SEARCH · Search PubMed

Results for “MIND”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 829 records · Page 46Linked to original sources

PubMed2006

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.

Mutations in Drosophila neuralized (Dneur) result in a variety of developmental defects that closely resemble those of Notch mutants and other Notch pathway mutants. However, mice with disrupted neur1 do not show any aberrant cell fate specifications in neurogenesis and somitogenesis. Thus, we speculated that other vertebrate neur homolog(s) might compensate for loss of the neur gene. Here, we report the paralog of mouse Neur1, named Neuralized-2 (Neur2), which is a ubiquitin-protein isopeptide ligase (E3) that interacts with and ubiquitinates Delta. Both murine Neur1 and Neur2 have similar degrees of homology to DNeur, and neur2 is expressed in patterns similar to those of neur1 in embryos, suggesting potential functional redundancy. Interestingly, two distinct classes of E3 ligases, Mind bomb-1 (Mib1) and Neur2, have cooperative but distinct roles in Delta endocytosis to Hrs-positive vesicles, i.e. Mib1 functions in the initial step of Delta endocytosis, and Neur2 is required for targeting endocytosed Delta to Hrs-positive vesicles. Thus, our study provides a new insight into how distinct E3 ligases work together in the endocytic pathways for Notch signaling.

Amino Acid Sequence↗

PubMed2004

Gene expression and brain plasticity in stroke rehabilitation: a personal memoir of mind-body healing dreams.

In this personal memoir the author describes the progress of his rehabilitation from a stroke and the dream manifestations of his mind-body healing. He also shares his reminiscences about Erickson's physical difficulties as well as Erickson's naturalistic or activity-dependent approach to therapeutic hypnosis and rehabilitation and emphasizes what he considers the least understood and most under appreciated aspect of Erickson's hypnotherapy--the fact that his patients frequently experienced intense emotional experiences as they accessed and replayed their traumas in a therapeutic manner. He also speculates about the neural mechanisms of his healing from the standpoint of his new neuroscience theory which includes the novelty-numinosum-neurogenesis effect.

Dreams↗

PubMed2000

In pursuit of precision: the calibration of minds and machines in late nineteenth-century psychology.

A prominent feature of late nineteenth-century psychology was its intense preoccupation with precision. Precision was at once an ideal and an argument: the quest for precision helped psychology to establish its status as a mature science, sharing a characteristic concern with the natural sciences. We will analyse how psychologists set out to produce precision in 'mental chronometry', the measurement of the duration of psychological processes. In his Leipzig laboratory, Wundt inaugurated an elaborate research programme on mental chronometry. We will look at the problem of calibration of experimental apparatus and will describe the intricate material, literary, and social technologies involved in the manufacture of precision. First, we shall discuss some of the technical problems involved in the measurement of ever shorter time-spans. Next, the Cattell-Berger experiments will help us to argue against the received view that all the precision went into the hardware, and practically none into the social organization of experimentation. Experimenters made deliberate efforts to bring themselves and their subjects under a regime of control and calibration similar to that which reigned over the experimental machinery. In Leipzig psychology, the particular blend of material and social technology resulted in a specific object of study: the generalized mind. We will then show that the distribution of precision in experimental psychology outside Leipzig demanded a concerted effort of instruments, texts, and people. It will appear that the forceful attempts to produce precision and uniformity had some rather paradoxical consequences.

Biotechnology↗

PubMed2003

Inferring the mental processes of other minds.

In 4 experiments, the authors examined how several variables influence the quality and quantity of information that people use to make judgments about other people. The results showed that when possible, participants consistently responded appropriately to variables that influenced information that they used to make inferences about other minds. The results also suggested that under circumstances with no opportunity to contrast behavior in different situations, people might not be sensitive to the quality and quantity of information present. The authors interpreted results to mean that under most circumstances, people make inferences in a way that efficiently uses information about the causes of behavior.

Cognition↗

PubMed2000

Have dual survival systems created the human mind?

