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Visual acuity in an Australian aboriginal population.

BACKGROUND: Australia is a developed country. However, Aboriginal Australians have rates of blindness comparable to Third World countries. There have been well-funded eye health programs for 15 years in Central Australia. This paper examines if there has been an improvement in visual disability of one traditional group of Aboriginal Australians. METHODS: Results from an eye health survey of the Anangu Pitjantjatjara of South Australia in 1990 are presented. These data are compared with results for 'blindness' and 'poor vision' from a national survey undertaken in 1976. The two surveys were comparable in design, both were cross-sectional population-based prevalence surveys. Prevalence rates were adjusted for the size of the source population. RESULTS: Young rural Aboriginal Australians have good visual acuity. Low vision and blindness (WHO definitions) occur in 19.6% and 10.4% of 60+ year olds, respectively. Women were more likely than men to be blind or have low vision (OR = 1.93; 1.06-3.58). There was a decline in 'poor vision' between surveys (OR = 2.86; 1.86-4.75) but not in 'blindness'. CONCLUSION: Although there has been a reduction in the prevalence of visual disability in rural Aboriginal Australians, improvements in the provision of eye care for the elderly need to occur.

Adolescent↗

The rarity of Charles Bonnet syndrome.

Charles Bonnet syndrome (CBS) is characterized by complex visual hallucinations in otherwise psychologically normal people. Estimates of the prevalence of CBS in different samples vary from a small percentage (around 1%), to a relatively large percentage (about 10%). The purpose of the present study is to determine whether CBS is rare or not. One-thousand ophthalmologic and optometric outpatients at a university hospital were consecutively screened by a questionnaire to identify patients possibly experiencing visual hallucinations. The mean corrected visual acuity in the best eye was 1.1. Those who positively responded to the questionnaire were further investigated to determine whether their symptoms were consistent with CBS. As a result, the prevalence of CBS was 0.5% (5/1000). In subclass analyses, the prevalence was 3 of 372 (0.8%) in the low vision group, 2 of 346 (0.6%) in the elderly, and 1 of 120 (0.8%) in both conditions. These were not significantly different from each other or from the overall prevalence (0.5%). This low prevalence of CBS in our subjects may be due to their relatively good visual acuity because previous studies with high prevalence of CBS investigated patients with a visual acuity of less than 0.3. The prevalence of CBS may be low in patients with these particular characteristics, and this syndrome seems to be rare in even ophthalmologic and optometric patients if they do not have seriously low vision. Further studies are needed to investigate the prevalence of CBS in general population.

Adult↗

Role of the optometrist in age-related maculopathy.

The increasing aging segment of our population presents both a challenge and an opportunity for optometry. The challenge is to provide sufficient manpower skilled in the problems of the aging and to assure participation in any therapeutic program. The opportunity is to help those with maculopathy to achieve the required visual performance. This entails prevention measures, detection diagnosis, and referral for medical care when indicated. When medical therapy is not helpful, the optometrist employs low vision techniques to surmount the visual handicaps to achieve visual performance commensurate with lifestyle needs. A discussion of retinal performance to aid in understanding age-related maculopathy (ARM) is presented. Similarly, the various low vision techniques used to aid the patient with ARM are considered.

Aged↗

New low-contrast vision charts: reliability and test characteristics in patients with multiple sclerosis.

The quantitative assessment of visual function in multiple sclerosis (MS) clinical trials has been limited to Snellen visual acuity. The purpose of this study was to examine the inter-rater reliability and test characteristics of a new visual outcome measure, the Low-Contrast Sloan Letter Charts, in patients with MS and visually-asymptomatic volunteers. Contrast letter acuity scores (letter scores) were measured at each of four contrast levels (100, 5, 1.25 and 0.6%) by two independent raters. Inter-rater agreement was described with the intraclass correlation coefficient (ICC) and comparison of mean scores. Excellent inter-rater agreement (ICC=0.86 - 0.95) was demonstrated at each contrast level among MS patients (n=100) and visually-asymptomatic volunteers (n=33). Average letter scores at the lowest contrast level (0.6%) were highly variable in the MS group, even among patients with visual acuities of 20/20 or better, and among those who required no assistance for ambulation. Low-Contrast Sloan Letter Chart testing is a highly reliable method of visual assessment, and provides information on an aspect of neurologic impairment in MS which is not captured by Snellen visual acuity or ambulation status. This new method demonstrates excellent potential as a visual function outcome measure for future MS clinical trials.

