Postreinforcement changes of steady potentials in premotor cortex of monkeys.
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Animals↗
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Results for “Contingent Negative Variation”
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Automatic detection and operant reinforcement of slow potential shifts.
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Biofeedback, Psychology↗
Motor, but not sensory, cortical potentials are amplified by high-protein diet.
Animals fed a high-protein diet (50% casein) are hyperactive and more responsive to nociceptive stimuli than those fed either a normal- or low-protein diet. The mechanisms mediating dietary protein-induced behavior are unknown and may include both central and peripheral neural effects. Adult, Sprague-Dawley rats were fed 50% casein (treatment group) and 24% casein (control group) ad lib for 36-40 weeks. The animals were anesthetized with alpha-chloralose and urethane (50 mg/kg and 1.5 mg/kg, IP). EEG recordings were averaged while the anesthetized animal was conditioned using an alerting stimulus-imperative stimulus (AS-IS) paradigm. AS consisted of a 1.5 kHz, 90 dB tone cue. This was followed 2 seconds later by IS, an electrical tail stimulation (11 V, 1.4 s duration). Two negative deflections (N1 and N2) were generated by the frontal cortex during the AS-IS interstimulus interval. N1, an alerting response, was not different between the two groups. N2 amplitude and peak latency were significantly increased in the high-protein group (205% and 117% of control, respectively; p less than 0.05). N2 represents the activation of cells in the motor cortex. Brainstem auditory-evoked responses and somatosensory-evoked potentials also were recorded, but no differences were observed between the two diet groups. These data suggest that consumption of a high-protein diet results in an increase in central arousal mechanisms (measured by cortical negativity response), specifically involving increased excitability of the motor cortex, that is not associated with a disorder of information processing in the cerebral cortex (measured by brainstem auditory-evoked responses and somatosensory-evoked potentials).
Animals↗
Electroencephalographic and dichotic indices of cerebral laterality in stutterers.
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Adult↗
Automatic and attentional processing: an event-related brain potential analysis of semantic priming.
Event-related brain potentials (ERPs) and behavioral measures (reaction time and percentage errors) were measured in a semantic priming lexical decision task. In one block of trials, instructions and the proportion of related word pairs were designed to influence subjects to process the first member of each pair (prime) automatically. In another block, subjects were induced to attend to the meaning of each prime. ERPs to the primes were more positive between 200 and 600 msec and more negative between 750 and 1150 msec when subjects attended to the primes as opposed to when only automatic processing was required. Target word ERP activity between 200 and 525 msec (N400) was more negative in the neutral than in the semantically related condition in both blocks of trials, but more so in the attentional block, while a late ERP positively between 525 and 1100 msec (Slow Wave) was more positive in the unrelated than the neutral condition, but only in the attentional block. The results are discussed in terms of the two-process model proposed by Posner and Snyder (1975a, 1975b).
Adolescent↗
Event-related potentials and the phonological matching of picture names.
Event-related potentials (ERPs) were recorded from one midline and three pairs of lateral electrodes while subjects determined whether a pair of sequentially presented pictures had rhyming or nonrhyming names. During the 1.56-sec interval between the two pictures, the slow ERP wave recorded over the left hemisphere was more negative-going than that over the right, especially at frontal electrodes. The ERPs evoked by the second picture differed as a function of whether its name rhymed with its predecessor. This difference, taking the form of increased negativity in ERPs to nonrhyming items, had an earlier onset and a greater magnitude at right than at left hemisphere electrodes. This pattern of ERP asymmetries is qualitatively similar to that found when words are rhyme-matched. It is therefore concluded that such asymmetries do not depend on the employment of orthographic material and may reflect some aspect(s) of the phonological processing of visually presented material.
Adolescent↗
Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain.