This article reviews pertinent psychological theory to argue for two discrete human motivational tracts. These dual systems appear to draw from disparate constellations of emotional energies that normatively become interactive across development. The article stipulates eight premises from the accepted tenets of psychology, development, and pathology along with corroborating evidence from laterality studies, neuropsychology, and the neurosciences. These premises lead to a verifiable hypothesis reflecting Richard Leakey's proposal that H. sapiens emerged from an interpersonal shaping of adaptation across several million years of group living. The totality of the supportive evidence suggests that the flexibility, agility, and creativity of the human mind was abetted by tensions and reconciliations between two disparate hemispheric perspectives, which express as a Personal Self and a Social Self, focused by a lens molded by survival pressures.

Adaptation, Physiological↗

PubMed2006

Theory of mind in children with traumatic brain injury.

OBJECTIVE: This study was designed to examine the existence of deficits in mentalizing or theory of mind (ToM) in children with traumatic brain injury (TBI). RESEARCH DESIGN: ToM functioning was assessed in 12 children aged 6-12 years with TBI and documented frontal lobe damage and compared to 12 controls matched for age, sex and verbal ability. Brief measures of attention and memory were also included. MAIN OUTCOME AND RESULTS: The TBI group was significantly impaired relative to controls on the advanced ToM measure and a measure of basic emotion recognition. No difference was found in a basic measure of ToM. CONCLUSION: Traumatic brain damage in childhood may disrupt the developmental acquisition of emotion recognition and advanced ToM skills. The clinical and theoretical importance of these findings is discussed and the implications for the assessment and treatment of children who have experienced TBI are outlined.

Brain Injuries↗

PubMed2003

Pilot evaluation of a mindfulness-based intervention to improve quality of life among individuals who sustained traumatic brain injuries.

PRIMARY OBJECTIVE: To examine the potential efficacy of a mindfulness-based stress reduction approach to improve quality of life in individuals who have suffered traumatic brain injuries. RESEARCH DESIGN: Pre-post design with drop-outs as controls. METHODS AND PROCEDURES: We recruited individuals with mild to moderate brain injuries, at least 1 year post-injury. We measured their quality of life, psychological status, and function. Results of 10 participants who completed the programme were compared to three drop-outs with complete data. EXPERIMENTAL INTERVENTION: The intervention was delivered in 12-weekly group sessions. The intervention relied on insight meditation, breathing exercises, guided visualization, and group discussion. We aimed to encourage a new way of thinking about disability and life to bring a sense of acceptance, allowing participants to move beyond limiting beliefs. MAIN OUTCOMES AND RESULTS: The treatment group mean quality of life (SF-36) improved by 15.40 (SD = 9.08) compared to - 1.67 (SD = 16.65; p = 0.036) for controls. Improvements on the cognitive-affective domain of the Beck Depression Inventory II (BDI-II) were reported (p = 0.029), while changes in the overall BDI-II (p = 0.059) and the Positive Symptom Distress Inventory of the SCL-90R (p = 0.054) approached statistical significance. CONCLUSIONS: The intervention was simple, and improved quality of life after other treatment avenues for these participants were exhausted.

Adaptation, Psychological↗

PubMed1995

Representation and identity - convergence of brain research and mind-brain philosophy.

The localization or representation of mental abilities in the brain have always been considered as key questions for understanding the organization of the human nervous system. Particularly with the advent of modern electrophysiological and imaging techniques that provide maps of electromagnetic fields and metabolic processes on the living central nervous system, the representation theory is experiencing a scientific renaissance in neurology, but is only one theory, however, in the succession of a long philosophical tradition dealing with the possible identification of mental phenomena and brain processes. This dichotomy was formulated at the latest in the Cartesian dualism of res cogitans and res extensa of the mind-body problem. Nowadays philosophical discussion, on the contrary, is dominated by monistic concepts that attempt to explain the mental realm on an organic foundation in order not to succumb to the problem of a psychophysical dualism. Of these, the identity theory offers a philosophically plausible concept postulating that the identity of brain conditions and mental phenomena is based on organic foundations. In this theory, the efforts of brain research converge on the representations of mental phenomena in the human nervous system. In a comprehensive approach, both concepts could complement each other.

Brain↗

PubMed2002

Phantom limbs: The body in mind.