Adolescent↗

Computer-based measurement of letter and word acuity.

Determining causes of poor reading ability is an important step in trying to ameliorate reading performance in low-vision patients. One important parameter is word acuity. The principal aim of the current study is to develop a method to reliably measure acuities for isolated lowercase letters and words of differing length that can be used to test low-vision patients. Using isolated stimuli means that testing is relatively free of potential crowding and/or distracting attentional effects from surrounding words, it is unambiguous which stimulus subjects are trying to read and response times can be recorded for each stimulus. Across a series of experiments, subjects with normal vision were asked to read isolated lowercase single letters and lowercase words of 4, 7 and 10 letters, in separate tests. Acuities for uppercase Sloan letters were also measured to provide a reference, as they are commonly used to measure visual acuity. Each test was based upon the design principles and scoring procedures used in the Bailey-Lovie and ETDRS charts. Acuities for uppercase Sloan letters were found to be equivalent whether measured using ETDRS charts or the computer-based method. Measurement of acuities for lowercase single letters and lowercase words of 4, 7 and 10 letters had a reliability that was no worse than acuities for uppercase Sloan letters. Lowercase word acuities were essentially independent of word length. Acuities for single lowercase letters and lowercase words were slightly better than uppercase Sloan letters acuity. Optimal processing of lowercase single letters and 4-, 7- and 10-letter words occurred at character sizes that were at least 0.2-0.40 log MAR above acuity threshold, i.e. between 1.5 and 3 times threshold acuity for that particular stimulus. In general, critical character sizes appear similar across word lengths as progressive increases or decreases in these values were not observed as a function of the number of letters in the stimulus. We conclude that a computer-based method of stimulus presentation can be used to obtain highly repeatable measures of acuity for lowercase single letters and lowercase words in normal vision.

Adult↗

The effect of relative distance enlargement on visual acuity in the visually impaired.

BACKGROUND: Prescribing magnification is typically based on distance or near visual acuity. This presumes a constant minimum angle of visual resolution with working distance and therefore enlargement of an object moved to a shorter working distance (relative distance enlargement). This study examines this premise in a visually impaired population. METHODS: Distance letter visual acuity was measured prospectively for 380 low vision patients (distance visual acuity between 0.3 and 2.1 logMAR) over the age of 57 years, along with near word visual acuity at an appropriate distance for near lens additions from +4 D to +20 D. Demographic information, the disease causing low vision, contrast sensitivity, visual field and psychological status were also recorded. RESULTS: Distance letter acuity was significantly related to (r = 0.84) but on average 0.1 +/- 0.2 logMAR better (1 +/- 2 lines on a logMAR chart) than near word acuity at 25 cm with a +4 D lens addition. In 39.8 per cent of patients, near word acuity was more than 0.1 logMAR worse than distance letter acuity. In 11.0 per cent of subjects, near visual acuity was more than 0.1 logMAR better than distance letter acuity. The group with near word acuity worse than distance letter acuity also had lower contrast sensitivity. The group with near word acuity better than distance letter acuity was less likely to have age-related macular degeneration. Smaller print size could be read by reducing working distance (achieved by using higher near lens additions) in 86.1 per cent, although not by as much as predicted by geometric progression in 14.5 per cent. DISCUSSION: Although distance letter and near word acuity are highly related, they are on average 1 logMAR line different and this varies significantly between individuals. Near word acuity did not increase linearly with relative distance enlargement in approximately one in seven visually impaired, suggesting that the measurement of visual resolution over a range of working distances will assist appropriate prescribing of magnification aids.

Aged↗

Longitudinal analysis of the relationship between regular eye examinations and changes in visual and functional status.

