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PubMed2006

The odour span task: a novel paradigm for assessing working memory in mice.

Impoverished odour recognition and memory are amongst the earliest symptoms observed in mild cognitive impairment, Alzheimer's disease and schizophrenia, and have been advocated as early disease bio-markers. Although transgenic animals modelling disease pathologies continually emerge, there remains a paucity of tasks to examine olfactory working memory in mice. The present studies describe a mouse odour span task, which assesses the ability to remember increasing numbers of odours. Since caspase-3 is highly expressed throughout the olfactory system, we postulated that mice over-expressing this apoptogenic protein would exhibit impaired performance in the odour span task. Mice over-expressing human caspase-3 (Tg) exhibited age-independent deficits in olfactory working memory (6-18 months) compared with wild-type littermates, requiring longer for task acquisition and exhibiting impaired asymptotic performance, with reduced span lengths, lower accuracy and increased error rates. These impairments appeared to be selective for working memory, as Tg mice had no deficits in odour discriminatory ability or in locomotor measures. Importantly, nicotine, which improves working memory span in man, reversed the deficits exhibited by Tg mice. In conclusion, the mouse odour span task can detect subtle changes in olfactory working memory induced by genetic manipulation and drug administration and therefore should be applied to animal models of neurological disease.

Analysis of Variance↗
PubMed2003

Working-memory and auditory localization: demand for central resources impairs performance.

Four experiments explored possible roles for working memory in sound localization. In each experiment, the angular error of localization was assessed when performed alone, or concurrently with a working-memory task. The role of the phonological slave systems in auditory localization was ruled out by Experiments 1 and 2, while an engagement of central resources was suggested by the results of Experiment 3. Experiment 4 examined the involvement of visuo-spatial systems in auditory localization and revealed impairment of localization by the concurrent spatial working-memory task. A comparison of dual-task decrement across all four studies suggests that localization places greater demand on central than on spatial resources.

Adult↗
PubMed2000

Parallel visuospatial and audiospatial working memory processes in the monkey dorsolateral prefrontal cortex.

The dorsolateral area of the prefrontal cortex (PFC) in primates is involved in visuospatial working memory, but the cellular basis of spatial working memory for auditory information is poorly understood. Here we examined dorsolateral PFC neurons using visual and auditory oculomotor delayed-response tasks. We found that the dorsolateral PFC contains two groups of neurons, each showing directional delay-period activity depending on the location of the visual or auditory cue, suggesting that parallel neuronal processes for visual and auditory spatial working memory occur in the dorsolateral PFC.

Action Potentials↗
PubMed2005

Working memory capacity and suppression of intrusive thoughts.

We sought to show that individual differences in working memory capacity are related to the ability to intentionally suppress personally relevant intrusive thoughts, and that this effect cannot be explained by differences in negative mood. Sixty participants identified their most frequent intrusive thought and then completed a thought suppression task. Better performance on a measure of working memory capacity (OSPAN) was related to having fewer intrusions in the suppression condition but was unrelated to number of intrusions in the expression condition, suggesting a specific association with attempts to inhibit unwanted thoughts. In contrast, a more negative mood was related to having more intrusions in both conditions, suggestive of a more general influence on the accessibility of unwanted thoughts. Working memory capacity was not associated with negative mood or with the frequency of intrusive thoughts reported in everyday life. The findings extend previous results to the domain of personally relevant intrusive thoughts and support the idea that individual differences in the cognitive abilities supporting inhibitory mechanisms are relevant to clinical conditions such as obsessive-compulsive disorder and posttraumatic stress disorder.

Adolescent↗
PubMed1985

Working-memory capacity, age, and memory for discourse.

Two experiments explored the issue of whether age-related differences in memory for discourse can be explained by age-related differences in working memory capacity. Young and older adults were given a series of tasks designed to measure working memory capacity and memory for paragraphs. Although age-related differences were observed on digit, word, and sentence spans as well as on recall (Experiment 1) and recognition (Experiment 2), retention was not predicted well by scores on any of the span measures for either young or older adults in either experiment. The implications of these findings for hypotheses that age-related declines in working memory are responsible for problems in memory for prose are considered.

Adult↗
PubMed2006

Is the binding of visual features in working memory resource-demanding?

