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At least 811 records · Page 45Linked to original sources
PubMed1981

Carotid-artery rupture as a late effect of Thorotrast angiography.

Thorotrast, a contrast medium containing radioactive thorium, was in use in the period 1930 to 1945. It is retained in the body after use, with harmful effects, including the induction of malignancies. Accidental, extravasal injection during carotid angiography results in cervical granulomas with progressive, local damage. A case is reported in which lesions of the vagus, glossopharyngeal, hypoglossal and facial nerves have developed over a 40-year period after carotid angiography. A limited removal of the injected Thorotrast was carried out and, in the postoperative period, rupture of the arterial wall necessitated ligation of the common carotid artery. No additional complications arose from this. The therapeutic implications are discussed

Angiography↗
PubMed1977

Thorotrast-induced renal tumours after retrograde pyelogram.

Seven cases of 'thorotrast kidney' after retrograde pyelogram with reflux are dealt with. In five instances cancer of the kidney developed, four of them obvious renal pelvic carcinoma between 14 and 41 years after the thorotrast pyelogram. In some cases the contrast deposits were misinterpreted and in one case the follow-up was also inadequate. There is a high risk of malignancy to connection with 'thorotrast kidneys'. These cases should be follewed up with intravenous pyelogram and exfoliative cytology from renal pelvis. Provided these tests are negative, nephro-ureterectomy should be put off.

Adenocarcinoma↗
PubMed2003

Raman scattering investigations of nanocrystalline thorium oxide.

Raman scattering investigations are carried out on nanocrystalline thorium oxide powders. Shift and broadening of the Raman peak associated with F2g phonons are observed for the nanocrystalline samples as compared with those of the bulk. The peak shift and broadening are found to increase further as the particle size decreases. A quantitative analysis of the Raman line shape is carried out with a Gaussian confinement model, and the estimated size is found to be consistent with that obtained from X-ray diffraction and transmission electron microscopy.

Crystallization↗
PubMedDate not supplied

Thorotrast induced pharyngeal necrosis.

Thorotrast, a radioactive contrast material used between 1930 and 1950, is often permanently retained within the patient. Individuals who have had diagnostic studies with Thorotrast may develop serious complications many years later. These complications fall into two major categories, desmoplastic and neoplastic. The inadvertent infiltration of Thorotrast into soft tissue, usually the neck during carotid arteriography, may later result in severe fibrosis with constriction of the surrounding vessels and nerves. Malignancies, the second major problem, have occurred at the site of previous Thorotrast instillations throughout the body. The following report describes the clinical course of an 82-year-old woman who presented with a Thorotrast induced desmoplastic reaction of her neck, complicated by pharyngeal necrosis and the development of a pharyngeal cutaneous fistula. The latter problem is quite rare, having been previously reported only once. Despite extensive tissue destruction conservative management prevailed. Repetitive debridement, controlling the intermittent infections, maintaining her nutritional status, and relieving her pain allowed spontaneous healing to occur.

Aged↗