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Results for “Intestinal Neoplasms”

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At least 829 records · Page 46Linked to original sources
PubMed1992

[Morphologic characteristics of microadenomas of the large intestine].

Tissue and cellular atypia, changes of the mucus chemical composition, protein secreting function, ATPase activity, differentiation of the epithelial cells and DNA replication with the widening of proliferation zone were registered morphologically in colon microadenomas. A pronounced increase of labelled small lymphocytes capable of proliferation is observed in the stroma. Fibrocytes are practically absent, fibroblasts are represented by young 3H-labelled forms. All these changes are considered as dysplastic.

Adenoma↗
PubMed1992

[The diagnosis of cancer of the stomach and large intestine under active dispensary observation].

Among patients placed under permanent medical observation carried out for 6-8 years, gastric carcinoma (GC) was revealed in 288 and colonic carcinoma (CC) in 377 cases. In 67 and 60% of the patients, respectively, the diagnosis was established as a result of systematic dispensary examinations. The first and second stage disease was identified in 50 and 43% of the cases, including 67% of GC and 62% of CC patients undergoing active examinations. In 40% of the cases on the average, the disease may run an asymptomatic course, including the late stages of the disease. In half the patients, the clinical manifestations did not last more than 3 months, with their duration being independent of the disease stage. It is assumed that at the initial stage the tumor may, during a short period of time, reach the size corresponding to both early and late stages of the disease, after which the rate of tumor growth is likely to be slower. The authors document the necessity of a comprehensive approach to the diagnosis of GC and CC, using the whole armamentarium of classical and up-to-date methods.

Aged↗
PubMedDate not supplied

Pathophysiology and palliation of inoperable bowel obstruction in patients with ovarian cancer.

Malignant bowel obstruction is the cause of death in the majority of women who die of ovarian cancer. Some patients are considered acceptable surgical candidates for relief of the obstruction. For many patients, however, lack of such surgical options has spawned a broad range of medical interventions, including palliative strategies to target pain and nausea and vomiting. This review discusses the general approach to patients with ovarian cancer and inoperable malignant bowel obstruction, with an emphasis on such palliative strategies.

Adrenal Cortex Hormones↗
PubMed1991

Differential tissue-specific expression of human apoA-I and apoA-II.

To evaluate the sources of high density lipoprotein (HDL) particles containing only apolipoprotein A-I (apoA-I), the synthesis of apoA-I and apolipoprotein A-II (apoA-II) was examined in human liver and small intestine as well as the human intestinally derived cell line, Caco-2. Human liver contained apoA-I, apoA-II as well as apolipoprotein B (apoB) mRNA. In contrast, human adult small intestine total and polyA+ RNA had little or no apoA-II despite the presence of apoA-I and apoB. Intestinal biopsies from normal individuals failed to show de novo apoA-II protein synthesis in the media of organ cultures during [35S]methionine pulse-chase labeling, whereas apoA-I could be readily detected. Caco-2 cells contained apoA-II mRNA and secreted apoA-II protein into the tissue culture media. These data indicate that the primary site of human apoA-II synthesis is in the liver and that the small intestine secretes apoA-I-containing high density lipoproteins.

Apolipoprotein A-I↗
PubMedDate not supplied

Abdominal metastases from lung cancer resulting in small bowel perforation: report of three cases.

Metastatic lung cancer to the small bowel is a rare occurrence. Acute complications such as perforation, hemorrhage and obstruction are even rarer. We present 3 cases of small bowel perforation from metastatic lung cancer. All 3 patients underwent emergency laparotomy. In 2 of them there was no obvious macroscopic appearance of metastatic disease either at the site of perforation or in any other area of the abdomen, whereas in the third patient there were hepatic metastases. The postoperative period was uneventful in all three cases. The longest survival was four months. Our cases bring the number of cases reported in the international literature to a total of 43.

Adenocarcinoma↗
PubMed1991

[The role of intestinal resection in primary surgery of ovarian carcinoma].

