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At least 829 records · Page 46Linked to original sources
PubMed1994

Acute heat acclimation and kidney function in broilers.

Broilers previously exposed to high environmental temperatures (heat-acclimated) are more resistant to heat stress and consume more water during heat stress than nonacclimated controls. Two experiments were conducted to determine whether heat-acclimated broilers conserve body water by reducing urine and solute (Na) excretion. In the first experiment, renal function studies were conducted at an ambient temperature (Ta) of approximately 21 C using anesthetized 7-wk-old male broilers. Control birds reared at a constant Ta of 24 C (Group N: noncycled Ta) were compared with birds that had been heat-acclimated by exposure for 3 to 6 d to a daily sinusoidal cycle of 24 to 35 to 24 C (Group C: cycled Ta). In the second experiment, renal function studies were conducted on anesthetized 5-wk-old control and heat-acclimated male broilers while they were exposed to a Ta of 21 C (Ambient Ta: Groups NA, CA), or to a Ta of 32 C (High Ta: Groups NH, CH). When high intravenous infusion rates (.37 mL/kg body mass per min) were used to simulate the volume expansion caused by thermogenic polydipsia, urine flow rates were significantly lower in Groups C and CA than in Groups N and NA, osmolal clearances were lower in Groups CA and CH than in Groups NA and NH, and all heat-acclimated groups in both experiments (Groups C, CA, CH) had significantly lower glomerular filtration rates (GFR), filtered loads of Na, and tubular Na reabsorption rates than the respective control groups (Groups N, NA, NH). These changes in kidney function potentially would minimize urinary fluid and solute loss when heat-acclimated broilers consume large quantities of water to support evaporative cooling. Reductions in GFR, filtered loads of Na, and tubular Na reabsorption rates also may help heat-acclimated broilers reduce the metabolic heat load associated with active (energy requiring) recovery of solute (Na) from the glomerular ultrafiltrate.

Acclimatization↗
PubMed2006

Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients.

OBJECTIVE: The bone-related peptide osteoprotegerin (OPG) has recently been found in increased amounts in the vasculature in diabetes. It is produced by vascular smooth muscle and endothelial cells, and may be implicated in the development of vascular calcifications. OPG is present in the circulation, where increased amounts have been observed in patients with diabetes. In this study, we examined whether plasma OPG is associated with the glycaemic and vascular status of patients with type 1 diabetes. METHODS: Two gender-, age- and duration-comparable groups of type 1 diabetic patients either with (n = 199) or without (n = 192) signs of diabetic nephropathy were studied. Plasma OPG was determined by an ELISA. RESULTS: The plasma OPG concentration was significantly higher in patients with nephropathy than those without (3.11 (2.49-3.99) vs 2.57 (2.19-3.21) (median (interquartiles), ng/ml), P < 0.001). Plasma OPG correlated with haemoglobin A1c (HbA1c), systolic blood pressure and age in both groups and, in addition, with kidney function in the nephropathic group. These correlations remained significant in multivariate models. In addition, we found that plasma OPG concentrations were increased among patients with cardiovascular diseases (CVD), both in the normoalbuminuric and the nephropathic groups. The differences between nephropathic and normoalbuminuric, as well as subgroups with and without CVD, could largely be ascribed to changes in HbA1c, age, systolic blood pressure and creatinine. CONCLUSION: OPG is associated with glycaemic control and CVD in patients with type 1 diabetes, compatible with the hypothesis that OPG is associated with the development of diabetic vascular complications.

Adult↗
PubMed1987

[Assessment of kidney function with 99mTc-pyrophosphate during the scintigraphy of the joints in rheumatoid arthritis patients].

Diagnostic potentialities of investigation of the kidneys using 99mTc-pyrophosphate were studied in 34 patients with rheumatoid arthritis (RA) for articular scintigraphy. The results obtained were compared with those of radionuclide renography with 131I-hippuran and excretory urography. A possibility of investigation of the kidneys with 99mTc-pyrophosphate for the assessment of parenchyma function and kidney urodynamics was shown. Taking into account a high prevalence of nephropathy in RA patients, dynamic renal scintigraphy and clearance registration were recommended at the first stage of articular scintigraphy with 99mTc-pyrophosphate in order to obtain information on the anatomotopographic site and accumulation-evacuatory function of the kidneys.

Adult↗