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At least 829 records · Page 46Linked to original sources
PubMed2007

Quadruple and juxta-articular pelvic osteotomy in children using anterior approach: technique and results.

The traditional indications of pelvic osteotomy in children are Salter's osteotomy in young patients and triple osteotomy in older patients. We performed the juxta-articular pelvic osteotomy with a single anterior approach. Our population included a group of young children necessitating a high degree of reorientation. In elder children a quadruple osteotomy of the ischium, pubis, ilium and ischial spine was achieved to release the sacrospinal ligament. Between 1993 and 2003, 30 osteotomies have been carried out on 26 patients. The mean age was 6.7 years, 10 patients were younger than 5 years, with 6 years of follow-up. The indications included acetabular dysplasia (15 cases), Perthes disease (14 cases) and one caput valgum. When compared with preoperative clinical examination, the postoperative flexion was decreased by 14 degrees, extension increased by 7 degrees, external rotation increased by 5 degrees, internal rotation decreased by 5 degrees. Radiographic assessment demonstrated an average angle of correction by 20 degrees for the acetabular angle of Sharp, 32 degrees for the center edge angle and 18 degrees for the slope of sourcil. We concluded that lateral coverage must be achieved in a frontal plan, avoiding the figure-of-four maneuvers and displacement in a transverse plan. Despite the significant reorientation of the acetabulum, we did not observe excessive external rotation. The quadruple osteotomy allowed important acetabular displacement in older patients. The single approach avoided prone position and permitted a simpler postoperative management.

Acetabulum↗
PubMedDate not supplied

The musculoskeletal manifestations of the Coffin-Lowry syndrome.

Coffin-Lowry syndrome (CLS) is a rare genetic disorder characterized by craniofacial abnormalities, mental retardation, short stature, and hypotonia. Patients with CLS may present with multiple musculoskeletal abnormalities. The purpose of this study was to identify and characterize the musculoskeletal findings in 10 patients with CLS. Eight patients presented with thoracolumbar kyphosis or kyphoscoliosis, with a mean Cobb angle of 45 degrees in the coronal plane and 31 degrees of thoracolumbar kyphosis. These may be progressive and difficult to treat, needing early surgical treatment. Close follow-up of the spinal deformities is strongly recommended to document progression. Sixty percent of the patients presented with bilateral flexible and painless planovalgus deformities. Hypoplasia of the ilium and hand deformities are common but do not seem to cause any functional problems. Observation is recommended for these asymptomatic hand, foot, and pelvic findings.

Adolescent↗
PubMed2003

Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells.

STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and human intervertebral disc (IVD) cells. OBJECTIVES: To demonstrate the effect of BMP-2 on mRNAs expression (collagen type I, collagen type II, aggrecan, and osteocalcin), proteoglycan synthesis, expression of alkaline phosphatase, bone nodule formation in human IVD cells. SUMMARY OF BACKGROUND DATA: BMP-2 was widely known as a powerful agent for osteoinduction and a crucial growth factor for early chondrogenesis and maintenance of cartilaginous phenotype. BMP-2 proved to be effective in stimulating proteoglycan synthesis in articular chondrocytes and IVD cells. Nevertheless, the effect of BMP-2 on IVD cells, whether chondrogenic or osteogenic, was not thoroughly elucidated in transcriptional level and histochemical stains. MATERIALS AND METHODS: Human IVDs were harvested and enzymatically digested. Then IVD cells were cultured three-dimensionally in alginate beads. Osteoblasts were cultured from cancellous bone of ilium for histochemical stains. Recombinant human BMP-2 (rhBMP-2) was produced by Chinese hamster ovary cells after transduction of BMP-2 cDNA, then concentrated and purified. Then IVD cell cultures were exposed to various concentrations of rhBMP-2. Reverse transcription-polymerase chain reaction for mRNA expression of aggrecan, collagen type I, collagen type II, and osteocalcin was performed. Newly synthesized proteoglycan was measured by 35S-sulfate incorporation on Sephadex G-25 M in PD 10 columns. As a histochemical examination, alkaline phosphatase and Alizarin red-S stains were used to detect osteogenic marker and bone nodule formation, respectively. RESULTS: In the rhBMP-2 treated cultures, there was increased newly synthesized proteoglycan (67% in 300 ng/mL and 200% in 1,500 ng/mL of rhBMP-2) and up-regulated expression of aggrecan, collagen type I, and collagen type II mRNA over untreated control. However, rhBMP-2 did not up-regulate expression of osteocalcin mRNA in the given dose and culture period. IVD cell cultures with rhBMP-2 showed no evidence of bone formation in histochemical stains, i.e., alkaline phosphatase and Alizarin red-S, while osteoblast culture exhibited strong positive stains. CONCLUSIONS: The rhBMP-2 clearly up-regulated mRNA expression of chondrogenic components and also stimulated proteoglycan synthesis without expression of osteogenic phenotype. Taken together, this study raise the possibility of rhBMP-2 can be anabolic agent for regenerating matrix of intervertebral disc.

