Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Piper”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 829 records · Page 46Linked to original sources

In situ digestion kinetics and ruminal turnover rates of normal and brown midrib mutant sorghum x sudangrass hays fed to nonlactating Holstein cows.

Four nonlactating Holstein cows were fed all-forage diets, consisting of two brown midrib mutant sorghum x sudangrass hybrids (Redlan x Greenleaf and Redlan x Piper) and their normal counterparts, to assess the effects of the brown midrib mutation on the rate and extent of in situ cell wall digestion and on ruminal liquid and particulate turnover rates. The four diets were preserved as hay and coarsely chopped prior to feeding in a 4 x 4 Latin square design. Brown midrib genotypes had lower NDF, acid detergent lignin, and hemicellulose concentrations than did normal genotypes. There was no significant difference between brown midrib and normal diets in the rate of in situ cell wall digestion or in digestion lag time. However, brown midrib diets had greater extent of digestion and greater apparent digestibility than normal diets. There was no difference between genotypes in ruminal liquid or particulate turnover rates. In this experiment, lignin concentration had no effect on the rate of in situ digestion or on the rate of ruminal digesta flow.

Animal Feed↗

Disappearance of hemicellulosic monosaccharides and alkali-soluble phenolic compounds of normal and brown midrib sorghum x sundangrass silages fed to Holstein steers.

Four ruminally cannulated Holstein steers fed ad libitum were used in a 4 x 4 Latin square design. Feeds were normal and brown midrib genotypes of Redlan x Piper and Redlan x Greenleaf sorghum-sudangrasses. An in situ trial was run in conjunction with the digestibility trial as part of the data collection for each period. Hemicellulosic monosaccharide and alkali-soluble lignin phenolic compound disappearances were quantitated. The xylose to arabinose ratio was higher in normal genotypes than in brown midribs. Normal genotypes had higher concentrations of alkali-soluble p-coumaric acid and lower vanillin, vanillic acid, and sinapic acid than did brown midrib mutants. Disappearance of p-coumaric acid was higher in steers consuming normal genotypes than in those consuming brown midribs. Neutral detergent fiber, acid detergent fiber, hemicellulose, cellulose, and acid detergent lignin showed no genotypic differences in rate of digestion, but extent of 72 h digestion was higher for brown midrib mutants than for normal genotypes. Extent of digestion of the hemicellulosic monosaccharides, xylose, and uronic acids was higher in situ for brown midrib silages compared with normal genotypes. Differences in alkali-soluble phenolic compound and cell wall monosaccharide profiles between normal and brown midrib genotypes may help explain digestibility differences between the two genotypes.

Animal Feed↗

Relationship between fatigue and nutritional status in patients with cancer undergoing radiotherapy.

PURPOSE: The purpose of this study was to identify the relationship between fatigue and nutritional status in patients undergoing radiotherapy. DESIGN: A correlational and crossectional study design was used. METHOD: One-hundred-fifty-one subjects with cancer receiving radiotherapy were recruited from a university hospital in Chonan, Korea. Fatigue was measured using Piper's Fatigue Scale (PFS). The parameters for nutritional status included body weight, body mass index, hemoglobin, and lymphocyte counts. Cancer stage was controlled in analyzing the differences in fatigue, body weight and body mass index. RESULTS: The patients who experienced most fatigue were in their fifties, employed, had head and neck cancer, received radiotherapy on the head and neck, and had concomitant chemotherapy. Disease-related characteristics such as cancer type, and treatment type were frequently related to poorer nutritional status. Patients who showed poorer nutritional status, such as those with lower body weight, lower body mass index and lower hemoglobin levels were more fatigued than those who did not exhibit such characteristics. Lymphocyte counts did not correlate with fatigue. CONCLUSION: The findings can be used by nurses who are taking care of patients undergoing radiotherapy. Considering the relationship between fatigue and nutritional status, nurses can identify the risk group most vulnerable to fatigue and malnourishment in order to provide appropriate interventions for them.