This paper presents a new method for localizing the electric activity in the brain based on multichannel surface EEG recordings. In contrast to the models presented up to now the new method does not assume a limited number of dipolar point sources nor a distribution on a given known surface, but directly computes a current distribution throughout the full brain volume. In order to find a unique solution for the 3-dimensional distribution among the infinite set of different possible solutions, the method assumes that neighboring neurons are simultaneously and synchronously activated. The basic assumption rests on evidence from single cell recordings in the brain that demonstrates strong synchronization of adjacent neurons. In view of this physiological consideration the computational task is to select the smoothest of all possible 3-dimensional current distributions, a task that is a common procedure in generalized signal processing. The result is a true 3-dimensional tomography with the characteristic that localization is preserved with a certain amount of dispersion, i.e., it has a relatively low spatial resolution. The new method, which we call Low Resolution Electromagnetic Tomography (LORETA) is illustrated with two different sets of evoked potential data, the first showing the tomography of the P100 component to checkerboard stimulation of the left, right, upper and lower hemiretina, and the second showing the results for the auditory N100 component and the two cognitive components CNV and P300. A direct comparison of the tomography results with those obtained from fitting one and two dipoles illustrates that the new method provides physiologically meaningful results while dipolar solutions fail in many situations. In the case of the cognitive components, the method offers new hypotheses on the location of higher cognitive functions in the brain.
Brain↗
Event related brain potentials and human pain: a first objective overview.
Since 1960 systematic studies of the human scalp-conducted cerebral slow-wave response to painful stimulation have shown only amplitude augmentation of the vertex components of the somatosensory evoked potential (SEP) to be indicators of subjective perception of a noxious or aversive quality in the stimulus. The vertex potential (VP) of the SEP occurs relatively late after onset of either transient or maintained stimuli (100-400 ms depending on stimulus mode and site), is amplitude-focal at vertex on scalp, and may be asymmetrically distributed hemispherically for unilateral stimulation of the hands. Its functional neuroanatomy seems undeterminable by scalp macroelectrodes, and its relationship to analogous vertex potentials in the auditory and visual modalities (AEP and VEP) unknown. Studies of the nociceptive SEP (SEPn) since 1977 concur that VP amplitude is more readily correlatable with subjective pain magnitude estimate than with objective stimulus parameters. They also suggest that the VP is amplitude-sensitive to (a) interstimulus-intervals less than about 350 ms; (b) analgesics and their antagonists; and (c) subjective cognitive status with regard to both the expected aversiveness of the stimulus and the previous experience of chronic pain. These studies have included electrical stimulation of toothpulp and teeth, mechanical and transcutaneous electrical stimulation of palmar and digital glabrous skin, noxious thermal stimulation of hands and forearms, and electrical stimulation of lips, fingers, toes, and anogenital perineum of both sexes. They have been done in the context of both classical and signal-detectability (TSD) methods for concurrent reports of painful versus painless, and in the methodological contexts of conventionally signal-averaged SEP and of single-epoch SEP recovered both raw and processed. Studies designed to analyze differences in the early-intermediate (25-95 ms) and late (500-1000 ms) time-segments of SEP for painful and painless stimulation have provided no convincing evidence of cortical nociceptive signals. Therefore existing data on the SEPn imply that the only cortical slow-wave sign of nociception reflects perceptual-cognitive and endogenous, rather than sensory-discriminative and exogenous, aspects of the conscious pain experience.
Brachial Plexus↗
Cerebral asymmetry and the psychophysiology of attention.
The literature relevant to psychophysiological aspects of the lateralized control of attention is reviewed. It is argued that the description of attention as a dynamic process tends to obscure examination of the structural determinants of attentional asymmetries. Psychophysiological evidence suggests that a right hemispheric predominance in attention is quite possibly the natural outcome of a similar asymmetry in activational, interoceptive and early visual processes.
Arousal↗
Asymmetry of brain potentials related to sensorimotor tasks.
The present study investigates the hemispheric specificity of event-related (ERP) and slow potentials (SP) of the brain during preparation and performance of sensorimotor (haptic) tasks. Tasks were selected which have been assumed to be processed primarily by only one brain hemisphere. ERPs, SPs and spontaneous EEGs were obtained from both hemispheres (C3-C4, P3-P4) and from Fz and Cz in a constant foreperiod (6 s) paradigm. Warning and task stimuli comprised up to four tactile stimuli, applied to index and middle finger of each hand. To maximize lateralized processing, the right-hand task required counting, the left hand task pattern matching. Components of the ERP (N1, P3, SW) and of SPs show task-dependent lateral asymmetry with the larger amplitudes contralateral to the preparing and responding hand. Results confirm hemisphere-specific processing of the tactile tasks but quantification as indicated by ERP amplitudes show considerable activity in both hemispheres. The SP-distribution rather reflects task-specific preparation than general alertness or orienting.
Adult↗
A peak detector program for event-related potentials.
