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Impact of neurocognitive function on academic difficulties in pediatric bipolar disorder: A clinical translation.

BACKGROUND: Previous research has demonstrated that academic and neuropsychological functions are compromised in pediatric bipolar disorder (PBD). Investigation of the degree to which neuropsychological deficits might contribute to those academic problems is needed to aid in the recognition and intervention for school achievement difficulties in PBD. METHODS: A sample of 55 children and adolescents with PBD with and without attention-deficit/hyperactivity disorder (ADHD) (PBD group, n = 28; PBD+ADHD group, n = 27) were tested with a computerized neurocognitive battery and standardized neuropsychological tests. Age range of subjects was 7-17 years, with the mean age of 11.97 (3.18) years. Parents completed a structured questionnaire on school and academic functioning. RESULTS: Logistic regression analyses indicated that executive function, attention, working memory, and verbal memory scores were poorer in those with a history of reading/writing difficulties. A separate logistic regression analysis found that attentional dysfunction predicted math difficulties. These relationships between neuropsychological function and academic difficulties were not different in those with PBD+ADHD than in those with PBD alone. CONCLUSIONS: In PBD neuropsychological deficits in the areas of attention, working memory, and organization/problem solving skills all contribute to academic difficulties. Early identification and intervention for these difficulties might help prevent lower academic achievement in PBD.

Adolescent↗

Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study.

BACKGROUND: Reduced lung function is a feature of chronic asthma, which becomes apparent at school age. Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life. METHODS: The German Multicentre Allergy Study followed 1314 children from birth to 13 years of age. We regularly interviewed parents about their child's asthma and measured IgE levels. Allergen exposure was assessed at age 6 months, 18 months, and at 3, 4, and 5 years; lung function was assessed at 7, 10, and 13 years; post-bronchodilator response at 10 and 13 years; and a bronchial histamine challenge was done at 7 years. RESULTS: 90% of children with wheeze but no atopy lost their symptoms at school age and retained normal lung function at puberty. By contrast, sensitisation to perennial allergens (eg, house dust mite, cat and dog hair) developing in the first 3 years of life was associated with a loss of lung function at school age. Concomitant exposure to high levels of perennial allergens early in life aggravated this process: forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio was 87.4 (SD 7.4) for those sensitised and with high exposure compared with 92.6 (6.0) for those not sensitised, p<0.0001; and maximal expiratory flow at 50% (MEF50) 86.4 (25.1) for sensitised and with high exposure compared with 101.5 (23.2; p=0.0031) for those not sensitised. Such exposure also enhanced the development of airway hyper-responsiveness in sensitised children with wheeze. Sensitisation and exposure later in life had much weaker effects and sensitisation to seasonal allergens did not play a part. INTERPRETATION: The chronic course of asthma characterised by airway hyper-responsiveness and impairment of lung function at school age is determined by continuing allergic airway inflammation beginning in the first 3 years of life. However, children with a non-atopic wheezing phenotype lose their symptoms over school age and retain normal lung function at puberty.

Adolescent↗

School children's perceptions of their families and parents as a function of peer relations.

Links were examined between three dimensions of peer relating at school among Australian children and selected family and parental background factors. Questionnaires containing measures of children's tendencies to bully others, to be victimized, and to act in a prosocial manner were administered to boys and girls (N = 1,012) aged 11 to 16 years. In addition, subjects completed a standardized 42-item measure of family functioning and reliable scales assessing attitudes toward, and relationships with, their mother and father. When differences in age were controlled for, multiple regression results for both boys and girls indicated that the tendency to bully peers and the tendency to act prosocially were independently predictive of family functioning and attitudes toward, and relationships with, each parent, negatively for bullying and positively for prosocial behavior. The tendency to be victimized by peers at school among girls was found to be associated with poorer family functioning and more negative attitudes toward mothers; negative relations with absent fathers in single-parent families characterized boys who reported being victimized at school.

Adolescent↗

Neurodevelopment of children with single suture craniosynostosis: a review.

INTRODUCTION: Rates of neurocognitive risk range from 35-50% of school-aged children with isolated single suture craniosynostosis (SSC). It has been hypothesized that early surgical intervention to release suture fusion reduces risk for increased intracranial pressure (ICP) and the corresponding risk to neurodevelopment. However, studies assessing children with SSC have been inconsistent in finding an association between neurocognitive development, age of surgery, and ICP. REVIEW: SSC produces notable distortion of the cranial vault and underlying brain mass. Although a linear relationship between skull distortion, ICP, and neurocognitive deficits has generally been assumed, recent studies have postulated an interactive process between the skull and developing brain that results in neuroanatomical changes that are not limited to areas directly beneath the fused suture. The specific neuropsychological deficits identified in children with SSC including problems with attention and planning, processing speed, visual spatial skills, language, reading, and spelling may be related to the anatomic differences that persist after correction of suture fusion. CONCLUSIONS: Available literature on neurocognitive development of children with SSC is suggestive of mild but persistent neuropsychological deficits, which become more significant as cognitive demands increase at school age. Anatomical studies of children without SSC are beginning to identify particular groups of brain structures that if disrupted or malformed, may be associated with specific cognitive deficits. Controlled research investigating the relationship between persistent anatomical changes and neurocognitive functioning of school-aged children with SSC is needed.

Adolescent↗

Neuropsychological effects of pediatric obstructive sleep apnea.

