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Linguistic abilities in Italian children with Williams syndrome.

Recent studies on subjects with Williams syndrome (WS) have revealed a particular facility for language, rarely observed in other mental retarded populations, inspiring much belief in the independence of language from cognition. Lexical and morphosyntactic abilities of 17 Italian WS individuals, between 4.10 and 15.3 years of age, were evaluated both in comprehension and production and compared with those of normally developing Italian children. WS subjects look similar to normal controls in lexical comprehension, but they appear to perform more poorly in grammatical comprehension. Furthermore they look deviant from normals in some morphosyntactic aspects of their production. They perform better than normal controls only with respect to phonological fluency, when semantic aspects are not involved. Our data show very little evidence for a dissociation between language and cognition.

Adolescent↗

Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semantics.

There has been a long debate on the functional characterization of left inferior frontal cortex, including proposals regarding syntactic and lexico-semantic involvement. We studied nine right-handed adults, using functional magnetic resonance imaging (fMRI) during performance on a semantic decision task in which subjects had to determine whether noun-verb pairs were semantically associated. In comparison with a visuoperceptual control task, activation clusters were seen in left inferior frontal and middle temporal regions, as well as the bilateral superior frontal gyrus. In agreement with previous studies, our findings suggest that Broca's area is involved in semantic processing. Findings of lexico-semantic as well as syntactic processing in the inferior frontal lobe may be accounted for in terms of working memory demands.

Adult↗

Linguistic dissociations in Williams syndrome: evaluating receptive syntax in on-line and off-line tasks.

Williams syndrome (WS) is a neurodevelopmental disorder of genetic origin which results in relatively spared language in the face of serious non-verbal deficits. There is controversy, however, about how intact WS language abilities are. The discussion has focused on impairments of lexico-semantics and of morphological feature analysis, with the presumption that WS syntax is intact. We challenged this view and assessed WS receptive syntax by using two tasks testing various syntactic structures: an on-line word monitoring task and an off-line picture-pointing task. WS performance on the off-line task was generally poor. By contrast, their performance on the on-line task was far better and allowed us to ascertain precisely which aspects of WS receptive syntax are preserved and which are impaired. WS participants were sensitive to the violation of auxiliary markers and phrase structure rules but, unlike both the normal young and elderly controls, they did not show sensitivity to violations of subcategory constraints. The present study suggests that there exist dissociations within WS language which are not restricted to lexico-semantics or to morphological feature analysis, but which also invade their processing of certain syntactic structures. We conclude by arguing that WS syntax is not intact and that their language might turn out to be more like second language learning than normal acquisition.

Adolescent↗

Impaired spelling in Alzheimer's disease: a linguistic deficit?

Different kinds of real words and pronounceable pseudowords (PWs) were presented for writing to dictation to patients with the diagnosis of probable Alzheimer's disease (AD) and to age- and education-matched healthy controls. Though spelling less accurately on all tasks, AD patients responded in a manner generally qualitatively similar to controls. Except for a slightly enhanced effect of spelling regularity in real word writing accuracy, AD patients showed the same sensitivity to various lexical, orthographic and phonological variables as controls. Both groups showed no difference in spelling accuracy for words and PWs with regular vs ambiguous spelling patterns, and groups also showed similar orthographic preferences when spelling PWs having several different acceptable pronunciations. Finally, AD patients and controls produced similar types of errors when spelling real words. Dementia severity was related to the overall accuracy, but not to the pattern, of spelling responses. It is suggested that the decline in response accuracy in cognitively demanding writing tasks in patients with more advanced dementia is most likely due to semantic impairment and impairments of nonlinguistic functions of attention, executive control and praxis, rather than to a disturbance within language specific processes.

Aged↗

A cross-linguistic data bank for oral picture naming in Dutch, English, German, French, Italian, Russian, Spanish, and Swedish (PEDOI).

The well established effect of word frequency on adult's picture naming performance is now called into question. This is particularly true for variables which are correlated with frequency, as is the case of age of word acquisition. Since the work of [Carrol and White, 1973] there is growing agreement among researchers to confer an important role in lexical access to this variable. Indeed, it has been shown ( [Hodgson and Ellis, 1998]) that for normal English-speaking adults only the variables 'age-of-acquisition' and 'name agreement' are independent predictors of naming success among the various variables considered. However, when brain-damaged subjects with and without degenerative pathologies are studied, word frequency and word length as well as concept familiarity all give significant effects ( [Hirsh and Funnell, 1995]; [Lambon Ralph et al., 1998]; [Nickels and Howard, 1995]). Finally, it has been suggested that the production of specific error types may be related to such variables. According to [Nickels and Howard, 1994] the production of semantic errors is specifically affected by 'imageability' and in the recent study by [Kremin et al., 2001] 'age of acquisition' predicts (frank) word finding difficulties.

Adolescent↗

Neuromagnetic auditory cortex responses to duration and pitch changes in tones: cross-linguistic comparisons of human subjects in directions of acoustic changes.

Our recent magnetic mismatch field (MMF) study found that shortened-vowel duration changes and level-to-falling pitch changes in Japanese words elicited a prominent MMF in two hemispheres for both native and nonnative speakers (Inouchi, M., Kubota, M., Ferrari, P. and Roberts, T.P.L., Magnetic mismatch fields elicited by Japanese words: vowel duration and pitch by native and nonnative speakers, Poster presented at the 31st Annual Meeting of Society for Neuroscience, November 10-15, San Diego, CA, 2001). The current study investigated whether shortened duration changes and level-to-falling pitch changes in non-speech (tones) would elicit a more prominent MMF component than lengthened duration changes and falling-to-level pitch changes, respectively. Stimuli included three computer-synthesized tones with varying duration or frequency modulation: (1). short duration and level pitch; (2). long duration and level pitch; (3). long duration and falling pitch. Magnetoencephalography responses were recorded with a dual 37-channel gradiometer system. The results showed that the prominent MMF component was generated in long-to-short duration changes and level-to-falling pitch changes in each hemisphere for both Japanese and American subjects. The component peaked at around 100 ms after change onset for duration changes and 170 ms for pitch changes. The MMF component in tones, like in words, was particularly sensitive to duration shortening and pitch falling. In summary, changes in duration shortening and pitch falling are particularly salient cues for pre-attentive auditory change detection in each hemisphere.

Adult↗

Motor mechanisms in speech ontogeny: phylogenetic, neurobiological and linguistic implications.

The rhythmic mandible-generated close-open alternations of the mouth, responsible for the series of consonant-vowel alternations characteristic of babbling and of languages, is receiving increased attention as a possible manifestation of an ontogenetic and phylogenetic 'frame' underlying the serial organization of speech. The supplementary motor area appears important for production of this consonant-vowel frame in adults.

Animals↗