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At least 829 records · Page 46Linked to original sources
PubMed1997

Effect of casting on forearm resistance vessels in young men.

The aim of this study was to determine whether physical deconditioning, induced by 6 wk of forearm casting, and the conditioning effects of recovery from casting would elicit changes in the response of forearm resistance vessels to substances that modulate vascular resistance. Forearm blood flow (FBF) responses to intrabrachial infusion of NGmonomethyl-L-arginine (LNMMA) and norepinephrine (NE) were examined in six subjects recovering from Colles', scaphoid, or metacarpal fractures within 72 h of cast removal and again after a 6-wk recovery period. Vascular responses were also examined in six noncasted controls. The FBF responses of casted and control subjects did not differ, and no changes occurred over the 6-wk study period. These results suggest that the effect of forearm casting and recovery from casting do not greatly influence control of vascular tone, including the basal activity of the NO dilator system in vivo.

Adult↗
PubMed1991

Vascular anatomy of the forearm muscles: a study of 50 dissections.

This anatomic study is based on 50 adult cadaver upper extremities. The general disposition of the forearm arteries and muscles and the main anatomic variations encountered are specified. Constant existence of an "anterior oblique artery" satellite of the pronator teres was established. The median nerve artery was principally dedicated to the flexor digitorum superficialis and participated appreciably in the constitution of palmar arches in only one case. A supernumerary intermedial radial muscle was found only in two cases. The abductor pollicis longus and extensor pollicis brevis appeared as a single muscular and vascular unit in 84 percent of cases. All the arteries destined for muscles were reckoned whatever their caliber might be. Despite its limitations, this study confirms the very great number of the forearm muscular pedicles. Each forearm contained an average of 264 muscular vascular pedicles. The systematization of the origins and destinations of the 13,158 muscular pedicles is described in a numbered manner for each of the 20 normal forearm muscles and for each of the 12 studied arterial segments. The pronator teres was likely to be supplied by all the anterior arteries of the upper limb. The flexor carpi radialis had one or two dominant pedicles originated from the recurrens ulnaris anterior, recurrens ulnaris, or ulnaris-interossea communis arteries, and many transversal branches originated from the radial artery. The flexor carpi ulnaris was supplied in its proximal third by the recurrens ulnaris posterior artery and in its distal two-thirds by many branches of ulnar artery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Neonatal Volkmann's ischemic contracture of the forearm: a report of five cases.

We report five cases of children born with forearm wounds associated with motor and sensory losses to the hand and forearm. Their evolution toward muscle retraction is very similar to the classic description of Volkmann's ischemic contracture. These cases should not be confused with upper extremity gangrene of the newborn or aplasia cutis congenita. Two cases of neonatal Volkmann's ischemia have already been reported in the literature and identified as such. Another very similar case has been reported as upper extremity gangrene of the newborn, and three more cases of a forearm wound with neuromuscular involvement have been reported as aplasia cutis congenita. We believe that neonatal Volkmann's ischemic contracture of the forearm should be recognized as a separate entity. Its early diagnosis may improve treatment, especially for children with recent injury, in whom intracompartmental pressures may still be elevated. Early hand therapy and splinting are mandatory to minimize late sequelae.

Compartment Syndromes↗
PubMed1996

Recovery of sensation in the radial forearm free flap in oral reconstruction.

The purpose of this study was to find out to what extent sensory function recovers in a free radial forearm flap used for intraoral reconstruction after surgery for oral cancer. In 40 free radial forearm flaps we investigated the perception of light touch, two-point discrimination, pain, directional sensation, and temperature between 6 months and 11 years after flap transfer to the oral cavity. Four flaps (10 percent) were anesthetic, 21 flaps (52.5 percent) recovered partly, and 15 flaps (37.5 percent) had perception of all sensory modalities tested in at least two-thirds of the flap area. All patients with positive sensation in the surrounding area subsequently had good sensory recovery in the flap. This suggests that recovery of sensation in a nonreinnervated free flap is due to nerve ingrowth from the surrounding mucosa. The present results suggest that sensory function in intraoral free radial forearm flaps returns again. Further study is necessary to define the use of neurofasciocutaneous radial forearm flaps in reconstruction of the oral cavity.

Carcinoma, Squamous Cell↗
PubMed1997

The lateral forearm flap: an anatomic study.

