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The action of anti-inflammatory drugs on the fertility of female rats with intrauterine contraceptive devices.

A silk thread (0-0) or a copper wire (0.18 mm diameter) was placed in the left uterine horn of rats, at least 3 days before fertilization. The animals were untreated or given daily injections of 3 mgh hydrocortisone or 30 mg aspirin beginning the day after insertion of the IUD; 2 weeks after coitus, the animals were killed. A longitudinal (less than or equal to 10 mm) silk thread and the copper wire were effective IUDs regardless of treatment. With the short silk thread (less than or equal to 2 mm), implantation occurred in all groups of rats but a high failure rate was observed in hydrocortisone-treated rats (5/9 with implantations). The no. of implantations/no. of corpora lutea (x 100) was much higher (20.4%) in rats treated with aspirin and hydrocortisone than in untreated animals (3.2%) (P less than 0.01). We conclude that the effectiveness of an IUD can be altered by treatment with an anti-inflammatory substance.

Animals↗

[Laparoscopic treatment of peri-appendicitis caused by intrauterine contraceptive device].

BACKGROUND: Intrauterine device may perforate the uterus and cause several complications. AIM: To report a case of laparoscopic treatment of peri-appendicitis caused by intrauterine device. PATIENT AND METHOD: A young female presented with pain in the right lower abdomen of 4 days of duration. On the physical examination, she had localized abdominal pain in the right lower abdomen with discrete guarding and pain on percussion and rebound tenderness. Ultrasonography showed an intrauterine device outside of the uterus, in the right lower of the abdomen. RESULTS: At laparoscopy, an inflammatory mass that consisted of the intrauterine device blocked by the mesoappendix and the appendix was observed. Appendectomy and removal of the intrauterine device were performed. CONCLUSION: Laparoscopy allows adequate treatment of peri-appendicitis caused by intrauterine device, inclusive with complete evaluation of the entire pelvic region to rule out associated complications

Adult↗