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PubMed1992

Serum thyroid hormone concentrations and thyrotropin responsiveness in dogs with generalized dermatologic disease.

Fifty-eight dogs with generalized dermatologic disease that had not been given glucocorticoids systemically or topically within 6 weeks of entering the study were evaluated for thyroid function by use of the thyrotropin-response test. Dogs were classified as euthyroid or hypothyroid on the basis of test results and response to thyroid hormone replacement therapy. Baseline serum thyroxine (T4), free T4 (fT4), and triiodothyronine (T3) concentrations were evaluated in the 58 dogs. Serum T4, fT4, and T3 concentrations were evaluated in 200 healthy dogs to establish normal values. Hormone concentrations were considered low if they were less than the mean -2 SD of the values for control dogs. Specificity of T4 and fT4 concentrations was 100% in predicting hypothyroidism; none of the euthyroid dogs with generalized skin disease had baseline serum T4 or fT4 concentration in the low range. Sensitivity was better for fT4 (89%) than for T4 (44%) concentration. Significant difference was not observed in serum T4 and fT4 concentrations between euthyroid dogs with generalized skin disease and healthy control dogs without skin disease. Serum T3 concentration was not accurate in predicting thyroid function; most of the euthyroid and hypothyroid dogs with skin disease had serum T3 concentration within the normal range.

Animals↗
PubMedDate not supplied

Hypothyroid-associated central vestibular disease in 10 dogs: 1999-2005.

BACKGROUND: With the exception of myxedema coma, central nervous system signs are rare in hypothyroid dogs. HYPOTHESIS: Central vestibular dysfunction is a possible and reversible manifestation of hypothyroidism. ANIMALS: Medical records of dogs with vestibular dysfunction and hypothyroidism were reviewed. Of 113 records identified, 10 dogs with at least 2 concurrent clinical neurologic abnormalities localizable to the central vestibular system were included. METHODS: Retrospective, descriptive study. RESULTS: Median age at diagnosis was 7 years (range, 5-10 years). All dogs were referred for progressive neurologic disease. Lesions were localized to the myelencephalic region in 5 dogs and to the vestibulocerebellum in 5 dogs. Two dogs had evidence of multifocal intracranial disease. Non-neurologic physical abnormalities suggestive of hypothyroidism were absent in 7 of 10 dogs. Hypercholesterolemia was the only consistent clinicopathologic abnormality detected, and was present in 7 of 10 dogs. All dogs had total thyroxine (TT4) and free thyroxine (fT4) concentrations below reference ranges, and 9 of 10 had increased TSH concentrations. Intracranial imaging studies were normal in 5 of 8 dogs, and identified lesions consistent with infarctions in 3 of 8 dogs. Albuminocytologic dissociation was detected in 5 of 6 CSF analyses. Brainstem auditory-evoked responses disclosed prolonged wave V latencies in 3 of 4 dogs tested. No other causes of central vestibular dysfunction were identified during other diagnostic investigations. The median time from initiation of treatment to clinical improvement was 4 days. Vestibular signs resolved in 9 of 10 dogs within 4 weeks. CONCLUSIONS AND CLINICAL IMPORTANCE: Although the pathogenesis in dogs without evidence of infarction is unknown, central vestibular dysfunction appears to be a rare but reversible neurologic sequelae of hypothyroidism.

Animals↗
PubMed2002

Studies of certain factors affecting the microenvironment and microflora of the external ear of the dog in health and disease.

A total of 187 dogs, 110 with clinical signs of otitis externa (OE), and 77 without history or clinical signs of OE, were examined microenvironment and microbiological analysis of their ear exudates made. The aural temperature and humidity of 160 dogs were measured. There were no significant difference between healthy dogs and OE dogs. German shepherd showed relatively lower temperature (p<0.01) and higher humidity (p<0.01). The mean log(10) number of microbial organisms of ears of OE dogs (4.16 +/- 0.31 cfu/g) was significantly increased, compared to that from the ears of non-OE group (2.55 +/- 0.24 cfu/g). Pseudomonas spp. and Proteus spp. were detected only from OE dogs. In addition, three enterotoxigenic Staphylococcus aureus were isolated from ear specimens.

