[Respiratory diseases in workers exposed to polyvinyl chloride].
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The manufacture of PVC is necessary for supplying the demands of modern society, for maintaining the equilibrium in the chemical industry such as the manufacture of caustic soda solution-chlorine by means of rocksalt electrolysis, and for the safe disposal of chlorine for environmental reasons. The manufacture of vinyl chloride and dichloroethane is illustrated. The conventional processing of PVC into consumer goods, after treatment of rigid and plasticized PVC compounds or granulate, is demonstrated.
Examination by wide-field capillary microscopy of the hands of 152 workers in vinyl chloride (VC) polymerization plants demonstrated scattered, scleroderma-like microvascular abnormalities in 21 workers and isolated capillary abnormalities in 27, as compared with only three isolated abnormalities in 50 manual workers not exposed to vinyl chloride. Thirteen of 17 VC workers with objective evidence of VC-associated abnormalities (angiosarcoma or fibrosis of liver, acroosteolysis, or scleroderma-like skin lesions) were observed to have microvascular abnormalities. If prospective studies confirm the implications of this study, capillary microscopy may become a useful mass-screening procedure in the early detection and prevention of VC-associated disease.
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