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At least 847 records · Page 47Linked to original sources
PubMed2006

Duplex sonography after living donor kidney transplantation: new insights in the early postoperative phase.

AIM: Vascular complications of kidney transplantation, including transplant vein thrombosis, are relevant causes for graft loss in the early postoperative phase. However, duplex flow characteristics after living renal transplantation are widely unknown. Aim of the study was to assess renal perfusion in the postoperative period with special emphasis on the renal vein. METHODS: 22 consecutive kidney graft recipients and their donors were included and prospectively followed up for three months. The following Doppler parameters were collected: in the donor before operation: the intrarenal resistive index (RI), in the recipient after transplantation and at one and three months: the intrarenal RI, peak flow velocities and area under the curve in the renal vein, as well as peak systolic velocities of the iliac and renal artery. RESULTS: None of the 22 transplants failed due to vascular complications. Highest median venous (92 cm/s [range 22-211]) and arterial peak velocities (271.5 cm/s [141.5-458]) were observed close to the anastomosis immediately after transplantation. During follow-up, flow parameters significantly decreased at three months (44.3 cm/s [13.3-156.9] and 186.8 cm/s [105.5-267.5]). The RI decreased from donor to recipient at the day of operation due to tachycardia (0.65 to 0.60; P = 0.06). After correction for heart rate, the RI was stable during follow-up. CONCLUSIONS: Initial high peak velocities in conjunction with stable resistive indices in a cohort, free of vascular graft complications, suggest a postoperative physiologic adaptation process rather than a relevant stenosis requiring medical intervention.

Adolescent↗
PubMed1990

Nutrition and enzyme inducers in liver tumor promotion in human and rat.

Phenobarbital and other substances that cause induction of P450 linked enzymes in the liver are potent tumour promoters when given to rats after a single dose of dimethyl or diethyl nitrosamine. The human population is known to be exposed to small amounts of nitrosamines and to inducers of P450 linked enzymes in the liver, from natural foods such as cabbage and other brassicas. Many individuals are exposed to induced doses of phenobarbital used as anti convulsants. Cohort studies have shown that there is no increased risk of liver cancer detectable in people taking phenobarbital who suffer from epilepsy. On investigating the dose response curve for tumour promotion one finds that hepatocellular carcinomas only appear at a high dosage of phenobarbital and it seems likely that the human exposure to inducers in food, and in therapy with anticonvulsants, is in the dosage range well below that which causes promotion of liver cancer. The physiological adaptation to environment must be clearly distinguished from the pathological events which take place in experimental overdose.

Animals↗
PubMed1988

Effects of age on metabolic responses to acute and chronic stress.

The effect of age on the capacity of an organism to mobilize glucose and free fatty acids during stress and to adapt these responses from an acute to a chronic stress situation is not known. The purpose of this study was to determine whether aging impaired the capacity to 1) raise glucose and free fatty acid levels and suppress insulin release in acute stress situations and 2) develop adaptation of these responses to exposure to chronic stress. Our results indicate that 6-mo-old rats (young) trained to escape electric shock (short-term modulation) showed greater acute stress-induced hyperglycemic, hypoinsulinemic, and lipolytic responses than untrained young rats. By contrast, in 22-mo-old rats (old), responses of trained and untrained animals were not different. In the chronic stress (long-term adaptation) experiments, it was found that 1) adaptation of stress-induced hyperglycemia occurred at a faster rate in young than in old animals; 2) in young but not in aged rats, a strong positive correlation was observed between adaptation of stress-induced hyperglycemia and hypoinsulinemia; and 3) in young rats, stress-induced lipolytic responses declined proportionately to the duration of chronic stress exposure, whereas by contrast in chronically stressed aged rats steady-state levels of free fatty acids were not raised during exposure to stress. Thus we conclude that 1) glucose intolerance may play a key role in the altered stress-induced metabolic responses of aged rats; 2) with age, there is a loss of plasticity in physiological adaptive response mechanisms associated with metabolic responses to stress.

Aging↗
PubMed1983

Aerobic fitness level and reactivity to psychosocial stress: physiological, biochemical, and subjective measures.

Aerobic fitness is associated with numerous physiological adaptations which permit physical stress to be coped with more efficiently. The present experiment examined whether aerobic fitness influences emotional response. Heart rate, biochemical measures (catecholamines, cortisol, prolactin, lactic acid), and self-reported arousal and anxiety were monitored in 15 highly trained and 15 untrained subjects at various points before, during and following exposure to a series of psychosocial stressors. Heart rate and subjective arousal level increased markedly during the stressors in both groups. Trained subjects showed higher levels of norepinephrine and prolactin early in the stress period, more rapid heart rate recovery following the stressors, and lower levels of anxiety at the conclusion of the session. This more rapid heart rate and subjective recovery from psychosocial stress, suggests that aerobically trained individuals may be capable of faster recovery in both physiological and subjective dimensions of emotionality. The differences in reactivity profiles between the aerobically trained and untrained were discussed in light of models that have dealt with the adaptiveness of emotional response.