In most ovarian cancer cases complete resection of the tumour masses is not possible, and tumour reduction at the primary operation has been shown to improve survival. In some cases optimal tumour reduction is only possible by resecting intestinal structures, and it remains to be shown whether aggressive approaches are justified. The impact of intestinal resection, among other prognostic factors, was analysed in 104 patients undergoing primary operation for ovarian cancer. Tumour spread to bowel, exceeding 2 cm in diameter occurred in 39% of the cases. Debulking to a maximal tumour diameter less than 2 cm was achieved in 68 (65%) cases. Successful debulking was achieved by performing large (n = 20) and small bowel (n = 4) in 22 patients with massive bowel involvement. Two patients died during the hospital stay, one after bowel resection. Four independent prognostic variables emerged from Cox's multiple proportional hazards regression: ascites (p = 0.001), massive bowel involvement (p = 0.007), residual tumour size (p = 0.002), and intestinal resection (p = 0.11). The authors contend that intestinal resection to achieve optimal tumour debulking at the primary operation will improve the survival of ovarian cancer patients.

Adolescent↗
PubMed1991

Peritoneal endosalpingiosis.

Macroscopic significant peritoneal endosalpingiosis has been reported in 7 cases including the presented case. The former reported cases were associated with ovarian cysts in four cases of which two were malignant, and two cases were associated with endometriosis. In the presented case endosalpingiotic cysts were located in the upper abdominal cavity without evidence of pelvic disease. It is believed that the pathogenesis is metaplastic change of coelomic epithelium into tubal like epithelium.

Adult↗
PubMed1979

Abdominal crisis due to metastasizing lung carcinoma to the small bowel.

A rare case of small-bowel perforation due to metastasizing primary bronchogenic carcinoma is reported. A 64-year-old man presented with acute abdominal crisis from perforation of a metastatic focus in the wall of the small intestine. A 13-cm segment of small bowel, containing a firm mass which surrounded a 1.0 X 2.0-cm perforation, was resected. Because of widespread metastases, the patient received only palliative treatment. He died 27 days after admission. Perforation of a metastatic focus in the small bowel is considered a late complication of carcinoma and indicates a very poor prognosis. This is only the eighth reported case of such a complication of metastasizing lung carcinoma.

Abdomen, Acute↗
PubMed1990

[Effects of the method and regimen of administration on the carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine in rats].

Peculiarities of carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine administered through a stomach tube on rats were studied in 30 rats given 1-2 ml MNNG dissolved in distilled water (5 mg/ml) through a gastric tube for 2-3 days. The procedure is repeated every 4-10 days. This intermittent carcinogen administration continued until week 20; the animals were killed on week 25. All effective 26 (100%) rats had multiple papillomas and squamous cell carcinomas of the forestomach, 5 (19.2%) had adenomatous hyperplasias and adenocarcinomas of the glandular stomach, 7 (26.9%) had adenocarcinomas and sarcomas of the small intestine.

Adenocarcinoma↗
PubMed1989

Massive hemorrhage secondary to metastatic testicular carcinoma.

Massive bleeding secondary to metastatic foci of testicular carcinoma is a rare finding. Two cases of metastatic testicular carcinoma in which massive intraabdominal and gastrointestinal hemorrhage occurred are reported. The first patient, who had metastasis to the duodenum and stomach, first underwent surgery because of the concern that chemotherapy might result in rapid tumor necrosis and bowel perforation. The bleeding was controlled, postoperative chemotherapy was administered, and the patient was alive 15 months after chemotherapy. In the second case, in which metastasis was to the liver and lungs, aggressive chemotherapy was begun because of the patient's poor pulmonary status. Three days later, the patient began to hemorrhage. Operative and massive resuscitative measures failed, and the patient died shortly after surgery.

Adolescent↗
PubMed1989

[Multiple leiomyosarcoma of the small intestine. Apropos of a case].

The authors report a case of multiple leiomyosarcomas of the small intestine, which is a very exceptional entity. After reviewing the pathological features and the distribution of leiomyosarcomas, they present the radiological and especially the computed tomographic findings of this type of tumour. They stress the difficulty of the differential diagnosis both in the solitary forms and in the exceptional multiple forms.

Aged↗