The anatomy of the lateral forearm flap has been studied in 12 fresh cadaver arms with methylene blue and latex injections and arteriography. The posterior radial collateral artery was found to divide constantly into two terminal branches, an anterior and a posterior division. The anterior division is the nutrient vessel of the flap. This artery extends significantly beyond the lateral epicondyle of the elbow into the lateral aspect of the forearm (range 13 to 18 cm, average 15 cm). This allows raising a fasciocutaneous flap in the proximal forearm with a much longer vascular pedicle than the classic lateral arm flap. Other advantages include very thin skin and subcutaneous tissue and less sensory deficit at the donor site. Based on these results, this newly designed lateral forearm flap has been used in 13 clinical cases. Its main indications are whenever soft, thin, pliable skin is needed for small to moderate-sized defects.

Cadaver↗
PubMed1995

Self-reported physical exposure and musculoskeletal symptoms of the forearm-hand among automobile assembly-line workers.

The aim was to study the prevalence of physical exposures and symptoms of the forearm-hand in a population with highly repetitive jobs. Automobile assembly-line workers (ALWs) (n = 521) and a control group (CG) from the general population answered a questionnaire. Consistent differences were found between the groups. ALWs reported more symptoms from the forearm-hand and higher exposure to repetitive movements, precision movements, and manual handling (< or = 15 kg) than the CG. Female ALWs reported more symptoms and higher exposure to known risk factors for work-related forearm-hand disorders than their male colleagues. In conclusion, automobile assembly-line workers appear to be a high-risk group for work-related symptoms from the forearm-hand. Also, exposure to physical load should be conscientiously analyzed, since women may perform different tasks than men.

Adolescent↗
PubMed2003

Reconstruction of forearm deformities in multiple cartilaginous exostoses.

The management of complex forearm deformities in patients with multiple cartilaginous exostoses is controversial. The objective of this study is to look into the outcome of treatment with the combined use of ulna lengthening, radial osteotomy, and excision of exostosis in our six patients, who all had Masada type 1 deformity of the forearm. Clinical assessment was performed using the pre- and postoperative range of motion of the wrist, forearm and elbow. The chief symptom each patient had was noted as well as the demographic data of all patients. Radiological assessment was performed by checking the degree of negative ulna variance, the radial articular angle, and the degree of carpal slip. The degree of satisfaction of the patients and their parents were noted. Good clinical and radiological results were obtained at a mean follow-up of 2.5 years. All patients and parents were satisfied and there was no recurrence of deformity in the latest follow-up. The authors believe in early and aggressive treatment of Masada type 1 deformity of the wrist and forearm for multiple cartilaginous exostoses with a combination of excision of exostosis, ulna lengthening and radial osteotomy.

Bone Lengthening↗
PubMedDate not supplied

Osteotomy for malunited forearm shaft fractures in children.

Osteotomy to correct malunion after forearm fracture in children is an uncommon procedure. The uncommon nature of this procedure and the complex nature of forearm anatomy contribute to the difficulty of restoring proper alignment. The purpose of this paper is to report nine cases and describe a simplified method for deformity correction. This is a retrospective review of the authors' experience with recommendations for surgical technique. Average maximum deformity prior to osteotomy was 31 degrees. All patients united with satisfactory postoperative alignment. There was one superficial wound infection. Average improvement in forearm rotation was 102 degrees. Based on these satisfactory results and a review of the literature, the authors recommend correction of forearm malunion when functional range of motion does not return by 6 months after the initial injury.

Child↗
PubMed2005

Diagnosis and treatment of longitudinal instability of the forearm.

Radio-ulnar dissociation can result from high-injury trauma that the compressive forces traverse the wrist forearm and elbow. This injury can be thought of as an "unhappy triad" of radial head fracture, triangular fibrocartilage complex failure, and a tear of the interosseous membrane. The radius is the primary stabilizer of the forearm with the forearm interosseous membrane enabling load sharing between the radius and the ulna. The central one-third of the interosseous membrane is 3 times stronger than the membranous portion and approaches the strength of the anterior cruciate ligament for determining interosseous membrane injury. Imaging studies with proven diagnostic efficacy include magnetic resonance imaging and ultrasound. Surgical treatment should be considered when circumstances imply longitudinal instability of the forearm. Surgical treatment includes open reduction/internal fixation or prosthetic replacement of the radial head as well as repair of the disrupted triangular fibrocartilage complex. Successful treatment of radioulnar dissociation is predicated on early diagnosis of the condition.

Biomechanical Phenomena↗
PubMedDate not supplied

Diet, activity, and other lifestyle risk factors for forearm fracture in postmenopausal women in China: a case-control study.

