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[The technology for manufacturing antiparasitic preparations. 1. The development of a technology for producing the anthelmintic triklazan in finely dispersed form and the evaluation of its antinematodal, anticestodal and antitrematodal activities].

The authors describe the technology of preparing a new anthelmintic agent triclazan, N-(3,4-dichlorophenyl)-2-[(benzo-2,1,3-thiadiazole-4-sulfonyl)amino]-5- chlorobenzamide, finely dispersed (the particles size 4-8 mu). Triclazan is highly effective not only in hymenolepiasis and trichocephaliasis, as was shown previously, but in fascioliasis, monieziasis and intestinal nematodiasis of sheep as well.

Animals↗

Food-borne parasitic infections--old stories and new facts.

A review is presented of food-borne parasitic infections. Parasitic infections with public health hazards both from conventional slaughter animals and from seafood (fish and shellfish) are discussed. The former category includes cysticercosis, echinococcosis, and trichinosis, the latter category covers various trematode, cestode, nematode, and possibly also protozoan infections. Examples of trematode infections are heterophyidiasis, transmitted to man by marine fish, and Paragonimus spp parasites, transmitted by crustaceans. Cestode infections include diphyllobothriasis transmitted by both fresh water fish and fish from brackish waters. Special attention is drawn to the condition known as sparganosis. Of the nematode infections, the eosinophilic granulomatous enteritis due to the genera Anisakis, Phocanema, and Contracaecum, transmitted to man by either marine fish or crustaceans, is mentioned. Two other nematode infections. Angiostrongylus cantonensis and Capillaria philippinensis, can also be transmitted to man by marine fish. Free living amoebae (a.o. Naegleria) may be transmitted to man via shellfish as vehicles. Apart from a possible direct effect of these parasites, chemical alterations in seafood resulting from the presence of parasites may also be deleterious to the consumer. Special attention is drawn to a newly developed serological detection method, the enzyme-linked immunosorbent assay, which makes detection of infection possible not only at the slaughterhouse but also at the farm or in large herds. Strategies to control parasitic infections both in conventional slaughter animals and in seafood are discussed.

Animals↗

[The question of pathogenesis of parasitic castration in snails infected with developmental stages of digenetic trematodes].

In the article several models of pathogenesis of parasitic castration of snails infected with developmental stages of digenetic trematodes are presented. Some aspects of mechanical and chemical damage of the gonad and changes in tissues of this organ, caused by its starvation--developing as a consequence of competition between the host and its parasites, are discussed. Particular attention was paid to potential effect of the parasitic larvae on physiology of the hormonal system of the host.

Animals↗

Praziquantel for treatment of human Nanophyetus salmincola (Troglotrema salmincola) infection.

Human nanophyetiasis is a zoonotic disease recently recognized in the coastal US Pacific Northwest and is caused by the digenetic trematode Nanophyetus salmincola. Ten additional stool-proven cases from the same geographic area have been identified; five presented with histories of gastrointestinal complaints and five had eosinophilia. Nine of 10 patients had histories of fish ingestion (incompletely cooked or home-smoked salmon or steelhead trout) and were treated with praziquantel. Several individuals noted prompt resolution of symptoms following therapy. In all treated cases subsequent stool examinations were negative for eggs of Nanophyetus. Nanophyetiasis may be the most commonly encountered trematodiasis endemic to North America, and the use of praziquantel in its treatment appears to be efficacious.

Adolescent↗

[Bird trematodes of lower Silesia. V. Trematodes of Diplostomatidae family parasitizing woodcock--Scolopax rusticola L].

Six dissections of Woodcock were conducted. Three birds were found to be infected by trematodes: Pulvinifer macrostomum and Scolopacitrema cubrensis (Diplostomatidae). Both of them are new species for the Polish parasite fauna. The examination of P. macrostomum has shown a greater variability in size of the body and organs than that described by other authors.

Animals↗

[Influence of environmental factors on the infection rates of fishes and shellfishes by trematodes of the Opisthorchidae family in the Krotovaya Lyaga Lake].

The relationship of the annual trends in the infection of crucians (Carassius carassius) (L.) with Opisthorchis felineus metacercariae, in that of verkhovkas (Leucasplius delineatus) (Hackel), and in that of lake minnows (Phoxinus percnurus) (L.) with O. felineus and Metorchis billis to the environmental factors under natural fluctuations of the level of water and under the man-made effects on the water regime of the reservoir was studied. When the level of water naturally changes, the infection of crucians with Metorchis was found to be affected by their size, water temperature, and environmental pH values, and the human Opisthorchis affliction depends on the severity of infection of commercial-sized crucians by metacercariae. The infestation of the verkhovka was determined by the temperature of water and that of the lake minnow was by its size and the increased areas of the lake with the depths salubrious to its existence. With man-made effects (dewatering for watering agricultural lands) on the water regime of the reservoir, the infestation of the lake minnow depended on its size in the shallow water and on the level of water. Environmental factors, such as pH values, the area of shallow waters, and the size of mollusks, positively affected the higher extensiveness of infestation of mollusks with the parthenitae of opisthorchid flukes.

Agriculture↗

Life cycle and identification of an eyefluke from Israel transmitted by Melanoides tuberculata (Müller, 1774).

A philophthalmid species from Israel using the freshwater snail Melanoides tuberculata as intermediate host was studied. The biological and morphological characteristics of all developmental stages of the life cycle of this philophthalmid were described, and compared to those of Philophthalmus lucipetus Rudolphi, 1819 from Israel, Philophthalmus gralli Mathis and Leger, 1910 from Jordan, Philophthalmus palpebrarum Looss, 1899, Philophthalmus nocturnus Looss, 1907, Cercaria distomatosa Looss 1896 from Egypt, and Philophthalmus lucknowensis Baugh, 1962 from India. The possible identity with 1 of these species is discussed. On the basis of comparative analysis of the data for all parasite stages in the life cycle, geographical distribution, snail hosts, and snail host specificity, we propose to designate the Israeli Melanoides tuberculata-transmitted eye fluke to Philophthalmus distomatosa n. comb. (Looss, 1896), (Digenea: Philophthalmidae).

Animals↗