Adult↗
PubMed2004

New technique in congenital scoliosis involving fixation to the pelvis after hemivertebra excision.

STUDY DESIGN: The authors conducted a retrospective study involving description of a new surgical technique. OBJECTIVES: The objective of this study was to describe and evaluate the efficacy of a new technique to stabilize the spine of young and small patients with congenital scoliosis after lumbosacral hemivertebra excision. SUMMARY OF BACKGROUND DATA: Congenital scoliosis develops as the result of anomalous vertebral development and asymmetric growth. The vertebral anomalies include congenital fusions and congenital hemivertebrae. With lumbosacral hemivertebrae at the lumbosacral junction, surgical excision followed by instrumentation to close the resulting space is frequently the best way to correct the deformity and obtain spinal balance. Surgical stabilization is required for preventing recurrent deformity and restoration of spinal balance. METHODS: A new surgical technique for spinal correction and stabilization in congenital scoliosis is described. The technique involves hemivertebra excision followed by fixation of the adjacent normal vertebra to the ilium with screws and cables. This technique allows efficient correction in both the coronal and sagittal planes. RESULTS: This construct was prospectively studied in 3 cases over a 3- to 5(1/2)-year period. All cases had solid fusion and well-balanced spine at latest follow up. CONCLUSIONS: This prospective study demonstrates a successful surgical technique for spinal stabilization after congenital hemivertebra excision in infants and young children with relatively small and soft bones when standard constructs like pedicle screws may not be optimal devices. Coronal and sagittal balance (restoration with improvement of lordosis) was successfully achieved in all cases.

Child↗
PubMed2005

Estimation of transverse plane pelvic rotation using a posterior-anterior radiograph.

STUDY DESIGN: Experimental and analytical study of transverse plane pelvic rotation. OBJECTIVES: To determine how pelvic rotation projected onto the transverse plane relates to coronal plane anatomic landmark location. SUMMARY OF BACKGROUND DATA: Current spine deformity instrumentation may be used to apply transverse plane loads to the spine that may be transmitted to regions not included in the instrumentation, including the pelvis. METHODS: An anatomically correct, sawbones model of an adult female pelvis was marked with lead shot at prominent radiographic landmarks, rotated at different angles in the sagittal, transverse, and coronal planes, and left/right (L/R) ratios of the medial-lateral distances between similar landmarks determined. An analytical equation was also derived to determine the degree of rotation in the transverse plane, using medial-lateral and anterior-posterior distances between same landmarks. RESULTS: The L/R ratio for the coronal plane distance between the inferior ilium at the sacro iliac joint (SI) and anterior superior iliac spine (ASIS), the SI-ASIS measurement, proved the most reliable of the four ratios studied to determine the extent of pelvic rotation in the transverse plane. Assuming the pelvis is symmetric, the most important factor is location of the compared landmarks. A long distance between the landmarks in both the coronal and transverse plane and a large angle between the line joining the two landmarks and the coronal plane of the pelvis, as viewed in the transverse plane, are best. Transverse plane pelvic rotation up to 20 degrees is accurately reflected nearly linearly by L/R SI-ASIS ratios. CONCLUSIONS: Bony pelvis landmarks visible on coronal plane radiographs can be used to estimate transverse plane pelvic rotation, but precise conversion to degrees rotation requires additional information on specific patient pelvic morphology.