OBJECTIVES: To determine whether regular eye examinations are associated with a greater or lesser rate of loss of ability to read newsprint, onset of blindness or low vision, or onset of limitations in instrumental activities of daily living (IADLs) and activities of daily living (ADLs). DESIGN: A sample of 14,215 Medicare beneficiaries observed between 1994 and 1999 linked to the 1994 and 1999 National Long-Term Care Surveys (NLTCS). Effects of annual examinations were assessed using instrumental variables. SETTING: The Medicare-linked NLTCS is representative of U.S. elderly persons from 1994 to 1999. PARTICIPANTS: Longitudinal observational study of persons aged 65 and older. MEASUREMENTS: Change in self-reported and provider-reported vision and change in functional limitations associated with vision related to the number of years with eye examinations and other factors. RESULTS: Persons with more-regular eye examinations between 1994 and 1998 were less likely to have experienced a decline in vision or in functional status between 1994 and 1999. On average, an additional year with an eye examination was associated with a decrease in the probability of becoming unable to read newsprint of 0.12 (P=.03), a lower probability of onset of low vision or blindness of 0.009 (P=.06), and a decrease in the probability that the number of functional limitations increased of 0.13 (P=.002) for IADLs and 0.05 (P=.003) for ADLs. CONCLUSION: Elderly persons who have regular eye examinations experience less decline in vision and functional status.

Activities of Daily Living↗

Visual acuity in a population aged 70 years or older; prevalence and causes of visual impairment.

Visual acuity and the prevalence and causes of impaired vision were studied in an epidemiological cross-sectional population study of inhabitants aged 70 years or older in three communities in the county of Oulu, Finland. 500 of the 560 eligible persons (89.3%) were examined. Information on visual acuity was obtained for 476 co-operative persons (85.0%). 59.0% had a visual acuity of 0.3-0.6 in the better eye. 10.1% (48 persons) had low vision and 1.9% (9 persons) were blind as categorized according to the classification of visual impairment by the World Health Organization. Experienced visual capacity did not, however, always correspond to objective tests. Age-related maculopathy and cataract were the leading causes of visual deterioration. Age-related maculopathy was the main cause of low vision and blindness in 4.6% of the population. In 1.3% the etiology was cataract, and in 2.1% both early age-related maculopathy and cataract were present without obvious dominance. Cataract was often associated with other conditions. Glaucoma was considered the main cause of visual deterioration in 1.5%, diabetic maculopathy in 0.6% and macula pucker in 0.4%. In 1.5% the visual deterioration was due to other causes.

Aged↗

Causes and prevalence of non-vision impairing ocular conditions among a rural adult population in sw Uganda.

Information is scanty about the extent of ocular morbidity in developing countries, particularly for non-vision impairing conditions (NVIC), although these constitute the majority of consultations in eye clinics. We have conducted a survey to determine the prevalence and causes of NVIC in a Ugandan adult population and compared our findings with the work pattern of the district hospital. Adults were screened using Snellen's illiterate E chart and those found with visual impairment (acuity less than 6/18) in either eye were referred to a low-vision clinic, and those with obvious ocular disease or symptoms, but without visual impairment, to an outreach clinic. A total of 2886 (53%) out of 5479 adults were screened. Of these, 257 (8.9%) were referred to the outreach clinic, of whom 173 (67%) attended. Of those attending the low-vision clinic 83% had visual impairment confirmed, and 92% of those attending the outreach clinic were confirmed not to have visual impairment. The four commonest NVIC observed at the outreach clinic were: presbyopia (48%), allergic conjunctivitis (20%), early cataract (9%) and infective conjunctivitis (8%), the same conditions as those most commonly seen at the district hospital. In this community, over 80% of NVIC are caused by four conditions which are potentially either correctable, operable or treatable. Training health workers to recognise and treat these conditions would serve the great majority of eye patients. Hospital activity data can be used cautiously to assess the relative frequency of NVIC in the community.

Adolescent↗

Changing pattern of childhood blindness in Maharashtra, India.

AIM: To determine the causes of severe visual impairment and blindness in children in schools for the blind in Maharashtra, India. METHODS: Children aged <16 years with a visual acuity of <6/60 in the better eye, attending 35 schools for the blind were examined between 2002 and 2005, and causes were classified using the World Health Organization's system. RESULTS: 1985 students were examined, 1778 of whom fulfilled the eligibility criteria. The major causes of visual loss were congenital anomalies (microphthalmos or anophthalmos; 735, 41.3%), corneal conditions (mainly scarring; 395, 22.2%), cataract or aphakia (n = 107, 6%), and retinal disorders (mainly dystrophies; n = 199, 11.2%). More than one third of children (34.5%) were blind from conditions which could have been prevented or treated, 139 of whom were referred for surgery. Low vision devices improved near-acuity in 79 (4.4%) children, and 72 (4%) benefited from refraction. No variation in causes by sex or region was observed. CONCLUSIONS: Congenital anomalies accounted for 41% of blindness, which is higher than in a similar study conducted 10 years ago. Corneal scarring seems to be declining in importance, low vision and optical services need to be improved, and research is needed to determine the aetiology of congenital anomalies.