Adult↗
PubMed2002

Pregnancy and lactation affect markers of calcium and bone metabolism differently in adolescent and adult women with low calcium intakes.

Physiologic adaptation to the high calcium demand during pregnancy and lactation may be different in adolescents than in adults, particularly at low calcium intake. The aim of this cross-sectional study was to compare biochemical markers of calcium and bone metabolism between adolescent (14-19 y) and adult (21-35 y) women with calcium intake approximately 500 mg/d, in three different physiologic states, i.e., control (nonpregnant, nonlactating; NPNL), pregnant and lactating. Markers of calcium metabolism [serum Ca, P and intact parathyroid hormone (iPTH); urinary Ca and P] and of bone turnover [urinary deoxypyridinoline (D-Pyr) and plasma bone alkaline phosphatase (BAP)] were measured in NPNL (adolescents, n = 12 and adults, n = 25), pregnant (adolescents, n = 30 and adults, n = 36) and lactating (adolescents, n = 19 and adults, n = 26) women. In the NPNL women, iPTH, D-Pyr and BAP were higher (P < 0.001) and urinary Ca was lower (P < 0.001) in adolescents than in adults. Serum iPTH was higher (P < 0.001) and urinary Ca was lower (P < 0.01) in adolescents than in adults also in pregnancy and lactation. Compared with NPNL women, serum Ca decreased (P < 0.001) with pregnancy in adolescents but not in adults. The increase in D-Pyr with pregnancy and lactation was very pronounced in adults ( approximately 130%, P < 0.001) but less in adolescents (<25%, P < 0.01). BAP increased (P < 0.001) with pregnancy and lactation in adults ( approximately 60%) but decreased (P < 0.001) with pregnancy in adolescents ( approximately 13%). Pregnancy and lactation appear to affect bone turnover in adolescent and adult women with low calcium intake differently.

Adolescent↗
PubMed2005

The adrenocortical response of tufted puffin chicks to nutritional deficits.

In several seabirds, nutritional state of a nest-bound chick is negatively correlated with the activity of its hypothalamus-pituitary-adrenal (HPA) axis. Increased corticosterone (cort) secretion has been shown to facilitate changes in behavior that allow hungry chicks to obtain more food from parents. However, if parents are not willing/able to buffer their young from temporary food shortages, increased cort secretion could be detrimental to undernourished chicks. In a system where parents are insensitive to chick demands, low benefits and high costs of activation of the HPA-axis in hungry chicks should lead to a disassociation of the nutritional state of the young and the activity of its HPA-axis. We tested this novel hypothesis for the tufted puffin (Fratercula cirrhata), a seabird with intermittent provisioning of a nest-bound semi-precocial chick. We examined the HPA-axis activity of captive chicks exposed to the following: (1) a short-term (24 h) food deprivation; and (2) an array of prolonged (3 weeks) restrictions in feeding regimens. We found that in response to a short-term food deprivation chicks decreased baseline levels of cort and thyroid hormones. In response to prolonged restrictions, food-limited chicks exhibited signs of nutritional deficit: they had lower body mass, endogenous lipid reserves, and thyroid hormone titers compared to chicks fed ad libitum. However, baseline and maximum acute stress-induced levels of cort were also lower in food-restricted chicks compared to those of chicks fed ad libitum. These results support a major prediction of the study hypothesis that puffin chicks suppress HPA-axis activity in response to short- and long-term nutritional deficits. This physiological adaptation may allow a chick to extend its development in the nest, while eluding detrimental effects of chronic cort elevation.

Adrenal Cortex↗
PubMed1989

A reusable adapter for collection of cerebrospinal fluid in chronically cannulated goats.

A lightweight, adjustable adapter has been designed for chronic cannulation of goats (Capra hircus) which provides an accurate, safe means of sampling cerebrospinal fluid (CSF). This cisternal cannula has been used for continuous perfusion of synthetic CSF into the fourth ventricle in unanesthetized goats. This method also has been used for examining changes in ionic composition of the CSF and cerebral interstitial fluid (ISF) during physiologic adaptations to high altitude (2-5).

Animals↗
PubMedDate not supplied

[Effect of chronic effect of the electrostatic field on various biochemical indicators of the tissues].

