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Rave drugs: pharmacological considerations.
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[A lazy patient--or is there more to the symptom?].
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[Three narcoleptic syndromes. Catamnestic and polygraphic results].
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[Illness. I am suddenly so sleepy!].
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Diagnosis of equine neurologic problems.
This is a review of the more common diseases of the spinal cord and various areas of the brain of horses. The results of a two and one-half year study of spinal cord disease are emphasized. After a description of the lesion the salient clinical signs are described and the features that differentiate them from other similar diseases. In the seminar, films of case and slides of lesions will be shown to document these diseases.
Narcolepsy: a family study.
We obtained medical and psychological assessments and 48-hr polysomnographic recordings on five sisters, three of whom had narcolepsy. Of the three, two were identical twins. All three narcoleptic sisters cited emotional stress and environmental demands for sustained performance as the major factors which aggravated their symptoms, and corresponding to this, the illness followed a different life course in each of the three. Most striking were the differences between the twin sisters in clinical symptoms and polysomnographic signs. One sister suffered from all the symptoms of narcolepsy and her sleep recording showed the typical sleep onset REM periods of the disease. Her twin suffered only from excessive daytime drowsiness and her sleep recording was normal--at least by the usual criteria. The sleep of all three narcoleptic sisters, however, was significantly more fragmented than that of their normal siblings. Our data suggested that excessive sleep fragmentation was a basic feature of narcolepsy and that it betrayed a constitutional predisposition for sleep to dissociate into its components and to become distributed around the nycthemeron. This process could be aggravated by emotional stress and by environmental demands for sustained vigilance, and this in turn, created the differences in symptoms and signs between individuals with identical genetic predispositions.
[Excessive daytime sleepiness. Implications in internal medicine].
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The effects of total sleep deprivation in narcoleptics.
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REM sleep and NREM sleep in narcolepsy and hypersomnia.
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Pathophysiological mechanisms of narcolepsy, hypersomnia and dissociated sleep disturbances.
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[119 cases of traumatic epilepsy].
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[Physiopathology of hypersomnias].
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[Neurophysiological characteristics of nercoleptic symptoms].
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