Adolescent↗

Face recognition in age related macular degeneration: perceived disability, measured disability, and performance with a bioptic device.

AIMS: (1) To explore the relation between performance on tasks of familiar face recognition (FFR) and face expression difference discrimination (FED) with both perceived disability in face recognition and clinical measures of visual function in subjects with age related macular degeneration (AMD). (2) To quantify the gain in performance for face recognition tasks when subjects use a bioptic telescopic low vision device. METHODS: 30 subjects with AMD (age range 66-90 years; visual acuity 0.4-1.4 logMAR) were recruited for the study. Perceived (self rated) disability in face recognition was assessed by an eight item questionnaire covering a range of issues relating to face recognition. Visual functions measured were distance visual acuity (ETDRS logMAR charts), continuous text reading acuity (MNRead charts), contrast sensitivity (Pelli-Robson chart), and colour vision (large panel D-15). In the FFR task, images of famous people had to be identified. FED was assessed by a forced choice test where subjects had to decide which one of four images showed a different facial expression. These tasks were repeated with subjects using a bioptic device. RESULTS: Overall perceived disability in face recognition did not correlate with performance on either task, although a specific item on difficulty recognising familiar faces did correlate with FFR (r = 0.49, p<0.05). FFR performance was most closely related to distance acuity (r = -0.69, p<0.001), while FED performance was most closely related to continuous text reading acuity (r = -0.79, p<0.001). In multiple regression, neither contrast sensitivity nor colour vision significantly increased the explained variance. When using a bioptic telescope, FFR performance improved in 86% of subjects (median gain = 49%; p<0.001), while FED performance increased in 79% of subjects (median gain = 50%; p<0.01). CONCLUSION: Distance and reading visual acuity are closely associated with measured task performance in FFR and FED. A bioptic low vision device can offer a significant improvement in performance for face recognition tasks, and may be useful in reducing the handicap associated with this disability. There is, however, little evidence for a correlation between self rated difficulty in face recognition and measured performance for either task. Further work is needed to explore the complex relation between the perception of disability and measured performance.

Aged↗

Local edge detectors: a substrate for fine spatial vision at low temporal frequencies in rabbit retina.

Visual acuity is limited by the size and density of the smallest retinal ganglion cells, which correspond to the midget ganglion cells in primate retina and the beta-ganglion cells in cat retina, both of which have concentric receptive fields that respond at either light-On or light-Off. In contrast, the smallest ganglion cells in the rabbit retina are the local edge detectors (LEDs), which respond to spot illumination at both light-On and light-Off. However, the LEDs do not predominate in the rabbit retina and the question arises, what role do they play in fine spatial vision? We studied the morphology and physiology of LEDs in the isolated rabbit retina and examined how their response properties are shaped by the excitatory and inhibitory inputs. Although the LEDs comprise only approximately 15% of the ganglion cells, neighboring LEDs are separated by 30-40 microm on the visual streak, which is sufficient to account for the grating acuity of the rabbit. The spatial and temporal receptive-field properties of LEDs are generated by distinct inhibitory mechanisms. The strong inhibitory surround acts presynaptically to suppress both the excitation and the inhibition elicited by center stimulation. The temporal properties, characterized by sluggish onset, sustained firing, and low bandwidth, are mediated by the temporal properties of the bipolar cells and by postsynaptic interactions between the excitatory and inhibitory inputs. We propose that the LEDs signal fine spatial detail during visual fixation, when high temporal frequencies are minimal.

Action Potentials↗

Dietary deficiency of docosahexaenoic acid impairs vision at low light intensities in juvenile herring (Clupea harengus L.).