Adult↗
PubMed2006

Biomechanical evaluation of conventional internal contemporary spinal fixation techniques used for stabilization of complete sacroiliac joint separation: a 3-dimensional unilaterally isolated experimental stiffness study.

STUDY DESIGN: Comparative 3-dimensional biomechanical testing. OBJECTIVE: To compare 5 fixation techniques, 3 using screws or screw and plates and 2 spinal, used for stabilization of complete unilateral sacroiliac dislocation in composite models. SUMMARY OF BACKGROUND DATA: Harrington compression rods have been used for posterior iliosacral stabilization. Recently, the use of compact spinal instrumentation has been introduced for stabilization of iliosacral joint separation to achieve immediate and permanent stability, allowing early mobilization. To the authors' knowledge, no comparative mechanical studies between commonly used internal fixation techniques and contemporary spinal instrumentation have been performed. METHODS: Fifteen identical composite models of the left hemipelvis and sacrum were used to simulate consistently the "worst-case scenario" of complete unilateral sacroiliac dislocation. Subgroups of 3 models each were used to apply 5 (A-E) alternative fixation iliosacral joint fixation techniques: 1 multiaxial 7.5 mm Cotrel-Dubousset screw inserted in the posterior superior iliac spine and connected with a long Cotrel-Dubousset horizontal rod with 6.5 mm multiaxial Cotrel-Dubousset screws inserted bilaterally in the S1 pedicles (technique A); 1 multiaxial 7.5 mm Cotrel-Dubousset titanium pedicle screw inserted in the posterior superior iliac spine and connected with a short horizontal Cotrel-Dubousset-rod to a 6.5 mm multiaxial Cotrel-Dubousset-screw inserted to the ipsilateral S1 pedicle (technique B); 1, 6.5 mm cancellous AO-screw (technique C); 2, 6.5 mm cancellous AO screws (technique D); and 2 dynamic stainless steel compression plates (technique E) placed anteriorly. Constructs were biomechanically tested. The ilium was unilaterally rigidly fixed, the sacrum was put horizontal in the mediolateral direction with a forward tilt of 30 degrees (close to physiologic conditions) in the sagittal plane, and a vertical quasi-static compressive load ranging from 0 to 500 N was applied on the endplate of S1, reproducing a "worst case" loading scenario. Construct stiffness, frontal plus sagittal kinematics, and iliosacral joint gap size for all 5 techniques were measured. RESULTS: The construct stiffness (N/mm +/- standard deviation) ranged for model: A, 121 +/- 18; B, 78 +/- 10; C, 168 +/- 13; D, 193 +/- 42; and E, 145 +/- 4. All other parameters exhibited minor variations between the different techniques of fixation: at the 400 N load level, the maximum iliosacral gap globally ranged 0.9-2.8 mm, the maximum mediolateral sacral tilt ranged 1.3-2.4 degrees, and the maximum anteroposterior sacral tilt ranged 0.6-3.0 degrees. CONCLUSIONS: The iliosacral fixation with 2 6.5 mm AO-cancellous screws for complete sacroiliac dislocation demonstrated the highest stiffness and the short spinal instrumentation the poorest stiffness. All other fixation techniques could be generally considered of equivalent stability value.

Biomechanical Phenomena↗
PubMed2007

Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible.