OBJECTIVE: Forearm fractures are a major cause of disability in postmenopausal women, but the risk factors have not been previously studied in China and the results from Western studies may not be applicable to the Chinese population. The aim of this study was to determine whether calcium intake, activity level, lifestyle, and other factors are associated with risk of forearm fracture among Chinese postmenopausal women. DESIGN: In this case-control study, the authors used a structured questionnaire to assess potential risk factors in 209 postmenopausal women 50 to 70 years old with new forearm fractures identified in eight hospitals in Chengdu and in age and location of residence-matched control subjects randomly selected from the community. RESULTS: Adjusted odds ratios (95% CIs) were as follows: each quintile increase in current energy intake 0.46 (0.36, 0.60); fifth quintile energy-adjusted current calcium intake versus lowest quintile, 0.17 (0.06, 0.47); eating bean products when 30 to 49 years old, 0.15 (0.05, 0.47); eating meat, 0.13 (0.02, 0.74) and eating pork ribs, 0.37 (0.17, 0.83) when 16 to 29 years old; greater past activity, 0.78 (0.68, 0.89) and present activity, 0.84 (0.74-0.96); greater height (per centimeter), 1.12 (1.06, 1.20); each year irregular menses before menopause, 1.25 (1.04, 1.49); each floor of residence, 1.71 (1.38, 2.12); and prior fracture in first- or second-degree relatives, 2.74 (1.08, 6.92). CONCLUSION: Some risk factors for forearm fractures were similar to those described in white women, whereas others were specific to this ethnic setting, and would need to be considered in future preventive programs.

Aged↗
PubMed2004

Effect of ascorbic acid on forearm reactive hyperaemia in patients with hypercholesterolaemia.

BACKGROUND: This study was designed to research the effect of hypercholesterolaemia and ascorbic acid on forearm blood flow (FBF) reactive hyperaemia (RH). Reactive hyperaemia seems to be at least partly endothelium-dependent. Endothelial dysfunction has been described in patients with hypercholesterolaemia, and has been reversed with ascorbic acid administration. METHOD: Forearm blood flow was studied with venous occlusion plethsmography in 26 healthy volunteers and 46 hypercholesterolaemic patients. Hypercholesterolaemic patients were divided into two groups. Group A comprised 25 patients, who received ascorbic acid and group B comprised 21 patients, who received placebo. All subjects underwent measurement of FBF at baseline and during RH (phase A). Forearm blood flow during RH was measured every 15 seconds for three minutes. Subsequently patients in group A received 2 g of ascorbic acid orally in the form of effervescent tablets, and patients in group B received placebo orally in the same form. Forearm blood flow measurements at baseline and during RH were repeated two hours later (phase B). RESULTS: Maximal percent increase of FBF was significantly higher in healthy subjects than in hypercholesterolaemic patients (139.1+/-12.1% versus 73.1+/-11.0% respectively, P<0.05). Duration of RH was smaller in hypercholesterolaemic patients compared to normal subjects (60.9+/-17.1 seconds versus 105.6+/-10.2 seconds, P<0.05). Administration of ascorbic acid but not of placebo increased the duration of RH (69.1+/-11.1 seconds versus 104.1+/-12.2 seconds, P<0.05) but not of peak RH FBF. CONCLUSION: Hypercholesterolaemia seems to impair both the early and late phase of RH. Ascorbic acid improves only the duration of RH, possibly due to its antioxidant effect on endothelium.

Adult↗
PubMed2005

Effect of mild endurance exercise training and pravastatin on peripheral vasodilatation of forearm resistance vessels in patients with coronary artery disease.

BACKGROUND: Improved endothelial function may contribute to the beneficial effects of cholesterol lowering therapy in patients with coronary artery disease (CAD), but results of the effect of statin therapy on endothelial function are disparate in these patients. Exercise training has been reported to improve endothelial function of patients at risk of or with established CAD. The goal of the study was to compare the effect of mild exercise training or statin therapy on forearm endothelial function in CAD patients with average cholesterol levels. DESIGN AND METHODS: Twenty-eight sedentary male patients with angiographically documented CAD and average pretreatment total plasma cholesterol levels (5.1+/-0.9 mmol/l) aged 42-75 years were included. They were randomly assigned in a 2 : 1 order to either statin therapy (pravastatin, 40 mg daily) or exercise training therapy (mild endurance exercise three or more times a week). The effects of 10 weeks of either treatment on endothelium-dependent and independent vasodilation of forearm resistance vessels was assessed by plethysmography. Cardiopulmonary exercise testing was performed at baseline and after 10 weeks. RESULTS: Ten weeks of pravastatin therapy significantly reduced low-density lipoprotein cholesterol (from 3.8+/-0.6 to 3.1+/-0.6 mmol/l at study end, P=0.04) and the ratio of total to high-density lipoprotein cholesterol (from 4.9+/-0.8 to 3.7+/-0.7 mmol/l, P=0.002). Exercise training did not significantly modify the lipid profile. Peak oxygen consumption, maximal achieved workload and exercise duration tended to improve in the exercise training group but remained unchanged in the pravastatin-treated group. Neither 10 weeks of pravastatin nor mild endurance exercise training improved endothelium-dependent or independent vasomotor function in forearm resistance vessels. CONCLUSIONS: In patients with CAD and average cholesterol levels, 10 weeks of treatment with mild endurance exercise training or with pravastatin failed to improve endothelium-dependent or independent vasomotor function in forearm resistance vessels.