Journal Article↗

Fatal fulminant hepatic failure induced by a natural therapy containing kava.

We describe a case of acute liver failure and death associated with the use of a preparation containing the "natural" anxiolytic kava (Piper methysticum) and passionflower (Passiflora incarnata). The patient died after a report by the Therapeutic Goods Administration (TGA) warning of the potential for hepatotoxicity associated with the use of kava-containing products. The general public and alternative medicine practitioners need to be aware of the potential for non-prescription drugs to cause serious hepatic reactions.

Complementary Therapies↗

Kava: herbal panacea or liver poison?

Following reports of liver toxicity, including liver failure, associated with extracts from the Pacific islands plant kava (Piper methysticum), these have been banned from sale as a herbal anxiolytic in many Western countries, to the detriment of Pacific island economies. Pacific Islanders have used kava extensively for centuries, without recognised liver toxicity. However, the population is small, and there has been no systematic evaluation of possible liver damage. For both economic and public health reasons, it is important to determine if kava is inherently hepatotoxic, and what the mechanisms of toxicity are. Such research could lead to safer kava extracts for sale in Western countries, or identification of a subpopulation who should not consume kava.

Australia↗

The impact and management of cancer-related fatigue on patients and families.

Fatigue has been identified as both a chronic and recurrent problem for individuals diagnosed with and treated for cancer, yet there is little information on how to manage the impact of fatigue. Describing what happens to individuals and their families as a result of fatigue and identifying what individuals do to manage or reduce the impact of fatigue are essential elements in determining multidimensional nursing interventions. The purpose of this pilot study was to examine the impact of fatigue on individuals with cancer of the lung and their families, and explore how they managed as a result of the fatigue. A semi-structured interview guide was used with 22 lung cancer patients and 14 family members six weeks post completion of radiation therapy. Results indicated that fatigue was not reported as a major concern by many of the participants in this study. For those who did experience fatigue, it was considered an inconvenience and a frustration that had to be dealt with for a limited time period. Some patients appeared to gradually adjust and accommodate to the fatigue and were not really aware of the changes that took place over time. Over half of the family members felt more of the impact of fatigue than did their loved ones. Family subtly assumed or took over responsibilities and activities the patient could no longer perform. The symptom of fatigue has been well documented in the cancer experience as both a chronic and recurrent problem for individuals diagnosed with and treated for cancer. The emphasis of previous work has been on deriving a conceptual definition of fatigue, achieving consensus on a definition, and developing theoretical frameworks to guide further study of this complex construct. Fatigue has been conceptualized as a multidimensional phenomenon, attributable to multiple causes and having a negative effect on quality of life (Piper, 1993; Tiesinga, Dasson, & Halfens, 1996). Describing what happens to individuals and their families as a result of fatigue and identifying what individuals do to manage or reduce the effects caused by the fatigue are essential elements in determining multidimensional nursing interventions.

Adaptation, Psychological↗

Anti-inflammatory activity of piperine.

Piperine (1-peperoyl piperidine) was isolated from Piper nigrum Linn for the evaluation of anti-inflammatory activity in rats. Different acute and chronic experimental models like carrageenin-induced rat paw edema, cotton pellet granuloma, and croton oil-induced granuloma pouch, were employed. Simultaneously, biochemical estimations were made to elucidate the underlying mechanism of the action. Piperine acted significantly on early acute changes in inflammatory processes and chronic granulative changes. It also acted partially through stimulation of pituitary adrenal axis. Exudative changes in both acute and chronic models, however, were insignificant.

Alkaloids↗

Prostaglandin endoperoxides and thromboxanes: role in platelets and in vascular and respiratory smooth muscle.

