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At least 829 records · Page 46Linked to original sources
PubMed1988

Pruritic rash with actinic keratosis and impending exfoliation in a patient with hypertension managed with minoxidil.

Dermatological toxicity has been reported following initiation of therapy with minoxidil, but no cases have been reported following prolonged use. We report the emergence of an erythematous weeping rash with impending exfoliation three years after the initiation of minoxidil therapy. Minoxidil was withdrawn and the patient responded to therapy with topical corticosteroids. Following minor surgery, the patient was inadvertently rechallenged with minoxidil. Within 24 hours of exposure bullous lesions reappeared in the extremities which again resolved with topical corticosteroids. Dermatological lesions observed on this patient were similar to those reported following acute minoxidil exposure and strongly implicate chronic minoxidil therapy.

Drug Eruptions↗
PubMed2004

Quantifying actinic keratosis: assessing the evidence.

Actinic keratoses are pre-malignant lesions, and it is standard practice to destroy them. Optimal management of actinic keratoses requires data on the efficacy of the numerous techniques employed in their treatment. Evaluating treatment efficacy requires before and after treatment quantification of actinic keratoses. Studies on the therapy and natural history of actinic keratoses have quantified these lesions by counting them. Counting actinic keratoses is unreliable because this technique lacks interobserver reproducibility. Consequently, studies based on counting actinic keratoses are fatally flawed and their conclusions of doubtful accuracy. Counting actinic keratoses should be abandoned as a technique for evaluating the therapy of actinic keratoses and the issue of spontaneous regression of actinic keratoses. A technique for reliably quantifying actinic keratoses is sorely needed.

Carcinoma, Squamous Cell↗
PubMed2004

Optimum treatment strategies for actinic keratosis (intraepidermal squamous cell carcinoma).

Actinic keratoses are superficial squamous cell carcinomas. Treatment of these lesions is indicated to prevent the cells from invading the dermis and possibly metastasizing. If a lesion exhibits evidence of possible dermal invasion, such as marked erythema, ulceration, tenderness, bleeding, and especially induration, the physician should always consider performing a biopsy. Cryosurgical destruction, the most common treatment employed, has been shown to be 98.8% effective in eliminating the lesions. Adverse reactions such as scarring, textural changes, infection, and pigmentation alteration rarely occur. Physical destruction using electrodesiccation and curettage is particularly effective when the patient has hyperkeratotic lesions. When a patient has a multitude of actinic keratoses, the use of other treatments including fluorouracil, nonsteroidal anti-inflammatory preparations, immune response modifiers, and photodynamic therapy should be considered. However, none of these treatments has proven to be as effective overall as cryosurgical destruction. If a lesion does not respond to treatment, obtaining a biopsy of the lesion should be considered to be certain that the lesion is not an invasive squamous cell carcinoma.

Administration, Cutaneous↗
PubMed1997

Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK-syndrome): a rare, autosomal recessive disorder of keratohyaline formation?

We report a 32-year-old man with an unusual combination of congenital ichthyosis, sclerosing palmoplantar keratoderma with pseudoainhum, and bizarre striate hyperkeratosis in the fixtures, but no systemic involvement. The condition, which improved on oral etretinate therapy, had not appeared previously in the family. On light microscopy the involved epidermis showed marked acanthosis with hypergranulosis and hyperkeratosis. Electron microscopy disclosed numerous large keratohyaline granules in superficial keratinocytes. The clinical picture and histology are virtually identical to those of a Spanish family suffering from an autosomally recessive skin disease of unknown etiology. We hypothesize that the condition is due to a genetic defect in the formation of keratohyaline granules.

Adult↗