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Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs.

OBJECTIVE: To evaluate use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. DESIGN: Prospective open clinical trial. ANIMALS: 40 dogs with storm phobia. PROCEDURE: Dogs received clomipramine at a dosage of 2 mg/kg (0.9 mg/lb), PO, every 12 hours for 3 months; then 1 mg/kg (0.45 mg/lb), PO, every 12 hours for 2 weeks; then 0.5 mg/kg (0.23 mg/lb), PO, every 12 hours for 2 weeks. Alprazolam was given at a dosage of 0.02 mg/kg (0.009 mg/lb), PO, as needed 1 hour before anticipated storms and every 4 hours as needed. Desensitization and counter-conditioning were conducted at home by the caregiver with an audio simulation of storm sounds that had induced a fear response during evaluation. RESULTS: 30 of the 32 dogs that completed the study had a degree of improvement, as measured by caregivers' global assessment. Two caregivers considered the storm phobia to be resolved. Panting, pacing, trembling, remaining near the caregiver, hiding, excessive salivation, destructiveness, excessive vocalization, self-trauma, and inappropriate elimination all decreased significantly during treatment. Improvement was greater during true storms (rain, thunder, and lightning) than during rain only. Response to audio simulation did not change during treatment. Four months after the study, improvement was maintained. CONCLUSIONS AND CLINICAL RELEVANCE: The combination of clomipramine, alprazolam, and behavior modification can be effective in decreasing or eliminating storm phobia. Improvement could not be evaluated by use of audio simulation of a storm.

Alprazolam↗

Myocardial injury after electrical burns: short and long term study.

Miscellaneous cardiac abnormalities can occur after electrical burns. The long term outcomes are still unknown. We studied 10 patients, 9 of whom suffered high-voltage electrocution, and one of whom was struck by lightning. Serial electrocardiograms (ECG) and serum MB creatine phosphokinase isoenzyme (MB-CPK) activities were obtained during their stay in hospital. ECG and thallium 201 cardiac scintigraphy at rest, as well as echocardiograms were obtained in all patients 4 to 48 months after discharge. In hospital, 9 patients showed one or more abnormal findings at physical examination (4 cases), ECG (8 cases), MB-CPK (1 case). At long term follow-up, 5 patients had one or more myocardial functions or conduction abnormalities, with or without symptoms. One patient had compensated heart failure. Nine patients were asymptomatic. Abnormal ECG findings persisted in 3 patients. Three cardiac scans showed evidence of regional myocardial hypoperfusion. Decreases in left ventricular indices measured by echocardiogram were found in 3 patients. We conclude that high-voltage electrocution is associated with a high incidence of cardiac abnormalities, which may persist. Long term evaluation, requiring cardiac T1 201 scintigraphy and echocardiogram, may be justified.

Adult↗

A simple method for the comparison of commercially available ATP hygiene-monitoring systems.

The purpose of this study was to evaluate a methodology which could easily be used in any test laboratory in a uniform and consistent way for determining the sensitivity and reproducibility of results obtained with three ATP hygiene-monitoring systems. The test protocol discussed here allows such comparison to be made, thereby establishing a method of benchmarking both new systems and developments of existing systems. The sensitivity of the LUMINOMETER K, PocketSwab (Charm Sciences) was found to be between 0.4 and 4.0 nmol of ATP with poor reproducibility at the 40.0 nmol level (CV, 35%). The sensitivity of the IDEXX LIGHTING system and the Biotrace UNILITE Xcel were both between 0.04 and 0.4 nmol with coefficients of variation (CVs) of between 9% at 0.04 nmol and 10% at 0.4 nmol for the IDEXX system and 17% at 0.04 nmol and 21% at 0.4 nmol for the Biotrace system. The three systems were tested with a range of dilutions of different food residues: orange juice, raw milk, and ground beef slurry. All three test systems allowed detection of orange juice and raw milk at dilutions of 1:1,000, although the CV of results from the Charm system (54 and 74% respectively) was poor at this dilution for both residues. The sensitivity of the test systems was poorer for ground beef slurry than it was for orange juice and raw milk. Both the Biotrace and IDEXX systems were able to detect a 1:100 dilution of beef slurry (with CVs of 17 and 10% respectively), whilst at this dilution results from the Charm system had a CV of 55%. It was possible by using the method described in this paper to rank in order of sensitivity and reproducibility the three single-shot ATP hygiene-monitoring systems investigated, with the IDEXX LIGHTNING being the best, followed by the Biotrace UNILITE Xcel, and then the charm LUMINOMETER K, PocketSwab.

