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Results for “Peripheral Nervous System”

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At least 829 records · Page 46Linked to original sources
PubMed1993

Sarcoidosis of the peripheral nervous system.

The clinical and electrophysiologic data of four new patients with sarcoidosis involving the peripheral nerves are presented and the subject is reviewed. Two had a symmetric polyneuropathy and two had polyradiculopathy. These plus the few cases in the literature indicate that the findings on electromyography are most consistent with axonal neuropathy, in a multifocal pattern. Needle electrolyography was more useful than nerve conduction studies in identifying lesions.

Adolescent↗
PubMed1981

Morphological studies in malignant tumors of the peripheral nervous system (neurofibrosarcoma, malignant schwannoma, schwann cell sarcoma).

9 cases of malignant tumors of the peripheral nerve sheaths have been observed and their morphology including ultrastructures have been studied. 5 cases could be classified as neurofibrosarcomas, I as a Schwann cell sarcoma. Another cases may be grouped with the melaninproducing Schwann cell sarcomas and 2 cases with the "epitheloid Schwann cell sarcomas". The latter group, their separation or their connection to soft tissue sarcomas and to the "medullo-epitheliomas" of peripheral nerves are discussed.

Adult↗
PubMed2002

Magnetic stimulation of the central and peripheral nervous systems.

Since 1985, when the technique of transcranial magnetic stimulation (TMS) was first developed, a wide range of applications in healthy and diseased subjects has been described. Comprehension of the physiological basis of motor control and cortical function has been improved. Modifications of the basic technique of measuring central motor conduction time (CMCT) have included measurement of the cortical silent period, paired stimulation in a conditioning test paradigm, repetitive transcranial magnetic stimulation (rTMS), and peristimulus time histograms (PSTH). These methods allow dissection of central motor excitatory versus inhibitory interplay on the cortical motor neuron and its presynaptic connections at the spinal cord, and have proven to be powerful investigational techniques. TMS can be used to assess upper and lower motor neuron dysfunction, monitor the effects of many pharmacological agents, predict stroke outcome, document the plasticity of the motor system, and assess its maturation and the effects of aging, as well as perform intraoperative monitoring. The recent use of rTMS in the treatment of depression and movement disorders is novel, and opens the way for other potential therapeutic applications.

Central Nervous System↗
PubMed1999

Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems.

Previous studies demonstrated expression of GM1 ganglioside in the nuclear envelope of differentiating neuroblastoma cells and cultured cerebellar granule cells from neonatal rat brain. In the present study, relatively few of the latter cells were shown to possess a nucleus with appreciable GM1 during the first few days in culture, but increasing numbers of such cells possessed GM1-expressing nuclei as morphological differentiation progressed. This phenomenon reached a plateau by the 8th day in culture, approximately 90% of observed nuclei showing cytochemical evidence of GM1 at that time. Cerebral cortical neurons from embryonic rat brain in culture also gave clear evidence of GM1 in the nuclear membrane. Similar results were obtained with cultured neurons from the superior cervical ganglion from embryonic rats, demonstrating developmental appearance of GM1 in the nuclear envelope of PNS neurons. Cytochemical evidence for GM1 in purified nuclei from freshly isolated cortical neurons of neonatal rat brain indicated that expression of nuclear GM1 is not an artifact of cell culture. Study of NG108-15 neuroblastoma x glioma hybrid cells showed upregulation of nuclear GM1 to lag somewhat behind neurite outgrowth, suggesting nuclear GM1 to have a functional role subsequent to onset of morphological differentiation.

Animals↗