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Results for “Splenic Neoplasms”

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At least 829 records · Page 46Linked to original sources
PubMed2004

Multipotential osteosarcoma with various mesenchymal differentiations in a young dog.

Apparently synchronous, aggressive, mixed mesenchymal tumors in the right tibia, right femur, left femur, and rib cage produced multiple microscopic metastases in the lungs and macroscopic metastases in the liver, kidney, and spleen in a 1.5-year-old, neutered male, mixed-breed dog. No primary soft tissue tumor mass was present. Microscopically, the neoplasm exhibited osteosarcomatous, chondrosarcomatous, liposarcomatous, leiomyosarcomatous, fibrosarcomatous, angiosarcomatous, and leukocytic differentiation and was diagnosed as a multipotential osteosarcoma with various mesenchymal differentiation. Immunohistochemically, the neoplasm was cytoplasmically immunoreactive for vimentin, osteonectin, osteocalcin, CD 18, CD 31, desmin, and muscle-specific actin. Oil Red O staining was positive within liposarcomatous areas. Skeletal metastases from a primary bone tumor are exceedingly rare in human and veterinary medicine. However, the history, clinical signs, location, microscopic and immunohistochemical features were similar to those described in aggressive, poorly differentiated osteosarcomas of children. In addition, the wide range of mesenchymal tissue differentiation of this neoplasm was unusual, and to the authors' knowledge, an osteosarcoma with this degree of multiple differentiation has not been previously reported in the dog.

Animals↗
PubMed2001

Primary malignant fibrous histiocytoma of the spleen and liver.

Malignant fibrous histiocytoma (MFH) is a distinct and pleomorphic form of sarcoma, which usually occurs in soft tissues but can be found in bones, kidney, larynx, lung, heart, and even aorta. Since the first description of MFH of the spleen by Govoni et al. in 1982, only 10 cases have been reported in the literature worldwide. We report on a 45-yr-old female with MFH of the spleen and liver, with special emphasizes on immunohistochemical findings.

Fatal Outcome↗
PubMed1975

Angiography in expansile lesions of the spleen.

The angiographic findings in a relatively large number of expansile lesions of the spleen are presented. In cysts our findings correspond to those in earlier reports, the hallmark being stretching of intrasplenic arteries and veins around an avascular espansile lesion. As to neoplasms (primary as well as secondary), however, our findings suggest that the criteria of malignancy, that is, neovascularity, vascular encasement, and arteriovenous shunting, may be more frequent than is evident from earlier reports.

Adolescent↗
PubMed1995

Digestive organs.

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Adolescent↗
PubMed1983

Systemic lupus erythematosus and lymphoma. A family study.

After 3 years of treatment with azathioprine and prednisone, immunoblastic lymphoma appeared in a patient with systemic lupus erythematosus. An increased incidence of immunological aberrations and malignancies was found in her family and their relation to the pathogenesis of this patient's diseases is discussed.

Adult↗
PubMed1992

Concomitant primary low grade non-Hodgkin's lymphoma of the spleen and breast carcinoma.

A case is described of a 71 year old woman with scirrhous breast cancer and multiple hypoechogenic lesions in the spleen. The patient was treated successfully by mastectomy and splenectomy. Morphologic examination of the spleen showed a primary, centroblastic-centrocytic, low grade non-Hodgkin's lymphoma. Eight months after splenectomy the patient still remains in complete remission.

Aged↗
PubMed1976

[Nuclear medicine in tumor diagnosis].

After introductory comments on the principle of the tumour scintigraphy and the factors influencing the scintigraphic demonstration the author adopts a definite attitude to the scintigraphy of thyroid gland, brain, lung, liver pancreas, kidney, bone, spleen as well as lymphatic nodes, liquor spaces and adrenal glands from the point of view of tumours diagnostics. For the purpose of a better survey for the first seven organs uniquely the problems are demonstrated according to the principle of examination, method of examination, indication to the tumour diagnostics, preliminary examination and prerequisite to the scintigraphy, the problems of scintigraphy and the functional capacity of other methods.

Adrenal Gland Neoplasms↗
PubMed1999

Hereditary melanoblastoma in miniature pigs and its successful therapy by devitalization technique.