A computer program, developed for peak detection of averaged evoked potential waveforms, is described. The program is able to automatically score up to 200 data files in a single session. The user is asked to define intervals (windows) in which a maximum peak is to be detected. The program can optionally search each EEG channel or a single 'reference' channel from which all other channels will be compared. The mean amplitude of several data points can also be computed within a particular window. When evoked potentials are particularly noisy, it is possible to estimate the 'signal' in the higher frequency background 'noise'. Because the program is written in BASIC, it can be readily transferred to many different computer systems.
Arousal↗
The 'oddball CNV' as an indicator of different information processing in patients with panic disorders.
In previous studies we found an inverse relationship between CNV amplitude and the probability of the occurrence of the warning stimulus (S1) in a cued reaction time task. The aim of the present study was to investigate this 'oddball effect' on CNV amplitude (Oddball CNV) in patients with anxiety disorders, since this effect describes the influence of event probability on reactive as well as proactive components of information processing. Patients suffering from panic disorders with or without agoraphobia and controls participated in a choice reaction time experiment. The subjects' task was to respond to flashes (S2s), cued 4 s in advance in random order by one of two easily distinguishable acoustic stimuli (S1a, S1b). In condition 1 the probability of S1a and S1b was 0.2 and 0.8, respectively, and in condition 2 0.5 for both S1s. The DC-EEG was recorded from F3, F4, C3, Cz, C4 and P3, linked mastoids as the reference. The data obtained confirm the oddball effect on the CNV amplitude, show clear deviations of patients in this effect, and also indicate remarkable differences in CNV shape between patients and controls. These observations are discussed as differences in information processing and information utilization.
Adult↗
Sensory-evoked potentials as indices of neurotoxicity in the rat: effect of 4-tert-butyltoluene.
The use of evoked potentials to measure neurotoxicity was evaluated using 4-tert-butyltoluene (TBT) as a test compound. Male Wistar rats were habituated to the recordings of auditory- and flash-evoked potentials until the combined waveform of the evoked potentials reached a steady state. The rats were then divided into three groups and exposed to 0, 50 and 150 ppm TBT for 6 h, and the auditory- and flash-evoked potentials were measured for up to 288 h after exposure. Event-related potentials specifically associated with the temporal pairing of auditory and visual stimuli were not apparent in the recordings. The peak-to-peak values of selected components, integrated amplitude and power spectra of the waveforms in exposed rats were significantly different from control values for at least 288 h in the group exposed to 150 ppm TBT and for 120 h in the group exposed to 50 ppm TBT. It is concluded that evoked potentials may be used for detection and characterization of minor neurofunctional changes due to low-dose exposure to chemicals.
Acoustic Stimulation↗
Cortical potentials associated with voluntary biting movement in humans.
We compared the distribution of Bereitschaftspotentials (BPs) on both sides of the scalp preceding jaw biting movements in order to identify the relationship between the cortical regions and the activation of the masseter muscle in 10 healthy subjects. The BPs were recorded from the midline-central, central and temporal areas of the scalp according to the international 10-20 system, preceding self-paced biting on one side. The cortical negative potentials began 1.0 approximately 1.5 s before the EMG onset of the masseter muscle. All of these negative potentials could be considered to be BPs, and the additional negative slope component (NS) occurred 70 approximately 80 ms before the EMG onset of the masseter muscle. The BPs were detected from all the recorded regions of the scalp, while the NS was observed only from the bilateral temporal area. The amplitudes of BPs and NSs were largest in the temporal areas (T3 and T4) that were ipsilateral to the biting. The rates of occurrence of NS at T3 and T4 ipsilateral temporal areas were 80% and 60%, respectively. These results suggest that unilateral biting movements may be controlled mainly from the ipsilateral hemisphere.
Adult↗
Spatial cueing, sensory gating and selective response preparation: an ERP study on visuo-spatial orienting.
Event-related brain potentials (ERPs) were recorded in a visuo-spatial attention task where the position of an imperative stimulus was indicated either validly or invalidly by a central arrow (trial-by-trial cueing). Subjects had to perform choice RT tasks with the response being dependent either on the identity of the target stimulus or on its position. When target identity was relevant for response selection, validly cued stimuli elicited amplitude enhancements of the early, sensory-evoked P1 and N1 components at lateral posterior sites. The N1 validity effect was limited to scalp sites ipsilateral to the visual field of stimulus presentation. Although these effects were found only when the sensory discrimination task was considerably difficult, they are in line with models assuming that modulations of sensory-perceptual processing ("sensory gating") are induced by spatial cueing. However, when target location was response-relevant, N1 amplitude enhancements were consistently elicited by invalidly cued letters. CNV and LRP measures indicated that the arrow elicited response-related processing in the cue-target interval. Such processes occurred even when the cue contained no information about an upcoming response. Two consecutive lateralization phases were distinguishable in the LRP, with experimentally induced response assignments becoming effective only during the second phase.
