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PubMed2002

[Clinical analysis of 50 cases of pulmonary complications associated with Tsutsugamushi disease].

OBJECTIVE: To study the clinical features of pulmonary complications associated with tsutsugamushi disease. METHODS: Two hundred and thirty two patients with tsutsugamushi disease were retrospectively analyzed by chest X-ray, ultrasonography and lung function test. The differential diagnosis of tsutsugamushi disease associated lung complications from mycoplasma pneumonia, streptococcal pneumonia and tuberculosis was discussed. RESULTS: Pulmonary complications were present in 21.6% (50/232) of the patients with tsutsugamushi disease. Of them 42% were initially misdiagnosed as other pulmonary diseases. The characteristic radiographic manifestation was exudative lesions. The lesions were bilateral in 36 cases (72%), and unilateral in 14 cases (28%). Pleural effusion was present in 16 cases. Chloromycetin was effective in all the cases. CONCLUSIONS: Pulmonary complications were common in tsutsugamushi disease. The prognosis was good if diagnosed and treated properly at an early stage.

Adolescent↗
PubMed2002

Evaluation of National Tsutsugamushi Disease Surveillance--Japan, 2000.

In Japan, Tsutsugamushi disease, which is caused by Orientia tsutsugamushi, is re-emerging with newly recognized strains and is now endemic in all prefectures except Hokkaido and Okinawa. We analyzed recent surveillance data to describe the epidemiology of Tsutsugamushi disease and to evaluate the newly implemented national surveillance system according to the CDC guidelines for evaluating surveillance systems. In 2000, 756 cases of Tsutsugamushi disease were reported from 37 of 47 prefectures; two of these cases were fatal. The median age of case-patients was 64 years (range: 2 - 94 years); 414 (54.8%) were male. In northern Japan, most cases were diagnosed in the months of May through July and in the months of October through December, and in southern Japan, cases were diagnosed almost year-round with a peak from October through December and in January. Reporting and transfer of surveillance information from the prefecture to the national level was effective and timely, but the completeness and quality of case reporting could still be improved. The current system for Tsutsugamushi disease surveillance is useful for describing epidemiologic patterns by time, prefecture, and demographic characteristics. However, collection of additional information on suspected place of transmission, activity performed at the place of transmission, or the case-patient's profession would likely make the system more valuable for outbreak detection and for better defining populations at risk.

Adolescent↗
PubMed1976

[Tsutsugamushi fever in the Kuril Islands].

The authors present the results of a 6-year study of tsutsugamushi fever at the Kuril islands. The area of the disease proved to include Southern Kuril islands - Shikotan and Kunashir. The principal natural carriers of tsutsugamushi among the mouse-like rodents and trombiculidae larvae were revealed; highly virulent strains were found to prevail among the tsutsugamushi rickettsia strains. Tsutsugamushi fever in the population is characterized by a benign course, pyrexia, primary affects and lymphadenitis.

Adult↗
PubMed2003

Short report: variation in the 56-kD type-specific antigen gene of Orientia tsutsugamushi isolated from patients in Thailand.

The sequences of a 300-base pair region of the 56-kD type-specific antigen gene from 12 Orientia tsutsugamushi isolates from Thailand were compared with isolates from other regions in Asia. A high degree of heterogeneity was found among the 12 Thai isolates, with the C3 strain most commonly found. The abundance of the C3 strain of O. tsutsugamushi is of particular concern because doxycycline and chloramphenicol resistance have previously been reported in this strain.

Antigens, Bacterial↗