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PubMedDate not supplied

Polyamines: current review and their perspectives in neurosurgery.

A short review of polyamines and their possible clinical interest and applications in the field of brain neoplasms is presented. Dosage of CSF polyamines was proved to be useful in monitoring patients with medulloblastomas and others malignancies with meningeal involvement. Polyamines and their enzymes in neoplastic tissue may correlate to tumor growth. Inhibition of polyamines synthesis by drugs may be a possible way of slowing down tumor growth.

Animals↗
PubMedDate not supplied

Needle aspiration cytology of intracranial lesions. A review of 84 cases.

Eighty-four needle aspirates of tumors and other intracranial lesions were diagnosed using smear preparations stained with Papanicolaou and Diff Quick stains. In 66 cases the cytologic diagnosis was compared with a histologic diagnosis on material removed during a craniotomy. In 92% of the cases the cytologic diagnosis agreed with the histologic diagnosis. In 21 cases the aspiration was performed under local anesthesia through a twist drill orifice. In none of these cases were there any complications secondary to the aspirations. The needle aspiration of intracranial lesions appears to be a safe and reliable diagnostic procedure.

Astrocytoma↗
PubMed1982

[Computed tomography and/or ventriculography? (author's transl)].

It is discussed if in intracranial tumors, especially in tumors of the posterior cranial fossa, a CT and/or a ventriculography should be practiced. We have made investigations of 134 patients, 93 of whom were children up to 14 years of age. Each case was undertaken computed tomography as well as ventriculography. The results are clearly demonstrating the superiority of computed tomography compared with ventriculography. Ventriculography is a surgical intervention stressing the patients, side-effects may occur, and sometimes serious complications are caused. Modern computed tomography is producing pictures of high quality, which are highly sufficient for neurosurgical intervention. Very rarely additional angiography has to be performed. The diagnosis of intracranial tumors can fully be established by computed tomography, whereas ventriculography is no longer necessary.

Adolescent↗
PubMed1982

[Metastases of the central nervous system: A prospective study. 2nd Communication: site and distribution patterns of brain metastases].

Among 737 malignant tumors, 93 (12.6%) cases showed metastases within the brain substance. There was no predominance for one of the both hemispheres. However, the cerebellum was a privileged site for metastases (48 out of 93 cases, 51.6%). Multiple metastatic nodules of the brain were found in 65 cases; single metastases occurred 18 times (ratio 3.6 to 1). 11 cases displayed a carcinosis of the leptomeninges and 5 a carcinosis of the brain (table 3). Within the cerebrum we observed 1,060 metastatic nodules (fig. 1). 210 secondary deposits, i.e. one sixth of all nodules, were localized in the cerebellum. Concerning the distribution patterns of the metastases, it is remarkable that an increasing frequency of nodules was seen from the frontal lobes (241) to the parietal (259) and occipital lobes (276), whereas the temporal lobes (146) were significantly less affected. 936 out of a total of 1,270 brain metastases (73.7%) showed a size of the nodules not larger than a pea (table 8.) The source of more than two thirds of all metastatic deposits (875/1,270 = 68.9%) was a carcinoma of the lung (bronchial carcinoma, resp.). With the exception of metastases in the pituitary gland, pineal gland and choroid plexus (compare with the 3rd communication on CNS metastases) 18.6 metastatic brain nodules were observed per lung carcinoma. However, the highest frequency per case with brain metastases was registered in thyroid cancer (40 nodules, table 8).

Aged↗
PubMedDate not supplied

[Basic principles of electron microscopic diagnosis of human brain tumors].

Electron microscopy of two hundred brain tumours of various origin allowed the authors to elaborate the main principles of electron microscopic diagnosis. A comprehensive approach to determining the comparative diagnostic value of the morphological signs of the tumour and the initial normal tissue and the high resolving capacity of the electron microscope provide for trustworthy identification of tissue origin of the new growth that is examined. The electron microscopic method is particularly important when diagnostic difficulties arise on the light-optic level of the morphological examination.

Astrocytes↗
PubMed1980

[Metastatic chorionepithelioma of the brain].

Under examination there were 37 patients with uterine, and 3 with testicle chorioepithelioma with metastases to the brain (35 patients) and the spinal cord (5 patients). The particular malignancy of the tumour which rapidly involved the vessels was the cause of perifocal hemorrhages and hemorrhages to the brain matter. This makes the clinical course of the disease especially grave. Twenty-eight patients died: most of them had multiple metastases to the brain. Twelve patients were dismissed: 5 of them with a certain improvement of the state and 7 with the disease still progressing.

Adolescent↗
PubMed1980

[Extracranial metastases from medulloblastoma: report of four cases (author's transl)].

Four cases of bone and pulmonary metastases of medulloblastoma histologically diagnosed and with an exhaustive clinical-radiological and scintigraphic documentation, are described. In three patients, one of which non operated, the metastases of the osteolytic and osteoblastic type affected diffusely the skeleton; in the fourth patient the bone lesions were associated with a single pulmonary metastasis. The modality of metastatic spread and the clinical course of the illness in the diagnostic and therapeutic aspects are discussed.

Adolescent↗
PubMedDate not supplied

[Computed X-ray tomography in cases of metastatic brain tumors].

The authors describe the role of computerized tomography in the diagnosis of metastases to the brain and orbit, and analyse computer tomography findings in different types of metastases. Because the metastases are visualized better after administration of contrast medium the importance of this tomography done before and after administration of contrast medium is discussed.

Adult↗
PubMed1995

Malignant cerebral edema and intracranial hypertension.

Cerebral edema and intracranial hypertension occur frequently in neurologic patients. Proper understanding of the pathophysiology of each entity allows prompt recognition and rational therapeutic goals, allowing for better neurologic outcome in many disease states. The recognition of cerebral edema as a distinct entity allows the clinician to treat focal pressure gradients in the brain separately from more diffuse intracranial pressure elevations, appreciating the benefits and pitfalls of directed therapies for each process. The treatment of many of the disorders that cause cerebral edema and intracranial hypertension is heuristic, challenging the managing physician's thorough understanding of cerebral hemodynamics and his or her ability to encounter the human aspects of determining appropriate levels of care for individual patients.

Aged↗