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Results for “developmental disorders”

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At least 811 records · Page 45Linked to original sources
PubMed2001

[Development and developmental disorders of the human brain. II. Development of the cerebral cortex and major tract systems].

In the development of the cerebral cortex, two phases can be distinguished: (a) the formation of the preplate, a superficial layer essential for a normal lamination of the cerebral cortex; (b) the formation of the cortical plate. The cortical plate divides the preplate into a superficial marginal zone (the future layer I) and the subplate. The transient subplate is important for the formation of thalamocortical projections. Most cortical neurons arise in the ventricular zone of the pallium and migrate along radial glial cells (radial migration) to the cortical plate. The gamma-aminobutyric acid (GABA)ergic cortical interneurons, however, originate from the ganglionic eminences and reach the cerebral cortex through tangential migration.

Brain↗
PubMed2001

[Development and developmental disorders of the human brain. III. Neuronal migration disorders of the cerebrum].

Neuronal migration disorders of the cerebral cortex form a heterogeneous group of abnormalities, characterised by mental retardation, epilepsy and hypotonia. They are prevalent in 1% of the population and in 20-40% of the untreatable forms of epilepsy. Disorders at the start of the migration result in nodular heterotopias. Bilateral periventricular nodular heterotopias are X-linked disorders, in which cortical neurons are unable to leave their position at the ventricular surface due to the absence of filamin 1. The large group of lissencephalies can be divided into a number of syndromes, each of which is characterised by a gene mutation (LIS1, DCX, RELN). These mutations result in agyria and pachygyria, which are characteristic for this group. A number of these abnormalities, especially the smaller nodular heterotopias and focal cortical dysplasia, may be treated by neurosurgical excision.

Cell Movement↗
PubMed2001

Genetics of central nervous system developmental disorders.

The construction of the nervous system is regulated by genetic and environmental factors. In this article, we have highlighted some of the important molecules and genes that contribute to early stages of CNS development. Future research in the neurosciences will address how genetic and environmental factors interact with each other during brain development and in the mature nervous system.

Adolescent↗
PubMedDate not supplied

[Occupational factors of intrauterine fetal developmental disorders by the ecological areas of Dagestan].

The paper assesses the epidemiology of retarded intrauterine development (RIUD) of a fetus by the ecological areas of the Republic of Daghestan. There is a positive and significant correlation of fetal RIUD with regional load an assortmental index of pesticides in the foothill and low areas and an inverse significant correlation with the standards of living in the mountainous districts of the Republic of Daghestan.

Adult↗
PubMed1992

The need for long-term multicenter treatment assessment of craniofacial developmental disorders including cleft lip and palate.

There has been an increase of interest in recent years in comparing treatment outcome in patients with craniofacial anomalies, including cleft lip and palate. When a treatment result is to be evaluated, it is important that it is multifaceted, taking all aspects into account. A comparison between treatment outcome in six centers showed that those with simple procedures and few surgeons involved in the primary operations had as good treatment results as those with more complicated treatment procedures. The center that used presurgical orthopedics with extraoral strapping in its treatment program ranked low as did the center employing primary bone grafting as part of the treatment program when compared with the other centers.

Cleft Lip↗