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Results for “VIRAL INTERFERENCE”

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At least 811 records · Page 45Linked to original sources
PubMed2005

Host-based antipoxvirus therapeutic strategies: turning the tables.

The potential threat of the smallpox virus as a bioterror weapon has long been recognized, and the need for developing suitable countermeasures has become especially acute following the events of September 2001. Traditional antiviral agents interfere with viral proteins or functions. In a new study, Yang et al. focus instead on host cellular pathways used by the virus. A drug that interferes with the cellular ErbB-1 signal transduction pathway, activated by smallpox growth factor, sheds new light on how the virus replicates in the cell. Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents.

Biological Warfare↗
PubMedDate not supplied

[Synthesis of virus-specific RNA under conditions of homologous and heterologous interference by Newcastle disease virus].

Homologous and heterologous interference by Newcastle disease virus (NDV) was manifested in a marked inhibition of virus-specific RNA synthesis of both the interacting viruses. Inactivation of the interfering NDV by irradiation reduced its capacity to inhibit the synthesis of virus-specific RNA of the homologous virus, leaving its effect on the synthesis of RNA of the heterologous virus unchanged. In contrast, treatment of cell cultures with heparin leading to reduced interferon production eliminated the heterologous interference but did not affect the homologous interference.

Animals↗
PubMed1994

Specific binding of herpes simplex virus type 1 (HSV-1) strain HSZP to host cell surface can provoke interference with early shutoff of host protein synthesis induced by HSV-1 strain KOS.

The HSZP strain of herpes simplex virus type 1 (HSV-1) is defective with respect to the early shutoff of host protein synthesis but is effective at interfering with the early shutoff function of the HSV-1 KOS strain, even when heat-inactivated or neutralized by antibody. The interference was not due to exclusion of strain KOS by HSZP at the level of adsorption or penetration. The component responsible for the interference is an integral part of HSZP virions. Strain HSZP inactivated with zinc ions failed to interfere with the early shutoff function of the superinfecting strain KOS. The same effect was also found with strain HSZP purified from cells treated with 2-deoxy-D-glucose. This finding supports the idea that a specific interaction between HSZP virions and the cell surface can be responsible for the interference phenomenon.

Animals↗