Photoaffinity labeling of ribosomes with the unmodified ligands puromycin and initiation factor 3.
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Affinity Labels↗
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Results for “Puromycin”
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Puromycin induction of transient regeneration in mammalian spinal cord.
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Animals↗
The effect of puromycin on retention of conditioned cardiac deceleration in the goldfish.
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Amplifiers, Electronic↗
Temperature-dependent consolidation of puromycin-susceptible memory in the goldfish.
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Animals↗
Anterograde and retrograde effects of electroconvulsive shock and of puromycin on memory formation in the goldfish.
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Amnesia↗
Puromycin-induced retention deficit in goldfish as a function of attained training performance level.
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Amnesia↗
Electroconvulsive shock- or puromycin-induced retention deficits in goldfish given two active-avoidance sessions.
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Amnesia, Retrograde↗
Effects of actinomycin D and puromycin upon excystment of Didinium nasutum.
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Animals↗
Photoaffinity labeling of Escherichia coli ribosomes by an aryl azide analogue of puromycin. On the identification of the major covalently labeled ribosomal proteins and on the mechanism of photoincorporation.
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Affinity Labels↗
Puromycin analogs. Ribosomal binding and peptidyl transferase substrate activity of a carbocyclic analog of 8-azapuromycin.
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Acyltransferases↗
Methylation of sugars and bases in ribosomal and rapidly labeled ribonucleates from normal and puromycin-treated L cells.
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Animals↗
Inhibition by sparsomycin and other antibiotics of the puromycin-induced release of polypeptide from ribosomes.
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Anti-Bacterial Agents↗
Effect of sparsomycin analogues on the puromycin-peptidyl transferase reaction on ribosomes.
Sparsomycin analogues in which the unique -S(O)CH2SCH3 moiety was replaced by a variety of more easily accessible side chains were evaluated as inhibitors of the peptidyl transferase reaction with bacterial ribosomes. Competitive inhibition of acetyl[14C]phenylalanylpuromycin formation revealed that the sulfur-containing side chain of sparsomycin could be replaced with hydrophobic moieties, whereas complete removal of the -S(O)CH2SCH3 side chain eliminated the ribosomal binding affinity of sparsomycin. The specificity for the D isomer of S-deoxo-S-propylsparsomycin has established that the chiral carbon of sparsomycin analogues must be identical with the chirality of D-cysteinol for ribosomal binding.
Acyltransferases↗
Synthesis of cyclohexyl carbocyclic puromycin and its inhibition of protein synthesis.
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Bacterial Proteins↗
An acyclic puromycin analog. 6-Dimethylamino-9-(2-hydroxy-3-(p-methoxyphenyl-L-alanylamino)propyl)purine.
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Amino Alcohols↗
Puromycin analogs. Synthesis and biological activity of 5'-deoxypuromycin and its aminonucleoside, 6-dimethylamino-9(3'-amin-3',5-dideoxy-beta-D-ribofuranosyl)purine.
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Amino Sugars↗
Synthesis and antimicrobial activity of a carbocyclic puromycin analog. 6-Dimethylamino-9-(R(2R-hydroxy-3R-(p-methoxyphenyl-L alanylamino))-cyclopentyl)purine.
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Animals↗
Identification and synthesis of the major nucleoside metabolite in rabbit urine after administration of puromycin aminonucleoside.
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Animals↗