Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Vinyl Compounds”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 829 records · Page 46Linked to original sources
PubMed1983

Neoplastic effect of vinyl chloride in mouse lung--lower doses and short-term exposure.

Neoplastic pulmonary effects of lower doses of vinyl chloride (0 = control, 1, 10, 100, 300, and 600 ppm) and short-term exposure (4 weeks) by inhalation have been studied by light and electron microscopy in 220 mice. Except for dead or seriously sick animals, a large majority of the animals were sacrificed at three different stages: immediately after exposure, 12 weeks later, and 40 or 41 weeks after exposure. Six mice (4: 600 ppm, 2: 0 ppm) were kept longer than 41 weeks to examine the effects of the chemical after a long-term recovery period. Alveologenic tumors were first observed 10 weeks after exposure to 600 ppm. In the subgroups exposed to higher concentrations (600 and 300 ppm) the incidence of tumors was higher and their appearance was earlier than in the subgroups exposed to lower concentrations (100, 10, and 1 ppm). These findings indicated a dose-response relationship for incidence of alveologenic tumors, and the latency period was inversely related to dose. By light and electron microscopy, there was no obvious evidence that tumor cells were derived from Clara cells of the terminal bronchioles. Rather, neoplastic cells in both the tubulopapillary and adenomatous forms of the pulmonary tumors possessed all or some of the ultrastructural characteristics of type II alveolar cells, based on observations of mitochondria, microvilli, osmiophilic lamellar bodies, and other criteria. Type II alveolar cells are therefore considered to be the most sensitive in mice to the neoplastic effect of vinyl chloride.

Animals↗
PubMed1986

Proton NMR study of the influence of heme vinyl groups on the formation of the isomeric forms of sulfmyoglobin.

The formation of sulfmyoglobin has been investigated for myoglobin reconstituted with hemins having vinyls replaced by hydrogens to determine the participation of the vinyl groups in the reaction processes. Green complexes are produced in all cases, proving that vinyls are not obligatory for the formation of sulfproteins. In the presence of the 4-vinyl group, the 1H NMR spectra of the met-cyano derivatives indicate the formation of three green species; however, the most stable of these products is not formed in the absence of this group, confirming reaction of the 4-vinyl in this species. Two new red extractable sulfmyoglobin derivatives are formed in the absence of the 4-vinyl group.

Heme↗
PubMed1989

Determination of the functionally important heme peripheral vinyl group orientation in paramagnetic hemoprotein by 2D NMR.

2D NMR spectroscopies have been successfully used to characterize the heme peripheral vinyl groups in paramagnetic hemoprotein in spite of the difficulties from the rapid paramagnetic relaxation and the low digital resolution of the 2D NMR map. The scalar coupling network system among the vinyl protons is clearly identified in the COSY spectra from its characteristic cross-peak pattern and the dipolar coupling connectivities of the vinyl proton resonances with other heme side-chain proton resonances not only provide the specific assignment of vinyl beta-proton resonances but also allow the determination of the vinyl group orientation with respect to the heme plane.

Animals↗
PubMed1996

Divinyl ether synthase from garlic (Allium sativum L.) bulbs: sub-cellular localization and substrate regio-and stereospecificity.

Sub-cellular localization and some properties of 13-hydroperoxide-specific divinyl ether synthase from garlic bulbs were studied. Sub-cellular fractions from garlic bulbs were incubated with [1-(14)C](9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoic acid (13-HPOD). The predominant part of divinyl ether synthase activity from garlic bulbs was found in the microsomal fraction. The enzyme utilizes 13(S)-HPOD as its preferential substrate. Other hydroperoxides, including 9(S)-HPOD, gave much poorer yields of divinyl ethers. Unreacted hydroperoxide after incubation of 13(R,S)-HPOD with enzyme was composed of up to 94% 13(R)-HPOD. Thus, divinyl ether synthase possesses stereoselectivity, utilizing preferentially the (S)-enantiomer.

Cytochrome P-450 Enzyme System↗
PubMed1985

Mild and regiospecific synthesis of 18F-labelled vinyl fluoride using [18F]fluorine reacted with silane.

A labelled vinyl fluoride of biological interest was prepared in good radiochemical yield by direct fluorination of the corresponding silane. The synthesis of 18F-labelled 4-fluoroantipyrine, a cerebral blood flow tracer, involved the reaction of 4-(trimethylsilyl) antipyrine with [18F]F2 (0.5% fluorine in neon) or 5% F2 in nitrogen in freon-11 as solvent. A radiochemical (chemical) yield of about 18% (42%) was obtained in a 25-min synthesis. The radiochemical and chemical purity of the final products was 99% after purification by HPLC.

Acrylic Resins↗