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PubMed1979

Psychiatric illness among adults adopted as infants.

In an epidemiological study of 2,323 adopted adults, the registrations about sick-leave, diagnoses and hospitalization (F-cards) from the National Health Insurance were studied. There was a significantly higher frequency of psychiatric illness among the adoptees compared with non-adopted controls. A classification into different diagnostic groups from the records of psychiatric hospitals showed an over-representation due to alcohol and drug abuse and personality disorders in both male and female adoptee groups compared with non-adopted controls. There was also an over-representation in the male adoptee group due to neuroses.

Absenteeism↗
PubMed1980

A prospective, longitudinal study of children registered for adoption. A 15-year follow-up.

A cohort of 624 children, candidates for adoption as infants, were investigated at 11 and 15 years of age. At 11 years these children ran a greater risk than classmates of developing nervous disturbances and symptoms of maladjustment, regardless of whether they were growing up in adoptive home, a foster home or with their biological mother. At 15 years there was little difference in adjustment between the adopted children and their classmates, whereas children growing up in foster homes or with their biological mothers displayed a high proportion of social maladjustment and/or underachievement at school. The implications of these findings for child placement policies are discussed.

Adolescent↗
PubMed1993

Does obesity run in families because of genes? An adoption study using silhouettes as a measure of obesity.

A number of studies, including the Danish adoption study, have shown that, in adults, the familial resemblance of obesity, as measured by the body mass index (weight in kg/(height in m)2), is mainly due to genes. The body mass index may reflect both fat and fat-free body mass. In this further analysis of the Danish adoption study, the degree of obesity was assessed by a silhouette score. There was a significant relationship in scores between the adult adoptees and their biological mothers and between the adoptees and their biological full siblings reared by the biological parents. Weaker, nonsignificant associations were found for the biological fathers and for the maternal and paternal half-siblings. There were no relationships in silhouette scoring between adoptees and adoptive parents. The results confirm the results of our previous analysis of body mass index. We conclude that human obesity is under genetic control, whereas the childhood family environment has little, if any, influence on obesity in adults. It is an important task for future research to identify the genes involved.

Adoption↗
PubMed2006

Adoptive transfer of paternal antigen-hyporesponsive T cells facilitates a Th2 bias in peripheral lymphocytes and at materno-fetal interface in murine abortion-prone matings.

PROBLEM: To investigate the Th1/Th2 cytokine changes in abortion-prone recipient mice adoptively transferred by the paternal antigen-hyporesponsive T cells. METHOD OF STUDY: The paternal antigen-hyporesponsive T cells were generated by the anti-B7 monoclonal antibody (mAb) treatment and adoptively transferred into pregnant CBA/J mice of abortion-prone matings on day 4 of gestation. The intracellular expressions of Th1 cell-derived cytokine, tumor necrosis factor-alpha, gamma-interferon and interleukin-2 (IL-2) and Th2 cell-derived cytokine, IL-4 and IL-10 in the maternal spleen were analyzed by flow cytometry, and secretions of the Th1 and Th2 cytokines in supernatant of the feto-placental unit culture were analyzed by an enzyme-linked immunosorbent assay. RESULTS: Our findings showed the increased secretion of Th1 cytokines and the decreased secretion of Th2 cytokines in abortion-prone matings. Treatment with anti-B7 mAbs on day 4 of gestation enhanced Th2 and reduced Th1 cytokine production in abortion-prone matings. Similarly, adoptive transfer of paternal antigen-hyporesponsive T cells induced maternal tolerance to the fetus and displayed a Th2 bias both in the peripheral lymphocytes and at the materno-fetal interface of the abortion-prone matings. CONCLUSIONS: These findings indicate that the Th2 cytokine bias and an increase in fetal viability induced by the anti-B7 mAb treatment can be transferred to other pregnant mice of the abortion-prone matings.

Abortion, Spontaneous↗
PubMed2005

Value of routine chest radiography in the medical screening of internationally adopted children.

