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[Quality of suicide mortality data].

Prevention of suicide is a public health priority in France. Indicators of suicide mortality have been widely used to describe epidemiological situations or to evaluate public health actions. It is therefore essential to examine the quality of suicide mortality data. The purpose of this work was to identify potential biases affecting the quality of such data and their comparability between different countries as well as to determine how they can affect conclusions. Potential biases were identified by studying the characteristics of the death certificate system and analyzing the international literature on data quality. The impact of biases was assessed by analyzing the causes of "concurrent" death with suicide in the official statistics (trauma and poisoning caused in an undetermined way concerning intention and unknown causes). The proportion of suicides listed as "concurrent" causes of death, estimated from specific surveys was extrapolated to official data. This method was also used to correct the international data. Practices concerning death certificates for violent deaths vary considerably from one country to another: type of certifying physician, frequency of medicolegal investigations, frequency of autopsies, suicide definition criteria, confidentiality regulations, religious and culture context. These practical differences lead to variability in undetermined and unknown causes. The corrections made on the mortality data after taking into account for these potential biases showed that the rate of suicide determined from official data is considerably underestimated, but that sociodemographic and geographic factors of suicide change little after correction. Likewise, the order by country was similar after taking into consideration concurrent causes. A reliable evaluation of the rate of suicide for a given country is of course important. However, it is possible to characterize populations at risk and analyze the determinants of suicidal behavior without necessarily recording all suicides, as long as the declaration bias is stable. Statistical analysis of death by suicide in France shows that, despite under-reporting, the principal sociodemographic and geographic features and trends over time can be considered as valid. A series of recommendations is proposed however to improve data quality and homogeneity for death certificate reporting. Designing operational criteria for deciding when to declare suicide as the cause of death would be helpful to guide physicians who report deaths. Classical autopsies could be completed by "psychological autopsies" with friends and family of the deceased. The death certificate form could be improved to include items for complementary information favoring or not suicide.

Adolescent↗

Ethnicity and body fatness in New Zealanders.

In light of alarming rises in the prevalence of obesity worldwide, tackling the obesity 'epidemic' is now a national health priority in many countries. Increasingly, population measures that provide accurate estimates of body fatness are required to assist public health organisations in identifying at-risk groups and developing appropriate preventative strategies. Body mass index (BMI) remains the most cost-effective and practical tool in this regard. The World Health Organization (WHO) has issued universal BMI standards for defining 'overweight' and 'obesity' in adults (BMI > or =25 kg x m(-2), and > or =30 kg x m(-2), respectively) based on the risk of obesity-related disease in Europeans. Although widely used, there is mounting evidence suggesting that these standards are not appropriate for all populations. Research indicates that the associations between BMI, percent body fat (%BF), and health risks can vary across different ethnicities. Accordingly, ethnic-specific and country-specific BMI cut-offs for overweight and obesity may be necessary to attain valid prevalence estimates. In New Zealand, this area is largely unexplored in both young people and Asian populations. There is a need for large-scale longitudinal studies investigating the relationships between excessive body fatness and related health outcomes across all major ethnic groups in New Zealand.

Adolescent↗

["Penis angina" or the current revolution in erectile dysfunction (ED)].