Adenosine Triphosphate↗

Book adds new chapters to managed-care debate.

Managed-care plans have become the nation's whipping boys, under attack from consumers, policymakers and some physicians alarmed by charges of treatment information being withheld and life-threatening denials of medical care. The issue of drive-through deliveries became a lightning rod for politicians who rushed to pass legislation requiring minimum stays for new mothers and their babies. Reports of forced outpatient treatments for mastectomy patients has reignited criticism. A new book by Wall Street Journal reporter George Anders promises to be a pivotal publication in the debate.

Cost-Benefit Analysis↗

The Zen of physician initiatives.

Many physicians today feel ravaged by the brutal speed with which change has been occurring. They see the beliefs and practices of a lifetime being abandoned and replaced by the flavor of the month, management du jour. But if you are willing and able to take the brave step of approaching your physicians without an agenda, meeting with them to listen to their concerns, and can also avoid hanging a lightning-rod label on every bright new idea that comes out of the sessions, you'll be on the way to effective new management. This new style is a "Zen" approach (but don't give it that label) that lets real collaboration come into the place that is supposed to be all about healing--the health care organization. From "never call it anything" to "stay with them until they get it," ideas on how to be a Zen manager are presented, with the ultimate goal of truly partnering with physicians and infusing them with a desire to move beyond the frustration and disenchantment they are feeling.

Adaptation, Psychological↗

Part II: What do employers mean by "value"?

With health care costs clearly on the rise again, and First Generation Managed Care having matured itself into market gridlock, it is inevitable that there will be a second "employer" revolt. As long as private purchasers do not see organizations fully focused on "value" as they see it, they will not be content with rising costs as "unavoidable". And whereas I do not believe we will see the double digit increases of the 1970's and 80's, consistent annual increases of greater than 5% (or 2-3 times the general inflation rate) will become a major problem, particularly when the current economic expansion ends, and top-line growth in revenues and profits outside the health care sector are once again under pressure. The timing of this second employer revolution is anyone's guess, but it is likely to occur with lightning speed on the heels of a major and sustained correction in the global market. Employers will be looking to move volume to organizations that can offer the best value. Integrated health systems have the potential to become these organizations but, they have significant hurdles to overcome. However, from the private sector point of view, if doctors are willing to listen, learn a new language and become committed to accountability and measurement, employers innately believe that those closest to the "customer" (i.e. patients) are best able to manage. Whether, provider systems can rise to this challenge is unclear. But the stakes, for physicians, purchasers and ultimately patients, have never been higher. And employers, as a group, are hopeful that these organizations can live up to their promise.

Consumer Behavior↗

Choosing a specialty during a generalist initiative: a focus group study.

BACKGROUND: Virginia Commonwealth University (VCU) (as part of a three-school consortium) was 1 of 12 sites awarded a Robert Wood Johnson Generalist Physician Initiative (RWJ-GPI) grant. Given the goals of this initiative--to promote a balanced output of generalists and specialists--program planners wanted to understand how medical students made career decisions in the context of this curriculum change and the larger social environment. METHODS: Seven focus groups (average size: six members each) of second-year and fourth-year students were recruited. Groups were homogeneous with respect to subspecialty or primary care orientation and career trajectory. An experienced moderator conducted all groups. The discussions were taped and transcribed. Analysis proceeded concurrently with data gathering, using a template style and with assistance from the NUD*IST software program. RESULTS: Students from all groups hoped for control of their practice, intellectual challenge, rewarding relationships with their patients and their own families, and fair compensation for effort. They worried about their future prospects, and specialty-oriented students felt that the emphasis on primary care production was being forced on the school. All groups saw managed care as doing more harm than good for patients, and all wished for improved career counseling. DISCUSSION: The RWJ-GPI at VCU became a lightning rod for student worry and resentment at being forced into primary care specialties. The backlash phenomenon was seen at other US medical schools and is one of the postulated reasons for a decline in US student numbers matching in family practice, internal medicine, and internal medicine-pediatrics. Medical school faculty should respond with constructive, pro-student policies and programs.

Adult↗

[Functional signs indicating retinal detachment].