AIM: To assess the value of the routine chest radiography as part of the medical evaluation of newly arrived, internationally adopted children. METHODS: We evaluated the use of routine chest radiography (CXR) in the medical screening of 1598 internationally adopted children. RESULTS: CXR showed abnormalities in 128 cases: 38 of these findings were already known and/or consistent with obvious clinical signs or symptoms, and 54 had no clinical relevance. In two patients, CXR raised the suspicion of tuberculosis. CONCLUSION: The routine use of CXR in the screening of internationally adopted children rarely yields new, clinically relevant, information and should be performed on indication only.

Adoption↗
PubMed2006

Gay-male couples who adopt: challenging historical and contemporary social trends toward becoming a family.

TOPIC: Gay-male couples who adopt children face ongoing challenges that stem from both historical and contemporary social issues. PURPOSE: To examine and identify key points and guidance for advanced practice psychiatric mental health nurses regarding multicultural awareness involved in counseling gay-male couples who explore or exercise their right to adopt and raise children. SOURCES: A comprehensive review of the extant scientific literature and public media, clinical anecdotes, therapeutic experiences, and an examination of Healthy People 2010 as it relates to how community health is profoundly affected by the collective beliefs, attitudes, and behaviors of everyone who lives in the community. CONCLUSIONS: Heterosexism, homophobic fears, oppression, and the general stigma that surround gay-male couples who choose to adopt children are a few of the relevant contemporary issues and community beliefs for which advanced practice psychiatric mental health nurses need to assess, explore, and intervene.

Adoption↗
PubMedDate not supplied

A primary prevention group for latency age children dealing with adoption issues.

The authors describe an eight-session primary prevention group program for latency age children who were dealing with adoption issues. The structure and the process of the group are described and the effectiveness of the program is evaluated. One of the authors, who is both an adoptive parent and a nurse psychotherapist, was the group leader. The group served to facilitate the lifelong process of dealing with adoption issues.

Adaptation, Psychological↗
PubMed1994

Evidence of heterogeneity of genetic effect in Iowa adoption studies.

This paper describes male adoption studies at the University of Iowa using private and public adoption agencies within the state of Iowa from 1974 to the present time. This research involves four large studies, the first two of which demonstrated significant genetic as well as environmental effects in the etiology of alcoholism as well as significant correlations between adoptee conditions of antisocial personality and alcohol abuse. Findings in the first two studies were similar. However, the third study, using a sample from Catholic-sponsored adoption agencies across the state, failed to show a genetic effect. The final and fourth study was designed in part to look for heterogeneity in the manifestation of a genetic factor from one sample to another in the Iowa studies. This was done by sampling from two agencies, one of which had shown a genetic effect and the other that had not. In this fourth study, the agency that had not shown a genetic effect in the previous study also failed to show an effect, but the agency that had shown a significant genetic effect in the past did demonstrate a significant genetic effect. There were two remaining agencies in the fourth study for which no comparison with past samples could be made. One of these agencies showed a marginally significant genetic effect and the other showed no effect. Statistical analysis of this last study suggested that observed variability in the odds ratio from sample to sample was due to differences in manifestation of the genetic effect.

Adoption↗
PubMed1990

Social factors associated with the decision to relinquish a baby for adoption.

Little is known about the characteristics, social circumstances and mental health of women who give a child up for adoption. This paper reports data from a longitudinal study of 8556 women interviewed initially at their first obstetrical visit. In total, 7668 proceeded to give birth to a live singleton baby, of which 64 then relinquished the baby for adoption. Relinquishing mothers were predominantly 18 years of age or younger, in the lowest family income group, single, having an unplanned and/or unwanted baby and reported that they were not living with a partner. These women were somewhat more likely to manifest symptoms of anxiety and depression both prior, and subsequent to, the adoption, but the majority of relinquishing mothers were of 'normal' mental health. The decision to relinquish a baby appears to be a consequence of an unwanted pregnancy experienced by an economically deprived single mother rather than the result of emotional or psychological/psychiatric considerations. These findings document a particular dimension of the impact of poverty on health.

Adolescent↗
PubMed1976

Some aspects of adoption in selected samples of adult adoptees.