BACKGROUND: The purpose of this study was to investigate whether injections of marrow-derived mesenchymal progenitor cells could be used to facilitate new bone formation during distraction osteogenesis. METHODS: Fifteen New Zealand rabbits underwent bilateral osteotomy. After a 1-week latency period, bone distraction was activated at a rate of 2.0 mm/day for 5 days. The marrow-derived mesenchymal progenitor cells derived from the ilium marrow were cultured to a population of 10 in 0.5 ml and then unilaterally transplanted to the gap of distracted callus immediately after distraction had been terminated. Rabbits were killed at 2, 4, and 6 weeks after completion of bone lengthening. The distracted areas were harvested and evaluated by histologic, histomorphometric, radiographic, and scanning electron microscopic analysis. Bone mineral density in the lengthened callus was evaluated using dual-energy x-ray absorptiometry. RESULTS: Radiographic evaluation indicated a significant increase in bony union of the distraction regenerate in the experimental side compared with the control side. Corresponding to the radiographic findings, the histologic examination showed an earlier and more intensive bone formation in the experimental side after 2, 4, and 6 weeks compared with the control side. Larger chondroid islands were found evident in distracted bone of the control side than in the experimental side. CONCLUSIONS: The results show that transplantation of osteoblast-like cells promotes maturity of the distracted callus, as observed on the second and fourth weeks after lengthening. The method appears promising as a means of shortening the consolidation period of osteodistraction and decreasing complications during bone lengthening.

Animals↗
PubMed2003

Sacroiliac screw fixation for tile B fractures.

BACKGROUND: The purpose of this comparative cadaveric study was to investigate whether the stability of partially unstable pelvic fractures can be improved by combining plate fixation of the symphysis with a posterior sacroiliac screw. METHODS: In six specimens, a Tile B1 (open-book) pelvic fracture was created. We compared the intact situation with isolated anterior plate fixation and plate with sacroiliac screw fixation. Using a three-dimensional video system, we measured the translation and rotation stiffness of the fixations and the load to failure. RESULTS: Neither absolute displacements at the os pubis or at the sacroiliac joint nor stiffness of the ilium with respect to the sacrum were significantly different for the techniques with or without sacroiliac screw or the intact situation. Load to failure was reached in only one of the six cases. In all other cases, the fixation of the pelvis to the frame failed before failure of the fixation itself. In these cases, a load of approximately 1,000 N or more could be applied. CONCLUSION: The addition of a sacroiliac screw in a Tile B1 fracture does not provide significant additional stability. Although cyclic loading was not tested, in these experiments forces could be applied that were similar to full body weight. Clinical experiments into direct postoperative weight bearing are recommended to examine the clinical situation.

Aged↗
PubMedDate not supplied

Radiologic pelvic asymmetry in unilateral late-diagnosed developmental dysplasia of the hip.

Eighty-three cases of unilateral late-diagnosed (older than 4 months of age) developmental dysplasia of the hip (DDH) were studied to evaluate pelvic shape and innominate bone relationships in the initial anteroposterior radiograph. To be included, each initial radiograph had to have no lumbar pedicle rotation, lumbar scoliosis, gas shadows, or metallic protectors. Measurements were done using as reference a medial pelvic line, which divides the pelvis into two innominate bones. Lineal parameters were defined to assess pelvic radiologic shape; angular parameters defined the relationship between the ilium, ischium and pubis, and sacrum. Statistically significant differences were observed in most cases, and pelvis asymmetry was evident. The asymmetry was more obvious in cases in which the teardrop had a negative value and in low dislocations. Similar changes have been observed in experimental dislocation of the hip secondary to a triplane pelvic deformity. We suggest that similar alterations of pelvic shape occur in DDH, possibly secondary to growth disturbance in the triradiate cartilage.

Age Factors↗
PubMed2007

Suctioning prevents emboli during insertion of acetabular components without holes.

