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PubMed1984

[Piperacillin].

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Bacterial Infections↗
PubMed1993

[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].

As has been proved before, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. In order to establish quality control, we checked the effectiveness of three different prophylactic antibiotic regimes in 422 patients in a prospective and randomized trial. Between the three groups were no significant differences as regards age, type of operation and risk factors like adipositas and diabetes. The wound infection rate according to CDC-criteria was from 7.0 to 9.5%. We did not find a significant difference between the three antibiotic regimes. It is therefore our conclusion, that in our setting each of the three different types of antibiotics is of equal value. This means, on the other hand, that the cheapest one is enough.

Aged↗
PubMed1997

[Use of piperacillin-tazobactam in abdominal surgery].

Piperacillin/tazobactam (P/T) was used in the monotherapy of 40 patients with various inflammatory diseases of the abdominal cavity organs. P/T was administered as dropwise intravenous infusions in a single dose of 4/0.5 g 3 times a day for 5 to 17 days. In 82.5 per cent of the patients with infection of the abdominal cavity: severe postoperative purulent wounds, peritonitis of various etiology (biliary, serous-fibrinous, hemorrhagic fibrinous), postnecrotic cyst of the pancrease, abscesses of the liver and subhepatic space P/T proved to be highly efficient. The P/T monotherapy resulted in practically complete eradication of anaerobic microbes, coagulase negative staphylococci, enterobacteria and nonfermenting bacteria except for Pseudomonas aeruginosa in the inflammation foci.

Adolescent↗
PubMed1998

In-vitro activity of piperacillin and tazobactam combination against clinically significant bacteria.

The in-vitro activity of piperacillin/tazobactum which is not among the routinely tested antibiotic at the Public Health Bacteriology Laboratory, Parirenyatwa Hospital, Harare, Zimbabwe was evaluated for its activity against bacterial pathogens using the Kirby-Bauer disk diffusion method. Piperacillin/tazobactum showed superior in-vitro activity against both gram positive and gram negative bacteria when compared with routinely tested antibiotics such as gentamicin, erythromycin, tetracycline, penicillin, chloramphenicol, fusidic acid and clindamycin and the difference was statistically significant (p < 0.05). Ciprofloxacin showed in-vitro activity comparable to that of tazobactam/piperacillin. Specifically, 96% of gram positive isolates (comprising Streptococcus pyogenes, Staphylococcus aureus, coagulase negative staphylococci and Streptococcus pneumoniae were sensitive to piperacillin/tazobactam. For gram negative organisms, 98% of Haemophilus influenzae Shigella spp, Klebsiella spp were also sensitive to the combination. The broad spectrum of activity of piperacillin/tazobactam shows that the potential of the drug combination for the treatment of infections caused by diverse microorganisms should not be underestimated. We recommend its inclusion in routine antibiotic sensitivity testing in our hospital.

Drug Evaluation, Preclinical↗