INTRODUCTION: Advances in our knowledge of corporeal awareness is not limited to patients with amputations, however, until recently, the study of ''phantom limbs'' was neglected by comparison with less common disorders of body perception. METHOD: Reasons for the neglect of this potentially informative and common condition are conspicuous by their absence in previous reviews. Over the past decade, however, experimental investigations of phantom limbs have revealed the dynamic neural processes that provide for both phantom and normal corporeal embodiment. Moreover, these findings helped to overturn widely held scientific assumptions regarding the extent of neural plasticity in the adult brain. RESULTS: It is suggested that throughout medical history, the construct of ''phantom limbs'' posed a challenge to fundamental folk assumptions regarding the assumed relationship between body and mind. CONCLUSION: Reluctance to entertain the counter-intuitive phenomenon of a ''limbless perception'' contributed to the comparative neglect of this fascinating phenomenon until the late 20th century.

Journal Article↗

PubMed2003

Is theory-of-mind impaired in Parkinson's disease?

INTRODUCTION: Theory-of-mind (ToM) refers to the ability to understand and predict the behaviour of others based on their mental states. Research from brain imaging and lesion studies indicate that the frontal lobes are both involved and necessary to understand mental states. METHODS: A total of 13 people with Parkinson's disease were compared with 11 age-matched controls on tasks involving ToM, based on the hypothesis that the frontal lobes are affected by Parkinson's disease. The four tasks included both ToM and non-ToM components, such as memory, to investigate the specific nature of the deficit. RESULTS: The group with Parkinson's disease scored significantly lower on three out of four of the ToM components of the tasks, relative to controls, but were not impaired on any of the non-ToM components of the four tasks. CONCLUSION: The results suggest the impairment was specific to ToM and thus have implications for a dedicated specific ToM module.

Journal Article↗

PubMed2005

Schizophrenia, theory of mind, and persecutory delusions.

INTRODUCTION: There is already a substantial body of evidence supporting Frith's (1992) theory that theory of mind (ToM) is impaired in people with schizophrenia. However, a specific relationship between impaired ToM and paranoid delusions, while intuitively reasonable, has only been demonstrated in two studies to date. METHODS: A total of 25 participants with schizophrenia were classified as paranoid or nonparanoid and compared with 38 healthy controls on a variety of ToM tasks. These tasks included verbal and nonverbal, and first and second order ToM tasks. RESULTS: Participants with schizophrenia performed significantly more poorly than healthy controls on both the first and second order verbal ToM tasks but not on the nonverbal ToM tasks. However, the ToM deficit was only observed for those participants with schizophrenia who had persecutory delusions. There was also a strong relationship observed between the severity of persecutory delusions and length of illness. CONCLUSIONS: This study represents only the third demonstration of a specific link between paranoid delusions and ToM impairment. Reasons why previous findings on this issue have been so inconsistent are considered. Further research is needed to explore the relationships among paranoia, ToM, and length of illness.

Journal Article↗

PubMed2005

Theory of mind in schizophrenia: a critical review.

INTRODUCTION: Frith's (1992) neuropsychological theory of schizophrenia posits a number of fundamental cognitive impairments underpinning the characteristic symptoms of this disorder. One of these is an impairment in the ability to correctly interpret and predict the mental states of other people, so-called theory of mind (ToM). There is already a substantial body of evidence that ToM is impaired in people with schizophrenia. Our aim was to critically review this literature. METHOD: A narrative review of the research literature was completed. Electronic searches of both Medline and PsycInfo were conducted to locate relevant articles. The bibliographies of relevant articles were scrutinised and in some cases researchers were contacted directly. RESULTS: A total of 30 studies that all examined some aspect of ToM in people with schizophrenia were located. These were summarised and key issues on this topic were identified. CONCLUSIONS: There is considerable evidence that ToM is impaired in people with schizophrenia. However, this is perhaps the only unequivocal finding on the topic to date. Issues that demand further clarification include: Is the deficit a state or a trait? How to measure ToM in schizophrenia research, and whether certain symptoms or groups of symptoms are associated with the ToM deficit. These issues are considered and the evidence evaluated. Some priorities for future research are suggested.

Journal Article↗

PubMed2005

Symptomatology and social inference: a theory of mind study of schizophrenia and psychotic affective disorder.