In the retina of herring (Clupea harengus L.), rods are recruited from about 8 wk after hatching, and from this time there is a linear relationship between the number of rods in the photoreceptor cell population and the content of di22:6n-3 molecular species of phospholipids. Juvenile herring were reared from four weeks' post-hatching for 15 wk on either Artemia nauplii deficient in 22:6n-3 or on enriched Artemia nauplii containing 4.3% 22:6n-3. The visual performance of the fish was then determined at three light intensities (0.01, 0.1, and 1.0 lux) by observing their frequency of striking at live Artemia nauplii using infrared video recording. Herring reared on the diet containing no 22:6n-3 were less active predators, especially at the lowest light intensity where very few strikes were observed. The eyes of these fish contained greatly reduced levels of di22:6n-3 molecular species of total phospholipid, 2.1% vs. 12.0% in fish supplemented with 22:6n-3. The contribution of saturated and monounsaturated fatty acids in the molecular species of phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) was virtually unchanged, while 20:5n-3 and 22:5n-3 largely replaced 22:6n-3. There was an almost complete disappearance of di22:6n-3 PC, while the amounts of di22:6n-3 PE and PS fell by 18.1 and 20.6% to 2.7 and 7.6%, respectively. The dipolyunsaturated molecular species di20:5n-3, 20:5n-3/22:5n-3, and di22:5n-3 made up a substantial part of the deficit. We conclude that a dietary deficiency of 22:6n-3 during the period early in rod development impairs visual performance such that the fish can no longer feed at low light intensities.

Animals↗

Causes of visual disability in children and young adults.

PURPOSE: Blindness and visual disability is a great problem all over the world. Loss of visual acuity in children requires special attention. The aim of the study was to determine the causes of uni- and bilateral low vision in children and young adults. Patients were from our clinic and from the School for the Blind and Visually Impaired in Lodz. MATERIAL AND METHODS: The study group included 271 patients aged from 3 months to 21 years, visually disabled and with uniocular reduction of visual acuity to 25% or less. RESULTS: The commonest cause of low visual acuity in the group was optic nerve atrophy (22%) due to perinatal hypoxia. Other important causes were retinopathy of prematurity (17%) and congenital abnormalities of the eye globe (11%). The main causes of uniocular low vision were anisometropia and strabismus. CONCLUSIONS: The main cause of visual impairment and disability in the study group from our region was optic nerve atrophy. Retinopathy of prematurity was also frequently seen in the handicapped children and was responsible for severe visual loss. Anisometropia and strabismus were predominant causes of uniocular visual deterioration, but not of visual disability.

Adolescent↗

Improved reading performance using individualized compensation filters for observers with losses in central vision.

By boosting the amplitudes of the intermediate spatial frequencies more than the amplitude of the lower spatial frequencies, reading performance improved significantly when observers with losses in central vision read words that were filtered. Words that were filtered using an image enhancement function based on an observer's losses in visual function relative to a normal observer (1) reduced the magnification (30-70% less magnification was needed) and (2) increased the reading rate (2-3 times), measured in words per minute. The greater the loss in central visual function, the more individualized compensation filters reduced the magnification needed for word recognition. Individualized compensation filters improved the clarity and visibility of words for low vision observers. This study also found that the shape of the enhancement function was important to determine the optimum compensation filter for improving reading performance. In addition, the individualized compensation filters can be implemented by inexpensive hardware, for example in a closed circuit television (CCTV), to provide a significantly more effective low vision aid for observers with losses in central vision to read text, than is provided using only magnification.

Adult↗

Psychometric properties of the National Eye Institute Visual Function Questionnaire (NEI-VFQ). NEI-VFQ Field Test Investigators.