Embolic events can occur when inserting uncemented press-fit acetabular components (cups), especially those without holes. However, there is a paucity of literature regarding prevention of embolic events. We asked whether suctioning in the acetabulum might be as effective as suctioning during femoral insertion. We compared embolic events in 30 hips (27 patients) (Group 1) that had conventional press-fit cup fixation without holes, with 30 hips (27 patients) (Group 2) treated by suctioning from a cannula in the ilium during cup impaction. We evaluated embolic events using transesophageal echocardiography, blood gas (PaO2, PaCO2), and blood pressure preoperatively and 5 minutes after cup placement. Echocardiography showed less severe embolic events in Group 2 (23%) than in Group 1 (100%). The decrease in rate of the PaO2 and the blood pressure from baseline to 5 minutes after cup placement were lower in Group 2 than in Group 1. Our data suggest the suctioning technique is effective to reduce embolic events by cup without holes which may cause intraoperative embolic complications.

Acetabulum↗
PubMed2005

Development of the pelvis and posterior part of the vertebral column in the Anura.

The anuran pelvic girdle is unique among all amphibians in that its acetabular portion is located far posterior to the sacrum, lateral to the postsacral (= caudal) vertebral column, which is reduced to a single rod-like element called the urostyle. This situation in the adult is strikingly different not only from that in ancestral temnospondyls but also in other modern amphibians. Because there is no fossil that would document this evolutionary anatomical modification except for Triadobatrachus, the only data may be inferred from development in modern anurans. We chose seven anuran species (belonging to the genera Discoglossus, Bombina, Pelobates, Bufo, Rana and Xenopus), representing the principal locomotory types (saltation, swimming, crawling and burrowing). Development of the pelvic girdle was studied on cleared and stained whole mounts and partly on serial histological sections. The basic developmental pattern was similar in all species: the pelvis on both sides develops from two centres (puboischiadic and iliac, respectively). The ilium then extends vertically towards the sacral vertebra and later rotates posteriorly so that ultimately the acetabulum is lateral to the tail (= urostyle). Only minor deviations from this pattern were found, mainly associated with differences in water and terrestrial dwelling.

Animals↗
PubMed1992

Treatment of osteoporosis with parathyroid peptide (hPTH 1-34) and oestrogen: increase in volumetric density of iliac cancellous bone may depend on reduced trabecular spacing as well as increased thickness of packets of newly formed bone.

OBJECTIVE: We wished to determine whether treatment of vertebral osteoporosis with human parathyroid peptide 1-34 (hPTH 1-34), given as a daily injection with supplementary treatment with hormone replacement therapy (HRT), increases cancellous bone area in the ilium by increasing the size of packets of new bone. DESIGN AND MEASUREMENTS: The width of packets of cancellous bone (wall width) was measured at random intercepts and mean values calculated. Cancellous bone area and perimeter were also measured. Indices of trabecular separation and the complementary quantity trabecular number were derived according to Parfitt's method, as well as trabecular width. Patients were used as their own controls and changes in these indices calculated. Correlations were calculated for data obtained from independent measurements. PATIENTS: We studied eleven women with post-menopausal osteoporosis, diagnosed by fractures after exclusion of causes of secondary osteoporosis. RESULTS: One woman did not comply with her HRT therapy. In the others, treatment with hPTH 1-34 + HRT restored the characteristically depressed pre-treatment values of wall width to normal. Trabecular width increased approximately four times more than wall width. Changes in wall width correlated with changes in cancellous bone area; however, bone area increased considerably more than could be accounted for statistically by changes in wall width. A decrease in trabecular separation was found to account for the additional increase in bone area (P = 0.056). CONCLUSION: hPTH 1-34 + oestrogen and progestagen therapy increases the width of packets of new cancellous bone with consequent increases in the width of trabecular plates.

Aged↗
PubMed1987

Distal rectus femoris transfer.