Various aspects of adoption--psychopathology, age at placement, agency versus independent placement, best age to tell child he is adopted, etc.--are studied in three groups of adoptees: biological parent schizophrenic or manic-depressive; adoptive parent schizoprenic or manic-depressive; biological parent with no psychiatric history. Findings raise questions about a number of common assumptions regarding adoptees.

Adoption↗
PubMed1985

Adoption through the eyes of adult adoptees.

This study presents results of a survey of 100 adopted adults who contacted a social service agency or search group. Their perspectives on the experience of adoption and their reasons for agency contact are compared with recommended adoption practice of a generation ago and with reports from the clinical literature.

Adolescent↗
PubMed1984

Genetic influences in criminal convictions: evidence from an adoption cohort.

The possibility that genetic factors are among the causes of criminal behavior was tested by comparing court convictions of 14,427 adoptees with those of their biological and adoptive parents. A statistically significant correlation was found between the adoptees and their biological parents for convictions of property crimes. This was not true with respect to violent crimes. There was no statistically significant correlation between adoptee and adoptive parent court convictions. Siblings adopted separately into different homes tended to be concordant for convictions, especially if the shared biological father also had a record of criminal behavior.

Adoption↗
PubMed1977

Assortative mating by unwed biological parents of adopted children.

Analyses of data obtained from 662 unwed couples whose children were relinquished for adoption reveal that biological parents of adopted children mate assortatively. For physical characters, assortative mating of unwed parents was similar to that of wed parents; for behavior characters, however, there was less assortative mating by the unwed parents. Because assortative mating inflates estimates of genetic parameters in adoption studies, future studies should collect information on both biological parents.

Adoption↗
PubMed1994

Cryptosporidium muris in adult mice: adoptive transfer of immunity and protective roles of CD4 versus CD8 cells.

The aim of this study was to investigate the role of the CD4 and CD8 T cells in immunity to cryptosporidia by using Cryptosporidium muris and a mouse model of infection. Two approaches were used, each involving the use of rat anti-T-cell surface marker monoclonal antibodies (MAbs). In the first, the adoptive transfer of immunity was studied by using the CB.17 SCID mouse (which lacks T and B cells) as the host; in the second, the effect on susceptibility of BALB/c mice to infection was examined following depletion of T cells or subsets of T cells. In adoptive immunity experiments, the conditions which differentiated between resistance associated with reconstitution of SCID mice with naive BALB/c lymphocytes and the transfer of immunity with primed lymphocytes from infected animals were determined. Primed spleen or mesenteric lymph node cells conferred better protection to recipients than naive cells when obtained from donors which had developed resistance to infection. Adoptive immunity was abrogated when Thy.1 cells or CD4 cells were depleted from primed cells, while depletion of CD8 cells could reduce the level of protection. In the study of C. muris in BALB/c mice, treatment with either anti-Thy.1 plus anti-Lyt.1 or anti-CD4 MAbs increased susceptibility to a primary infection as determined by the size and duration of oocyst production, but an anti-CD8 MAb produced an increase only in oocyst shedding. Thus, both CD4 and, to a lesser extent, CD8 cells appeared to be involved in resistance to primary and secondary C. muris infection.

Animals↗
PubMed1995

CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract.

The ability of CD4+ and CD8+ T cells to adoptively immunize mice against Chlamydia trachomatis infection of the mouse genital tract was studied. Adoptive transfer experiments were performed with splenic CD4+ or CD8+ T cells obtained from mice following resolution of a primary genital tract infection and after a secondary chlamydial challenge. The results show that donor CD4+ T cells, but not CD8+ T cells, obtained from mice following resolution of a primary infection or after secondary challenge were effective in transferring significant antichlamydial immunity to the genital tracts of naive animals. The lymphokine profiles in the culture supernatants of proliferating Chlamydia-specific CD4+ T cells obtained from mice following resolution of a primary infection and after secondary challenge were assayed by an enzyme-linked immunoadsorbent assay. Protective CD4+ T cells restimulated in vitro secreted interleukin 2, gamma interferon, and interleukin 6, lymphokine profiles characteristic of both Th1- and Th2-like responses. Resting CD4+ T cells obtained from mice 4 months following resolution of a primary infection were also capable of conferring significant levels of adoptive protective immunity to naive mice. These findings support an important role for CD4+ T cells in acquired immunity to chlamydial infection of the genital tract and indicate that protective CD4+ immune responses in this model are relatively long lived.