1. Two groups of unstable (t 1/2 = 5 min) endoperoxides, PGG and PGH compounds, have been isolated and shown to be precursors of the prostaglandins. 2. A new group of compounds (thromboxanes) derived from the endoperoxides has been discovered. Thromboxanes have so far been found in platelets, leucocytes, lung tissue, spleen, kidney and umbilical artery. In platelets the thromboxane constitute the major products derived from the endoperoxides. 3. A highly unstable (t 1/2 = 30-40 s) intermediate, thromboxane A2, between the endoperoxides and thromboxane B2 has been detected. Structural work indicates that it has a bicyclic oxaneoxetane structure. 4. Thromboxane A2 induces platelet aggregation and causes contraction of the isolated rabbit aorta. Rabbit aorta contracting substance (RCS) discovered by PIPER and VANE consists mainly of thromboxane A2 and to some extent of the endoperoxides PGG2 and PGH2. 5. Endoperoxides and thromboxanes are essential for platelet aggregation. Platelet cyclo-oxygenase deficiency gives rise to a hemostatic defect due to an abnormal release mechanism. 6. The endoperoxides have unique actions on vascular and air-way smooth muscle. The effects are not due to conversion to the stable prostaglandins (PGE, PGF etc). 7. The biologically active compounds formed from polyunsaturated fatty acids via the cyclo-oxygenase catalyzed pathway can be divided into three groups depending on the stability, viz. the stable prostaglandins (PGE etc.), the endoperoxides (PGG and PGH) and the thromboxanes.

Animals↗

Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.

Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/ prodrug combinations. The enzymes are targeted to tumor cells either with antibodies (ADEPT, antibody directed enzyme prodrug therapy) or with viruses (VDEPT). The goal of the present study was to identify an appropriate enzyme for use in activating the prodrug 7-ethyl-10-[4-(1-piper-idino)-1-piperidino]carbonyloxycamptothe cin (CPT-11). In this study, we compared the efficiency of CPT-11 metabolism by rabbit and human carboxylesterases in in vitro and in situ assays. Although the rabbit and human enzymes are very similar (81% identical; 86% homologous) and the active site amino acids are 100% identical, the rabbit enzyme was 100-1000-fold more efficient at converting CPT-11 to SN-38 in vitro and was 12-55-fold more efficient in sensitizing transfected cells to CPT-11. In vivo, Rh30 rhabdomyosarcoma cells expressing the rabbit carboxylesterase and grown as xenografts in immune-deprived mice were also more sensitive to CPT-11 than were control xenografts or xenografts expressing the human enzyme. Each of the three types of xenografts regressed when the mice were treated with CPT-11 given i.v. at 2.5 mg of CPT-11/kg/daily for 5 days/week for 2 weeks [(dx5)2] (one cycle of therapy), repeated every 21 days for a total of three cycles. However, following cessation of treatment, recurrent tumors were detected in seven of seven mice bearing control Rh30 xenografts and in two of seven mice bearing Rh30 xenografts that expressed the human enzyme. No tumors recurred in mice bearing xenografts that expressed the rabbit carboxylesterase. We conclude that rabbit carboxylesterase/CPT-11 may be a useful enzyme/prodrug combination.

Amino Acid Sequence↗

Consumerism in hospitals--hospitals are, or should be, for people.

The factory situation: are people seen as number patients or are they handled with care and compassion? Hospital care should aim at treatment of the whole person--role of non clinical services within hospitals, partnership with community--role of parents; better communication needed between treating professionals and patients--would reduce complaints and possible litigation; people wish to be partners with health professionals in their own treatment and recovery not articles on an assembly line; rights of patients to be given full facts of their illness and prospects for recovery. Who "pays the piper"? Medical audit, accountability, peer review; iatrogenesis or "doctor induced" illness e.g. adverse reaction to prescribed drugs, hospital induced infections, malnutrition, faulty diagnosis or failure to diagnose. Who motivates the provider and support personnel and how? Institutionalisation and its effects on treatment and recovery, attitudes by providers and receptors. New trends in treatment patterns and delivery facilities: high technology, birthing centers, is there a role for alternative professions within hospitals? Who looks after the consumer? Ombudsman , medical boards, licensing authorities, Australian Council on Hospital Standards.

