case), and computerized tomography have recently been used for establishing preoperative diagnosis.

Echinococcosis↗

[Detection of the larva of Taenia multilocularis in 2 voles (Microtus arvalis and Clethrionomys glareolus) in a focus of alveolar echinococcosis in the Massif Central (France)].

Small wild rodents were collected and examined during 1983-1984 to investigate parasite-host relationships of Echinococcus multilocularis in one habitat suitable for red foxes of Auvergne (France). The natural infestation of the liver of two different voles, Microtus arvalis and Clethrionomys glareolus, by the larval stage of the cestode is recorded for the first time. In the both cases, the larvae were fully developed and numerous protoscolices were present with some calcareous corpuscules; the expansion of the larvae involved several hepatic lobes in Microtus and was restricted to a single lobe in Clethrionomys. Epidemiological consequences of the receptivity of the two hosts are not yet investigated in the field. However several species of voles inhabiting the same endemic area and which are receptive to the larval stage of alveolar echinococcosis should be a favourable factor of durability for the cestodiasis of the foxes; so the parasite is able of surviving the cyclic and considerable but not simultaneous fluctuations of the three populations of voles which are locally implicated in the zoonosis: M. arvalis, C. glareolus and Arvicola terrestris, by changing from one species to the others.

Animals↗

[Evaluation of the role of angiography in the diagnosis and surveillance of hepatic alveolar echinococcosis].

The authors recall the main pathologic and physiopathologic data necessary to understand the angiographic patterns of hepatic alveolar echinococcosis, by means of a rereading of a personal series of 37 cases. They show that this affection has a diagnostic angiographic shape which associate four signs: avascular aspect of the lesions, regular invasion of vessels, presence of a collateral circulation, absence of neovascularisation. Digestive angiography stays a good diagnostic method for the parasitosis, when epidemiological context, ultrasound or CT scan gave no explicit conclusion. It keeps an interest in the preoperative evaluation and in the supervision of portal vein.

Adult↗

[Hepatocellular drug reaction caused by mebendazole therapy in cystic echinococcosis].

A 76 years-old male patient received mebendazole, 500 mg four times a day (appr. 29 mg per kg body weight) for treatment of sonographically and serologically proven cystic echinococcosis of the liver. On day 49 of this therapy he developed an exanthema, and mebendazole-administration was interrupted. At the same time a striking rise of serum transaminases was observed. When enzyme levels normalized, a reexposure using a low dose of mebendazole lead to a new more pronounced rise of transaminases suggesting a drug-induced hepatocellular damage. No measurable change of the Echinococcus cyst was observed during treatment.

Aged↗

[Complications of surgical treatment of echinococcosis of the liver].

Under analysis were postoperative complications in 250 out of 1187 patients operated for hydatid echinococcosis of the liver. It was shown that the right choice of the access and the rational method of treatment could prevent complications and lethality after operations. The method of choice is believed to be a one-step closed echinococcectomy with different modifications.

Anesthesia, Local↗

[Immunological diagnosis of echinococcosis. A study of 146 cases, including 8 with bone involvement (author's transl)].

After a study about 146 cases of echinococcosis which 8 osseous localizations, indirect immunofluorescence reactions and immunoprecipitation reactions allow for comparing between right immunologic answers in hydatid cyst of liver and hydatid cyst of bone. The right immunogenicity of osseous hydatid cyst can be explained by a close contact host-parasite and by a good vascularization and a good fertility.

Antibody Formation↗

Evaluation of five immunodiagnostic techniques in echinococcosis patients.

Double diffusion (DD), indirect haemagglutination (IHA), immunoelectrophoresis (IEP), latex agglutination (LA), and complement fixation (CF) tests were evaluated for sensitivity and specificity in the diagnosis of 141 surgically-proven Turkana echinococcosis patients and 10 controls. The overall sensitivities for the tests were: IHA, 86.7%; LA, 53.3%; CF, 63.3%; DD, 55.0%; IEP, 55.0%. LA and CF tests produced a high number of false positive results; IHA gave a false positive result in 10% of cases; no false positives were obtained with IEP and DD. A combination of the latter three tests would therefore offer the best chance of detecting specific anti-Echinococcus antibodies, with an average sensitivity of 62.7%. The possible reasons for the relatively high incidence of false negative values are discussed.

Animals↗

[Treatment of alveolar echinococcosis with flubendazole. Pharmacological study (author's transl)].

Several publications mention a relative efficacy of flubendazole in the treatment of alveolar echinococcosis of the liver (AE). It may seem surprising, being considered the poor intestinal absorption of this drug. A study of the plasma levels was performed in 6 patients, during the treatment with oral flubendazole (approximatively 50 mg/kg/24 h) : 3 patients with normal or subnormal liver functions, 1 hydatidosis and 2 clinically nearly latent AE (group I) ; 3 patients with a highly developed AE (group II). The levels were measured by radioimmunoassay. In the group I, the plasma levels were very low, more often inferior to 3 ng/ml, without distinct peaks. In the group II, the valley levels were higher than 0 ng/ml, and the peaks ranged from 47,4 to 50,4 ng/ml (1 to 3 hours after an intake). The increase in the dosage allowed higher levels, as opposed to previous assertions. The bile and faeces concentrations, as well as the urinary elimination, were studied in a patient with external biliary drainage. The intramusculary injectable flubendazole was used in a patient, without benefit as far as plasma levels are concerned.

Anticestodal Agents↗