The action of electrostatic field (320 kV/m) on the adaptability has been studied in experiments on young Wistar rats (females). Some parameters of carbohydrate, lipid and protein metabolism, and the process of lipid peroxidation were observed in blood serum, liver and brain. Glucose content was observed to increase in all the tissues, liver glycogen, cholesterol/phospholipid ratio. The urea and malondialdehyde increased in the liver and brain. The experiments have shown that the physiological adaptability is high.

Animals↗
PubMed1998

Endocrine modulation of physiological responses to catabolic disease.

Disease or endotoxemia alters the plasma concentrations of anabolic hormones, particularly growth hormone (GH) and insulin-like growth-factor I (IGF-I). In general, these hormones are inhibited during the catabolic disease state. A hypothesis has evolved that anabolic hormones might be useful in patients' recovery under these and other catabolic circumstances. The treatment of cattle with GH has provided significant improvement in the physiological response of the animals to the subsequent injection of bacterial lypopolysaccharide (LPS), perhaps via inhibition of tumor necrisis factor (TNF) release. However, this improved response to disease was not observed with animals treated with GH and infected with one of two parasitic organisms, Sarcocystis cruzi or Eimeria bovis. Recent attempts with other anabolic hormones, estradiol and progesterone, have proven remarkably effective in improving the adaptive physiological responses of calves to either E. bovis infection or to the injection of LPS. All animals displayed signs of infection, but the intensity and duration of symptoms were reduced. Although a mechanism is not yet known, there were no effects on TNF; cortisol; the percentages of lymphocytes expressing CD2, 4, or 8 antigens; or the production of antibodies.

Animals↗
PubMedDate not supplied

Male pregnancy in seahorses and pipefishes (family Syngnathidae): rapid diversification of paternal brood pouch morphology inferred from a molecular phylogeny.

In contrast to the majority of vertebrate species, primary male parental care is common in fishes and encompasses a remarkable diversity of adaptations. Seahorses and pipefishes (Family Syngnathidae) exhibit some of the most specialized forms of paternal care in animals and so are ideally suited to the study of the evolution of male parental care. During mating, female syngnathids transfer eggs to specialized morphological structures that are located on either the abdomen or tail of the male. The male provides all postfertilization parental care and has morphological and physiological adaptations to osmoregulate, aerate, and even nourish the developing embryos. While all syngnathid species are adapted for paternal care, the brooding structure with which this is accomplished varies between species, from simple ventral gluing areas to much more complex structures such as the completely enclosed pouches of the seahorses. Our combined cytochrome b-, 12S rDNA-, and 16S rDNA-based molecular phylogeny of syngnathid fishes demonstrates that rapid diversification of male brooding structures has been associated with the major evolutionary radiation of the group, suggesting that development and diversification of structures involved in paternal care may have been key evolutionary innovations of the Syngnathidae. Molecular analyses also highlight geographical centers of biodiversity and suggest interoceanic migration of Syngnathus pipefishes from their center of origin in the Pacific.

Animals↗
PubMed2002

The physiology of flatfish chromatophores.

Most flatfish, of the order Pleuronectiformes, possess a white lower side, and a brown or grey upper side. This upper side can display integumentary patterning with dark areas and colored or white spots. Chromatophores in flatfish are dermal and epidermal melanophores, as well as dermal xanthophores, erythrophores, iridophores, and leucophores, combinations of which contribute to the color and patterning. Cellular studies demonstrate pattern-related differences in numerical distribution between the types of chromatophores, and in their size, both of which will enhance contrast between areas of the pattern. As well as these morphological characteristics, there are also clear physiological differences, with melanophores from various areas of the patterns demonstrating differential responsiveness to background and to stress/excitement stimuli. Regulation of flatfish melanophore responses is predominantly neural, through the sympathetic nervous system; the pituitary hormones in these fish function in maintaining final equilibria in physiological adaptations to backgrounds. Melanophores from main components of patterns also respond differently in vitro to electrical stimulation, to pituitary hormones, and to sympathomimetic drugs and their antagonists. Sensitivity characteristics with alpha- and beta-adrenergic pharmacological reagents in vitro indicate the existence of a pattern-related balance in alpha- and beta-adrenoceptor mediation in melanophore regulation. The patterning mechanism is complex, with both morphological and physiological differences at the chromatophore level, as well as involvement of central processing and control, which remains to be analysed.

Animals↗
PubMed2003

Valve adaptation as a cause of disc opening reduction in mechanical heart valves: the case of the Lillehei-Kaster valve.

