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PubMed1979

A study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids: concise communication.

The study was undertaker to evaluate the effect on bone localization of substitutions at the bridge carbon atom of methylenediphosphonic acid. Two monosubstituted compounds (ethylidenediphosphonic acid and benzylmethylenediphosphonic acid), and one disubstituted compound (isopropylidenediphosphonic acid), were synthesized. The biological behavior was compared with that of MDP and dichloro-MDP in the rat, using Tc-99m as a label. Ethylidenediphosphonic acid showed the highest femur-to-liver and femur-to-muscle ratios. MDP exhibited a slightly faster blood clearance than ethylidenediphosphonic acid.

Animals↗
PubMed1978

The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease.

The limited role of bone scanning in the diagnosis of metabolic bone disease might be considerably improved by accurate quantification of skeletal uptake of the radiopharmaceutical. Using a standard shadow-shield whole-body monitor, we have measured whole-body retention (WBR) of Tc-99m HEDP up to 24 hr in 11 patients with renal osteodystrophy (mean WBR 88.6% at 24 hr); in ten patients with Paget's disease (mean 56.9%); in seven patients with osteomalacia (mean 40.7%); in five patients with primary hyperparathyroidism (mean 50.7%); in four patients with osteoporosis (mean 21.2%); and in 12 normals (mean 19.2%). The osteoporotic group could not be differentiated from the normal group, but the other groups were significantly different from the normal group at 24 hr (p less than 0.002), and each individual rest for the 24-hr WBR of Tc-99m HEDP in these groups lay outside our normal range. This test may, therefore, provide a sensitive means of detecting conditions with increased bone turnover. We obtained measurements of plasma activity of Tc-99m HEDP in these patients up to 24 hr, and 4-hr bone to soft-tissue ratios from bonescan images, but little additional information resulted.

Adolescent↗
PubMedDate not supplied

The value of early and late 99mTc-methylene diphosphonate scintigrams of hands in patients with rheumatoid arthritis and other inflammatory rheumatic diseases.

Scintigrams of hands performed immediately after injection of 555 MBq 99mTc-methylene disphosphonate (99mTc-MDP) have been found to be the same and to have the same diagnostic value as those performed with 99mTcO4 both in persons without arthritic changes and in patients with inflammatory rheumatic diseases. Increased accumulation at this point is caused by hypervascularity due to inflammation, bone accretion being still negligible. Additional exposure to radiation from 99mTcO4 scintigraphy can therefore be avoided. The late scintigrams performed 3 h after 99mTc-MDP injection in the same patient can give us additional information on the amount of bone remodeling caused by chronic inflammation. Comparison of early and late scintigrams and the radiographs of hands in the same patient can provide us with better understanding of intensity, duration, and nature of joint changes under observation.

Arthritis, Rheumatoid↗
PubMed1983

[Regional blood flow and bone uptake of methylene-diphosphonate-technetium-99m].

Sudeck's atrophy of the foot is an acute, patchy osteoporosis that, on bone scan, shows an increase in both bone blood flow and local bone uptake of bone-seeking radionuclides. The purpose of this study was to evaluate the relationship between bone uptake of 99mTc-MDP and local bone blood flow. In some patients with Sudeck's atrophy of one foot we measured local bone blood flow and bone uptake of 99mTc-MDP. External counting of radioactivity, with a count-rate of 1 second was performed for 60 minutes after i.v. injection of a known dose of 99mTc-MDP in some patients with Sudeck's atrophy of the foot. The regions of interest (ROI) were selected on the basis of a bone scan performed 24 hours earlier. We assumed that the data recorded during the first seconds (7-10) reflect local blood flow and the data at 60 minutes reflect the bone uptake. The ratio between the local blood flow in the involved and healthy foot was higher than the local bone uptake ratio. The ratio between bone uptake and local bone blood flow was higher in the normal foot than in the affected one. These results suggest that the bone avidity for bone-seeking radionuclides is lower in Sudeck's atrophy than in normal bone.

Adult↗