Adult↗
PubMed2005

Radial forearm osteocutaneous free flap in maxillofacial and oromandibular reconstructions.

OBJECTIVES/HYPOTHESIS: The radial forearm osteocutaneous free flap is an excellent reconstructive modality for oromandibular and maxillofacial reconstruction in certain well-defined circumstances. The initial concern over donor site morbidity and the ability of the bone to reconstruct mandibular defects have led to only a few published series. STUDY DESIGN: Retrospective study of the experience of two tertiary medical centers with radial forearm osteocutaneous free flap. METHODS: Retrospectively, 52 patients were studied who underwent radial forearm osteocutaneous free flap reconstruction for cancer (49 cases) and trauma (3 cases). Bone length and skin paddle harvested, general morbidity (hematoma, wound infection, and dehiscence), recipient site morbidity (nonunion of neomandible, flap failure, and bone or plate exposure), and donor site morbidity (radius bone fracture, plate exposure, and skin graft failure) were reviewed. RESULTS: The average skin paddle size was 55.1 cm (range, 15-112 cm). The average radius bone harvest length was 6.3 cm (range, 2.5-11 cm). Donor site complications included tendon exposure (3 cases), radius bone fracture (1 case), and exposure of the plate (0). Recipient site complications included nonunion of the mandible (4), exposed mandible (1), exposed mandibular plates (2), exposed maxillary plates or bone (0), venous compromise (1), and flap failure (1). Two patients had perioperative deaths. CONCLUSION: Radial forearm osteocutaneous free flap is a valuable and viable option for oromandibular and maxillofacial reconstruction.

Adolescent↗
PubMed2003

Effect of counterforce forearm bracing on wrist extensor muscles performance.

OBJECTIVES: We examined (1) the effect of a counterforce forearm brace on isokinetic strength, stretch reflex, passive stretching, and proprioception of the forearm muscles in healthy subjects and (2) the effect of different strap tensions of the brace on the above variables. DESIGN: The dominant hand of 15 healthy subjects were tested under four randomized conditions: (1) no brace, (2) brace with minimal tension, (3) brace with 2.5 kg force tension, and (4) brace with 5 kg force tension. The tests included isokinetic wrist extensors strength, passive stretching to the wrist extensors until onset of pain, joint proprioception, and reflex latency of forearm extensor muscles. A repeated measures multivariate analysis of variance test was used to analyze the data, and significant results were further analyzed with post hoc linear contrasts with alpha at 0.0083. RESULTS: There was no difference in isokinetic strength, proprioception, and stretch reflex latency among the four conditions. For passive stretching, there was a significant difference (P = 0.001) in that using a brace produced a higher pain threshold than without a brace. CONCLUSION: A forearm counterforce brace has no effect on strength, proprioception, and stretch reflex latency, but it increases the pain threshold.

Adult↗
PubMed2005

Use of the artificial dermis for free radial forearm flap donor site.

The radial forearm free flap has been popular in many area of reconstructive surgery. Despite the many attributes of this flap in surgical reconstruction, one of the clear disadvantages has been the morbidity of the donor site. To solve problems associated with closure of the radial forearm flap donor site, the artificial dermis was used for better outcome in the donor site. From July of 2001 to October 2003, 13 patients (12 male, 1 female) ranging in age from 27 to 67 years underwent free radial forearm transfers. Flap size measured 49 to 144 cm2. Donor-site defects secondary to the flap elevation was closed first with the artificial dermis (Terudermis), marketed by Terumo Inc, Japan, and secondary split-thickness skin graft to the artificial dermis was performed in 15 days (range, 13 to 17 days) on average. There was no flap failure in all cases. Partial loss of the artificial dermis graft was noticed in 2 cases, but it was negligible. Secondary skin graft take was noticed in about 7 days, and there was no remarkable skin graft loss. The artificial dermis was used successfully in 13 patients with the donor defects of free radial forearm flap. Despite the disadvantage to need the secondary split-thickness skin graft, use of the artificial dermis gave us not only soft-tissue augmentation and graft-skin quality similar to full-thickness skin graft but also fast graft healing and diminished morbidity of the skin-graft donor site.

