Phyto-oestrogens in soy-based infant formula.
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Milk (Similac), sucrose (12% wt/vol), or water were delivered to crying normal newborns once per minute for 5 minutes, in a volume of 0.1 mL/delivery. Milk and sucrose markedly reduced infant crying, and this calm persisted during the 3 minutes after substance delivery. Infants who received water were only marginally quieted, and this calm did not persist. Despite quieting agitated infants, milk did not cause them to bring their hands to their mouths during the period of milk treatment, whereas infants who received sucrose did bring their hands to their mouths. These data demonstrate that milk effectively quiets human newborns, that its quieting effects endure, and that the mechanisms that quiet and that underlie hand-in-mouth engagement are separable and independent.
The 'satisfying' quality of a typical, current formula milk was compared with that of an earlier type with higher protein and mineral content in a double blind, cross over trial in 10 infants. There were no significant differences in the amount of crying or volume consumed which meant that there was a higher sodium and protein intake but no associated improvement in 'satisfaction'.
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