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PubMed2002

From overshoot to voltage clamp.

In 1939, A.L. Hodgkin and I found that the nerve action potential shows an "overshoot"--that is, the interior of the fibre becomes electrically positive during an action potential. In 1948, we did our first experiments with a voltage clamp to investigate the current-voltage relations of the nerve membrane. Between those dates, we spent much time speculating about the mechanism by which ions cross the membrane and how the action potential is generated. This article summarizes these speculations, none of which has been previously published.

Action Potentials↗

PubMed2000

From colloids to proteases.

The present autobiographical review describes my professional experiences as a graduate student in Vienna, Austria, the postdoctoral experiences at the University of London, University of Minnesota, and at Cornell University, Ithaca, NY. This was followed by a faculty appointment at Duke University where I rose through the ranks from assistant professor to professor of physical biochemistry from 1938 to 1950. This account includes both scientific and cultural episodes and anecdotes. In 1950 I moved to Seattle to become founding chairman and professor in the Department of Biochemistry as will be described elsewhere.

Austria↗

PubMed2000

Genomics - the new rock and roll?

The end of the beginning of the Human Genome Project was announced on 26 June when the working draft or first assembly was announced. Here, Ian Dunham who led the group at the Sanger Centre that produced the first complete sequence of a human chromosome reflects on how it felt to be with the genome project from the beginning.

Chromosomes, Human, Pair 22↗

PubMed1990