INTRODUCTION: There is evidence that certain patients with schizophrenia have deficits in theory of mind (ToM) capabilities. It is, however, unclear whether these are symptom or diagnosis-specific. METHODS: A ToM hinting task was given to 15 patients with a DSM-IV diagnosis of schizophrenia, 15 patients with affective disorder and 15 healthy controls. Severity of the current psychopathology was measured using the Krawiecka standardised scale of psychotic symptoms (Krawiecka, Goldberg, & Vaughan, 1977); IQ was estimated via the Ammons and Ammons Quick Test (Ammons & Ammons, 1962). RESULTS: The group with schizophrenia performed significantly worse than the affective and control groups. Poor performance on the hinting task was found to be significantly related to the presence of positive symptoms (instead of negative ones) and specifically related to delusions and hallucinations. These findings remained when covariance for potentially confounding variables was applied. CONCLUSIONS: Individuals with high levels of delusions and hallucinations performed significantly worse on this ToM task, regardless of diagnosis, implying ToM impairment is not exclusive to schizophrenia but is evident in other forms of psychosis. Between-group analyses showed the schizophrenia group had a significantly poorer performance on this task than the others.

Journal Article↗

PubMed2006

Theory of mind in Asperger's syndrome, schizophrenia and personality disordered forensic patients.

INTRODUCTION: The ability to conceptualise other individuals' mental states is dependent on having a 'theory of mind' (ToM). Individuals with Asperger's syndrome typically display ToM impairments, as do some individuals with schizophrenia, notably those with paranoid delusions. The presenting features of these and other individuals, such as those with some personality disorders, particularly in forensic patients, are often unclear. ToM performance was examined to see whether it could distinguish forensic patients with Asperger's syndrome from other patient groups. METHODS: The performance of three male patient groups (N = 39) detained in high security psychiatric care, including those with Asperger's syndrome, schizophrenia (with paranoid delusions and/or auditory hallucinations as their predominant symptoms), or a dissocial and/or borderline personality disorder were compared using the revised eyes task and the modified advanced ToM test. RESULTS: The Asperger's syndrome and schizophrenia groups performed significantly worse than the personality disorder group on both ToM measures. However, the Asperger's syndrome and the personality disorder groups had significantly higher levels of general intellectual functioning than the schizophrenia group. CONCLUSIONS: Whilst ToM performance may help to discriminate patients with Asperger's syndrome or schizophrenia from personality disorder ed patients, a wide range in performance made it difficult to specify a patient to a particular group. Theoretical and methodological issues are discussed along with the usefulness of ToM assessments with forensic patients.

Adult↗

PubMed2006

Empathetic perspective-taking is impaired in schizophrenia: evidence from a study of emotion attribution and theory of mind.

INTRODUCTION: Schizophrenia and autism are clinically distinct yet both disorders are characterised by theory of mind (ToM) deficits. Autistic individuals fail to appreciate false beliefs, yet understand the causal connections between behavioural events and simple emotions. Findings of this type have promoted the view that ToM deficits in autism reflect a domain-specific difficulty with appreciating the representational nature of epistemic mental states (i.e., beliefs and intentions and not emotions). This study examines whether the same holds true for schizophrenia. METHODS: A picture-sequencing task assessed capacity to infer false beliefs in patients with schizophrenia and healthy controls. To assess emotion attribution, participants were shown cartoon strips of events likely to elicit strong emotional reactions in story characters. Characters' faces were blanked out. Participants were instructed to think about how the characters would be feeling in order to match up the cards depicting facial affect appropriately. Participants later named emotions depicted in facial affect cards. RESULTS: Patients were as capable as controls of identifying cartoon facial expressions, yet had greater difficulties with: (a) attributing emotions based on circumstances; and (b) inferring false beliefs. CONCLUSIONS: Schizophrenia patients, unlike autistic individuals, suffer a domain-general difficulty with empathetic perspective-taking that affects equally their appreciation of other people's beliefs, percepts, and emotions.

Adult↗

PubMed2006

Theory of mind and its relation to schizotypy.