Animals↗
PubMed1992

Chronic lower airway disease in the dog and cat.

The most common form of lower airway disease (LAD) in dogs is chronic bronchitis, whereas in cats a syndrome resembling chronic bronchial asthma in humans is commonly reported. In most cases, the cause(s) of LAD remains unproven. The primary symptom of LAD in dogs and cats is chronic cough, although many cats are free of symptoms between episodes of acute, life-threatening bronchoconstriction. Diagnosis is based on a careful history, physical examination, and diagnostic tests designed to rule out other causes of cough and dyspnea such as pneumonia, heartworm infestation, and congestive heart failure. More sophisticated tests, such as bronchoscopy, flow volume loops, and radioisotope ventilation scans are available to define the extent of the disease process better. Glucocorticoids remain the mainstay of chronic therapy for most dogs and cats with LAD. Bronchodilators are indicated for most cats with symptoms of acute bronchoconstriction, whereas a smaller number of dogs may respond to bronchodilator administration and demonstrate an increase in exercise capacity and a decrease in cough frequency. LAD in dogs and cats is a progressive disorder, and prognosis is guarded. Nevertheless, with aggressive medical management many of these animals can live relatively symptom-free lives.

Animals↗
PubMedDate not supplied

Review of diagnostic imaging of ear diseases in the dog and cat.

Diagnostic imaging techniques (conventional radiography, computed tomography and magnetic resonance imaging) are an essential tool in the diagnostic work-up of ear diseases. Conventional radiography is commonly used, but often lacks sensitivity. Computed tomography (CT) and magnetic resonance (MR) are complementary imaging studies of the middle ear, labyrinth, internal auditory canal and their contents. CT provides excellent images of bony structures and is indicated where osseous changes are of greatest diagnostic importance. MR is superior in imaging soft tissue components including intralabyrinthine fluid. Therefore, more than one of these imaging techniques may be required in order to make a diagnosis.

Animals↗
PubMed1981

Anemia of inflammatory disease in the dog: ferrokinetics of adjuvant-induced anemia.

Anemia of inflammatory disease induced by injection of adjuvant was characterized by decreases in hematocrit (mean +/- 1 SD, 37.5 +/- 2.7%, as compared with base-line values of 49.8 +/- 2.4%) and hemoglobin (12.54 +/- 1.22 g/dl, as compared with base line of 16.87 +/- 0.96 g/dl) and was classified as unresponsive, normocytic, and normochromic. Disordered iron metabolism was manifest by decreases in serum iron (62.3 +/- 13.6 g/dl, as compared with base line or 113.0 +/- 8.2 g/dl) and shortened mean radioiron clearance half-times (50.0 +/- 12.6 minutes, as compared with base line of 74.0 +/- 13.6 minutes) in the presence of increased bone marrow reticuloendothelial iron. Shortened radioiron clearance half-times reflected maximal extraction of iron from the plasma by the erythroid marrow due to suboptimal iron supply, since extraction of iron by other tissues is minor. Shortened mean marrow transit times (2.79 +/- 0.46 days, as compared with base line of 5.4 +/- 0.64 days) were indicative of adequate erythropoietin stimulation in the anemia of inflammatory disease. Increases in plasma iron turnover rate over base line (1.73 +/- 0.33 mg/dl/day to 1.51 +/- 0.34 mg/dl/day), erythron iron turnover rate (1.50 +/- 0.27 mg/dl/day, as compared with base line of 0.99 +/- 0.27 mg/dl/day), and RBC iron utilization (86 +/- 8.3%, as compared with base-line utilization of 65 +/- 9.3%) indicated erythroid marrow proliferation was effective. The magnitude of erythroid response appeared to be limited mainly by iron supply.

Anemia↗
PubMed1990

Enhanced intestinal permeability to 51Cr-labeled EDTA in dogs with small intestinal disease.

Intestinal permeability in dogs with small intestinal disease was measured by quantitation of 24-hour urinary excretion of 51Cr-labeled EDTA following intragastric administration. Permeability was high in dogs with a variety of naturally acquired small intestinal diseases including wheat-sensitive enteropathy of Irish Setters, small intestinal bacterial over-growth, and giardiasis, and permeability was decreased after successful treatment. These findings indicate that the assessment of intestinal permeability may be a useful technique for detecting small intestinal disease and for monitoring the efficacy of treatment in dogs.

