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At least 829 records · Page 46Linked to original sources
PubMed1996

Effects of altered olfactory experiences on the development of infant rats' responses to odors.

A "natural" olfactory learning paradigm was used to assess the effects of an altered perinatal olfactory environment on the development of odor-elicited behavior in young rats. Infant rats (from 3 to 12 days of age) reared by dams fed a eucalyptol-adulterated diet responded to the odor of eucalyptol with high levels of activity, mouthing, and probing, and also demonstrated a marked preference for that odor in a two-choice situation (Experiment 1). The effects were observed only in pups whose dam was fed eucalyptol-adulterated diet and were not observed in pups exposed to nonmaternal sources of odor. The intensity of behavioral activity elicited by eucalyptol odor varied, to some extent, with the concentration of the eucalyptol in the dam's diet during prenatal exposure (Experiment 2). Cross-fostering revealed that these effects were due almost entirely to the pups' postnatal exposure to the eucalyptol odor (Experiment 3). These findings indicate that novel odors specifically associated with the mother can gain control over orientation and ingestion-related behaviors.

Animals↗
PubMed2000

Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils.

1,8-Cineole (cineole), a terpenoid oxide present in many plant essential oils displays an inhibitory effect on some types of experimental inflammation in rats, i.e. paw oedema induced by carrageenan and cotton pellet-induced granuloma. Cineole also inhibits in mice, the acetic acid-induced increase in peritoneal capillary permeability and the chemical nociception induced by intraplantar formalin and intraperitoneal acetic acid. Activity was present in these tests, at an oral dose range of 100-400 mg/kg. In the formalin test, the antinociceptive effect of cineole was not reversed by pretreatment of mice with naloxone (1 mg/kg, s.c.), a mu-opioid receptor antagonist, suggesting the involvement of a non-opioid mechanism. Cineole demonstrated a significant inhibitory effect on locomotion and also potentiated the pentobarbital sleeping time in mice, indicating a plausible depressant effect on the central nervous system. The present results, when taken together with the recent reports that describe the inhibitory effects of cineole on the formation of prostaglandins and cytokines by stimulated monocytes in vitro, may provide additional evidence for its potential beneficial use in therapy as an antiinflammatory and analgesic agent.

Analgesics↗
PubMed2002

Preparation and self-assembly of chiral porphyrin diads on the gold electrodes of quartz crystal microbalances: a novel potential approach to the development of enantioselective chemical sensors.

Porphyrin diad 1 was synthesized by reaction of the acyl chloride of porphyrin 2 and trans-1,2-dithiane-4,5-diol. The Co complex of this diad was studied as a potential enantioselective receptor for chiral recognition in solution and in the solid state. In solution both enantiomers of limonene induce significant changes in the visible and circular dichroism (CD) spectra of [Co2(1)], while a different behavior is observed in the case of the enantiomeric pair of trans-1,2-diaminocyclohexane. A different efficiency of [Co2(1)] chiral recognition is obtained for these compounds, with a remarkable degree of enantiodiscrimination observed in the case of limonene. Self-assembled monolayers of [Co2(1)] were deposited onto the gold electrodes of quartz crystal microbalances to be used as sensing materials of nanogravimetric sensors operating in the gas phase. The enantiodiscrimination properties of these sensors towards the enantiomeric pairs of chiral analytes have been studied. While in the case of analytes bearing donor ligand atoms we did not observe a remarkable enantioselectivity, a significant degree of chiral discrimination was observed in the case of limonene; this result is particularly encouraging for the potential development of enantioselective chemical sensors for use in an array configuration.

Cobalt↗