A major concern in the management of children with cerebral palsy is crouch gait with its excessively flexed knee and hip stance. Earlier, attention was given to the flexed hip and it was assumed that the rectus femoris, as an active component of the quadriceps, contributed an unwanted effect. Proximal surgical release of the rectus from its attachment on the ilium was recommended. However, dynamic electromyographic records of 45 children with cerebral palsy demonstrated that the rectus more commonly was active in the swing phase, and such an approach is appropriate only when electromyography confirms that rectus function is occurring in stance. The recording technique must be capable of differentiating rectus femoris action from that of the underlying vasti, which surface electrodes are not able to do. Past experience indicates that routine inclusion of a proximal rectus femoris release (without confirmation that the muscle's action was limited to stance) resulted in the patient having a stiff-legged gait. Hence the actions of the rectus femoris need closer attention.

Cerebral Palsy↗
PubMed1979

Life cycle of Isospora rivolta (Grassi, 1879) in cats and mice.

The endogenous development of Isospora rivolta (Grassi) was studied in cats fed oocysts, and was compared with the endogenous cycle after feeding them mice infected with I. rivolta. For the mouse-induced cycle, 14 newborn cats were killed 12 to 240 h after having been fed mesenteric lymph nodes and spleens ofmice. Asexual and sexual development occurred throughout the small intestine, in epithelial cells of the villi and glands of Lieberkühn. The number of asexual generations was not determined with certainty, but there were at least 3 structurally different meronts. Type I meronts appeared at 12-48 h postinoculation (HPT). They were 8.5(6-13) x 5.1(3-6) micrometer, contained 2-8 merozoites, and divide by binary division or endodyogeny. Type II meronts were multinucleate merozoite-shaped meronts within a single parasitophorous vacuole. They were found at 48-172 HPI and measured 12.6(9-18) x 9.8(9-13) micrometer. Individual multinucleate merozoite-shaped meronts were 7-13 x 3-5 micrometer in sections and contained 2-30 slender (5.5 x 1.0 micrometer) merozoites. Type III meronts occurred at 72-192 HPI and gamonts at 72-96 HPI. Mature microgamonts measured 11.3(9-15) x 8.0(6-9) micrometer in sections and up to 21.5 x 14 micrometer in smears, and contained up to 70 microgametes. Macrogamonts measured 13.3(11-18) x 9.0(5-13) micrometer in sections and 18 x 16 micrometer in smears, and contained up to 70 microgametes. Macrogamonts measured 13.3(11-18) x 9.0(5-13) micrometer. Sporulation was completed within 24 h at 22-26 C. For the study of the oocyst-induced cycle in cats, 18 newborn cats were killed between 6 and 192 HPI. The endogenous development was essentially similar to the mouse-induced cycle, but merogony and gametogony occurred 12-48 h later than in the latter cycle. Isospora rivolta was pathogenic for newborn but not for weaned cats. Newborn cats fed 10(6) sporocysts or infected mice usually developed diarrhea 3-4 days after inoculation. Microscopically, desquamation of the tips of the villi and cryptitis were seen in the ilium and cecum in association with meronts and gamonts. For the study of the development of I. rivolta in mice, mice were killed from day 1 to 23 months after having been fed 10(5)-10(6) sporocysts, and their tissues were examined for the parasites microscopically, and by feeding to cats. The following conclusions were drawn. (A) Isospora rivolta most freqeuntly invaded the mesenteric lymph nodes ofmice and remained there for 23 months at least. Ii also invaded the spleen, liver, and skeletal muscles of mice. This species could not be passed from mouse to mouse. Sporozoites increased in size from approximately 6.8 x 4.9 micrometer on day 1 to approximately 13.4 x 6.9 micrometer on day 31 postinoculation. Division was not seen. Prepatent period was 4-7 days and patent periods ranged from 2 to several weeks.

Animals↗
PubMed1978

Some considerations on the role of cementum in periodontal disease.