Adult↗
PubMed2004

Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm.

Sepsis-induced vasodilation is characterized by an attenuated sensitivity to vasoconstrictor substances such as norepinephrine, possibly mediated by activation of vascular potassium channels. We determined whether vasodilation associated with potassium channel activation resulted in an attenuated vasoconstrictive response to norepinephrine in humans and whether the vasodilation associated with potassium channel activation could be inhibited by pharmacological potassium channel blockers. In 30 volunteers, the brachial artery was cannulated for infusion of drugs. Forearm blood flow (FBF) was measured in both arms using strain-gauge venous occlusion plethysmography. Forearm vascular resistance (FVR, mean arterial pressure/FBF) was calculated. The effects of vasodilation induced by sodium nitroprusside (SNP, nitric oxide donor) or diazoxide (activator of the ATP-dependent potassium channel) on norepinephrine-mediated vasoconstriction were examined. Also, the effects of potassium channel blockers on vasodilation associated with potassium channel activation were determined. Intraarterial SNP infusion (2 microg/min/dL) increased forearm blood flow by 235%, from (mean +/- SEM) 2.8 +/- 0.7 to 9.4 +/- 1.5 mL/min/dL (P < 0.0001). Subsequent norepinephrine infusion (10, 30, 100, 300, 1000 ng/min/dL) increased FVR dose-dependently from 13 +/- 4 AU to 249 +/- 45 AU at the highest norepinephrine infusion. Intraarterial diazoxide infusion (1 mg/min/dL) increased FBF by 209% from 2.2 +/- 0.3 to 6.8 +/- 1.0 mL/min/dL (P < 0.001). Subsequent norepinephrine infusion increased FVR from 18 +/- 5 to 51 +/- 6 AU at the highest norepinephrine infusion rate (n = 10), significantly different from the norepinephrine-induced effects during SNP coinfusion (P < 0.001). Diazoxide-induced fall in FVR in the infused forearm was inhibited by potassium channel blockers tetraethyl ammonium (1 mg/min/dL, n = 10, P = 0.004) and quinine (50 microg/min/dL, n = 10, P = 0.016). Vasodilation induced by vascular potassium channel activation is associated with an impressive reduction in the vasoconstrictor response to norepinephrine in humans. In accordance with animal experiments, this indicates that potassium channel activation could account for the diminished norepinephrine sensitivity in septic patients. Vasodilation associated with potassium channel activation can be inhibited by pharmacological potassium channel blockade. The possible role of potassium channel blockers during sepsis-induced potassium channel activation and vasodilation in humans needs further elucidation.

Adult↗
PubMed2003

The role of cardiopulmonary baroreceptors during the forearm vasodilatation response to mental stress.

The forearm vasodilatation response to mental stress in humans is thought to be mediated by sympathetic withdrawal and beta-adrenergic mechanisms. However, the mechanisms of altered neural control during sympathetic withdrawal are unclear. Thus, cardiopulmonary baroreceptor activity in relation to sympathetic withdrawal during mental stress was examined. Forearm blood flow was measured during mental stress in males (n = 18) during control and lower body negative pressure at -20 mmHg. Forearm blood flow was significantly increased during mental challenge; however, during lower body negative pressure the vasodilatation response was significantly attenuated in comparison with control. The results suggest the cardiopulmonary baroreceptors are involved with the sympathetic withdrawal response during forearm vasodilatation to mental stress.

Adult↗
PubMed1983

Reduction of the veno-arteriolar reflex induced arteriolar constriction in forearm subcutaneous tissue after surgical repair of aortic coarctation.

Arteriolar constriction in subcutaneous tissue elicited by the local sympathetic veno-arteriolar axon reflex was studied in subcutaneous tissue of forearm and leg in 4 patients before and after correction of aortic coarctation. Before the operation the local axon reflex induced an average increase of 154% in vascular resistance in the "hypertensive" forearm and of 76% in the leg. Following coarctectomy the local axon reflex induced increase in vascular resistance decreased in the forearm within 6 months in all patients. Now average increase in vascular resistance was only 109% 3 months after the operation and 45% 6 months after. Minimal vascular resistance in the papaverine relaxed vascular bed was reduced, whereas no systemic changes were seen in the distensibility of the vascular bed. The results indicate that adaptive vascular changes underlying the augmented arteriolar constriction during lowering as well as the increased "minimal vascular resistance" in the forearm are at least partly reversible following coarctectomy.

Adolescent↗