Obstructive sleep apnea (OSA) is a fairly common nocturnal breathing disorder, affecting 2-4% of individuals. Although OSA is associated with medical morbidity, its most functionally disruptive effects in adults appear to be neuropsychological in nature. Research on the neuropsychological effects of pediatric OSA has been limited. This study compared the neuropsychological functioning of school-aged children with OSA to that of healthy children. The primary goal was to clarify the presence and pattern of neuropsychological morbidity associated with pediatric OSA. Sleep was assessed with parent-report questionnaires and laboratory sleep studies. Neuropsychological functioning was assessed by formal tests and parent- and teacher-report questionnaires. Data indicated OSA-related cognitive and behavioral impairment that was particularly marked on measures of behavior regulation and some aspects of attention and executive functioning. Minimal effects were observed on measures of intelligence, verbal memory, or processing speed. Exploratory analyses failed to indicate any clear relationship between neuropsychological functioning and objective indexes of hypoxia or sleep disruption, though the sample was small. These data add to a growing literature which suggests that significant neuropsychological deficits are associated with pediatric OSA. Findings suggest a pattern of neuropsychological morbidity that is similar but not identical to that seen in adult OSA.

Attention↗

"Condom distribution in high school" -- a rebuttal.

To challenge the distribution of condoms on school campuses with accusations of immorality and "lack of good character" appears shallow at best. Considering the home situation of many young people and their immediate environment, the act of securing a condom could be totally consistent with "good character." Certainly, abstinence up to a certain stage in a youth's life is prudent, but who is to determine the age to which, and the environment in which, abstinence must be observed universally? The litany of virtues to which Gow refers (kindness, courtesy, the Golden Rule, and so forth) all could be attributed to the youth who obtains a condom at school and uses it in an effort to protect himself and his partner. Use of a condom even by a teenager is not an unvirtuous act. Gow refers to two "misguided assumptions." The first is that "it is the legitimate function of the schools to dispense contraceptives." He maintains that parents and physicians, not schools, constitute the proper source of medical information and medication. Granted, they are the most logical and desirable sources, but what if a student has incompetent or perhaps no parental guidance and has little if any access to a physician? Schools have acted in loco parentis ever since public education first evolved. Why should it stop now during a devastating health crisis? The second "misguided assumption"--that "teen sex and pregnancies result from ignorance"--happens to be true. Ignorance is a major cause of pregnancies and AIDS. Distribution of condoms on campuses will help to counteract ignorance because it leads to explanations and discussion, two essential components of education. I find no quarrel with Gow's call for reevaluation of values and methods of communication. His belief that institutions such as churches, families, social organizations, and so forth must assume a larger role in clarification of values is logical. But until that occurs, what institution other than a public school has a better chance to reach the greatest number of young people?

Americas↗

Spirometric findings among school-aged First Nations children on a reserve: a pilot study.

BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are increasing concerns for First Nations peoples in Canada. Although hospital utilization for asthma and COPD among First Nations peoples has been increasing, the prevalence of asthma or wheezing is comparable to national averages. OBJECTIVES: A pilot study was conducted to determine the prevalence of impaired lung function in school-aged First Nations children. PATIENTS AND METHODS: A First Nations community in northern Alberta was selected to participate. Consent forms and a school health survey were completed by parents or guardians. Children with consent completed spirometry at school, and results were compared with predicted values. RESULTS: A total of 36 children participated (response rate 70.6%). Of these, 19.4% of parents reported that their child had received a physician diagnosis of asthma at some point in their life; only 28.6% had a parental report of still having asthma. Parents smoked in 73.1% of the children's homes. The mean (+/- SD) percentage of forced expiratory volume in 1 s (FEV1) over forced vital capacity (FVC) was 82.6%+/-6.9% (94.4%+/-0.08% of predicted). Evidence of airflow obstruction was found in 25% of the children. Parental report of the child ever having asthma was associated with impaired lung function (OR 3.20; P=0.033). Children in a home with reported mold exposure were less likely to have impaired lung function (OR 0.68; P=0.030). CONCLUSIONS: Many children in this study already have established airflow obstruction and may be at increased risk for asthma or COPD. Exposure to mold appeared to be protective. Further research is needed to evaluate the lung health concerns of this population.

Alberta↗

Measuring symptoms and functioning of youth with ADHD in middle schools.

The identification of reliable and valid means for evaluating the effectiveness of school-based treatments and completing diagnostic evaluations of middle school aged students are needed. The present study examined the inter-rater agreement of teacher ratings and the relationship between ratings and observational data in a middle school setting. The data are interpreted in the context of differences between a secondary and elementary school setting. Teacher ratings and observational data were collected regularly over the course of two academic years for middle school students diagnosed with ADHD. The results indicate low rates of inter-rater agreement as well as low rates of agreement between teachers and observational data, and between observational data collected in different classrooms. Inter-rater agreement was lowest in late fall and gradually increased over the second half of the year. Implications for conducting treatment outcome evaluations of school-based treatment programs and diagnostic evaluations are discussed.

Adolescent↗

Racial attitudes in young children as a function of interracial contact in the public schools.

The relative effects of integrated and segregated schooling on racial attitudes were studied in a comparison of young children attending all-black, all-white, and integrated schools. Results of this photo-choice study suggest that segregated classes discourage realistic perceptions of the excluded race and promote a preference for whites among whites and blacks, whereas interracial schooling contributes to acceptance of blacks by all students and has especially profound and complex effects on black children.

Black or African American↗

The school nurse's role: early intervention with preschool children.

With the advent of PL99-457, preschoolers are increasingly appearing in the educational system. The school nurse must have an understanding of the basis for early entrance of these children and methods by which they obtain entry. This article focuses on the diagnosis of developmental delay in preschool children and identifies some of the specific roles and functions involving the school nurse.

Child, Preschool↗