Erectile dysfunction (ED) can no longer be neglected by the medical profession, as the presence of ED is never entirely benign, but is always a reliable marker of a sexual disorder but also (and sometimes especially) a non-sexual disorder (physical and/or mental). Its documented association with many chronic diseases and high-risk situations is in the process of extending the significance of ED beyond the purely sexual domain, as this symptom, easily detected by simple clinical interview, appears to be not only a barometer of health, but also a warning indicator of situations that can sometimes be dangerous for the patient's health. For example, in male populations with a high vascular risk, ED is as frequent as diabetes and metabolic syndrome, and must be considered, until proof to the contrary, to reflect angina of the penis, i.e. an exercise-induced vascular symptom, which has a double warning value: 1) marker of deterioration, 2) potential prodrome of acute vascular accidents. These close relations between ED and cardiovascular disease give a completely different dimension to ED, which now constitutes a potential candidate for a new clinical vascular marker and possibly, in some cases, a new marker of cardiovascular risk. These unexpected roles of revealing factor and clinical marker of multiple health states (cardiovascular or other) paradoxically contribute to "desexualization" of ED, as sexual health no longer appears to be the major risk involved. In particular, they open the realistic perspective of opportunistic and proactive detection of ED in well targeted populations for the purposes of primary prevention of cardiovascular disease, a public health priority. For all these reasons, the development of ED requires a minimal evaluation of the patient's state of health, regardless of the doctor's qualification, by clearly distinguishing quality of life and health objectives. This modern management of ED is part of an individual (humanistic) and social (civic and ethical) approach. This "revolution" complies with the requirements of a good quality scientific approach, which comprises the concepts of evidence-based medicine and a rational approach to the service rendered to the patient, as management of his sexual health (and not his sexuality) also comprises management of his general health.

Cardiovascular Diseases↗

The politics of priority setting for reproductive health: breast and cervical cancer in Ghana.

Priority setting for reproductive health is affected by health sector reform policies, the often politically charged nature of issues such as abortion, decreasing funding for reproductive health activities and the broad agenda of the ICPD Programme of Action. This paper examines the influence of political and organizational factors on national priority setting for reproductive health and argues that existing priority setting tools such as disability-adjusted life years and cost-effectiveness analysis do not consider the influence of politics on the priority setting process or account for the interpretation of evidence in priority setting. It suggests that priority setting tools can be strengthened by incorporating empirical measures of political and organizational attention to an issue, and through a new measure--policy priority. The paper applied this new measure to a case study of attention to breast and cervical cancer in Ghana from 1990-97, illustrating how traditional priority setting methods cannot explain the priority given to breast cancer in Ghana. It demonstrates how local politics can trump scientific and economic evidence and suggests that the priority setting process can have unforeseen equity and social implications. It concludes by arguing that the policy priority measure provides a more complete picture of reproductive health priorities and is useful for better understanding the implications of the priority setting process for reproductive health.

Breast Neoplasms↗

Cultural factors and international epidemiology.

The debate on the role of culture on psychiatric epidemiology has evolved considerably in the past two decades. There is now a general consensus that the integration of the universalist and culturally relativist approaches, and their methodologies, is required to generate a truly international psychiatric epidemiology. The large body of research investigating the influence of culture on the epidemiology of depression has produced a number of key findings: the clinical presentation of depression in all cultures is associated with multiple somatic symptoms of chronic duration; psychological symptoms, however, are important for diagnosis and can be easily elicited. The diagnostic differentiation between depression and anxiety in general health care settings is not clinically valid. Culturally appropriate terminology for depression can be identified and their use may improve levels of recognition and treatment compliance. It is also evident that culture is only one factor in the difference between, and within, human societies which has a bearing on the epidemiology of depression. Other factors, which may interact with culture, such as gender and income inequality, are major risk factors for depression. Future international research must focus on two themes: (i) intervention studies including cost-effectiveness outcomes; and (ii) research aiming to bridge the gap between regional public health priorities and the concern that psychiatrists have about depression.

Community Mental Health Services↗

Advancing tuberculosis control within reforming health systems.

In developing nations, diverse health reform programs are affecting the design, financing and delivery of health care services as well as public health practice. This paper summarizes the characteristics of major reform strategies seeking to improve efficiency, equity and quality. Opportunities and risks for tuberculosis control are identified, as are responses in managing the reform transition. Recommendations are provided to advance tuberculosis control in this dynamic environment. These include participation in the planning process; demonstration of synergy between reform objectives and tuberculosis control; articulation of core functions to be protected; technical, managerial and leadership capacity-building; documentation of effects and best practices; and collaboration with those pursuing other public health priorities and reform analysis.

Benchmarking↗

Toward a VA Women's Health Research Agenda: setting evidence-based priorities to improve the health and health care of women veterans.