Animals↗
PubMed1998

Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model.

We have developed an adoptive cell transfer model in mice to study the ability of a glycoprotein conjugate vaccine to induce immunologic memory for the polysaccharide moiety. We used type III capsular polysaccharide from the clinically relevant pathogen group B streptococci conjugated to tetanus toxoid (GBSIII-TT) as our model vaccine. GBS are a major cause of neonatal infections in humans, and type-specific antibodies to the capsular polysaccharide protect against invasive disease. Adoptive transfer of splenocytes from mice immunized with the GBSIII-TT conjugate vaccine conferred anti-polysaccharide immunologic memory to naive recipient mice. The transfer of memory occurred in a dose-dependent manner. The observed anamnestic immune response was characterized by (i) more rapid kinetics, (ii) isotype switching from immunoglobulin M (IgM) to IgG, and (iii) 10-fold-higher levels of type III-specific IgG antibody than for the primary response in animals with cells transferred from placebo-immunized mice. The adoptive cell transfer model described in this paper can be used for at least two purposes: (i) to evaluate conjugate vaccines with different physicochemical properties for their ability to induce immunologic memory and (ii) to study the cellular interactions required for an immune response to these molecules.

Adoptive Transfer↗
PubMed2004

SHV-12-like extended-spectrum-beta-lactamase-producing strains of Salmonella enterica serotypes Babelsberg and Enteritidis isolated in France among infants adopted from Mali.

From December 2002 to June 2003, 14 cultures of Salmonella enterica serotype Babelsberg and 6 cultures of serotype Enteritidis, isolated in France from internationally adopted children, were identified at the French National Reference Center for Salmonella. All serotype Babelsberg isolates were related, as determined by pulsed-field gel electrophoresis, and all serotype Enteritidis strains displayed the same phage type. All serotype Enteritidis and seven serotype Babelsberg isolates produced an SHV-12-like extended-spectrum beta-lactamase as determined by sequencing of PCR products and by isoelectrofocusing. Some serotype Enteritidis isolates exhibited additional antimicrobial resistance (aminoglycosides, tetracycline, chloramphenicol, sulfonamides, and trimethoprim). Our investigation indicated that these Salmonella isolates were certainly acquired in the same orphanage in Bamako, Mali, before the children were adopted by French families. An inappropriate use of ceftriaxone was probably the cause of the emergence of such strains. There is an urgent need to determine the origin of the contamination and to introduce adequate antibiotic protocols into this orphanage to prevent further transmission and dissemination. Screening for infections and follow-up, adapted to the origin of the internationally adopted children, should be recommended.

Adoption↗
PubMed1997

Outcome in placements for adoption or long-term fostering.

OBJECTIVES: To describe a five year cohort of children whose placements for adoption or long-term (permanent) fostering were recommended by Newcastle upon Tyne Family Placement Panel and to determine the outcome of these placements. DESIGN: Retrospective total five year cohort study. Outcome data were extracted from records three to five years after placement. SETTING: Newcastle upon Tyne Social Services Adoption and Fostering Unit. SUBJECTS: All 234 permanent family placements recommended by the Family Placement Panel from 1 January 1986 to 31 December 1990. MAIN OUTCOME MEASURE: Disruption of the placement. RESULTS: A total of 20% of the placements had disrupted (2% of adoptive placements and 51% of long-term fostering placements). Disruption was generally associated with increased age at placement. Disruption was not associated with special needs, the sex of the child, previous disruption, or being placed with siblings. Forty four percent of children from disrupted placements returned to live with their birth families. CONCLUSION: In view of the poor outcome for older children, there is a case for more preventative work and also for more support after placement.

Adolescent↗