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PubMed1991

Seborrheic inclusion cyst.

Epidermoid cysts with seborrheic keratosis-like linings are a recently described rare variant of epidermoid cysts. We report a case in which such a cyst developed following the excision of a typical seborrheic keratosis.

Aged↗
PubMed1989

Cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea.

Cell proliferation kinetic values were established for the epidermis, hair follicle epithelium, and sebaceous glands of 8 Cocker Spaniels with primary idiopathic seborrhea. Values were established by intradermal pulse labeling injections of tritiated thymidine followed by cutaneous biopsy and autoradiography. The epidermal basal cell-labeling index was 4.96 +/- 0.97%, and the epidermal nucleated cell-labeling index was 3.33 +/- 0.71%. Calculated epidermal cell renewal time for the viable layers of the epidermis was 7.85 +/- 1.80 days. The hair follicle infundibulum basal cell-labeling index was 5.48 +/- 2.01%, and the sebaceous gland basal cell-labeling index was 5.94 +/- 4.15%. When compared with previously reported cell kinetic values for Cocker Spaniels and Beagles with healthy skin, these data indicate accelerated cellular proliferation in all 3 cutaneous structures in seborrheic Cocker Spaniels.

Animals↗
PubMed1987

Melanosome macrocomplex: an ultrastructural component of patterned and nonpatterned seborrheic keratoses.

An ultrastructural study of five seborrheic keratoses arising in a symmetrical, patterned distribution following the lines of cleavage on the backs of two patients showed the presence of melanosome macrocomplexes 2 to 5 microns in size. Identical findings were seen in fifteen pigmented seborrheic keratoses randomly distributed on the skin of five patients. The membrane-bound macrocomplexes were clusters of closely packed, discrete melanosomes. Present in melanocytes, keratinocytes, Langerhans cells, and dermal macrophages, they were considered to result from sequestration of melanosomes in cell phagosomes. No homogeneous inclusions typical of melanin macroglobules ("giant melanosomes") were found in any of the specimens, supporting the view that neither patterned nor nonpatterned seborrheic keratoses are nevoid in nature.

Dermatitis, Seborrheic↗
PubMed1978

Inflammatory seborrheic keratoses with mononuclear cell infiltration.

Inflammation in inflammatory seborrheic keratoses was found to be composed of mononuclear cells, particularly lymphocytes. Accumulations of mononuclear cells in the papillary and subpapillary dermis frequently showed no tendency to infiltrate the epithelium. However, dramatic interaction of the seborrheic keratosis and the inflammatory process also was common. The lymphocytic exocytosis into the epithelium followed two basic patterns: eczematous, characterized by intercellular and intracellular edema, microvesicle formation, and epithelial necrosis; and lichenoid, in which a bandlike infiltrate attacked the dermoepidermal junction and hyaline bodies occurred in the infiltrated epithelium and in the dermis. Epithelial changes consisted of necrosis of epithelial cells and related parakeratosis; squamous eddies were occasionally found. Inflammatory cell infiltration in seborrheic keratoses possibly represents a process other than irritation, and we propose that mononuclear cell infiltration in seborrheic keratoses may be related to an involutionary process.

Dermatitis, Seborrheic↗
PubMed1982

[Use of cyproterone acetate in the treatment of acne].

Forty two female patients with strong acne and oiliness were studied all of them were treated with a tablet daily of 2 mg. of cyprosterone Acetate and 0.05 mg of ethinyl oestradiol for 3 weeks and a week without it. We found intolerance to the treatment in 9 out of 42 patients and a high percentage of cure or marked improvement in 96.9% of patients. In conclusion this drug is a good help to the treatment of female acne with seborrheic skin.

Acne Vulgaris↗