The expansion of women in the military is reshaping the veteran population, with women now constituting the fastest growing segment of eligible VA health care users. In recognition of the changing demographics and special health care needs of women, the VA Office of Research & Development recently sponsored the first national VA Women's Health Research Agenda-setting conference to map research priorities to the needs of women veterans and position VA as a national leader in Women's Health Research. This paper summarizes the process and outcomes of this effort, outlining VA's research priorities for biomedical, clinical, rehabilitation, and health services research.

Delivery of Health Care↗

Evaluation of an immunochemical fecal occult blood test with automated reading in screening for colorectal cancer in a general average-risk population.

Colorectal cancer screening is a high public health priority in all industrialized countries. However, the low sensitivity of the common guaiac screening test (HemoccultII) makes practitioners and public health decision makers reluctant to set up a national screening program. In recent years, immunochemical tests based on the use of a specific antibody have been found to be more sensitive than the HemoccultII test. However, for screening purposes, any gain in sensitivity is of interest only if specificity and positive predictive value are satisfactory. Our aim was to assess the performance of an immunochemical test with an automated reading technique (Magstream 1000) for different hemoglobin content cut-off points. The study was carried out in the general population aged 50-74 years in the geographic area of Cotentin (Normandy, France). From 1 January 2001 to 31 December 2002, 7,421 one-time screening tests (Magstream) were administered by general practitioners and occupational physicians to patients at the end of regular consultations. Colonoscopy was proposed to the 434 people with a positive test. All cancers occurring in the study population between 1 January 2001 and 31 December 2003 were collected by general practitioners, gastroenterologists and the local registry. At the usual positivity threshold (20 ng hemoglobin/ml), screening sensitivity and specificity at 2 years of follow-up with 95% CIs were, respectively, 0.85 (0.72-0.98) and 0.94 (0.94-0.95). If the hemoglobin content cut-off point had been set at 50 ng/ml instead of the usual cut-off, positivity would have been 3.1% and positive predictive value for a cancer or a large adenoma would have been 0.49, with sensitivity of 0.68-0.83 and specificity of 0.97. Our results suggest that use of an immunochemical test with an automated reading technique could improve the prospects for mass-screening for colorectal cancer since it offers a promising alternative to guaiac tests.

Aged↗

Strategies for the prevention and control of osteoporosis in developing countries.

The frequency of osteoporosis and fragility fractures has been studied to a very limited extent in few developing countries. The aim of this paper is to review briefly the burden of osteoporosis and fragility fractures in these countries and to propose some strategies for the prevention and control of those conditions, considering barriers and facilitators for their implementation. The evolution of the demographic composition in most regions with developing countries shows a considerable increase in life expectancy and therefore, a significant growth in elderly population can be expected. Reports on the incidence of fragility fractures show figures in many of those countries that are comparable to those found in developed nations. Health resources (for acute treatment of fractures, their rehabilitation and chronic management, for diagnostic centers and drug therapy for osteoporosis) are limited in most of those regions and are allocated to other health priorities. Internationally accepted guidelines can be adapted to the realities of developing nations and may be promoted by organizations of health professionals and patients, but require endorsement and support by health authorities. The steps should include: (a) campaigns to increase awareness, both among the population at risk and relevant health workers; (b) the promotion of a preventive lifestyle in the general population; (c) the development of national or regional, evidence-based guidelines for the diagnosis and treatment of osteoporosis; (d) development and implementation of guidelines for the treatment of fragility fractures, their rehabilitation and prevention of falls; (e) collection of economic data on fractures and osteoporosis; and (f) development of country-specific fracture databases. These steps may help in reducing the increasing burden of osteoporotic fractures. Their implementation will require solid scientific basis and commitment from policy makers, health professionals, patient organizations, and ultimately the general population.

Developing Countries↗

Health education to promote community involvement in the control of tropical diseases.

Health Education is any combination of learning activities that promote voluntary adaptations in health-related behaviour. In pursuing this definition, health workers generally work in two main directions, a community development approach and a behavioristic, communications approach. While Health Education in tropical, developing countries often takes the developmental approach with full community involvement, including the setting of programme priorities, Health Education for disease control has more often been characterized as the behavioristic mode utilizing simplistic, professionally determined messages and short-term campaigns to attempt to influence health behaviours related to disease transmission. Efforts in Idere, Nigeria, have tried to merge the two approaches building on community concern about one endemic tropical disease, Guinea worm. From this base, volunteer village health worker (VHW) training was developed. VHWs, once trained, developed their own association, which served as an organizational base for further health development programming, directed by the VHWs themselves.