INTRODUCTION: Frith (1992) suggested that many psychotic symptoms are associated with impaired theory of mind (ToM), the ability to represent the mental states of others. Langdon and Coltheart (1999) found an association in a nonclinical adult population between schizotypal traits and poorer ToM on a picture-sequencing task. The present study attempted to replicate and extend this finding using a ToM story task. METHODS: A total of 62 nonclinical individuals completed a schizotypy questionnaire (the Oxford-Liverpool Inventory of Feelings and Experiences; O-LIFE) and a set of ToM stories. Matched "physical" control stories were administered to control for general reasoning ability. Executive function and current verbal IQ were assessed using the Cognitive Estimates Test and the Quick Test, respectively. RESULTS: Schizotypal traits analogous to positive symptoms of schizophrenia (UE scale of the O-LIFE) predicted poorer scores on the ToM task, but were unrelated to scores on physical stories. Individuals with high scores for total schizotypy on the O-LIFE did not differ in ToM from those with low total scores. There was no association between poorer ToM and schizotypal traits analogous to the "behavioural signs" of schizophrenia. Executive function and verbal IQ did not significantly predict story scores. CONCLUSIONS: Positive schizotypal traits in the normal population are associated with subtle impairments in ToM, independent of reasoning ability, executive function, or verbal IQ. A strong association between poor ToM and "behavioural signs" may only appear in studies of schizophrenic patients, and not in studies of nonclinical individuals. The findings are discussed in relation to Frith's (1992) cognitive neuropsychological model of schizophrenia.

Adolescent↗

PubMed1999

Mind and action.

The author argues that Cutting's Principles of psychopathology (1997) is a remarkable compendium of ideas on psychopathology and philosophy, and offers a valuable resource for those interested in this area. There is, however, a marked contrast between the way in which Cutting views philosophy (as a source of ideas) and the way contemporary philosophy views itself (as being about the skills of deepening understanding and arriving at original ideas through the application of analytical and critical thinking skills). In addition, Cutting's survey of the philosophy literature is highly selective and is concentrated largely on pre-World War II philosophy. As a result of both these features, the book underemphasises the potential value of philosophy for psychopathology. It is argued in this paper that philosophy provides strategies for inquiry into the nature of the mind and its pathologies, rather than being merely a source of ideas. This point is made in more detail by exploring the contrast between the approach Cutting adopts and the approach used by both Karl Jaspers and in recent work on the philosophy of psychopathology, specifically K.W.M. Fulford (1989). Although the author of this paper is entirely in agreement with Cutting's general view (that psychopathology is underpinned by philosophy), it is argued that he does not take his exploration far enough to extract from his survey the fundamental underlying implications for psychopathology-that psychopathology is inherently evaluative and normative in its stance, but that this aspect is rendered opaque, currently, by psychopathology's status as an empirical science.

Journal Article↗

PubMed2006

Theory of mind and the right cerebral hemisphere: refining the scope of impairment.

The neuropsychological and functional characterisation of mental state attribution ("theory of mind" (ToM)) has been the focus of several recent studies. The literature contains opposing views on the functional specificity of ToM and on the neuroanatomical structures most relevant to ToM. Studies with brain-lesioned patients have consistently found ToM deficits associated with unilateral right hemisphere damage (RHD). Also, functional imaging performed with non-brain-injured adults implicates several specific neural regions, many of which are located in the right hemisphere. The present study examined the separation of ToM impairment from other deficits associated with brain injury. We tested 11 patients with unilateral right hemisphere damage (RHD) and 20 normal controls (NC) on a humour rating task, an emotion rating task, a graded (first-order, second-order) ToM task with non-mentalistic control questions, and two ancillary measures: (1) Trails A and B, in order to assess overall level of impairment and set-shifting abilities associated with executive function, and (2) a homograph reading task to assess central coherence skills. Our findings indicate that RHD can result in a functionally specific deficit in attributing intentional states, particularly those involving second-order attributions. Performance on ToM questions was not reliably related to measures of cognitive impairment; however, performance on non-ToM control questions was reliably predicted by Trails A and B. We also discuss individual RHD patients' performance with attention to lesion locus. Our findings suggest that damage to the areas noted as specialised in neuroimaging studies may not affect ToM performance, and underscore the necessity of combining lesion and imaging studies in determining functional-anatomical relations.

Adult↗