PURPOSE: Retinal detachment is a rare but potentially blinding disease. Incidence of retinal detachment is stable in France, in spite of argon laser prophylaxis. METHOD: We have performed a prospective study on 100 patients with reghmatogenous, idiopathic retinal detachment. RESULTS: Functional signs were carefully recorded in 89% of cases. Vitreous signs were frequent (85%) mostly black points (67% of cases) myodesopia (32% of cases) floating images (14% of cases) black stains and filaments (11% of cases). Phosphens were recorded in 45% of cases and described as flashes of lightning in 30% of cases. Macular detachment was significantly more frequent among patients consulting after retinal signs appeared. CONCLUSION: Our study shows the frequency of functional signs in retinal detachment disease for rapid take over of these patients.

Adult↗

[In Process Citation]

The results of treatment of 13,246 patients with acute surgical disease of the abdominal organs have been analysed. In 48 patients, bleeding from a stress ulcer occurred. The symptoms of bleeding were studied. The variants of the clinical course of postoperative acute erosion and ulcer, such as the lightning-like, double-phase, single-phase ones, have been distinguished. Their predictive value is shown. In 89.6% of the patients, a postoperative stress ulcer developed in diseases of the hepatopancreatobiliary zone organs.

Journal Article↗

Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy.

We performed long-term video/ EEG monitoring and a single photon emission computed tomographic (SPECT) study to clarify generating mechanism of bilateral tonic motor seizures resembling seizures generated by the supplementary motor area (SMA), in patients with bilateral parietal lesions. We describe 2 patients (age 24 and 32 years), with bilateral parietal lesions. Clinically, seizures were preceded by lightning sensation in the body, followed by asymmetric tonic posturing of both hands and thrashing movements of the feet, lasting for less than 1 min. Ictal rhythmic (7-15 Hz) activity at the vertex was observed on the EEG in 1 patient. Interictal SPECT in 2 patients showed decreased blood flow in both parietal areas, consistent with bilateral parietal abnormalities on T2- and T1-weighted MRIs. Ictal SPECT in 1 patient showed increased blood flow in the right parietal and frontopolar areas. The present 2 patients had clinically asymmetric tonic seizures, most likely resulting from spreading of the ictal activity from the parietal lesions via the superior longitudinal fasciculus to the SMA. Bilateral, homologous lesions in the parietal area might cause disinhibition on the unilateral epileptogenic side.

Adult↗

The nature of nitrogen: an overview.

Most of the nitrogen available to the biosphere exists as N2 in the atmosphere, and is not useful to most organisms until it is "fixed" either biologically or abiotically (by lightning or aurorae, or industrially). Once it is fixed into NH3, usually it is either assimilated and transformed into organic N or nitrified into NO3-. Organic N can be transformed back into NH3 by ammonification. Nitrate can be converted into N2O by nitrification and denitrification, and to N2 by denitrification. Such N2O and N2 production results in nitrogen loss from ecosystems and a nitrogen gain to the atmospheric nitrogen reservoir. The different steps of the nitrogen cycle require different environmental conditions. These differences result in a spatial distribution pattern of the different nitrogen transformation reactions. Biological nitrogen fixation occurs universally in soils, sediments, fresh water, and marine systems that are both aerobic and anaerobic. Nitrification occurs primarily in aerobic habitats, whereas denitrification predominates in anaerobic habitats such as sediments and water-logged soils. In closed systems, such as plant growth chambers for CELSS, denitrification and nitrification result in a loss of fixed nitrogen available to plants.

Ammonia↗

Leapfrog Group patient safety initiatives draw kudos, criticism.

Just over a year ago, the Leapfrog Group proposed a three-pronged patient safety initiative. One year later, the group is finding that many hospitals and health systems across the country are looking closely at the recommendations and making changes. But, it also is finding that it has become a lightning rod within the health care community in debates on whether these proposals are the best way now to proceed in improving patient safety.

Health Care Surveys↗

[Nosocomial infectious: the realities of an endless fight].