Applying selective breeding for 10 years we established the MeLiM (Melanoblastoma-bearing Libechov Minipigs) strain. Melanoblastoma (MB) in this strain shows a hereditary occurrence. Cutaneous tumours are usually nodular, multiple and distributed on various parts of body. They appear in darkly pigmented animals already at the birth or during two months thereafter (57% of all animals). Numerous organ metastases mainly into the spleen, lymph nodes and lungs are regularly ascertained in animals with cutaneous MB. Tumour cells were surprisingly found also in the inner organs of phenotypically healthy minipigs in which no cutaneous MBs were observed visually (27% of all animals). About 34% of all affected piglets die during the first 2 months of age. These features document a malignancy of this tumour in the MeLiM strain. Original surgical technique was applied in more than 40 affected minipigs at 1-2 months of age. It consists in a devitalization (ischemization) of one of cutaneous tumours by the mattress sutures conducted around the tumour base without any excision of tumour tissue. This simple procedure causes a total destruction of MB cells in all cutaneous tumours as well as in all organ metastases during 4-6 months. Animals treated by this technique were fully healed of tumour cells and no relapses were observed. This technique could bring similar positive results also in therapy of human MB.

Animals↗
PubMed1975

[The place of ultrasound diagnosis in internal medicine].

The applications of ultrasound diagnosis within the framework of general medicine are discussed on the basis of case reports. Ultrasonic equipment with manual moving of the probe is used in this department for the investigation of the abdomen in cases of occult neoplasms and metastases to differentiate between cysts and solid tumours and to determine the situation and size of parenchymatous organs like liver and kidney and spleen. Special fields of application are: follow up of patients after renal transplantation, investigation of systemic haematological diseases such as lymphogranuloma, or the demonstration of abnormal fluid masses such as haematomata in haemophilic patients, ascites or pericardial effusions.

Diagnosis, Differential↗
PubMedDate not supplied

Combined resection of the involved organs in T4 gastric cancer.

BACKGROUND/AIMS: It remains controversial whether extended surgeries for gastric cancer can improve the postoperative survival rate. This study was designed to evaluate the effectiveness of a combined resection of the involved organs for improving the survival of gastric cancer patients. METHODOLOGY: Of the 1600 patients treated at our Department, from 1969-1993, 231 patients were found to have evidence of adjacent organ spread at laparotomy. Of the 231 patients, 174 underwent a combined resection of the adjacent organs with a gastrectomy due to direct invasion of these organs by the gastric cancer. The clinicopathological characteristics of 231 patients who had adjacent organ spread were compared retrospectively with 495 patients who had no adjacent organ spread. RESULTS: Although the postoperative survival rate of those patients who underwent a gastrectomy with a combined resection of the involved organs was poor, 14 patients survived for 5 years or longer after the surgery. The clinicopathologic factors characteristic of these 14 surviving patients were a lesser extent of lymph node metastasis and high operative curability. CONCLUSIONS: A combined resection of the involved organs with a gastrectomy should be performed when lymph node metastasis is not evident.

Adult↗
PubMed1999

[A clinicopathological study of pancreatoblastoma].

OBJECTIVE: To investigate the clinicopathological, immunohistochemical features and the histogenesis of pancreatoblastoma (PB) in 14 pediatric cases, including 9 male and 5 female patients, their age ranged from 1.5 to 8 years with a mean of 4.4 years. METHODS: Routine pathological, histochemical, and immunohistochemical methods were utilized to analyse the PB specimens. RESULTS: Tumors of 6 patients had metastasized to the liver, spleen and lymph nodes, 8 patients were alive 10 months to 105 months after diagnosis. Histologically, the tumors were composed of dense epithelial elements separated by fibro-stromal tissue, resulting in a nesting or organoid pattern. Immunohistochemically and histochemically, the tumors exhibited acinar, endocrine and ductal differentiation. The positive rates for were: CK 100%, EMA 86%, NSE 79%, CEA 71%, SYN 64%, CgA 43%, alpha1-AT 57%, PAS 100% and mucicarmine 57%. CONCLUSIONS: PB is the most common malignant pancreatic neoplasm of childhood. PB arises from primitive pluripotential cells capable of differentiating into 3 pancreatic cell types: acinar, endocrine and ductal. The prognosis is better than pancreatic carcinoma in adults.

Carcinoembryonic Antigen↗
PubMed1975

Radiation therapy planning with ultrasound.

Diagnostic ultrasound is a relatively new diagnostic modality which is a practical method of acquiring anatomical information important in radiation treatment planning. Patient contour, port margins, location of tumors and normal structures, and tissue inhomogeneities can be recorded simply, safely, rapidly, and accurately. This information can then be utilized in developing radiation therapy plans that deliver irradiation more precisely to the malignant disease while avoiding normal structures. The proper application of ultrasound in radiation therapy planning has the potential of significantly improving cure rates and minimizing complication rates in the treatment of patients with malignant disease.

Abdominal Neoplasms↗