Community Health Planning↗

[Preventive clinical messages for children from 0 to 3 years of age].

Prevention is a part of the medical visit during this critical period. The main preventive messages for children up to 3 years concern the immediate environment of the child and its consequences on his health. Sleeping position, passive tobacco use, his nutrition: prevention of infantile obesity, food imbalances, impairment of the mother to child relationship. Hygiene procedures have to be discussed with the families. Injury prevention is based on the vigilance of the human entourage, the safety environment, more than eventual modifications of the child behaviour. The detection of lead exposed children is a public health priority so the consequences are fearsome. The knowledge of the seriousness signs of the usual diseases is the basis oh health education to achieve two goals: behaviours to adopt to avoid the complication, early diagnosis of complications.

Child Welfare↗

International program on the health effects of the Chernobyl accident.

The International Program on the Health Effects of the Chernobyl Accident (IPHECA) was established by the World Health Organization (WHO) in 1991. Currently, the technical part of IPHECA consists of five projects addressing the following areas of priority health problems or needs: thyroid, hematology, brain damage in utero, epidemiological registry and oral health. Important findings are: 1) a significant increase of thyroid cancer in children in Belarus and Ukraine since 1989, and in Russia since 1992 though not so pronounced. A relationship between detected thyroid cancers and radiation exposure is yet to be established, 2) no increase yet in the incidence of hemoblastoses in the three States, 3) no relationship established between mental retardation and radiation exposure in utero in 4,500 children investigated. The importance of dosimetry and biological indicators of radiation damage has been recognized by IPHECA. Several methods of biological and physical dosimetry are being employed using instrumentation provided by IPHECA. Some preliminary results indicate: 1) unstable aberrations can indicate an integral exposure but it is heavily biased to recent exposures, 2) when comparing healthy persons and patients with hematological diseases in contaminated areas, there is a higher ratio of total aberrations compared to their background and that the level of stable is lower than unstable aberrations, and 3) by applying electron spin resonance (ESR) it has been shown that the individual distribution of doses approaches a log-normal one, especially for adults, and that a peak shift towards higher doses is noticeable for children.

Adult↗

An educational intervention for front-line health professionals in the assessment and management of suicidal patients (The STORM Project).

BACKGROUND: Suicide prevention is a health priority in many countries. Improved management of suicide risk may improve suicide prevention. This study aimed to assess the feasibility of health district-wide training in the assessment and management of people at risk of suicide; and to assess the impact of training on assessment and management skills. METHODS: Staff in three health care settings, namely primary care, accident and emergency departments and mental health services (N = 359), were offered suicide risk management training in a district-wide programme, using a flexible 'facilitator' approach. The main outcomes were the rate of attendance at training, and changes in suicide risk assessment and management skills following training. RESULTS: It was possible to deliver training to 167 health professionals (47 % of those eligible) during a 6 month training period. This included 95 primary care staff (39%), 21 accident and emergency staff(42%) and 51 mental health staff (78%). Of these, 103 (69%) attended all training. A volunteer sample of 28 staff who underwent training showed improvements in skills in the assessment and management of suicide risk. Satisfaction with training was high. The expected costs of district-wide training, if it were able to produce a 2.5% reduction in the suicide rate, would be 99,747 pound sterling per suicide prevented and 3,391 pound sterling per life year gained. CONCLUSIONS: Training in the assessment and management of suicide risk can be delivered to approximately half the targeted staff in primary care, accident and emergency departments and mental health services. The current training package can improve skills and is well accepted. If it were to produce a modest fall in the suicide rate, such training would be cost-effective. However, a future training programme should develop a broader training package to reach those who will not attend.

Adult↗

Health impact assessment.