Adult↗
The modulation of somatosensory evoked potentials during the foreperiod of a forewarned reaction time task.
During the foreperiod of a forewarned reaction time (RT) task reflexes in the executing limb increase to a lesser extent than those in the contralateral limb. This is possibly due to input modulation. The present study investigates the possibility of cutaneous sensory modulation during motor preparation by studying the amplitudes of somatosensory evoked potentials (SEPs). Eighteen subjects performed a forewarned RT task with the same fingers as the ones which were electrically stimulated. SEPs evoked during the 4 sec preparatory period were compared to those evoked during movement execution and during the resting period after the motor response respectively. During response execution most SEP components showed smaller amplitudes, i.e., they were gated, which agrees with other studies. In the first part of the foreperiod no SEP modulation was observed. Towards the end of the foreperiod, 500 msec before the response stimulus (RS), the amplitude of the contralateral parietal N70-P100 was significantly decreased, while the P45-N70 showed a similar tendency. However, at the same time the P100-N140 was increased in amplitude. The decrease of the intermediate latency components towards the end of the foreperiod is discussed in terms of gating, while the increase in the long latency component is discussed with respect to a decrease in RT on trials where the fingers were stimulated just before the RS, pointing to the role of attentional mechanisms.
Adult↗
CNV-like potentials on the cortical surface associated with conditioning in head-restrained rats.
Head-restrained rats were conditioned to perform a CNV task: to press a lever in response to an imperative auditory stimulus (S2) given 1.5 sec after a warning stimulus (S1) for a drop of jelly food. With an electrode on the surface of the forelimb cortex, (1) sharp wave complexes immediately after S1 and S2, and (2) a negative slow potential (SP) between S1 and S2, on which early and late components were discernible, were recorded in association with performance of this task. With the electrode at a depth of 2 mm in the same cortical area, the corresponding field potential showed a long-lasting positive shift in addition to the components of the surface potential. These monopolar recordings were obtained with respect to a common reference at the frontal sinus. The surface-minus-depth potential (the transcortical potential), consequently, showed a surface-negative tonic wave, confirming Pirch's report (1980). During extinction of this conditioning, the SP between S1 and S2 disappeared, while the sharp waves following S1 and S2 remained with little modification, suggesting that the sharp waves are a kind of evoked potential (EP) elicited by the stimuli. Recording from 5 surface electrodes set in an array over the left hemisphere contralateral to the used forelimb during development of the conditioning revealed not only a spatial distribution of the SP but also a transition of the potentials. As the conditioning progressed, the negativity of the early SP component tended to increase, while that of the late component tended to decrease and was confined to the sensorimotor cortex.(ABSTRACT TRUNCATED AT 250 WORDS)
Acoustic Stimulation↗
Bereitschaftspotential in idiopathic and symptomatic restless legs syndrome.
Patients with idiopathic and symptomatic restless legs syndrome (RLS) suffer from "dyskinesia while awake" or "daytime myoclonus" when at rest preceded by sensory symptoms. In order to characterise the RLS either as reflex movement or as voluntary movement we measured movement-related cortical potentials in 5 idiopathic and 8 uraemic RLS patients. Movements from both legs were polygraphically recorded concomitantly with cortical activity 2000 msec before to 500 msec after onset of EMG activity. These data were compared with a voluntary simulation of each patient's movement pattern and with 5 age-matched controls performing dorsiflexion of the right, left and both feet. Cortical activity preceding daytime myoclonus was absent in RLS patients whereas self-initiated leg movements in patients elicited onset times (1180-1380 msec) and amplitudes of Bereitschaftspotential (readiness potential) not significantly different from readiness potentials in control subjects (P > 0.05). Lack of movement-related potentials in myoclonus and/or dyskinesias during daytime in RLS patients is compatible with an involuntary mechanism of induction and points towards a subcortical or spinal origin of RLS.
Adult↗