Nosocomial infections (N.I.), contracted while patients are being cured, are the direct price of lightning progress in medicine in the course of the last fifty years. Absolute paradox of the end of century, the very place, where the most famous surgical and medical events are achieved, is also the same scene where a patient may contract infections that sometimes lead to a fatal outcome. With 10000 deaths per year and millions of additional hospitalization days, NI have become a real Public Health problem. They reach especially patients but also the staff, and they can be found everywhere a treatment is given (hospital, clinic, patient's home). Paradoxically, the first great myth of anti-NI struggle is the discovery of antibiotics, one of the hugest advancements for humanity. An excessive antibiotherapy prescription, added to a laxism in basic hygiene actions (individual or collective) increased for the last thirty years this phenomenon, which has now become so extensive that international and national authorities are managing this problem. The fight versus NI is an endless struggle because treatments will always exist. The rising emergence of antibiotics bacterial multiresistance has promoted this whole subject called Hospital Hygiene, a discipline which, little by little, regains a dominating place in our Health establishments. Bacteria are liable for 85% of NI, while virus and fungi are responsible for 15%. Omnipresent on a milliards scale, ubiquitous, the bacterial species will be thwarted only if the staff, who is taking care of patients, shows a constant vigilance. Immunosuppressive pathologies, age and nutritional conditions of the patient, new invasive diagnosis or assistance methods, antibiotics selection pressure, and at least a mismanagement of individual Hygiene and/or of the premises, are the main conditions leading to the outbreak of NI. The NI occurs basically within an early period of ten days after the patient's care. Catheter urinary infections, broncho-pneumonic infections with ventilation assistance, post-operative wounds and catheter bacteremia are the main nosocomial pathologies found in France, and in other european countries or in the United States. Staphylococci, Enterococci, Enterobacteria and Pseudomonas are the leaders of responsible bacteria but any kind of bacterium, can generate a NI, due to associated risk factors. Committees against nosocomial infections (Clin) have been organized in France in every public health establishment in 1988, then in every private health establishment in 1999. Since 1992 inter-aeras coordination committees and one national technical committee were instituted. In that way was the struggle officially set up. At last the Health National Agency of Accredidation and Valuation (ANAES), within the scope of an improvement policy concerning the security of and the quality of treatments in every health establishment, accepted about ten "standards" or "criterions" recommending supervision, education, written proceedings, informations diffusion modes, indicators definition in hospital hygiene. 85% of NI are in relation with direct or indirect hand transmission: that is the main point. So the first measure versus NI is just a fact: "HANDWASHING". It is the most effective method, the least expensive but unfortunately the least steady process. Beyond the struggle versus NI, all iatrogenic risks must be fought with a coherent control strategy. This "multivigilance" is a hard job for every health professional because it must be a daily, steady, rigorous and multidisciplinary task. The "Clin" is the privileged place for abilities round-up with an effective and permanent contribution between clinical structures, microbiology labs, pharmacy, administrative and technical sections. Every people belonging to a care unit must be equally involved in the rising of NI which activated a real mobilization of politicians and professionals who have become sensitive, on a socio-economic and an ethical basis. It is a collective and individual problem. Furthermore, the strict use of basic rules in hospital hygiene appears to be the KEYSTONE of the struggle.

Cross Infection↗

Expensing options solves nothing.

The use of stock options for executive compensation has become a lightning rod for public anger, and it's easy to see why. Many top executives grew hugely rich on the back of the gains they made on their options, profits they've been able to keep even as the value they were supposed to create disappeared. The supposed scam works like this: Current accounting regulations let companies ignore the cost of option grants on their income statements, so they can award valuable option packages without affecting reported earnings. Not charging the cost of the grants supposedly leads to overstated earnings, which purportedly translate into unrealistically high share prices, permitting top executives to realize big gains when they exercise their options. If an accounting anomaly is the problem, then the solution seems obvious: Write off executive share options against the current year's revenues. The trouble is, Sahlman writes, expensing option grants won't give us a more accurate view of earnings, won't add any information not already included in the financial statements, and won't even lead to equal treatment of different forms of executive pay. Far worse, expensing evades the real issue, which is whether compensation (options and other-wise) does what it's supposed to do--namely, help a company recruit, retain, and provide the right people with appropriate performance incentives. Any performance-based compensation system has the potential to encourage cheating. Only ethical management, sensible governance, adequate internal control systems, and comprehensive disclosure will save the investor from disaster. If, Sahlman warns, we pass laws that require the expensing of options, thinking that's fixed the fundamental flaws in corporate America's accounting, we will have missed a golden opportunity to focus on the much more extensive defects in the present system.

Accounting↗

[The involutional vitreoretinal syndrome].