There is growing concern about the environmental, social and health consequences of development projects. Environmental impact assessment (EIA), which aims to address this concern, is often conducted with little input from the health sector. Quantifying the health benefits and risks of a project or policy requires an innovative synthesis of socio-demographic, environmental health, epidemiological and health systems data. This article provides a simple framework for health impact assessment (HIA), a method for describing and measuring the impact of a project or policy on health and wellbeing, and designing appropriate interventions. The key components of HIA are: review of available data; research and identification of priority health issues through the use of rapid assessment methods; design of a health action plan with stakeholder consultation; implementation of interventions and the monitoring of long-term health impacts. HIA can assist in ensuring that development and policies are 'health promoting' and that the health sector plays a meaningful role in EIA.

Africa↗

[Evaluation of a new form of care: the permanently maintained health care facility at the university hospital center in Nantes].

Considering the consequences of social instability within the health care system has become a public health priority. Each public hospital center in France is obliged to create a unit for welcoming impoverished and vulnerable people (Permanently Maintained Health Care Facilities). The university hospital in Nantes opened a socio-medical out-patient consultation service in November 1999 with the main objective being to bring these patients back into the usual ambulatory care system. The evaluation of the first few months of its operation reveals that one out of every two patients is a young person with a low-income and without any social protection. The possibilities of reorientation towards the regular care system are discussed.

Adolescent↗

Building a healthier northern Michigan.

Over the last 10 years, hospitals in the north central region of Michigan have collaborated with human service agencies across a 21-country area of northern Lower Michigan on the Community Health Assessment Project: Building A Healthier Northern Michigan. A survey was completed in 1995 that provided insight into the health status of adults in the region. The survey helped communities identify health priorities and implement plans to address them.

Adolescent↗

[Of mice, vaccines and men: the Rockefeller Foundation Yellow Fever Program in Columbia, 1932-1948].

From 1927 on, a series of technological innovations revolutionized the study of yellow fever, leading to a re-conceptualization of the disease. The Rockefeller Foundation (RF) was at the vanguard of these developments, which made specialized laboratories an imperative. This paper explores the activities of the RF yellow fever cooperative programme in Colombia and their consequences, and shows how the RF constructed yellow fever as a continental problem and a public health priority for the American republics, investing heavily in basic research - its primary interest-, thus deviating attention and resources from other pressing health needs. At the same time, Colombian health authorities gained legitimacy through the prestige and resources of the programme, and were in a better position to advocate the role of research in national public health.

Allergy and Immunology↗

[Advantage of immunochemical fecal occult blood test in screening for colorectal cancer].

Colorectal cancer screening is a high public health priority in all industrialized countries. However, the low sensitivity of the common guaiac screening test (Haemoccult II) makes practitioners and public health deciders reluctant to set up national screening program. In recent years, immunochemical tests based on the use of a specific antibody have been found to be more sensitive than the Haemoccult II test. However, for screening purposes, any gain in sensitivity is of interest only if specificity and positive predictive value are satisfactory. As instance, rehydration of the Haemoccult II test prior to lecture can increase sensitivity, but the associated decrease in specificity and positivity predictive value and the high positivity rate render its value in mass screening debatable. Moreover, extra costs, if existing, must be acceptable for the society. Until recently, immunochemical tests costs made it unaffordable in our societies. The arrival of automated reading is likely to remove this obstacle. Moreover it offers the opportunity of positivity cut-off choice. A recent study was conducted in Cotentin (France) to assess the performance of an immunochemical test with an automated reading technique (Magstream 1000) for different haemoglobin content cut-off points. As previous American, Japanese, Chinese and Italian studies, this study suggests that the use of immunochemical tests could lead a substantial gain, in screening sensitivity. Moreover by choosing a higher haemoglobin content as cut-off point (50 ng/ml instead of usual cut-off at 20 ng/ml), a gain in sensitivity can be obtained with a satisfactory specificity (97%) and positivity rate (3%). Considering the increasing number of publications, the use of an immunochemical test with an automated reading technique could improve the prospects for mass-screening for colorectal cancer, since it offers a promising alternative to guaiac tests.

Colorectal Neoplasms↗