Australia↗

Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys.

The antiparkinsonian and antidyskinetic profile of two N-methyl-D-aspartate (NMDA) receptor antagonists, a competitive antagonist, (R)-4-oxo-5-phosphononorvaline (MDL 100,453), and a novel noncompetitive allosteric site antagonist, 4-hydroxy-N-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piper idi ne (Co 101244/PD 174494), was assessed in six levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine-lesioned parkinsonian monkeys. The effects on motor function of these two drugs, alone and in combination with levodopa, were then correlated with NMDA subtype selectivity and apparent affinity for four diheteromeric NMDA receptor subunit combinations expressed in Xenopus oocytes. MDL 100, 453 (300 mg/kg s.c.) by itself increased global motor activity (p =. 0005 versus vehicle) and administered 15 min after a low dose of levodopa/benserazide s.c., MDL 100,453 (50, 300 mg/kg s.c.) showed dose-dependent potentiation of antiparkinsonian responses and also produced dyskinesias. Following injection of a fully effective dose of levodopa, MDL 100,453 (300 mg/kg s.c.) also produced a 25% increase in mean dyskinesia score (p =.04). In contrast, Co 101244 did not change motor activity by itself and only showed a tendency to potentiate the antiparkinsonian response when given in combination with a low dose of levodopa, which did not attain statistical significance. However, with a high dose of levodopa, Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit. In vitro, MDL 100,453 was an NMDA glutamate-site antagonist, with approximately 5- to 10-fold selectivity for the NR1A/NR2A subtype combination (K(b) = 0.6 microM) versus NR1A in combination with 2B, 2C, or 2D. In contrast, the allosteric site antagonist Co 101244 showed approximately 10,000-fold selectivity for the NR1A/NR2B (IC(50) = 0.026 microM) versus the other three subunit combinations tested. Taken together, the data suggest that the NR2 subunit selectivity profile of NMDA receptor antagonists can play an important role in predicting behavioral outcome and offer more evidence that NR2B-selective NMDA receptor antagonists may be useful agents in the treatment of Parkinson's disease.

Animals↗

[Treatment with Kava--the root to ocombat stress].

Kava-kava (Piper methysticum), a shrub which grows on the islands of the Pacific Ocean, contains the so-called kavapyrones as active substances; these have been pharmacologically investigated in detail and are comparable with the benzodiazepine tranquilizers with regard to their mode and strength of action. The good tolerance and absence of both the soporific effect and risk of dependence should be emphasized. The present article describes the origin and history of the kava plant as well as its pharmacology, action, possibilities for therapeutic use, and significance in medical practice. Also discussed are the advantages of the standardized kavapyrone complex of active substances as a modern phyto-anxiolytic and daily tranquilizer for nervous anxiety, tension, and agitation states.

Anti-Anxiety Agents↗

The influence of daytime inactivity and nighttime restlessness on cancer-related fatigue.

PURPOSE/OBJECTIVES: To identify indicators involving circadian activity/rest cycles associated with higher levels of cancer-related fatigue (CRF) during the first three chemotherapy cycles after surgery for stage I/II breast cancer. DESIGN: Prospective, descriptive, repeated measures. SETTING: Midwestern oncology clinics and subjects' homes. SAMPLE: 72 women, ages 33-69 and free of unstable chronic illnesses, entered the study. Complete data were obtained from 30-47 subjects at each time. METHODS: CRF was measured using the Piper Fatigue Scale at the start and midpoint of each chemotherapy cycle. Circadian activity/rest indicators were obtained using Mini-Motionlogger wrist actigraphs for 96 hours at the start of each treatment and for 72 hours at the midpoint of each chemotherapy cycle. MAIN RESEARCH VARIABLES: Fatigue and circadian activity/rest indicators. FINDINGS: Women who were less active and had increased night awakenings reported higher CRF levels at all three cycle midpoints, with the strongest association being number of night awakenings. During the third chemotherapy cycle, women who were less active during the day, took more naps, and spent more time resting during a 24-hour period experienced higher CRF. CONCLUSIONS: Women whose sleep is disrupted at cycle midpoints are at risk for CRF. The cumulative effects of less daytime activity, more daytime sleep, and night awakenings are associated with higher CRF levels. IMPLICATIONS FOR NURSING PRACTICE: Assessment of CRF and night awakenings at the midpoints of each chemotherapy cycle and development of nursing interventions to promote daytime activity and nighttime rest are key to managing fatigue and preventing loss of biologic rhythmicity.