The episodic buffer component of working memory is assumed to play a role in the binding of features into chunks. A series of experiments compared memory for arrays of colors or shapes with memory for bound combinations of these features. Demanding concurrent verbal tasks were used to investigate the role of general attentional processes, producing load effects that were no greater on memory for feature combinations than for the features themselves. However, the binding condition was significantly less accurate with sequential rather than simultaneous presentation, especially for items earlier in the sequence. The findings are interpreted as evidence of a relatively automatic but fragile visual feature binding mechanism in working memory. Implications for the concept of an episodic buffer are discussed.

Analysis of Variance↗
PubMed2005

Working memory for order information: multiple cognitive and neural mechanisms.

Working memory for order information is mediated by different cognitive mechanisms that rely on different neural circuits. Here we discuss evidence that order memory involves mechanisms that range from general supervisory processes to process that maintenance fine-grained temporal position information. We suggest that neural regions-including the prefrontal cortex, motor cortex, parietal cortex and medial temporal structures-operate at different levels and processing stages to give rise to working memory for order information.

Cerebral Cortex↗
PubMed2004

Working memory and syllogistic reasoning.

The purpose of this study was to examine the relation between working memory span and syllogistic reasoning performance. In addition, performance for the reasoning task was compared to predictions made by mental model theory and the probability heuristics model. According to mental model theory, syllogisms that require the use of more mental models are more difficult. According to the probability heuristics model difficulty is related to the number of probabilistic heuristics that must be applied, or (for invalid syllogisms) inconsistencies between the derived and correct conclusion. The predictions of these theories were examined across two experiments. In general, people with larger working memory capacities reasoned better. Also, the responses made by people with larger capacities were more likely to correspond to the predictions made by both mental model theory and the probability heuristics model. Relations between working memory span and performance were also consistent with both theories.

Adult↗
PubMed1999

Working memory and intrusions of irrelevant information in a group of specific poor problem solvers.

An important body of evidence has shown that reading comprehension ability is related to working memory and, in particular, to the success in Daneman and Carpenter's (1980) reading and listening span test. This research tested a similar hypothesis for arithmetic word problems, since, in order to maintain and process the information, they require working memory processes. A group of children possessing average vocabulary but poor arithmetic problem-solving skills was compared with a group of good problem solvers, matched for vocabulary, age, and socioeconomic status. Poor problem solvers presented lower recall and a greater number of intrusion errors in a series of tasks testing working memory and memory for problems. The results obtained over a series of six experimental phases, conducted during a 2-school-year period, offer evidence in favor of the hypotheses that groups of poor problem solvers may have poor performance in a working memory test requiring inhibition of irrelevant information (Hypothesis 1), but not in other short-term memory tests (Hypothesis 2), that this difficulty is related to poor recall of critical information and greater recall of to-be-inhibited information (Hypothesis 3), that poor problem solvers also have difficulty in remembering only relevant information included in arithmetic word problems (Hypothesis 4) despite the fact that they are able to identify relevant information (Hypothesis 5). The results show that problem-solving ability is related to the ability of reducing the memory accessibility of nontarget and irrelevant information.

Child↗
PubMed2002

Individual differences in working memory during reading with and without parafoveal information: a moving-window study.

We examined individual differences in working memory appearing in the effective visual field size while reading Japanese text. Working memory capacity was measured by a Japanese reading span test, and the subjects were divided into high- and low-score groups. Reading performance was measured by reading time, comprehension, and eye movements using a variable moving window through which the subject could read areas of the Japanese text. As the window size decreased, the reading time increased significantly. High-span subjects showed better performance in reading time, comprehension, and fixation duration than low-span subjects even in small visual fields. Interestingly, high-span subjects appear to show better information integration during reading, whereas low-span subjects showed less integration without parafoveal vision. These findings suggest that reading performance was better for subjects with larger working memory resources in a parafoveal restriction condition.

Eye Movements↗
PubMed2004

Mapping of verbal working memory in nonfluent Chinese-English bilinguals with functional MRI.