Animals↗
PubMed2026

Antimicrobial resistance in Staphylococcus pseudintermedius isolated from asymptomatic and symptomatic dogs in Montevideo, Uruguay: characterization of MRSP strains and genetic determinants of resistance.

Staphylococcus pseudintermedius&#xa0;is a common opportunistic pathogen in dogs and an increasing concern in veterinary medicine due to rising antimicrobial resistance, particularly to methicillin. This study aimed to characterize resistance profiles and genetic mechanisms in isolates from healthy and diseased dogs in Montevideo, Uruguay. A total of 133 isolates was analyzed (83 from clinical infections and 50 from asymptomatic carriers). Antimicrobial susceptibility was assessed by disk diffusion following veterinary guidelines. Resistance genes and SCCmec types were detected by PCR. Ten representative isolates underwent whole genome sequencing. High resistance rates were observed for penicillin (81%), erythromycin (49.6%), and clindamycin (45%). Overall, 48.9% of isolates were multidrug-resistant. Phenotypic resistance to oxacillin was detected in 26% of isolates; however, 23% carried mecA gene and were therefore classified as genotypic MRSP. These isolates were more frequent among dogs with clinical infections. These strains showed higher resistance to all antimicrobials tested. SCCmec type V was the most prevalent, and greater genetic diversity was found among isolates from symptomatic dogs. Genomic analysis revealed circulating strains of unassigned sequence types (STs), a variety of resistance genes within specific lineages, the circulation of SCCmec XIV cassette carrying strains, and an Oxacillin-susceptible Methicillin-resistant Staphylococcus pseudintermedius (OS-MRSP) isolate. These findings demonstrate the clinical and epidemiological relevance of&#xa0;S. pseudintermedius&#xa0;in Uruguay and the role of asymptomatic dogs as reservoirs of resistant strains. The results emphasize the need for surveillance, prudent antimicrobial use, and integrated control strategies within a One Health framework.

Animals↗
PubMed2006

Vaccine use and disease prevalence in dogs and cats.

A yearly revaccination of adult pets against distemper, the adenoviral and parvoviral diseases is scientifically unwarranted, professionally obsolete and ethically questionable; other vaccinal antigens, however, may need yearly or even more frequent injections. Base immunisation is redefined: it is complete only after the multivalent booster in the second year of life. A yearly revaccination interview, not necessarily an injection, should become the new standard. This interview is a professional service that must be taught, expertly performed and invoiced. Adult animals should be "vaccinated to measure", taking age, breed, lifestyle, the epidemiologic situation, etc. into account. Post-vaccination serology should become a guide in revaccination decisions. For a solid herd immunity, more animals of the population must be vaccinated. The profession should issue regular updates of the 'code of vaccination practice'. To counteract vaccination antagonism, a concerted action of academia, the veterinary profession and industry is required.

Adenoviridae Infections↗
PubMed2004

Surgery of the ear and pinna.

There are several disease processes of the ear and pinna that warrant surgical intervention. This article reviews surgical anatomy and common surgical procedures of the ear and pinna, including aural hematomas, lateral wall resection, vertical ear canal resection, total ear canal ablation and lateral bulla osteotomy, partial pinna resection, and feline inflammatory polyps. The clinical signs, diagnosis, and surgical treatment along with potential complications for each disease process are discussed.

Animals↗
PubMed1984

Hypercalcemia.

Explore the source record for details and available documents.

Addison Disease↗
PubMed2000

Overestimation of the predictive value of positives by the usual calculations of the specificity of diagnostic tests.

The specificity of a diagnostic test for a given disease, i.e. the percentage of true negatives, can be calculated from either the results from a group of healthy animals or possibly from a group which also contains diseased animals which are free of the particular disease for which the test has been performed. The specificity may be much lower in the latter case and the predictive value of positives thus greatly reduced. In the example of creatine kinase being used for the diagnosis of muscle diseases in dogs, the specificity at the thresholds of 105 and 150 U/L (upper limits of the 95% and 99.7% interquantiles) decreased from 0.98 and 1.0 to 0.66 and 0.78, respectively.

Animals↗