Ocular changes in elderly subjects are described, that may be regarded as manifestations of a disease, denoted by the author as the involution vitreoretinal syndrome. The subjective signs of the syndrome are floating 'moths', photopsias presenting as a 'lateral lightning', sudden appearance of a central macula (central positive scotoma). The objective signs are destruction and posterior detachment of the vitreous body, peripheral retinal dystrophy, stable light reflexes (coin-shaped, flap, etc.) on the fundus oculi, previously described by the author. The syndrome complications are fibroplasia of the fundus oculi central area, macular edema, perforation of the macula and characteristic lenticular changes. The author singled out the cases with combined changes of the vitreous body, fundus oculi and lens involvement as a lentivitreoretinal form of the involution vitreoretinal syndrome.

Aged↗

[A case of early syphilis presenting general paresis-like symptoms and bilateral tonic pupils].

A 40-year-old man was admitted after 8 months of speech disturbance and locomotive ataxia. He had no seizures, lightning pains, paresthesia, visual loss, bladder disturbance or rectal incontinence. He had never been neurologically or psychiatrically ill and had no history of syphilis. When the patient was admitted, his general physical examination including blood pressure and dermatologic examination was normal. His consciousness was alert. He was found to have a deterioration of mental status such as inability to concentrate, failing memory, amnesia and circumstantiality. His pupils were anisocoric and Achilles jerks were absent. No rigidity of the neck muscles, paralysis and sensory disturbance were recognized. Romberg's sign was absent. The right pupil was 7.0 mm and the left was 6.0 mm in room illumination. The pupils were nonreactive to bright light and both did not constricted to near stimuli. 0.125% pilocarpine eyedrops produced bilateral pupillary constriction. The results indicated bilateral tonic pupils. Laboratory data revealed white cell count of 12,600/mm3 and normal erythrocyte sedimentation rate of 8 mm/hr. Cerebrospinal fluid (CSF) examination revealed the following: opening pressure, 140 mm of water; cell counts, 76/mm2 (mononuclear cells); total protein, 116 mg/dl; glucose, 57 mg/dl. A serum venereal disease research laboratories (VDRL) test was positive in a 1:32 titer confirmed by positive treponema pallidum hemagglutination (TPHA) test in a 1:40,960 titer and positive fluorescent treponemal antibody-absorption (FTA-ABS) test. Serum TPHA-IgM was positive in a 1:320 titer but TPHA-IgG was negative. CSF examination revealed positive TPHA test (titer of 1:2,560) and positive FTA-ABS test.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Circadian light input in plants, flies and mammals.

The rotation of our planet results in daily changes in light and darkness, as well as seasons with characteristic photoperiods. Adaptation to these daily and seasonal changes in light properties (and associated changes in the environment) is important to the sustained survival of higher life forms on our planet. Many organisms use their intrinsic circadian oscillator or clock to orchestrate daily rhythms in behaviour and physiology to adapt to diurnal changes. Some higher organisms use the same oscillator to monitor day length in selecting the appropriate season for reproductive behaviour. Organisms have developed irradiance measurement mechanisms to ignore photic noise (lightning, moonlight), and use the light of dusk and dawn for circadian photoentrainment. They have also devised multiple photoreceptors and signalling cascades to buffer against changes in the spectral composition of natural light. The interaction of the clock with ambient light is, therefore, quite intricate.

Animals↗

How global brands compete.

It's time to rethink global branding. More than two decades ago, Harvard Business School professor Theodore Levitt argued that corporations should grow by selling standardized products all over the world. But consumers in most countries had trouble relating to generic products, so executives instead strove for global scale on backstage activities such as production while customizing product features and selling techniques to local tastes. Such "glocal" strategies now rule marketing. Global branding has lost more luster recently because transnational companies have been under siege, with brands like Coca-Cola and Nike becoming lightning rods for antiglobalization protests. The instinctive reaction of most transnational companies has been to try to fly below the radar. But global brands can't escape notice. In fact, most transnational corporations don't realize that because of their power and pervasiveness, people view them differently than they do other firms. In a research project involving 3,300 consumers in 41 countries, the authors found that most people choose one global brand over another because of differences in the brands'global qualities. Ratherthan ignore the global characteristics of their brands, firms must learn to manage those characteristics. That's critical, because future growth for most companies will likely come from foreign markets. Consumers base preferences on three dimensions of global brands--quality (signaled by a company's global stature); the cultural myths that brands author; and firms' efforts to address social problems. The authors also found that it didn't matter to consumers whether the brands they bought were American--a remarkable finding considering that the study was conducted when anti-American sentiment in many nations was on the rise.

Commerce↗