Existing cognitive and neural imaging studies have suggested a frontoparietal network of multiple, cooperative components for verbal working memory (WM). We used functional MRI to investigate whether this neural network is also involved in the processing of second language by nonfluent bilinguals. Twelve (five males, seven females) native Chinese speakers who had limited English proficiency were scanned while performing working memory tasks in Chinese and English. They were asked to make judgment continuously whether the word presented on the screen was semantically related to (i.e., the semantic tasks) another word presented two words earlier. On a different task (i.e., the phonological tasks), they were asked to make judgment whether the target word rhymed with the other word. A naming and judgment task in each language was adopted to control for the visual process, initial lexical process, and motor responses. Behavioral data showed that subjects performed better at tasks in their native language (Chinese, L1) than in English (L2). Imaging results showed that all working memory tasks in both L1 and L2 elicited a very similar pattern of left-hemisphere-dominated activation in the dorsolateral prefrontal cortex, pars opercularis region, pars triangularis region, precentral cortex, and parietal lobule. Consistent with the behavioral data, the volume of activation in the left opercularis region, left parietal lobule, and right precentral region was greater for L2 than for L1. These results suggest that working memory in L1 and L2 is mediated by a unitary neural system (i.e., frontoparietal region), which is capable of recruiting surrounding cortical resources to meet the increased computational demand caused by low L2 proficiency.

Adult↗
PubMed2006

Hemispheric processing of inferences: the effects of textual constraint and working memory capacity.

In this study, we investigated hemispheric differences in the generation of bridging and predictive inferences. Participants read texts that provided either strong or weak causal constraints for a particular bridging (Experiment 1) or predictive (Experiment 2) inference and performed a lexical decision task to inference-related targets presented to the left or the right hemisphere. Facilitation for strongly constrained bridging and predictive inferences was found in both hemispheres. In contrast, facilitation for weakly constrained inferences was stronger in the right than in the left hemisphere for both bridging and predictive inferences, although for the latter there was some facilitation in the left hemisphere as well. We also considered whether these effects differ as a function of the working memory capacity of the reader. High working memory capacity readers showed greater facilitation for strongly constrained inferences than for weakly constrained inferences in both hemispheres, whereas low working memory capacity readers showed this same pattern in the left hemisphere but showed equal facilitation for strongly and weakly constrained inferences in the right hemisphere. These results suggest that hemispheric processing, textual constraint, and working memory capacity interact to affect how readers generate causal inferences.

Adolescent↗
PubMed2003

Phonological and visual working memory in mental addition.

The goal of the present research was to examine the role of working memory in mental arithmetic. Adults (n = 96) solved multidigit arithmetic problems (e.g., 52 + 3; 3 + 52) alone and in combination with either a phonological memory load (i.e., nonwords, such as gup) or a visual memory load (i.e., random pattern of asterisks). The participants solved problems presented in a vertical format significantly faster than problems presented in a horizontal format. They also solved double digit first problems (e.g., 52 + 3) more quickly than the reverse (e.g., 3 + 52), but only when the problems were presented horizontally. Performance was worse in the phonological load condition than in the visual load condition for the participants who solved problems presented horizontally, whereas performance was worse in the visual load condition than in the phonological load condition when problems were presented vertically. The present research provides evidence that both phonological and visual aspects of working memory are involved in mental arithmetic but that the role of each working memory component will depend on such factors as presentation format.

Adolescent↗
PubMed1999

Spatial working memory assessment by a visual-manual delayed response task: a controlled study in schizophrenia.

'Working memory' dysfunction has been proposed as a central cognitive feature in schizophrenia. To further explore this issue we developed a computerized easy and fast to administer test using the standard keyboard as visual-manual subject-computer interface along a delayed-response paradigm. The test has been administered to 25 patients who met the DSM-III-R criteria for schizophrenia and 25 healthy control subjects matched as possible for sex. The data confirm the visuo-spatial 'working memory' dysfunction in schizophrenic patients. The test maintains the discriminative capacity of similar previously devised tasks with the advantages of being usable on almost every standard computer and shorter and more acceptable for severely disabled patients also. The test can be considered an useful tool to study the 'working memory' impairment in the cognitive deficit of schizophrenia.

Adult↗
PubMed2006

Developmental changes in oculomotor control and working-memory efficiency.

In the present study, we examined the developmental changes in the efficiency of saccadic inhibitory control. More specifically, the contribution of age-related changes in working-memory engagement was investigated. We manipulated the efficiency of inhibitory oculomotor control in antisaccade tasks by using fixation-offset conditions, which are supposed to affect inhibitory demands, and by adding increasing working-memory loads to the antisaccade task. In general, in comparison to antisaccade performance of adults, the antisaccade performance of 8-year-old and 12-year-old children was characterized by an increase in direction errors, and/or longer saccadic onset latencies on correct antisaccades. However, this pattern was not altered by the fixation-offset manipulations. In contrast, increased working-memory demands deteriorated 8-year-olds' antisaccade performance unequally as compared to older children and young adults. These findings suggest that - at least in young children - the available functional working-memory capacity is engaged in oculomotor inhibition.