The protective role of cementum against root resorption is discussed in relation to buried teeth, orthodontic treatment, replantation and periodontal disease. The essential feature seems to be a layer of partially calcified precementum or vital cementoblasts. Root resorption close to the epithelial attachment, although not common, is probably the result of death of cementoblasts caused by irritants from bacterial plaque, and the presence of severe of prolonged inflammation. Cementum exposed in the pocket can be affected in different ways by these irritants, and rendered unacceptable for re-attachment to periodontal tissue. Successful re-attachment procedures involve either the removal of the affected cementum or its treatment with agents partially to decalcify such as acids, or detoxify by phenol for example. Examples of treatment embodying some of these principles are illustrated by two case histories of localised gingival recession and one of intra-bony pocketing associated with an acute lateral periodontal abscess. In this case a follow-up radiograph taken 16 years later is presented as evidence of the permanence of repair which can be achieved. Root resorption which often follows the use of fresh autogenous bone from the ilium is then discussed and the conclusion reached that the vital cells in the transplant discourage the migration of cementoblasts from the adjacent periodontium. The cementum and dentine thus remain unprotected and susceptible to resorption.

Dental Cementum↗
PubMedDate not supplied

Low-field magnetic resonance imaging of bone marrow in the lumbar spine, pelvis, and femur in the adult dog.

The purpose of this study was to describe the appearance of normal bone marrow in seven adult dogs using low-field (0.3T) magnetic resonance (MR) imaging. The areas imaged included the lumbar spine, pelvis, and femur. T1-weighted, fast spin-echo T2-weighted, and short tau (T1) inversion recovery (STIR) sequences were obtained at all locations. Histopathology was performed on sections from the sixth lumbar vertebral body, the wing of the ilium, and the femur (head and neck, mid-diaphysis, and condyle) for evaluation of cellularity and fat content. The lumbar spine and pelvic marrow MR images were similar in all dogs. The lumbar vertebral bone marrow was uniform, intermediate signal intensity, and isointense to muscle on all sequences. There was variation between dogs in the bone marrow distribution with MR imaging of the femur. In the proximal and mid-diaphysis of the femur there was patchy high-signal intensity on T1- and T2-weighted images, and hypointense foci on the STIR images. The distal femoral metaphysis had a variable pattern ranging from intermediate-to-high signal on T1- and T2-weighted images and intermediate-to-low signal on STIR images. The femoral condyles were uniformly high signal on T1- and T2-weighted images and hypointense on STIR images. Histopathologically there was a normal variation in the bone marrow cellularity. The marrow was normocellular (25-75% cellularity) for all sites examined except the femoral condyles, which were hypocellular (<25% cellularity).

Adipose Tissue↗
PubMed1979

Villous tissue osmolality and intestinal transport of water and electrolytes.

The villous tissue hyperosmolality created by the intestinal countercurrent multiplier has been proposed to be of importance for fluid transport across the intestinal epithelium in vivo. This study was performed to test this hypothesis. Net transport of fluid and electrolytes (sodium, potassium and chloride), as well as unidirectional fluxes of water and sodium were determined in the small intestine of the cat. The villous osmolality was altered by varying the composition of sodium and glucose in the isotonic solutions perfusing the intestinal lumen. Net transport of fluid was correlated to tissue osmolality mainly due to an increase of the unidirectional flux of water from lumen to tissue with augmented tissue osmolality. The results are thus consistent with the view that the intestinal countercurrent multiplier is of essential importance for net water transport. A correlation was found between net water and net sodium intestinal transport. A similar correlation was also demonstrated between net sodium and net chloride absorption rates in the jejunum while in the ileum net loss of sodium into the intestinal lumen was not accompanied by any corresponding loss of chloride ions. This observation suggests the presence of a sodium independent transport mechanism for chloride in the ilium but not in the jejunum.

Animals↗
PubMed1996

Triple pelvic osteotomy for the treatment of pelvic canal stenosis in a cat.

A mature female domestic shorthaired cat with obstipation as a result of pelvic canal narrowing due to a pelvic fracture malunion was treated by triple pelvic osteotomy to widen the canal. The right hemipelvis was moved laterally and a modified bone plate was applied to the right ilium. A mild lick dermatitis occurred over the dorsum of the hind paw seven days postoperatively but resolved without treatment. The cat made an uneventful recovery without recurrence of the obstipation.

Animals↗