At fluoroscopy a decreased disc motion in mechanical heart prostheses is often a sign of valve thrombosis. On occasion, however, despite an exhaustive diagnostic work-up, common causes of prosthetic valve thrombosis are not found. In these cases the valve disc abnormalities are thought to be due to functional changes. We here report our experience with 5 consecutive patients carrying the Lillehei-Kaster prosthesis who had this fluoroscopic finding that was lately attributed to "valve physiologic adaptation". The time of onset, differential diagnosis and clinical/hemodynamic impact of valve adaptation are discussed.

Aged↗
PubMed2000

Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training.

Exercise enhances cardiac output and blood flow to working skeletal muscles but decreases visceral perfusion. The alterations in nitric oxide synthase (NOS) activity and/or expression of the cardiopulmonary, skeletal muscle, and visceral organs induced by swim training are unknown. In sedentary and swim-trained rats (60 min twice/day for 3-4 wk), we studied the alterations in NOS in different tissues along with hindquarter vasoreactivity in vivo during rest and mesenteric vascular bed reactivity in vitro. Hindquarter blood flow and conductance were reduced by norepinephrine in both groups to a similar degree, whereas N(G)-nitro-L-arginine methyl ester reduced both indexes to a greater extent in swim-trained rats. Vasodilator responses to ACh, but not bradykinin or S-nitroso-N-acetyl-penicillamine, were increased in swim-trained rats. Ca(2+)-dependent NOS activity was enhanced in the hindquarter skeletal muscle, lung, aorta, and atria of swim-trained rats together with increased expression of neuronal NOS in the hindquarter skeletal muscle and endothelial NOS in the cardiopulmonary organs. Mesenteric arterial bed vasoreactivity was unaltered by swim training. Physiological adaptations to swim training are characterized by enhanced hindquarter ACh-induced vasodilation with upregulation of neuronal NOS in skeletal muscle and endothelial NOS in the lung, atria, and aorta.

Animals↗
PubMed2003

Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice.

Bile acids are potentially toxic end products of cholesterol metabolism and their concentrations must be tightly regulated. Homeostasis is maintained by both feed-forward regulation and feedback regulation. We used humanized transgenic mice incorporating 13 kb of the 5' regulatory flanking sequence of CYP3A4 linked to a lacZ reporter gene to explore the in vivo relationship between bile acids and physiological adaptive CYP3A gene regulation in acute cholestasis after bile duct ligation (BDL). Male transgenic mice were subjected to BDL or sham surgery prior to sacrifice on days 3, 6, and 10, and others were injected with intraperitoneal lithocholic acid (LCA) or vehicle alone. BDL resulted in marked hepatic activation of the CYP3A4/lacZ transgene in pericentral hepatocytes, with an 80-fold increase in transgene activation by day 10. Individual bile acids were quantified by liquid chromatography/mass spectrometry. Serum 6beta-hydroxylated bile acids were increased following BDL, confirming the physiological relevance of endogenous Cyp3a induction to bile acid detoxification. Although concentrations of conjugated primary bile acids increased after BDL, there was no increase in LCA, a putative PXR ligand, indicating that this cannot be the only endogenous bile acid mediating this protective response. Moreover, in LCA-treated animals, 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside staining showed hepatic activation of the CYP3A4 transgene only on the liver capsular surface, and minimal parenchymal induction, despite significant liver injury. This study demonstrates that CYP3A up-regulation is a significant in vivo adaptive response to cholestasis. However, this up-regulation is not dependent on increases in circulating LCA and the role of other bile acids as regulatory molecules requires further exploration.

Animals↗
PubMed2004

Phycobilisome diffusion is required for light-state transitions in cyanobacteria.

Phycobilisomes are the major accessory light-harvesting complexes of cyanobacteria and red algae. Studies using fluorescence recovery after photobleaching on cyanobacteria in vivo have shown that the phycobilisomes are mobile complexes that rapidly diffuse on the thylakoid membrane surface. By contrast, the PSII core complexes are completely immobile. This indicates that the association of phycobilisomes with reaction centers must be transient and unstable. Here, we show that when cells of the cyanobacterium Synechococcus sp. PCC7942 are immersed in buffers of high osmotic strength, the diffusion coefficient for the phycobilisomes is greatly decreased. This suggests that the interaction between phycobilisomes and reaction centers becomes much less transient under these conditions. We discuss the possible reasons for this. State transitions are a rapid physiological adaptation mechanism that regulates the way in which absorbed light energy is distributed between PSI and PSII. Immersing cells in high osmotic strength buffers inhibits state transitions by locking cells into whichever state they were in prior to addition of the buffer. The effect on state transitions is induced at the same buffer concentrations as the effect on phycobilisome diffusion. This implies that phycobilisome diffusion is required for state transitions. The main physiological role for phycobilisome mobility may be to allow such flexibility in light harvesting.

Cyanobacteria↗