Activity Cycles↗

Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats.

BACKGROUND: The effect of spices on gastric acid secretion is variable. Their mechanism of action is also not well established. AIM: To study the effect of spices on gastric acid secretion in anesthetized rats. METHODS: Aqueous extracts (10% w/v) of red pepper (Capsicum annuum), fennel (Foeniculum vulgare), omum/ajwan (Carum copticum), cardamom (Elettaria cardamomum), black pepper (Piper nigrum), cumin (Cuminum cyminum) and coriander (Coriandrum sativum) were prepared. The stomach of pentobarbitone-anesthetized rats was perfused at 0.15 mL/min with aqueous extracts of spice or acetylcholine (1 microgram/mL or 10 micrograms/mL solutions, in 40 min blocks, twice in each experiment bracketed by saline perfusions. The acid content in the samples was estimated by titration with 0.1N NaOH with phenolphthalein as indicator. Atropine 1 microgram/mL was added to the perfusion fluid in 28 experiments. In 32, acute gastric mucosal injury was induced by leaving aspirin 125 mg/Kg in the stomach for 2 h before perfusion. RESULTS: All the spices tested increased acid secretion in the following declining order: red pepper, fennel, omum, cardamom, black pepper, cumin, coriander. Red pepper increased acid secretion (mean [SEM] 0.93 [0.16] mL 0.1N HCl) to about 7 times the basal secretion (0.14 [0.05]; p < 0.005). The increase in acid secretion by the other spices was as follows: fennel 0.42 (0.11) mL 0.1 N HCl from basal secretion (0.12 [0.03]) (p < 0.02); omum 0.33 (0.05) from 0.09 (0.02) (p < 0.01); cardamom 0.28 (0.04) from 0.10 (0.03) (p < 0.005); black pepper 0.19 (0.03) from 0.04 (0.01) (p < 0.005); cumin 0.12 (0.02) from 0.08 (0.01) (p < 0.05); coriander 0.18 (0.03) from 0.09 (0.02) (p < 0.005). Atropine abolished the acid secretion induced by acetylcholine and significantly reduced acid induction by red pepper, omum and coriander, but not that by fennel. In experiments with aspirin-induced mucosal injury the basal acid secretion was low; acid secretion by red pepper and fennel was reduced significantly, but not that by acetylcholine. Cumin and coriander increased acid secretion in injured stomachs. CONCLUSION: The spices tested increased gastric acid secretion, in some by a cholinergic mechanism but by other mechanism(s) as well. Red pepper produced maximum increase in acid secretion, but this was significantly reduced in injured stomachs. Cumin and coriander increased gastric secretion in injured stomachs.

Acetylcholine↗

Correlates of fatigue during and following adjuvant breast cancer chemotherapy: a pilot study.