Adolescent↗
PubMed1996

Working memory deficits following traumatic brain injury in the rat.

This study was designed to examine working memory following fluid-percussion traumatic brain injury (TBI) using the Morris water maze (MWM). Rats were injured (n = 9) at a moderate level of central fluid percussion injury (2.1 atm) or were prepared for injury but did not receive a fluid pulse (sham injury) (n = 10). On days 11-15 postinjury, working memory was assessed using the MWM. Each animal received 8 pairs of trials per day. For each pair of trials, animals were randomly assigned to one of four possible starting points and one of four possible escape platform positions. On the first trial of each pair, rats were placed in the maze facing the wall and were given 120 sec to locate the hidden escape platform. After remaining on the goal platform for 10 sec, they were placed back into the maze for the second trial of the pair. The platform position and the start position remained unchanged on this trial. After the second trial, the animal was given a 4 min intertrial rest. Between pairs of trials, both the start position and the goal location were changed. Analyses of the latency to reach the goal platform indicated that sham-injured animals performed significantly better on the second trial than on the first trial of each pair. However, injured animals did not significantly differ between first and second trial goal latencies on any day. These results indicate that injured animals have a profound and enduring deficit in spatial working memory function on days 11-15 after TBI.

Animals↗
PubMed2001

Spatial working memory deficits in schizophrenia: relationship with tardive dyskinesia and negative symptoms.

OBJECTIVE: This study examined the interrelationship between negative symptoms, orofacial tardive dyskinesia, and specific neurocognitive processes, particularly those involved in memory and executive function, in patients with schizophrenia. METHOD: A set of computerized neurocognitive tasks, the Cambridge Neuropsychological Test Automated Battery, was used to assess executive and memory function in 54 hospitalized patients with chronic schizophrenia. Analysis of covariance was used to examine differences between groups with or without the topographical syndromes of orofacial tardive dyskinesia and between groups with high or low negative symptom scores. Principal-components and path analyses were used to examine further the influence of negative symptoms and orofacial tardive dyskinesia on performance on tests of memory and executive function. RESULTS: Both orofacial tardive dyskinesia and negative symptoms were significantly and independently associated with deficits on measures of spatial working memory span derived from principal-components analysis, but only orofacial tardive dyskinesia was associated with deficits on measures of spatial working memory strategy. Both were also associated with impairment on the delayed-matching-to-sample task, a test of memory. These associations were not explained by deficits in global intellectual function. Path analysis suggested that the relationships between the clinical symptoms and performance on the delayed-matching-to-sample task were mediated entirely through their relationship with the spatial working memory measures. CONCLUSIONS: In schizophrenia, orofacial tardive dyskinesia and evident negative symptoms are relatively independent markers of compromise of the cerebral systems that mediate spatial working memory. Candidate neural circuits include the frontal-striatal-thalamic systems, particularly those involving the dorsolateral prefrontal cortex.

Adult↗
PubMed2005

Coherence between fMRI time-series distinguishes two spatial working memory networks.

Widespread and distributed brain regions are thought to form networks that together support working memory. We recently demonstrated that different cortical areas maintain relatively different codes across a memory delay (Curtis et. al., J Neurosci, 2004; 24:3944-3952). The frontal eye fields (FEF), for example, were more active during the delay when the direction of the memory-guided saccade was known compared to when it was not known throughout the delay. Other areas showed the opposite pattern. Despite these task-dependent differences in regional activity, we could only assume but not address the functional interactions between the identified nodes of the putative network. Here, we use a bivariate technique, coherence, to formally characterize functional interactions between a seed region and other brain areas. We find that the type of representational codes that are being maintained in working memory biases frontal-parietal interactions. For example, coherence between FEF and other oculomotor areas was greater when a motor representation was an efficient strategy to bridge the delay period. However, coherence between the FEF and higher-order heteromodal areas, e.g., dorsolateral prefrontal cortex, was greater when a sensory representation must be maintained in working memory.

Adolescent↗