OBJECTIVE: To test the reliability and validity of the 51-item Field Test Version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ) across 5 common chronic eye conditions. DESIGN: Prospective observational cohort study of persons with 1 of 5 chronic eye diseases who were scheduled for nonurgent visits in ophthalmology practices or had low vision from any cause, and a reference sample of persons without eye disease. SETTING: Six university-based ophthalmology practices and the National Eye Institute Clinical Center, Bethesda, Md. PATIENTS: Eligible participants had to have 1 of the following eye conditions: age-related cataracts, age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, cytomegalovirus retinitis, or low vision from any cause. Each of the 7 sites also enrolled persons in a reference sample. Reference sample participants had no evidence of underlying eye disease but were scheduled for either screening eye examinations or correction of refractive error. All eligible persons had to be aged 21 years or older, English speaking, and cognitively able to give informed consent and participate in a health status interview. MEASUREMENTS AND MAIN RESULTS: To provide the data needed to assess the reliability and validity of the 51-item NEI-VFQ, all subjects completed an interview that consisted of the 51-item NEI-VFQ, the Medical Outcomes Study 36-Item Short-Form Health Survey, and at least 1 measure of vision-targeted functional status. Estimates of internal consistency and test-retest reproducibility indicate that the 51-item NEI-VFQ is reliable. Tests of association with other scales and clinical variables support the construct validity of the survey. CONCLUSIONS: In this cross-sectional study, the 51-item NEI-VFQ seems to be reliable and valid and should be a useful tool for group-level comparisons of vision-targeted, health-related quality of life in clinical research. Additionally, the psychometric properties of the NEI-VFQ were not influenced by the type or severity of the underlying eye disease, suggesting that the measure will provide reproducible and valid data when used across multiple eye conditions.

Activities of Daily Living↗

Pattern of eye diseases in children of 5-15 years at Bazzertaline Area (South Karachi) Pakistan.

OBJECTIVE: To assess the prevalence and pattern of eye diseases in children aged 5-15 years. DESIGN: Population based cross-sectional survey. PLACE AND DURATION OF STUDY: Bazzertaline area of Karachi (South) from July to August, 2003. PATIENTS AND METHODS: A community-based survey was carried out at the Bazzertaline Area, South Karachi, Pakistan on 5110 children 5-15 years of age. The socioeconomic status of the area was low, with many living below the poverty line. The survey used the WHO definitions of visual impairment as criteria for classification. Standard Snell's literate and illiterate charts were used for assessing the visual acuity. An anterior segment examination with a torch light and loupe was carried out and the posterior segment examined with a direct ophthalmoscope, initially without pupil dilation. Suspected cases of amblyopia, albinism, traumatic cataract and squint, etc. were examined with pupil dilatation. RESULTS: Refractive error of 2% was found to be the primary ocular morbidity, followed by conjunctivitis 1.2%, and squint was found as third ocular morbidity with the prevalence of 0.6%. Those diseases that were less than 0.5% included unilateral amblyopia, corneal ulcer/opacity, cataract, aphakia, trauma, blepharitis, albinism, stye, chalazion and unilateral/bilateral blindness. Bilateral blindness was present in 2.7/1000 children, the major causes being cataract and corneal diseases. Low vision was found in 2.2%, the leading cause being uncorrected refractive error. Visual acuity according to 2.42%. Gender showed higher visual impairment in girls as compared to boys 1.72%. Only one case of vitamin-A deficiency was seen. CONCLUSION: Provision of spectacles would address the most commonly found problem of uncorrected refractive error. Lack of trained personnel and facilities for low vision services in addition to lack of advocacy and awareness in the community contribute to the pattern of eye disease in the area.

Adolescent↗

Screening for hearing and visual loss among elderly with questionnaires and tests: which method is the most convincing for action?

OBJECTIVE: To examine the extent to which self-report and performance-based measures identify the same people, and also whether one of these methods any more than the other induces the general practitioner (GP) to offer a patient help? DESIGN: Comparison of tests and questionnaire in a screening programme for hearing and visual loss. SETTING: Twelve general practices in the western part of The Netherlands. PATIENTS: 1121 people 75 years of age and older. MAIN OUTCOME MEASURES: Hearing loss according to the whispered voice test and two questions (Q1, Q2) and visual loss according to the Snellen and low vision charts and two questions (Q3, Q4). The extent to which test and questions influence the GP's judgment regarding intervention is calculated using logistic regression. RESULTS: For hearing loss, the concordance of the whispered voice test with Q1 was 67%, and with Q2, 71%. For visual loss, the concordance of the Snellen chart with Q3 was 79% and of the Low Vision Chart with Q4, 69%. For hearing loss, the results of the test were noticeably more significant for the GP in offering help than the answers to the questions, and for visual loss the results of the Snellen chart slightly more convincing than the answers to the questions. CONCLUSION: When in a screening programme with simple instruments for visual and hearing loss the choice has to be made between questionnaire and tests, the tests will be the best choice.

Aged↗