PURPOSE/OBJECTIVES: To examine patterns of and relationships between activity, sleep, symptom distress, health status, and fatigue during and following adjuvant breast cancer chemotherapy with doxorubicin and cyclophosphamide. DESIGN: Prospective, descriptive, repeated measures. SETTING: Midwestern, urban, oncology clinics. SAMPLE: 14 women, ages 32-69 (X = 52.4), with stage I or II breast cancer receiving four cycles of chemotherapy. METHODS: Wrist actigraph, modified Morin Sleep Diary, Symptom Experience Scale, Medical Outcomes Study-Short Form 36, and Piper Fatigue Scale were used to collect data two days prior to and during the 21-day cycle 3, and for three days at three weeks and two months following treatment 4. MAIN RESEARCH VARIABLES: Activity, sleep, symptom distress, health status, and fatigue. FINDINGS: Fluctuating patterns of lowered activity, disturbed sleep, mild-to-moderate symptom distress, and moderate fatigue were identified. Mean activity levels ranged from 65%-80% of norms during and following treatments. Patterns of sleep (total rest, sleep latency, wake after sleep onset, and sleep efficiency) differed from established norms. Patients experienced the highest levels of fatigue and symptom distress during the first four days after treatment 3. Correlates of fatigue were greater symptom distress, lower activity, and poorer physical and social health status; variables representing disturbed sleep trended toward associations with fatigue. CONCLUSION: Activity, sleep, symptom distress, and health status cluster in patterns associated with either lower or higher fatigue. IMPLICATIONS FOR NURSING PRACTICE: Efforts to manage symptoms, remain active, and obtain quality sleep, especially in women with poorer health status, may assist in modifying fatigue.

Antibiotics, Antineoplastic↗

Relationship between fatigue and nutritional status in patients receiving radiation therapy to treat lung cancer.

PURPOSE/OBJECTIVES: To describe the relationship between fatigue and nutritional status in patients receiving radiation therapy for lung cancer. DESIGN: Prospective, observational study. SETTING: Radiation therapy department of a large mid-western cancer center. SAMPLE: 45 adults with primary cancer of the lung receiving outpatient primary or adjuvant radiation therapy. METHODS: Measurements taken before radiation therapy, at week four of treatment, and at completion included the Piper Fatigue Scale, prealbumin levels, and weights. MAIN RESEARCH VARIABLE: Fatigue, nutritional status. FINDINGS: Weight loss over the course of treatment was significant but did not correlate with fatigue; fatigue did not change significantly during the measurement period. CONCLUSIONS: Fatigue and nutrition are major problems for patients with lung cancer, but nutritional changes do not correlate with fatigue. An increase in fatigue during radiation therapy was not identified. IMPLICATIONS FOR NURSING PRACTICE: Nurses should continue efforts to intervene with the problems of nutrition and fatigue. The study should be repeated using different fatigue Instruments and with other cancer populations.

Adult↗

MT-500 (POZEN).

MT-500 (formerly RS-127445) is a 5-HT2B antagonist being developed for the prophylactic treatment of migraine. POZEN acquired MT-500 from Roche in November 1999, and assumed full responsibility for its development for migraine propylaxis. Roche may elect to reacquire the compound at certain stages. The company expected to commence phase II trials during the first half of 2000 [348204]. POZEN has three other compounds, MT-400, MT-300 and MT-100, in phases I, II and III, respectively, for the treatment of acute migraine. Before outlicensing the compound, Roche Bioscience had completed phase I trials with MT-500 which indicate that it has a favorable side effect and safety profile [348204]. In January 2001, US Bancorp Piper Jaffray predicted phase II development beginning in 2001, with a launch in 2006 [396247].

Animals↗

[Studies on the crude drugs used for the folk medicine described in "mimi-bukuro"].

"Mimi-bukuro" is a book written by Moriyasu Negishi in the Edo period. M. Negishi (1737-1815) was a magistrate in the town of Edo. He was very much interested in listening and recording many kinds of stories, which were told by the various kinds of people, such as public officers, samurais, merchants, doctors, etc. Among the stories of this book, some stories were found concerning folk medicine, medicinal substance and charms. In this report, I studied the medicines which were used in these stories. The medicines originated from zoological, botanical and mineral substances. As the results of my studies, there were zoological, botanical and mineral medicines were 13, 36 and 4 species, respectively. The examples of such medicines were as follows. Zoological samples: Felis catus, Gallus gallus domesticus, Anguilla japonica and Rapana venosa. Botanical samples: Artemisia princeps, Nicotiana tabacum, Panax ginseng, Terminaria chebula and Piper nigrum.

History, 18th Century↗