[Experimental biped monkeys as a model for multi-purpose studies in the field of gravitational biology and physiology].
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The effects of acceleration of different value (up to 2 g) on the level of motion sickness, vestibular and postural reactions to rotation were studied. The experiments were carried out in a centrifuge equipped with a cabin that could be mounted at a different distance from the axis of rotation. Three experimental runs were conducted with a rate of rotation of 15.3 and accelerations values of 1.09, 1.6 and 2.0 g. Vestibular stimulation was produced by head movements of a predetermined number. It was found that with increase in the acceleration value the level of motion sickness decreased and the nystagmic reaction and balance dysfunction enhanced.
The paper reviews biomedical investigations concerning artificial gravity performed so far in the USSR. It is believed that at the present stage the major task is to identify the minimum value of artificial gravity which may eliminate adverse effects of weightlessness on the human body. In ground-based investigations high priority should be given to the development of methods of increasing human tolerance to a rotating environment.
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The content of water-soluble proteins in the grey and white matter of the spinal cord, spinal ganglia, and the sensory-motor area of the large hemispheres of the brain of rats after a 18.5-day space flight was measured. The content of water-soluble proteins in the grey and white matter of the spinal cord and spinal ganglia of rats exposed to weightlessness showed a significant decrease 4.5--9.5 hours postflight. The water-soluble protein content in the white matter of the spinal cord diminished in rats exposed to artificial gravity inflight. The water-soluble proteins content in the grey matter of the spinal cord of rats exposed to weightlessness increased significantly 25 days postflight. The content of water-soluble proteins in the grey matter of the cortex of the sensory-motor area of the large hemispheres of the brain of rats exposed to weightlessness and artificial gravity remained unchanged in comparison with the vivarium controls both 4.5--9.5 hours and 25 days postflight.
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A prolonged maintenance of rats with the long axis of the body positioned at +15 degrees or -15 degrees to the horizontal influenced their fluid-electrolyte metabolism. The experiments were carried out on 56 noninbred rats whose motor activity was diminished for 32 days. A close correlation between fluid-electrolyte metabolism and body position was established. As compared to the horizontal rats, the rats with the head at +15 degrees showed decreases in body weight losses, diuresis, kali- and natriuresis, whereas the rats with the head at -15 degrees exhibited increases of the parameters.
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The maintenance of hemodynamic stability is a functional characteristic of the cerebral circulatory system. This characteristic developed during the evolutionary process. It can be of use as an indicator of the activity of the central processes regulating cerebral blood flow under different stress conditions, particularly, during a long space mission. Rheoencephalographic methods are qualitative and yield information that permits assessment of the changes in the functional status of the cerebral circulatory system. This was confirmed by results obtained during the Salut-4 space mission. The observations permitted us to assess indirectly the status of the cosmonauts.
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